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  1. Article ; Online: ASH Guideline Oversight Subcommittee Response to Jacobs et al. (Industry Payments to ASH Guideline Panelists).

    Pai, Menaka / Byrne, Michael T / Cuker, Adam / Djulbegovic, Benjamin / George, James N / Seftel, Matthew D / Terrell, Deirdra R / Kunkle, Robert / Cheung, Matthew C

    Blood advances

    2024  

    Language English
    Publishing date 2024-05-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2915908-8
    ISSN 2473-9537 ; 2473-9529
    ISSN (online) 2473-9537
    ISSN 2473-9529
    DOI 10.1182/bloodadvances.2024013293
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    Zs.A 7153: Show issues Location:
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  2. Article ; Online: Where Are They Now: Spatial and Molecular Diversity of Tissue-Resident Macrophages in the Kidney.

    Cheung, Matthew D / Agarwal, Anupam / George, James F

    Seminars in nephrology

    2022  Volume 42, Issue 3, Page(s) 151276

    Abstract: Kidney resident macrophages (KRMs) are involved in homeostasis, phagocytosis, defense against infectious agents, response to insults, inflammation, and tissue repair. They also play critical roles in the pathogenesis and recovery from many kidney ... ...

    Abstract Kidney resident macrophages (KRMs) are involved in homeostasis, phagocytosis, defense against infectious agents, response to insults, inflammation, and tissue repair. They also play critical roles in the pathogenesis and recovery from many kidney diseases such as acute kidney injury. KRMs historically have been studied as one homogenous population, but the wide-ranging roles and phenotypes observed suggest that there is greater heterogeneity than previously understood. Advancements in RNA sequencing technologies (single-cell RNA sequencing and spatial transcriptomics) have identified specific subsets of KRMs that are molecularly, functionally, and spatially distinct with dynamic changes after kidney injury. Multiple studies have identified unique markers that represent these subpopulations, permitting further characterization of the function and roles they play in the kidney. Understanding the diversity of KRM subpopulations will be key in the development of novel therapies used in treating kidney diseases and promoting kidney health.
    MeSH term(s) Humans ; Macrophages ; Kidney/pathology ; Acute Kidney Injury/pathology ; Inflammation ; Phenotype
    Language English
    Publishing date 2022-11-24
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 604652-6
    ISSN 1558-4488 ; 0270-9295
    ISSN (online) 1558-4488
    ISSN 0270-9295
    DOI 10.1016/j.semnephrol.2022.10.002
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  3. Article ; Online: COVID-19 vaccine response in patients with hematologic malignancy: A systematic review and meta-analysis.

    Gong, Inna Y / Vijenthira, Abi / Betschel, Stephen D / Hicks, Lisa K / Cheung, Matthew C

    American journal of hematology

    2022  Volume 97, Issue 4, Page(s) E132–E135

    MeSH term(s) COVID-19/prevention & control ; COVID-19 Vaccines ; Hematologic Neoplasms/therapy ; Humans ; SARS-CoV-2
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2022-01-13
    Publishing country United States
    Document type Letter ; Meta-Analysis ; Systematic Review
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.26459
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    Zs.A 1251: Show issues Location:
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  4. Article ; Online: Distinguishing ASH Clinical Practice Guidelines from Other Forms of ASH Clinical Advice.

    Cuker, Adam / Kunkle, Robert / Bercovitz, Rachel Sara / Byrne, Michael T / Djulbegovic, Benjamin / Haberichter, Sandra L / Holter-Chakrabarty, Jennifer / Lottenberg, Richard / Pai, Menaka / Rezende, Suely Meireles / Seftel, Matthew D / Silverstein, Roy L / Terrell, Deirdra R / Cheung, Matthew C

    Blood advances

    2024  

    Abstract: The American Society of Hematology (ASH) develops a variety of resources that provide guidance to clinicians on the diagnosis and management of blood diseases. These resources include clinical practice guidelines (CPGs) and other forms of clinical advice. ...

    Abstract The American Society of Hematology (ASH) develops a variety of resources that provide guidance to clinicians on the diagnosis and management of blood diseases. These resources include clinical practice guidelines (CPGs) and other forms of clinical advice. While both ASH CPGs and other forms of clinical advice provide recommendations, they differ with respect to the methods underpinning their development, the principal type of recommendations they offer, their transparency and concordance with published evidence, and the time and resources required for their development. It is crucial that end users be aware of the differences between CPGs and other forms of clinical advice and that producers and publishers of these resources use clear and unambiguous terminology to facilitate their distinction. The objective of this article is to highlight similarities and differences between ASH CPGs and other forms of ASH clinical advice and to discuss the implications of these differences for end users.
    Language English
    Publishing date 2024-04-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2915908-8
    ISSN 2473-9537 ; 2473-9529
    ISSN (online) 2473-9537
    ISSN 2473-9529
    DOI 10.1182/bloodadvances.2023011102
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 7153: Show issues Location:
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  5. Article ; Online: Microinterfaces in biopolymer-based bicontinuous hydrogels guide rapid 3D cell migration.

    Xu, Karen L / Di Caprio, Nikolas / Fallahi, Hooman / Dehghany, Mohammad / Davidson, Matthew D / Laforest, Lorielle / Cheung, Brian C H / Zhang, Yuqi / Wu, Mingming / Shenoy, Vivek / Han, Lin / Mauck, Robert L / Burdick, Jason A

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 2766

    Abstract: Cell migration is critical for tissue development and regeneration but requires extracellular environments that are conducive to motion. Cells may actively generate migratory routes in vivo by degrading or remodeling their environments or instead utilize ...

    Abstract Cell migration is critical for tissue development and regeneration but requires extracellular environments that are conducive to motion. Cells may actively generate migratory routes in vivo by degrading or remodeling their environments or instead utilize existing extracellular matrix microstructures or microtracks as innate pathways for migration. While hydrogels in general are valuable tools for probing the extracellular regulators of 3-dimensional migration, few recapitulate these natural migration paths. Here, we develop a biopolymer-based bicontinuous hydrogel system that comprises a covalent hydrogel of enzymatically crosslinked gelatin and a physical hydrogel of guest and host moieties bonded to hyaluronic acid. Bicontinuous hydrogels form through controlled solution immiscibility, and their continuous subdomains and high micro-interfacial surface area enable rapid 3D migration, particularly when compared to homogeneous hydrogels. Migratory behavior is mesenchymal in nature and regulated by biochemical and biophysical signals from the hydrogel, which is shown across various cell types and physiologically relevant contexts (e.g., cell spheroids, ex vivo tissues, in vivo tissues). Our findings introduce a design that leverages important local interfaces to guide rapid cell migration.
    MeSH term(s) Hydrogels/chemistry ; Cell Movement ; Extracellular Matrix/metabolism ; Spheroids, Cellular ; Biopolymers/metabolism
    Chemical Substances Hydrogels ; Biopolymers
    Language English
    Publishing date 2024-03-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-46774-y
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  6. Article ; Online: [No title information]

    Skorupski, Clarissa P / Cheung, Matthew C / Lin, Yulia

    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

    2023  Volume 195, Issue 31, Page(s) E1059–E1060

    Title translation Anémie préopératoire dans le contexte d’une intervention chirurgicale importante non urgente.
    Language French
    Publishing date 2023-08-15
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 215506-0
    ISSN 1488-2329 ; 0008-4409 ; 0820-3946
    ISSN (online) 1488-2329
    ISSN 0008-4409 ; 0820-3946
    DOI 10.1503/cmaj.221635-f
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    Ua VI Zs.136: Show issues Location:
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  7. Article ; Online: Vaccine response following anti-CD20 therapy: a systematic review and meta-analysis of 905 patients.

    Vijenthira, Abi / Gong, Inna / Betschel, Stephen D / Cheung, Matthew / Hicks, Lisa K

    Blood advances

    2021  Volume 5, Issue 12, Page(s) 2624–2643

    Abstract: The objective of this study was to perform a systematic review of the literature on vaccine responsiveness in patients who have received anti-CD20 therapy. PubMed and EMBASE were searched up to 4 January 2021 to identify studies of vaccine immunogenicity ...

    Abstract The objective of this study was to perform a systematic review of the literature on vaccine responsiveness in patients who have received anti-CD20 therapy. PubMed and EMBASE were searched up to 4 January 2021 to identify studies of vaccine immunogenicity in patients treated with anti-CD20 therapy, including patients with hematologic malignancy or autoimmune disease. The primary outcomes were seroprotection (SP), seroconversion (SC), and/or seroresponse rates for each type of vaccine reported. As the pandemic influenza vaccine (2009 H1N1) has standardized definitions for SP and SC, and represented a novel primary antigen similar to the COVID-19 vaccine, meta-analysis was conducted for SC of studies of this vaccine. Pooled estimates, relative benefit ratios (RBs), and 95% confidence intervals (CIs) were calculated using a random-effects model. Thirty-eight studies (905 patients treated with anti-CD20 therapy) were included (19 studies of patients with hematologic malignancies). Patients on active (<3 months since last dose) anti-CD20 therapy had poor responses to all types of vaccines. The pooled estimate for SC after 1 pandemic influenza vaccine dose in these patients was 3% (95% CI, 0% to 9%), with an RB of 0.05 (95% CI, 0-0.73) compared with healthy controls and 0.22 (95% CI, 0.09-0.56) compared with disease controls. SC compared with controls seems abrogated for at least 6 months following treatment (3-6 months post anti-CD20 therapy with an RB of 0.50 [95% CI, 0.24-1.06] compared with healthy and of 0.44 [95% CI, 0.23-0.84] compared with disease controls). For all vaccine types, response to vaccination improves incrementally over time, but may not reach the level of healthy controls even 12 months after therapy.
    MeSH term(s) COVID-19 ; COVID-19 Vaccines ; Humans ; Influenza A Virus, H1N1 Subtype ; Influenza, Human ; SARS-CoV-2
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2021-06-21
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Systematic Review
    ZDB-ID 2915908-8
    ISSN 2473-9537 ; 2473-9529
    ISSN (online) 2473-9537
    ISSN 2473-9529
    DOI 10.1182/bloodadvances.2021004629
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  8. Article: Inhibition of NFAT promotes loss of tissue resident uterine natural killer cells and attendant pregnancy complications in humans.

    Asiimwe, Rebecca / Knott, Brittney / Greene, Morgan E / Wright, Emma / Bell, Markayla / Epstein, Daniel / Yates, Stefani D / Cheung, Matthew D / Gonzalez, Michael V / Fry, Samantha / Boydston, Emily / Clevenger, Stephanie / Locke, Jayme E / George, James F / Burney, Richard / Arora, Nitin / Duncan, Virginia E / Richter, Holly E / Gunn, Deidre /
    Freud, Aharon G / Little, Shawn C / Porrett, Paige M

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Uterine natural killer cells (uNKs) are a tissue resident lymphocyte population that are critical for pregnancy success. Although mouse models have demonstrated that NK deficiency results in abnormal placentation and poor pregnancy outcomes, the ... ...

    Abstract Uterine natural killer cells (uNKs) are a tissue resident lymphocyte population that are critical for pregnancy success. Although mouse models have demonstrated that NK deficiency results in abnormal placentation and poor pregnancy outcomes, the generalizability of this knowledge to humans remains unclear. Here we identify uterus transplant (UTx) recipients as a human population with reduced endometrial NK cells and altered pregnancy phenotypes. We further show that the NK reduction in UTx is due to impaired transcriptional programming of NK tissue residency due to blockade of the transcription factor nuclear factor of activated T cells (NFAT). NFAT-dependent genes played a role in multiple molecular circuits governing tissue residency in uNKs, including early residency programs involving AP-1 transcription factors as well as TGFβ-mediated upregulation of surface integrins. Collectively, our data identify a previously undescribed role for NFAT in uterine NK tissue residency and provide novel mechanistic insights into the biologic basis of pregnancy complications due to alteration of tissue resident NK subsets in humans.
    One sentence summary: Role of NFAT in uterine NK cell tissue residency.
    Language English
    Publishing date 2024-03-12
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.03.07.583906
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: A Comparison of In Vivo Bone Tissue Generation Using Calcium Phosphate Bone Substitutes in a Novel 3D Printed Four-Chamber Periosteal Bioreactor.

    Al Maruf, D S Abdullah / Cheng, Kai / Xin, Hai / Cheung, Veronica K Y / Foley, Matthew / Wise, Innes K / Lewin, Will / Froggatt, Catriona / Wykes, James / Parthasarathi, Krishnan / Leinkram, David / Howes, Dale / Suchowerska, Natalka / McKenzie, David R / Gupta, Ruta / Crook, Jeremy M / Clark, Jonathan R

    Bioengineering (Basel, Switzerland)

    2023  Volume 10, Issue 10

    Abstract: Autologous bone replacement remains the preferred treatment for segmental defects of the mandible; however, it cannot replicate complex facial geometry and causes donor site morbidity. Bone tissue engineering has the potential to overcome these ... ...

    Abstract Autologous bone replacement remains the preferred treatment for segmental defects of the mandible; however, it cannot replicate complex facial geometry and causes donor site morbidity. Bone tissue engineering has the potential to overcome these limitations. Various commercially available calcium phosphate-based bone substitutes (Novabone
    Language English
    Publishing date 2023-10-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2746191-9
    ISSN 2306-5354
    ISSN 2306-5354
    DOI 10.3390/bioengineering10101233
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  10. Article: Microinterfaces in bicontinuous hydrogels guide rapid 3D cell migration.

    Xu, Karen L / Caprio, Nikolas di / Fallahi, Hooman / Dehgany, Mohammad / Davidson, Matthew D / Cheung, Brian Ch / Laforest, Lorielle / Wu, Mingming / Shenoy, Vivek / Han, Lin / Mauck, Robert L / Burdick, Jason A

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Cell migration is critical for tissue development and regeneration but requires extracellular environments that are conducive to motion. Cells may actively generate migratory routes in vivo by degrading or remodeling their environments or may instead ... ...

    Abstract Cell migration is critical for tissue development and regeneration but requires extracellular environments that are conducive to motion. Cells may actively generate migratory routes in vivo by degrading or remodeling their environments or may instead utilize existing ECM microstructures or microtracks as innate pathways for migration. While hydrogels in general are valuable tools for probing the extracellular regulators of 3D migration, few have recapitulated these natural migration paths. Here, we developed a biopolymer-based (i.e., gelatin and hyaluronic acid) bicontinuous hydrogel system formed through controlled solution immiscibility whose continuous subdomains and high micro-interfacial surface area enabled rapid 3D migration, particularly when compared to homogeneous hydrogels. Migratory behavior was mesenchymal in nature and regulated by biochemical and biophysical signals from the hydrogel, which was shown across various cell types and physiologically relevant contexts (e.g., cell spheroids, ex vivo tissues, in vivo tissues). Our findings introduce a new design that leverages important local interfaces to guide rapid cell migration.
    Language English
    Publishing date 2023-10-05
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.09.28.559609
    Database MEDical Literature Analysis and Retrieval System OnLINE

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