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Article ; Online: Glutamate delta-1 receptor regulates oligodendrocyte progenitor cell differentiation and myelination in normal and demyelinating conditions.

Gakare, Sukanya G / Bhatt, Jay M / Narasimhan, Kishore Kumar S / Dravid, Shashank M

2023 Volume 18, Issue 11, Page(s) e0294583

Abstract: In this study, we investigated the role of glutamate delta 1 receptor (GluD1) in oligodendrocyte progenitor cell (OPC)-mediated myelination during basal (development) and pathophysiological (cuprizone-induced demyelination) conditions. Initially, we ... ...

Abstract	In this study, we investigated the role of glutamate delta 1 receptor (GluD1) in oligodendrocyte progenitor cell (OPC)-mediated myelination during basal (development) and pathophysiological (cuprizone-induced demyelination) conditions. Initially, we sought to determine the expression pattern of GluD1 in OPCs and found a significant colocalization of GluD1 puncta with neuron-glial antigen 2 (NG2, OPC marker) in the motor cortex and dorsal striatum. Importantly, we found that the ablation of GluD1 led to an increase in the number of myelin-associated glycoprotein (MAG+) cells in the corpus callosum and motor cortex at P40 without affecting the number of NG2+ OPCs, suggesting that GluD1 loss selectively facilitates OPC differentiation rather than proliferation. Further, deletion of GluD1 enhanced myelination in the corpus callosum and motor cortex, as indicated by increased myelin basic protein (MBP) staining at P40, suggesting that GluD1 may play an essential role in the developmental regulation of myelination during the critical window period. In contrast, in cuprizone-induced demyelination, we observed reduced MBP staining in the corpus callosum of GluD1 KO mice. Furthermore, cuprizone-fed GluD1 KO mice showed more robust motor deficits. Collectively, our results demonstrate that GluD1 plays a critical role in OPC regulation and myelination in normal and demyelinating conditions.
MeSH term(s)	Mice ; Animals ; Myelin Sheath/metabolism ; Oligodendrocyte Precursor Cells/metabolism ; Cuprizone ; Glutamic Acid/metabolism ; Mice, Knockout ; Oligodendroglia/metabolism ; Cell Differentiation/physiology ; Corpus Callosum/metabolism ; Receptors, Glutamate/metabolism ; Demyelinating Diseases/chemically induced ; Demyelinating Diseases/metabolism ; Mice, Inbred C57BL
Chemical Substances	Cuprizone (5N16U7E0AO) ; Glutamic Acid (3KX376GY7L) ; Receptors, Glutamate
Language	English
Publishing date	2023-11-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0294583
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Article ; Online: Consequences of the 340B Drug Pricing Program.

Bhatt, Jay / Orlowski, Janis M

The New England journal of medicine

2018 Volume 378, Issue 21, Page(s) 2053

MeSH term(s)	Costs and Cost Analysis ; Drug Costs ; Humans
Language	English
Publishing date	2018--24
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMc1802999
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Article ; Online: Glutamate delta-1 receptor regulates oligodendrocyte progenitor cell differentiation and myelination in normal and demyelinating conditions.

Sukanya G Gakare / Jay M Bhatt / Kishore Kumar S Narasimhan / Shashank M Dravid

PLoS ONE, Vol 18, Iss 11, p e

2023 Volume 0294583

Abstract	In this study, we investigated the role of glutamate delta 1 receptor (GluD1) in oligodendrocyte progenitor cell (OPC)-mediated myelination during basal (development) and pathophysiological (cuprizone-induced demyelination) conditions. Initially, we sought to determine the expression pattern of GluD1 in OPCs and found a significant colocalization of GluD1 puncta with neuron-glial antigen 2 (NG2, OPC marker) in the motor cortex and dorsal striatum. Importantly, we found that the ablation of GluD1 led to an increase in the number of myelin-associated glycoprotein (MAG+) cells in the corpus callosum and motor cortex at P40 without affecting the number of NG2+ OPCs, suggesting that GluD1 loss selectively facilitates OPC differentiation rather than proliferation. Further, deletion of GluD1 enhanced myelination in the corpus callosum and motor cortex, as indicated by increased myelin basic protein (MBP) staining at P40, suggesting that GluD1 may play an essential role in the developmental regulation of myelination during the critical window period. In contrast, in cuprizone-induced demyelination, we observed reduced MBP staining in the corpus callosum of GluD1 KO mice. Furthermore, cuprizone-fed GluD1 KO mice showed more robust motor deficits. Collectively, our results demonstrate that GluD1 plays a critical role in OPC regulation and myelination in normal and demyelinating conditions.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
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Article ; Online: Organizational capacity among hospitals in Medicare and commercial bundled payments.

Urwin, John / Navathe, Amol S / Zhou, Lingmei / Bhatt, Jay / Kralovec, Peter D / Liao, Joshua M

The American journal of managed care

2022 Volume 28, Issue 12, Page(s) 678–683

Abstract: Objectives: Hospitals must strategically build organizational capacities to succeed in bundled payment arrangements. Given differences between Medicare and commercial arrangements, capacities may vary between hospitals in Medicare vs both Medicare and ... ...

Abstract	Objectives: Hospitals must strategically build organizational capacities to succeed in bundled payment arrangements. Given differences between Medicare and commercial arrangements, capacities may vary between hospitals in Medicare vs both Medicare and commercial bundled payment programs. This study compared organizational capacities between these 2 hospital groups. Study design: National survey of American Hospital Association (AHA) member hospitals with experience in bundled payment programs. Methods: We analyzed data from October 31, 2017, to April 30, 2018, collected from AHA member hospitals with bundled payment experience in only Medicare (Medicare-only hospitals) or in both Medicare and commercial insurers (multipayer hospitals). Survey questions examined capacity in 4 areas: (1) physician performance feedback, (2) care management, (3) postacute care provider utilization, and (4) health information technology. Results: Our sample included 114 hospitals reporting experience in Medicare or commercial bundled payment programs. Both Medicare-only and multipayer hospitals reported high organizational capacities in performance measurement of physician-level quality and cost feedback and in incorporation of health information technology. More multipayer hospitals reported high capacity for coordinating hospital to postacute care settings (88% vs 52%). Although nearly all hospitals in both groups reported formalized relationships with skilled nursing facilities (98%), fewer hospitals reported such relationships with long-term acute care hospitals (83%) and inpatient rehabilitation facilities (80%). Conclusions: Although they have similar capacity in a number of areas, Medicare-only and multipayer hospitals differed with respect to other aspects of organizational capacity.
MeSH term(s)	Aged ; United States ; Humans ; Medicare ; Capacity Building ; Subacute Care ; Skilled Nursing Facilities ; Hospitals
Language	English
Publishing date	2022-12-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2035781-3
ISSN	1936-2692 ; 1088-0224 ; 1096-1860
ISSN (online)	1936-2692
ISSN	1088-0224 ; 1096-1860
DOI	10.37765/ajmc.2022.89276
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Article: First Year Course-Based Undergraduate Research Experience (CURE) Using the CRISPR/Cas9 Genome Engineering Technology in Zebrafish.

Bhatt, Jay M / Challa, Anil Kumar

Journal of microbiology & biology education

2017 Volume 19, Issue 1

Abstract: Genetic analysis in model systems can provide a rich context for conceptual understanding of gene structure, regulation, and function. With an intent to create a rich learning experience in molecular genetics, we developed a semester-long course-based ... ...

Abstract	Genetic analysis in model systems can provide a rich context for conceptual understanding of gene structure, regulation, and function. With an intent to create a rich learning experience in molecular genetics, we developed a semester-long course-based undergraduate research experience (CURE) using the CRISPR-Cas9 gene editing system to disrupt specific genes in the zebrafish. The course was offered to freshman students; nine students worked in four groups (two to three members per group) to design, synthesize, and test the nuclease activity of the CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats)/sgRNAs for targeted disruption of specific genes in the zebrafish. Each group worked with a gene with an already known mutant phenotype that can be visually scored and a gene that had not been studied in zebrafish previously. Embedded in the course were a series of workshop-styled units or tutorials, including tours to core facilities. The focus was on introducing and developing skills that could be accommodated within the span of a semester. Each group successfully cloned at least one plasmid-encoding CRISPR/sgRNA template, visually analyzed injected embryos, and performed genotyping assays to detect CRISPR-Cas9 activity. In-class discussions, a final end-of-semester written test, and group oral presentations were assessed for an understanding of the CRISPR-Cas9 system, application of the CRISPR-Cas9 system as a gene manipulation tool, and experimental methods used to create plasmid vectors and synthesize sgRNA. In addition, poster presentations were evaluated by faculty, graduate students, and senior undergraduate students at a University research exposition. Self-reflections in the form of group conversations were video recorded. All students (9/9) distinctly showed learning gains after completing the activity, but the extent of the gains was variable, as seen from results of a written test and poster presentation assessment. Qualitative analysis of evaluations and self-reporting data indicated several gains, suggesting that all students found many aspects of the CURE valuable and gained project-specific (conceptual) and transferrable skills (science process and science identity).
Language	English
Publishing date	2017-01-29
Publishing country	United States
Document type	Journal Article
ISSN	1935-7877
ISSN	1935-7877
DOI	10.1128/jmbe.v19i1.1245
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Article: The Arf-GEF GBF1 undergoes multi-domain structural shifts to activate Arf at the Golgi.

Meissner, Justyna M / Akhmetova, Katarina / Szul, Tomasz / Viktorova, Ekaterina G / Sha, Bingdong / Bhatt, Jay M / Lee, Eunjoo J / Kahn, Richard A / Belov, George A / Chesnokov, Igor / Sztul, Elizabeth

Frontiers in cell and developmental biology

2023 Volume 11, Page(s) 1233272

Abstract: Golgi homeostasis require the activation of Arf GTPases by the guanine-nucleotide exchange factor requires GBF1, whose recruitment to the Golgi represents a rate limiting step in the process. GBF1 contains a conserved, catalytic, Sec7 domain (Sec7d) and ... ...

Abstract	Golgi homeostasis require the activation of Arf GTPases by the guanine-nucleotide exchange factor requires GBF1, whose recruitment to the Golgi represents a rate limiting step in the process. GBF1 contains a conserved, catalytic, Sec7 domain (Sec7d) and five additional (DCB, HUS, HDS1-3) domains. Herein, we identify the HDS3 domain as essential for GBF1 membrane association in mammalian cells and document the critical role of HDS3 during the development of
Language	English
Publishing date	2023-09-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2023.1233272
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Article ; Online: Supplemental oxygen requirement after tonsillectomy in children >3 years of age.

Martin, Elaine / Frank, Madelyn / Nguyen, Cecilia / Bhatt, Jay / Huoh, Kevin / Ahuja, Gurpreet / Pham, Nguyen

International journal of pediatric otorhinolaryngology

2024 Volume 178, Page(s) 111893

Abstract: Introduction: The indications for postoperative admission after tonsillectomy in children >3 years of age are less well defined than for children <3 years old, and typically include severe obstructive sleep apnea (OSA), obesity, comorbidities, or ... ...

Abstract	Introduction: The indications for postoperative admission after tonsillectomy in children >3 years of age are less well defined than for children <3 years old, and typically include severe obstructive sleep apnea (OSA), obesity, comorbidities, or behavioral factors. Inpatient care after tonsillectomy typically consists of respiratory monitoring and support, as respiratory compromise is the most common complication after pediatric tonsillectomy. We aim to evaluate risk factors associated with postoperative oxygen supplementation and to identify high risk populations within the admitted population who use additional resources or require additional interventions. Methods: Retrospective chart review of patients between the ages of 3 and 18 years old who underwent tonsillectomy by four surgeons at a tertiary care children's hospital was performed. Data including demographics, comorbidities, surgical intervention, pre- and postoperative AHI, admission, postoperative oxygen requirement, and postoperative complications was collected and analyzed. Results: There were 401 patients included in the analysis. Of the patients in this study, 65.59% were male, 43.39% were Latino, and 53.87% were ages 3 to 7. Of the 397 patients with a record for supplemental oxygen, 36 (9.07%) received supplemental oxygen. The LASSO regression odds ratios (OR) found to be important for modeling supplemental oxygen use (in decreasing order of magnitude) are BMI ≥35 (OR = 2.30), pre-op AHI >30 (OR = 2.28), gastrointestinal comorbidities (OR = 2.20), musculoskeletal comorbidities (OR = 1.91), cardiac comorbidities (OR = 1.20), pulmonary comorbidities (OR = 1.14), and BMI 30 to <35 (OR = 1.07). Female gender was found to be negatively associated with risk of supplemental oxygen use (OR = 0.84). Age, race, AHI ≥15-30, neurologic comorbidities, syndromic patients, admission reason, and undergoing other procedures concomitantly were not found to be associated with increased postoperative oxygen requirement. Conclusion: BMI ≥30, pre-op AHI >30, male gender, and gastrointestinal, musculoskeletal, cardiac, and pulmonary comorbidities are all associated with postoperative supplemental oxygen use. Age, race, AHI ≥15-30, neurologic comorbidities, syndromic patients, admission reason, and undergoing other procedures concomitantly were not found to be associated with increased postoperative oxygen requirement.
MeSH term(s)	Child ; Humans ; Male ; Female ; Child, Preschool ; Adolescent ; Tonsillectomy/adverse effects ; Tonsillectomy/methods ; Retrospective Studies ; Sleep Apnea, Obstructive/surgery ; Sleep Apnea, Obstructive/epidemiology ; Comorbidity ; Hospitalization ; Postoperative Complications/etiology ; Adenoidectomy/adverse effects ; Adenoidectomy/methods
Language	English
Publishing date	2024-02-08
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	754501-0
ISSN	1872-8464 ; 0165-5876
ISSN (online)	1872-8464
ISSN	0165-5876
DOI	10.1016/j.ijporl.2024.111893
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Article ; Online: Otolaryngological manifestations of Measles (Rubeola): A case report and brief review.

Bhatt, Jay M / Huoh, Kevin C

The Laryngoscope

2016 Volume 126, Issue 6, Page(s) 1481–1483

Abstract: Measles is an acute viral respiratory illness caused by a virus of the Paramyxoviridae family. Despite being eliminated from the United States, small outbreaks across the country continue to occur. The United States experienced a record number of cases ... ...

Abstract	Measles is an acute viral respiratory illness caused by a virus of the Paramyxoviridae family. Despite being eliminated from the United States, small outbreaks across the country continue to occur. The United States experienced a record number of cases in 2014, with 668 cases seen across the country, a record since its elimination in 2000. Here, we present a case of an acute presentation of measles illness and discuss the otolaryngologic manifestation of the disease. Laryngoscope, 126:1481-1483, 2016.
Language	English
Publishing date	2016-06
Publishing country	United States
Document type	Case Reports
ZDB-ID	80180-x
ISSN	1531-4995 ; 0023-852X
ISSN (online)	1531-4995
ISSN	0023-852X
DOI	10.1002/lary.25549
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Article ; Online: Time for Value-Based Payment Models to Adopt a Disparities-Sensitive Frame Shift.

Chaiyachati, Krisda H / Bhatt, Jay / Zhu, Jane M

Annals of internal medicine

2018 Volume 168, Issue 7, Page(s) 509–510

MeSH term(s)	Delivery of Health Care/economics ; Economics, Hospital ; Health Care Reform/economics ; Health Equity ; Healthcare Disparities/economics ; Humans ; Models, Economic ; Reimbursement Mechanisms/economics ; United States
Language	English
Publishing date	2018-02-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	336-0
ISSN	1539-3704 ; 0003-4819
ISSN (online)	1539-3704
ISSN	0003-4819
DOI	10.7326/M17-2590
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Article ; Online: Epidemiology and gender differences in pediatric recreational and firearms noise exposure in the USA.

Bhatt, Jay M / Lin, Harrison W / Bhattacharyya, Neil

The Laryngoscope

2019 Volume 130, Issue 2, Page(s) 541–545

Abstract: Objective: We aim to identify contemporary noise exposures and hearing protection use among U.S. children in a large, population-based study.: Methods: Cross-sectional analysis of the 2014 National Health Interview Series was performed. Results from ... ...

Abstract	Objective: We aim to identify contemporary noise exposures and hearing protection use among U.S. children in a large, population-based study. Methods: Cross-sectional analysis of the 2014 National Health Interview Series was performed. Results from in-person interviews of families with children under 18 years of age in all 50 states were queried. Potentially harmful exposures to loud sounds and patterns of hearing protection use in the last 12 months were analyzed after representative sample weights were applied. Results: Among 73.4 million children, 18.4% (9.1 ± 0.4 million) (boys: 23.2%, girls: 13.5%; P < 0.001) were exposed to firearms noise, and 28.2% (20.7 ± 0.6 million) (boys: 30.5%, girls: 25.8%; P < 0.001) to firecrackers and other explosive sounds. Exposure to recreational "very-loud" noise exposure was more common (7.9%; 5.8 ± 0.3 million), consisting of music players (46.5%), fireworks (44.8%), lawnmowers (42.6%), and firearms (32.5%). However, only 17.1% of boys and 15.6% of girls, totaling 16.4% of all children, always used hearing protection during noise exposures. Conclusion: Children in the United States are commonly exposed to firearms and recreational loud noises. Hearing protection is infrequently used, and gender disparities in patterns of exposure and use of hearing protection are prevalent. Those children and families at risk should be identified via public health initiatives and appropriately counseled by healthcare providers. Level of evidence: NA Laryngoscope, 130:541-545, 2020.
MeSH term(s)	Adolescent ; Child ; Cross-Sectional Studies ; Ear Protective Devices/statistics & numerical data ; Explosions ; Female ; Firearms ; Hearing Loss, Noise-Induced/epidemiology ; Hearing Loss, Noise-Induced/prevention & control ; Humans ; Male ; Music ; Prevalence ; Sex Factors ; United States
Language	English
Publishing date	2019-05-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	80180-x
ISSN	1531-4995 ; 0023-852X
ISSN (online)	1531-4995
ISSN	0023-852X
DOI	10.1002/lary.27958
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