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  1. Article ; Online: Revisit the signatures of γδ T cells in hepatocellular carcinoma.

    Gao, Yanan / You, Maojun / Yang, Pengyuan

    Clinical and translational medicine

    2022  Volume 12, Issue 5, Page(s) e859

    MeSH term(s) Carcinoma, Hepatocellular/pathology ; Humans ; Liver Neoplasms/pathology ; Receptors, Antigen, T-Cell, gamma-delta ; T-Lymphocytes/pathology
    Chemical Substances Receptors, Antigen, T-Cell, gamma-delta
    Language English
    Publishing date 2022-05-11
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2697013-2
    ISSN 2001-1326 ; 2001-1326
    ISSN (online) 2001-1326
    ISSN 2001-1326
    DOI 10.1002/ctm2.859
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Revisit the signatures of γδ T cells in hepatocellular carcinoma

    Yanan Gao / Maojun You / Pengyuan Yang

    Clinical and Translational Medicine, Vol 12, Iss 5, Pp n/a-n/a (2022)

    2022  

    Keywords Medicine (General) ; R5-920
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Synergistic interplay of redox homeostasis and polysaccharide synthesis promotes cotton fiber elongation.

    Tian, Xuehan / Ji, Mengyuan / You, Jiaqi / Zhang, Yuqi / Lindsey, Keith / Zhang, Xianlong / Tu, Lili / Wang, Maojun

    The Plant journal : for cell and molecular biology

    2024  Volume 118, Issue 2, Page(s) 405–422

    Abstract: Cell polarity is the foundation of cell development and tissue morphogenesis. The investigation of polarized growth provides opportunities to gain profound insights into morphogenesis and tissue functionality in organisms. Currently, there are still many ...

    Abstract Cell polarity is the foundation of cell development and tissue morphogenesis. The investigation of polarized growth provides opportunities to gain profound insights into morphogenesis and tissue functionality in organisms. Currently, there are still many mysteries surrounding the mechanisms that regulate polarized cell growth. Cotton fiber cells serve as an excellent model for studying polarized growth, and provide important clues for unraveling the molecular mechanisms, signaling pathways, and regulatory networks of polarized growth. In this study, we characterized two functional genes, GhMDHAR1A
    MeSH term(s) Cotton Fiber ; Antioxidants ; Hydrogen Peroxide ; Gene Expression Profiling ; Oxidation-Reduction ; Homeostasis ; Polysaccharides ; Gossypium/genetics ; Gene Expression Regulation, Plant
    Chemical Substances Antioxidants ; Hydrogen Peroxide (BBX060AN9V) ; Polysaccharides
    Language English
    Publishing date 2024-01-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 1088037-9
    ISSN 1365-313X ; 0960-7412
    ISSN (online) 1365-313X
    ISSN 0960-7412
    DOI 10.1111/tpj.16615
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 6071: Show issues

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  4. Article: Genetic interrogation of phenotypic plasticity informs genome-enabled breeding in cotton.

    Huang, Yuefan / Qi, Zhengyang / Li, Jianying / You, Jiaqi / Zhang, Xianlong / Wang, Maojun

    Journal of genetics and genomics = Yi chuan xue bao

    2023  Volume 50, Issue 12, Page(s) 971–982

    Abstract: Phenotypic plasticity, or the ability to adapt to and thrive in changing climates and variable environments, is essential for developmental programs in plants. Despite its importance, the genetic underpinnings of phenotypic plasticity for key agronomic ... ...

    Abstract Phenotypic plasticity, or the ability to adapt to and thrive in changing climates and variable environments, is essential for developmental programs in plants. Despite its importance, the genetic underpinnings of phenotypic plasticity for key agronomic traits remain poorly understood in many crops. In this study, we aim to fill this gap by using genome-wide association studies to identify genetic variations associated with phenotypic plasticity in upland cotton (Gossypium hirsutum L.). We identified 73 additive quantitative trait loci (QTLs), 32 dominant QTLs, and 6799 epistatic QTLs associated with 20 traits. We also identified 117 additive QTLs, 28 dominant QTLs, and 4691 epistatic QTLs associated with phenotypic plasticity in 19 traits. Our findings reveal new genetic factors, including additive, dominant, and epistatic QTLs, that are linked to phenotypic plasticity and agronomic traits. Meanwhile, we find that the genetic factors controlling the mean phenotype and phenotypic plasticity are largely independent in upland cotton, indicating the potential for simultaneous improvement. Additionally, we envision a genomic design strategy by utilizing the identified QTLs to facilitate cotton breeding. Taken together, our study provides new insights into the genetic basis of phenotypic plasticity in cotton, which should be valuable for future breeding.
    MeSH term(s) Gossypium/genetics ; Cotton Fiber ; Genome-Wide Association Study ; Plant Breeding ; Phenotype ; Adaptation, Physiological
    Language English
    Publishing date 2023-05-19
    Publishing country China
    Document type Journal Article
    ZDB-ID 2374568-X
    ISSN 1873-5533 ; 1673-8527
    ISSN (online) 1873-5533
    ISSN 1673-8527
    DOI 10.1016/j.jgg.2023.05.004
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  5. Article ; Online: A dominant negative mutation of GhMYB25-like alters cotton fiber initiation, reducing lint and fuzz.

    Zhao, Guannan / Le, Yu / Sun, Mengling / Xu, Jiawen / Qin, Yuan / Men, She / Ye, Zhengxiu / Tan, Haozhe / Hu, Haiyan / You, Jiaqi / Li, Jianying / Jin, Shuangxia / Wang, Maojun / Zhang, Xianlong / Lin, Zhongxu / Tu, Lili

    The Plant cell

    2024  

    Abstract: Cotton (Gossypium hirsutum) fibers, vital natural textile materials, are single-cell trichomes that differentiate from the ovule epidermis. These fibers are categorized as lint (longer fibers useful for spinning) or fuzz (shorter, less useful fibers). ... ...

    Abstract Cotton (Gossypium hirsutum) fibers, vital natural textile materials, are single-cell trichomes that differentiate from the ovule epidermis. These fibers are categorized as lint (longer fibers useful for spinning) or fuzz (shorter, less useful fibers). Currently, developing cotton varieties with high lint yield but without fuzz remains challenging due to our limited knowledge of the molecular mechanisms underlying fiber initiation. This study presents the identification and characterization of a naturally occurring dominant negative mutation GhMYB25-like_AthapT, which results in a reduced lint and fuzzless phenotype. The GhMYB25-like_AthapT protein exerts its dominant negative effect by suppressing the activity of GhMYB25-like during lint and fuzz initiation. Intriguingly, the negative effect of GhMYB25-like_AthapT could be alleviated by high expression levels of GhMYB25-like. We also uncovered the role of GhMYB25-like in regulating the expression of key genes such as GhPDF2 (PROTODERMAL FACTOR 2), CYCD3; 1 (CYCLIN D3; 1) and PLD (Phospholipase D), establishing its significance as a pivotal transcription factor in fiber initiation. We identified other genes within this regulatory network, expanding our understanding of the determinants of fiber cell fate. These findings offer valuable insights for cotton breeding and contribute to our fundamental understanding of fiber development.
    Language English
    Publishing date 2024-03-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 623171-8
    ISSN 1532-298X ; 1040-4651
    ISSN (online) 1532-298X
    ISSN 1040-4651
    DOI 10.1093/plcell/koae068
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    In stock of ZB MED Bonn / Germany

    Z 4952: Show issues

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  6. Article ; Online: Gossypium mustelinum genome and an introgression population enrich interspecific genetics and breeding in cotton.

    Yang, Yang / You, Chunyuan / Wang, Nian / Wu, Mi / Le, Yu / Wang, Maojun / Zhang, Xianlong / Yu, Yu / Lin, Zhongxu

    TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik

    2023  Volume 136, Issue 6, Page(s) 130

    Abstract: Key message: Genomic and genetic resources of G. mustelinum were effective for identifying genes for qualitative and quantitative traits. Gossypium mustelinum represents the earliest diverging evolutionary lineage of polyploid Gossypium, representing a ... ...

    Abstract Key message: Genomic and genetic resources of G. mustelinum were effective for identifying genes for qualitative and quantitative traits. Gossypium mustelinum represents the earliest diverging evolutionary lineage of polyploid Gossypium, representing a rich gene pool for numerous desirable traits lost in cotton cultivars. Accurate information of the genomic features and the genetic architecture of objective traits are essential for the discovery and utilization of G. mustelinum genes. Here, we presented a chromosome-level genome assembly of G. mustelinum and developed an introgression population of the G. mustelinum in the background of G. hirsutum that contained 264 lines. We precisely delimited the boundaries of the 1,662 introgression segments with the help of G. mustelinum genome assembly, and 87% of crossover regions (COs) were less than 5 Kb. Genes for fuzzless and green fuzz were discovered, and a total of 14 stable QTLs were identified with 12 novel QTLs across four independent environments. A new fiber length QTL, qUHML/SFC-A11, was confined to a 177-Kb region, and GmOPB4 and GmGUAT11 were considered as the putative candidate genes as potential negative regulator for fiber length. We presented a genomic and genetic resource of G. mustelinum, which we demonstrated that it was efficient for identifying genes for qualitative and quantitative traits. Our study built a valuable foundation for cotton genetics and breeding.
    MeSH term(s) Gossypium/genetics ; Chromosome Mapping ; Cotton Fiber ; Plant Breeding ; Quantitative Trait Loci
    Language English
    Publishing date 2023-05-18
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2170-2
    ISSN 1432-2242 ; 0040-5752
    ISSN (online) 1432-2242
    ISSN 0040-5752
    DOI 10.1007/s00122-023-04379-x
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1692: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: The rhizospheric bacterial diversity of Fritillaria taipaiensis under single planting pattern over five years.

    Zhou, You / Mu, Maojun / Yang, Min / Yang, Xiaohong / Zhang, Hua / Guo, Dongqin / Zhou, Nong

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 22544

    Abstract: Rhizospheric microorganisms can profoundly influence the nutritional status of soil and the growth of plant. To reveal the change on the bacterial diversity in the rhizosphere of Fritillaria taipaiensis under long-term single planting, the bacterial ... ...

    Abstract Rhizospheric microorganisms can profoundly influence the nutritional status of soil and the growth of plant. To reveal the change on the bacterial diversity in the rhizosphere of Fritillaria taipaiensis under long-term single planting, the bacterial community structure in the rhizospheric soils of F. taipaiensis with different cultivation years from 1 to 5 were analyzed. The result showed the Chao1 and the ACE indices of the bacterial community had no significant difference among samples while the Shannon and Simpson indices declined with the cutivation year; the intra group beta diversity of the rhizospheric bacteria increased after a initial decline with the cultivation year; in the sample with 1 year of cultivation, the dominant bacterial genera were mainly the species that can improve the soil nutrient status and promote plant growth while with the increase of cultivation year, the dominant genera in samples then gradually reflected the pathogen accumulation and soil nutrient status deterioration; pH was the most significant factor affected by the bacterial community composition. These results indicated long term continuous cropping changed the bacterial community structure and soil nutritional status in the F. taipaiensis rhizospheric soils, which could badly affect its growth.
    MeSH term(s) Fritillaria ; Soil Microbiology ; Bacteria ; Soil/chemistry ; Rhizosphere
    Chemical Substances Soil
    Language English
    Publishing date 2022-12-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-26810-x
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  8. Article ; Online: SnO

    Zhang, Wenlan / Zheng, Maojun / Li, Fanggang / You, Yuxiu / Jiang, Dongkai / Yuan, Hao / Ma, Li / Shen, Wenzhong

    Nanotechnology

    2021  Volume 32, Issue 19, Page(s) 195407

    Abstract: Tin and its oxides are promising anode materials owing to their high theoretical capacity, rich resource, and environmental benignity. To achieve low cost and green synthesis, a facile synthetic route of ... ...

    Abstract Tin and its oxides are promising anode materials owing to their high theoretical capacity, rich resource, and environmental benignity. To achieve low cost and green synthesis, a facile synthetic route of SnO
    Language English
    Publishing date 2021-02-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362365-5
    ISSN 1361-6528 ; 0957-4484
    ISSN (online) 1361-6528
    ISSN 0957-4484
    DOI 10.1088/1361-6528/abe2c9
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  9. Article: Comparative genomic analyses reveal cis-regulatory divergence after polyploidization in cotton

    You, Jiaqi / Lin, Min / Liu, Zhenping / Pei, Liuling / Long, Yuexuan / Tu, Lili / Zhang, Xianlong / Wang, Maojun

    crop journal. 2022 Mar. 01,

    2022  

    Abstract: Polyploidization has long been recognized as a driver for the evolutionary formation of superior plant traits coupled with gene expression novelty. However, knowledge of the effect of regulatory variation on expression changes following polyploidization ... ...

    Abstract Polyploidization has long been recognized as a driver for the evolutionary formation of superior plant traits coupled with gene expression novelty. However, knowledge of the effect of regulatory variation on expression changes following polyploidization remains limited. In this study, we characterized transcriptional regulatory divergence by comparing tetraploid cotton with its putative diploid ancestors. We identified 144,827, 99,609, and 219,379 Tn5 transposase-hypersensitive sites (THSs) in Gossypium arboreum, G. raimondii, and G. hirsutum, respectively, and found that the conservation of promoter THSs was associated with coordination of orthologous genes expression. This observation was consistent with analysis of transcription-factor binding sites (TFBS) for 262 known motifs: genes with higher TFBS conservation scores (CS) showed less change than those genes with lower TFBS CS in expression levels. TFBS influenced by genomic variation were involved in the novel regulation networks between transcriptional factors and target genes in tetraploid cotton. We describe an example showing that the turnover of TFBS was linked to expression pattern divergence of genes involved in fiber development (fiber-related genes). Our findings reveal the regulatory divergence of the transcriptional network in cotton after polyploidization and characterizes the regulatory relationships of genes contributing to desirable traits.
    Keywords Gossypium arboreum ; cotton ; diploidy ; gene expression ; genetic variation ; genomics ; tetraploidy ; transcription (genetics) ; transcription factors
    Language English
    Dates of publication 2022-0301
    Publishing place Elsevier B.V.
    Document type Article
    Note Pre-press version
    ZDB-ID 2745450-2
    ISSN 2214-5141
    ISSN 2214-5141
    DOI 10.1016/j.cj.2022.03.002
    Database NAL-Catalogue (AGRICOLA)

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  10. Article: Genetic and Transcriptomic Variations for Amoxicillin Resistance in

    Han, Xiurui / Zhang, Yiyao / He, Lihua / Fan, Ruyue / Sun, Lu / Fan, Dongjie / Gong, Yanan / Chen, Xiaoli / You, Yuanhai / Zhao, Fei / Zhang, Maojun / Zhang, Jianzhong

    Pathogens (Basel, Switzerland)

    2021  Volume 10, Issue 6

    Abstract: Some amoxicillin-resistant strains ... ...

    Abstract Some amoxicillin-resistant strains of
    Language English
    Publishing date 2021-05-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens10060676
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