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Article ; Online: Network pharmacology and experimental evidence reveal the protective mechanism of Yi-Qi Cong-Ming decoction on age-related hearing loss.

Yang, Yi-Fang / Yan, Xi-Rui / Wu, Rui-Xin / Li, Ning / Chu, Min / Dong, Yang / Fu, Shu-Ping / Shi, Jian-Rong / Liu, Qing

Pharmaceutical biology

2022 Volume 60, Issue 1, Page(s) 1478–1490

Abstract: Context: Yi-Qi Cong-Ming (YQCM) decoction has been widely used to prevent age-related hearing loss ...

Abstract	Context: Yi-Qi Cong-Ming (YQCM) decoction has been widely used to prevent age-related hearing loss (ARHL), the most prevalent neurodegenerative disease in the elderly. Objective: To explore the mechanism of YQCM decoction in the treatment of ARHL. Materials and methods: The chemical constituents of YQCM were screened from the Traditional Chinese Medicine Systems Pharmacology Database. Potential targets of YQCM against ARHL were predicted by DrugBank, GeneCards, and OMIM database. Protein-protein network and enrichment analysis were used for exploring possible molecular mechanisms. Molecular docking and an Results: The main compounds have good affinities with hub targets, especially AKT1, PTGS2, and CASP3. GO and KEGG analysis showed that the main biological process and key targets were related to negative regulation of the apoptotic process. H Conclusions: Our study suggested that YQCM prevents ARHL by modulating the apoptosis process in auditory hair cells. Moreover, this study proved that bioinformatics analysis combined with molecular docking and cell model is a promising method to explore other possible pharmacological interventions of ARHL.
MeSH term(s)	Aged ; Caspase 3 ; Drugs, Chinese Herbal/therapeutic use ; Hearing Loss/drug therapy ; Humans ; Hydrogen Peroxide/toxicity ; Medicine, Chinese Traditional/methods ; Molecular Docking Simulation ; Network Pharmacology ; Neurodegenerative Diseases/drug therapy
Chemical Substances	Drugs, Chinese Herbal ; Hydrogen Peroxide (BBX060AN9V) ; Caspase 3 (EC 3.4.22.-)
Language	English
Publishing date	2022-08-08
Publishing country	England
Document type	Journal Article
ZDB-ID	1440131-9
ISSN	1744-5116 ; 1388-0209
ISSN (online)	1744-5116
ISSN	1388-0209
DOI	10.1080/13880209.2022.2101671
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Article ; Online: Nao-Fu-Cong ameliorates diabetic cognitive dysfunction by inhibition of JNK/CHOP/Bcl2-mediated apoptosis in vivo and in vitro.

Jing, Guang-Chan / Liu, Di / Liu, Yu-Qin / Zhang, Meng-Ren

Chinese journal of natural medicines

2020 Volume 18, Issue 9, Page(s) 704–713

Abstract: Chinese herbal compound Nao-Fu-Cong (NFC) has been mainly used to treat cognitive disorders ...

Abstract	Chinese herbal compound Nao-Fu-Cong (NFC) has been mainly used to treat cognitive disorders in Traditional Chinese Medicine (TCM). The present study aimed to investigate whether its neuroprotective effects might be related to the inhibition of JNK/CHOP/Bcl2-mediated apoptosis pathway or not. We randomly assigned STZ (60 mg·kg
MeSH term(s)	Acetylcysteine/pharmacology ; Animals ; Anthracenes/pharmacology ; Apoptosis/drug effects ; Cognitive Dysfunction/drug therapy ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/physiopathology ; Dose-Response Relationship, Drug ; Drugs, Chinese Herbal/pharmacology ; Hippocampus/drug effects ; MAP Kinase Signaling System/drug effects ; Male ; Membrane Potential, Mitochondrial/drug effects ; Neurons/drug effects ; Neuroprotective Agents/pharmacology ; Proto-Oncogene Proteins c-bcl-2/drug effects ; Random Allocation ; Rats ; Transcription Factor CHOP/antagonists & inhibitors
Chemical Substances	Anthracenes ; Bcl2 protein, rat ; Drugs, Chinese Herbal ; Neuroprotective Agents ; Proto-Oncogene Proteins c-bcl-2 ; naofucong ; Transcription Factor CHOP (147336-12-7) ; pyrazolanthrone (1TW30Y2766) ; Acetylcysteine (WYQ7N0BPYC)
Language	English
Publishing date	2020-08-12
Publishing country	China
Document type	Journal Article
ZDB-ID	2192577-X
ISSN	1875-5364 ; 2095-6975 ; 1672-3651
ISSN (online)	1875-5364
ISSN	2095-6975 ; 1672-3651
DOI	10.1016/S1875-5364(20)60009-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Mechanisms of Cong Rong Shu Jing Compound Effects on Endoplasmic Reticulum Stress in a Rat Model of Parkinson's Disease.

Lin, Yao / Tang, Lanfang / Huang, Peizhen / Liu, Ting / Zhong, Jianan / Xu, Qian / Li, Xiyu / Lin, Youning / Xiao, Shaojian / Cai, Jing

Evidence-based complementary and alternative medicine : eCAM

2020 Volume 2020, Page(s) 1818307

Abstract: This study investigated the effects of the Cong Rong Shu Jing (CRSJ) compound ...

Abstract	This study investigated the effects of the Cong Rong Shu Jing (CRSJ) compound on endoplasmic reticulum stress in a rat model of Parkinson's disease (PD). A total of 40 rats were subcutaneously injected with rotenone-sunflower oil emulsion into the back of the neck to establish a rat model of PD. These PD rats were randomly divided into low-, medium-, and high-dose groups (intragastric administration of 0.5, 1, and 2 g/kg CRSJ, respectively) and a model group (intragastric administration of the solvent; 10 rats per group). Furthermore, 10 rats each were attributed to the control and vehicle groups (both received intragastric administration of the CRSJ solvent, and the vehicle group were injected additionally with sunflower oil alone). A traction test was conducted two times, after the PD model establishment and after 14 days of CRSJ gavage. The numbers of tyrosine hydroxylase- (TH-) positive cells and the dopamine levels in the substantia nigra were assessed using immunohistochemistry and high-performance liquid chromatography, respectively. Western blotting detected the expression levels of
Language	English
Publishing date	2020-05-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2020/1818307
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Network pharmacology and experimental evidence reveal the protective mechanism of Yi-Qi Cong-Ming decoction on age-related hearing loss

Yang, Yi-Fang / Yan, Xi-Rui / Wu, Rui-Xin / Li, Ning / Zhu, Min / Dong, Yang / Fu, Shu-Ping / Shi, Jian-Rong / Liu, Qing

Pharmaceutical Biology. 2022 Dec. 31, v. 60, no. 1 p.1478-1490

2022

Abstract: Yi-Qi Cong-Ming (YQCM) decoction has been widely used to prevent age-related hearing loss (ARHL ...

Abstract	Yi-Qi Cong-Ming (YQCM) decoction has been widely used to prevent age-related hearing loss (ARHL), the most prevalent neurodegenerative disease in the elderly. To explore the mechanism of YQCM decoction in the treatment of ARHL. The chemical constituents of YQCM were screened from the Traditional Chinese Medicine Systems Pharmacology Database. Potential targets of YQCM against ARHL were predicted by DrugBank, GeneCards, and OMIM database. Protein-protein network and enrichment analysis were used for exploring possible molecular mechanisms. Molecular docking and an in vitro model of ARHL by exposing auditory cells with 100 μM H₂O₂ for 3 h were applied. Cell viability and mitochondrial membrane potential (ΔΨM) were detected by CCK-8 and high-content analysis. γH2AX and cleaved caspase-3 were detected by Western blot. The main compounds have good affinities with hub targets, especially AKT1, PTGS2, and CASP3. GO and KEGG analysis showed that the main biological process and key targets were related to negative regulation of the apoptotic process. H₂O₂ treatment could reduce the cell viability by 68% and impaired ΔΨM, while 90 μg/mL YQCM pre-treatment could restore the cell viability by 97.45% and increase ΔΨM (2-fold higher). YQCM pre-treatment also reduced γH2AX and cleaved caspase-3 protein levels. Our study suggested that YQCM prevents ARHL by modulating the apoptosis process in auditory hair cells. Moreover, this study proved that bioinformatics analysis combined with molecular docking and cell model is a promising method to explore other possible pharmacological interventions of ARHL.
Keywords	Oriental traditional medicine ; Western blotting ; apoptosis ; bioinformatics ; caspase-3 ; cell viability ; databases ; elderly ; membrane potential ; mitochondrial membrane ; models ; neurodegenerative diseases ; pharmacology ; Molecular docking ; molecular dynamics simulation ; HEI-OC1 ; mitochondrial membrane potential ; AKT1
Language	English
Dates of publication	2022-1231
Size	p. 1478-1490.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	1440131-9
ISSN	1744-5116 ; 1388-0209
ISSN (online)	1744-5116
ISSN	1388-0209
DOI	10.1080/13880209.2022.2101671
Database	NAL-Catalogue (AGRICOLA)

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Article: Nao-Fu-Cong ameliorates diabetic cognitive dysfunction by inhibition of JNK/CHOP/Bcl2-mediated apoptosis in vivo and in vitro

JING, Guang-Chan / LIU, Di / LIU, Yu-Qin / ZHANG, Meng-Ren

Chinese journal of natural medicines. 2020 Sept., v. 18, no. 9

2020

Abstract: Chinese herbal compound Nao-Fu-Cong (NFC) has been mainly used to treat cognitive disorders ...

Abstract	Chinese herbal compound Nao-Fu-Cong (NFC) has been mainly used to treat cognitive disorders in Traditional Chinese Medicine (TCM). The present study aimed to investigate whether its neuroprotective effects might be related to the inhibition of JNK/CHOP/Bcl2-mediated apoptosis pathway or not. We randomly assigned STZ (60 mg·kg⁻¹)-induced diabetic rats into control group, diabetic model group and NFC groups (low-dose, medium-dose and high-dose). The primary culture of hippocampal neurons were transferred into different culture media on the third day. The cells were then divided into control group, high-glucose group, NFC (low-dose, medium-dose and high-dose) groups, CHOP si-RNA intervention group, JNK pathway inhibitor SP600125 group and oxidative stress inhibitor N-acetylcysteine (NAC) group. NFC significantly improved the cognitive function of diabetic rats, and had neuroprotective effect on hippocampal neurons cultured in high glucose. Further research results showed that NFC could reduce the apoptosis of hippocampal neurons in rats with diabetic cognitive dysfunction. NFC had inhibitory effects on CHOP/JNK apoptosis pathway induced by high glucose, and also decreased the levels of ROS and increased the mitochondrial membrane potential. These suggested that the neuroprotective effect of NFC might be related to the inhibition of CHOP and JNK apoptotic signaling pathways, and the cross pathway between oxidative stress and mitochondrial damage pathway.
Keywords	Oriental traditional medicine ; acetylcysteine ; apoptosis ; cells ; cognition ; cognitive disorders ; culture media ; glucose ; membrane potential ; mitochondria ; mitochondrial membrane ; models ; neurons ; neuroprotective effect ; oxidative stress ; rats ; research ; signal transduction
Language	English
Dates of publication	2020-09
Size	p. 704-713.
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-light
ZDB-ID	2192577-X
ISSN	1875-5364 ; 2095-6975 ; 1672-3651
ISSN (online)	1875-5364
ISSN	2095-6975 ; 1672-3651
DOI	10.1016/S1875-5364(20)60009-7
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Mechanisms of Cong Rong Shu Jing Compound Effects on Endoplasmic Reticulum Stress in a Rat Model of Parkinson’s Disease

Yao Lin / Lanfang Tang / Peizhen Huang / Ting Liu / Jianan Zhong / Qian Xu / Xiyu Li / Youning Lin / Shaojian Xiao / Jing Cai

Evidence-Based Complementary and Alternative Medicine, Vol

2020 Volume 2020

Abstract: This study investigated the effects of the Cong Rong Shu Jing (CRSJ) compound ...

Abstract	This study investigated the effects of the Cong Rong Shu Jing (CRSJ) compound on endoplasmic reticulum stress in a rat model of Parkinson's disease (PD). A total of 40 rats were subcutaneously injected with rotenone-sunflower oil emulsion into the back of the neck to establish a rat model of PD. These PD rats were randomly divided into low-, medium-, and high-dose groups (intragastric administration of 0.5, 1, and 2 g/kg CRSJ, respectively) and a model group (intragastric administration of the solvent; 10 rats per group). Furthermore, 10 rats each were attributed to the control and vehicle groups (both received intragastric administration of the CRSJ solvent, and the vehicle group were injected additionally with sunflower oil alone). A traction test was conducted two times, after the PD model establishment and after 14 days of CRSJ gavage. The numbers of tyrosine hydroxylase- (TH-) positive cells and the dopamine levels in the substantia nigra were assessed using immunohistochemistry and high-performance liquid chromatography, respectively. Western blotting detected the expression levels of α-synuclein, endoplasmic reticulum stress pathways-related proteins, cerebral dopamine neurotrophic factor (CDNF), mesencephalic astrocyte-derived neurotrophic factor (MANF), and phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) pathway-related proteins. Compared with the model group, the number of TH-positive cells in the substantia nigra was increased in the CRSJ groups. The expression levels of α-synuclein and the endoplasmic reticulum stress pathways-associated proteins glucose regulatory protein 78, inositol-requiring enzyme 1, apoptosis signal-regulating kinase 1, phosphorylated c-Jun N-terminal kinase, and caspase-12 were reduced. However, CRSJ administration elevated the expression levels of the neurotrophic factors CDNF and MANF, as well as those of p-PI3K and p-AKT. The CRSJ compound can relieve endoplasmic reticulum stress in PD rats and exerts protective effects in this animal model. These effects may be ...
Keywords	Other systems of medicine ; RZ201-999
Subject code	630
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book: Cong bei da zou chu de wen xue jia

Liu, Guosheng

(Ming jia shi jie shu ku cong shu ; 名家视界书库丛书)

2008

Institution	Beijing da xue
Author's details	Liu guo sheng zhu bian
Series title	Ming jia shi jie shu ku cong shu 名家视界书库丛书
Language	Chinese
Size	2, 2, 313 S, Ill
Edition	Di 1 ban
Publisher	Nei meng gu wen hua chu ban she
Publishing place	Hu lun bei er shi
Document type	Book
ISBN	9787806755891 ; 7806755896
Database	Former special subject collection: coastal and deep sea fishing

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Article ; Online: Metabolite identification of seven active components of Huan-Nao-Yi-Cong-Fang in rat plasma using high-performance liquid chromatography combined with hybrid ion trap/time-of-flight mass spectrometry.

Wang, Minchao / Lu, Yanzhen / Liu, Jiangang / Li, Hao / Wei, Yun

Biomedical chromatography : BMC

2016 Volume 30, Issue 2, Page(s) 269–279

Abstract: Huan-Nao-Yi-Cong-Fang (HNYCF) is a potential prescription in treating Alzheimer's disease. Seven ...

Abstract	Huan-Nao-Yi-Cong-Fang (HNYCF) is a potential prescription in treating Alzheimer's disease. Seven constituents [ferulic acid (FA), 2,3,5,4'-tetrahydroxystilbene-2-O-β-d-glucoside (THSG), berberine hydrochloride (BHCl), emodin, ginsenoside Rg1 (Rg1), ginsenoside Re (Re) and ginsenoside Rb1 (Rb1)] have been used as quality chemical markers of HNYCF owing to their biological significance and high contents in crude plant materials. This study explored the metabolites of the seven bioactive components in rat plasma to give useful data for further study of the action mechanism of HNYCF. LC/MS-IT-TOF was used to simultaneously characterize the metabolites of the seven components. Using the combination of MetID Solution 1.0 software and accurate mass measurements, the metabolites of HNYCF were reliably characterized. Their structures were elucidated based on the accurate MS(2) spectra and comparisons of their changes in accurate molecular masses and fragment ions with those of parent compounds. A total of five parent active compounds (BHCl, emodin, Rg1, Rb1 and Re) and 10 metabolites were found from the rat plasma 2 h after oral administration of HNYCF dosage, of which two metabolites of emodin were observed for the first time. The proposed metabolic pathways of the bioactive components in the rat plasma are helpful for further studies on the pharmacokinetics and real active compound forms of this drug.
MeSH term(s)	Administration, Oral ; Animals ; Berberine/blood ; Berberine/chemistry ; Berberine/pharmacokinetics ; Chromatography, High Pressure Liquid/methods ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/pharmacokinetics ; Emodin/blood ; Emodin/chemistry ; Emodin/pharmacokinetics ; Ginsenosides/blood ; Ginsenosides/chemistry ; Ginsenosides/pharmacokinetics ; Male ; Mass Spectrometry/methods ; Rats ; Rats, Wistar
Chemical Substances	Drugs, Chinese Herbal ; Ginsenosides ; Berberine (0I8Y3P32UF) ; Emodin (KA46RNI6HN)
Language	English
Publishing date	2016-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632848-9
ISSN	1099-0801 ; 0269-3879
ISSN (online)	1099-0801
ISSN	0269-3879
DOI	10.1002/bmc.3546
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 2166: Show issues

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Article: [Summary of professor Tian Cong-huo's commonly-used acupoint prescriptions].

Zhang, Hua / Liu, Bao-yan / Zhou, Xue-zhong / Wang, Ying-hui / Liu, Zhi-shun

Zhongguo zhen jiu = Chinese acupuncture & moxibustion

2007 Volume 27, Issue 9, Page(s) 673–676

Abstract: Clinically, professor TIAN Cong-huo pays attention to treatment based on syndrome differentiation ...

Abstract	Clinically, professor TIAN Cong-huo pays attention to treatment based on syndrome differentiation, with acupoint selection based on syndrome differentiation. In this present paper, clinically commonly-used 19 acupoint prescriptions, and relatively fixed indication ranges, manipulation methods, modified acupoint prescriptions, and professor TIAN's experience in application of these acupoints are summarized and introduced.
MeSH term(s)	Acupuncture Points ; Acupuncture Therapy/methods ; Diagnosis, Differential ; Humans ; Medicine, Chinese Traditional
Language	Chinese
Publishing date	2007-09
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	0255-2930
ISSN	0255-2930
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: Gu wen zi kao shi cong gao

Liu, Zhao

A collection of articles on ancient characters research

(Nan qiang shi xue cong shu)

2005

Title variant	Collection of articles on ancient charaters research
Author's details	Liu Zhao zhu
Series title	Nan qiang shi xue cong shu
Keywords	Chinese language/Etymology ; Chinese language
Language	Chinese
Size	3, 456 p, ill, 21 cm
Edition	Di 1 ban
Publisher	Yue lu shu she
Publishing place	Changsha Shi
Document type	Book
Note	Includes bibliographical references
ISBN	7806655131 ; 9787806655139
Database	Former special subject collection: coastal and deep sea fishing

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