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  1. Article ; Online: IL-22: Immunity's bittersweet symphony.

    Duan, Jinzhi / Matute, Juan D / Blumberg, Richard S

    The Journal of experimental medicine

    2023  Volume 220, Issue 11

    Abstract: Epithelial cells play a crucial role in barrier defense. Here, Moniruzzaman et al. (2023. J. Exp. Med.https://doi.org/10.1084/jem.20230106) discovered that interleukin-22 (IL-22) represses MHC class II expression by epithelial cells with an opposite ... ...

    Abstract Epithelial cells play a crucial role in barrier defense. Here, Moniruzzaman et al. (2023. J. Exp. Med.https://doi.org/10.1084/jem.20230106) discovered that interleukin-22 (IL-22) represses MHC class II expression by epithelial cells with an opposite impact on chronic inflammatory disease and viral infection.
    MeSH term(s) Interleukins ; Epithelial Cells ; Genes, MHC Class II ; Interleukin-22
    Chemical Substances Interleukins
    Language English
    Publishing date 2023-09-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20231210
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    Ua VI Zs.107: Show issues Location:
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  2. Article ; Online: Characterizing CD4 T cell differentiation in mouse small intestine using T cell transfer, lamina propria preparation, and flow cytometry.

    Duan, Jinzhi / Sun, Yanan / Matute, Juan D / Blumberg, Richard S

    STAR protocols

    2023  Volume 4, Issue 3, Page(s) 102485

    Abstract: Studying gene function in T cells is crucial for understanding physiology and disease pathogenesis. Here, we provide a protocol to examine the role of specific genes in ... ...

    Abstract Studying gene function in T cells is crucial for understanding physiology and disease pathogenesis. Here, we provide a protocol to examine the role of specific genes in CD4
    MeSH term(s) Animals ; Mice ; CD4-Positive T-Lymphocytes ; Flow Cytometry ; Mucous Membrane ; Cell Differentiation ; Intestine, Small
    Language English
    Publishing date 2023-08-09
    Publishing country United States
    Document type Journal Article
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2023.102485
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  3. Article ; Online: The healing power of language: caring for patients with limited english proficiency and COVID-19.

    Herzberg, Emily M / Barrero-Castillero, Alejandra / Matute, Juan D

    Pediatric research

    2021  Volume 91, Issue 3, Page(s) 526–528

    MeSH term(s) Adult ; Boston ; COVID-19/epidemiology ; COVID-19/therapy ; Child ; Communication Barriers ; Female ; Hispanic or Latino ; Humans ; Infant, Newborn ; Language ; Limited English Proficiency ; Male ; Multilingualism ; Pandemics ; Patient Care ; Pediatricians ; Pediatrics ; Pregnancy ; SARS-CoV-2
    Language English
    Publishing date 2021-03-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 4411-8
    ISSN 1530-0447 ; 0031-3998
    ISSN (online) 1530-0447
    ISSN 0031-3998
    DOI 10.1038/s41390-021-01487-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 564: Show issues Location:
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    Zs.MO 373: Show issues

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  4. Article ; Online: Microbial RNAs Pressure Piezo1 to Respond.

    Matute, Juan D / Duan, Jinzhi / Blumberg, Richard S

    Cell

    2020  Volume 182, Issue 3, Page(s) 542–544

    Abstract: Serotonin production by enterochromaffin cells (ECs) is microbiota-dependent, but the mechanism of this is unknown. In this issue of Cell, Sugisawa et al. demonstrate that Piezo1 in ECs senses single-strand RNA (ssRNA) from intestinal microbiota to ... ...

    Abstract Serotonin production by enterochromaffin cells (ECs) is microbiota-dependent, but the mechanism of this is unknown. In this issue of Cell, Sugisawa et al. demonstrate that Piezo1 in ECs senses single-strand RNA (ssRNA) from intestinal microbiota to promote serotonin production. Deletion of Piezo1 in intestinal epithelium promotes bone formation, decreases peristalsis, and protects from colitis because of decreased serotonin.
    MeSH term(s) Enterochromaffin Cells ; Gastrointestinal Microbiome ; Ion Channels/genetics ; RNA ; Serotonin
    Chemical Substances Ion Channels ; Serotonin (333DO1RDJY) ; RNA (63231-63-0)
    Language English
    Publishing date 2020-09-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2020.07.015
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    Zs.MG 58: Show issues

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  5. Article: Microbial RNAs Pressure Piezo1 to Respond

    Matute, Juan D / Duan, Jinzhi / Blumberg, Richard S

    Cell. 2020 Aug. 06, v. 182, no. 3

    2020  

    Abstract: Serotonin production by enterochromaffin cells (ECs) is microbiota-dependent, but the mechanism of this is unknown. In this issue of Cell, Sugisawa et al. demonstrate that Piezo1 in ECs senses single-strand RNA (ssRNA) from intestinal microbiota to ... ...

    Abstract Serotonin production by enterochromaffin cells (ECs) is microbiota-dependent, but the mechanism of this is unknown. In this issue of Cell, Sugisawa et al. demonstrate that Piezo1 in ECs senses single-strand RNA (ssRNA) from intestinal microbiota to promote serotonin production. Deletion of Piezo1 in intestinal epithelium promotes bone formation, decreases peristalsis, and protects from colitis because of decreased serotonin.
    Keywords RNA ; bone formation ; colitis ; intestinal microorganisms ; intestinal mucosa ; peristalsis ; serotonin
    Language English
    Dates of publication 2020-0806
    Size p. 542-544.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2020.07.015
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Case 30-2022: A Newborn Girl with Hypoglycemia.

    Sen, Sarbattama / Westra, Sjirk J / Matute, Juan D / Sherwood, Jordan S / High, Frances A / Kwan, Melanie C

    The New England journal of medicine

    2022  Volume 387, Issue 13, Page(s) 1218–1226

    MeSH term(s) Female ; Humans ; Hyperinsulinism ; Hypoglycemia/etiology ; Infant, Newborn
    Language English
    Publishing date 2022-09-28
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMcpc2201243
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    Ua VI Zs.34: Show issues Location:
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  7. Article ; Online: Necrotizing Enterocolitis in Neonates With Hyperinsulinemic Hypoglycemia Treated With Diazoxide.

    Keyes, Madeline L / Healy, Helen / Sparger, Katherine A / Orth, Lucas E / Geha, Mayya / Roumiantsev, Sergei / Matute, Juan D

    Pediatrics

    2021  Volume 147, Issue 2

    Abstract: The most common cause of persistent hypoglycemia in the neonatal period is hyperinsulinism. Severe, refractory hypoglycemia resulting from hyperinsulinism can lead to significant brain injury and permanent cognitive disability. Diazoxide is the first- ... ...

    Abstract The most common cause of persistent hypoglycemia in the neonatal period is hyperinsulinism. Severe, refractory hypoglycemia resulting from hyperinsulinism can lead to significant brain injury and permanent cognitive disability. Diazoxide is the first-line and only US Food and Drug Administration-approved, pharmacologic treatment for refractory hyperinsulinism. In recent years, the use of diazoxide in neonates with persistent hyperinsulinemic hypoglycemia has increased in the United States. Known adverse effects of diazoxide include fluid retention, hypertrichosis, neutropenia, thrombocytopenia, and more recently, pulmonary hypertension. It is currently unknown if diazoxide exposure is associated with an increased risk of necrotizing enterocolitis (NEC) in neonates. We reviewed the cases of 24 patients in a level IV NICU at Massachusetts General Hospital who received diazoxide over 12 years (April 2006-April 2018). All 24 patients received enteral diazoxide for refractory hyperinsulinemic hypoglycemia. A total of 5 patients developed NEC after initiation of diazoxide based on clinical and radiographic findings, corresponding to 20% of infants exposed to diazoxide. This is above our baseline incidence of NEC (1% for all inborn infants and 6% for all inborn very low birth weight infants). More research and monitoring are necessary to characterize the potential risk of NEC associated with the use of diazoxide in the neonatal period.
    MeSH term(s) Congenital Hyperinsulinism/drug therapy ; Diazoxide/adverse effects ; Diazoxide/therapeutic use ; Enterocolitis, Necrotizing/chemically induced ; Enterocolitis, Necrotizing/diagnosis ; Enterocolitis, Necrotizing/epidemiology ; Fatal Outcome ; Female ; Humans ; Incidence ; Infant, Newborn ; Infant, Premature ; Infant, Premature, Diseases/chemically induced ; Infant, Premature, Diseases/diagnosis ; Infant, Premature, Diseases/drug therapy ; Infant, Premature, Diseases/epidemiology ; Male ; Retrospective Studies ; Risk Factors
    Chemical Substances Diazoxide (O5CB12L4FN)
    Language English
    Publishing date 2021-01-22
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 207677-9
    ISSN 1098-4275 ; 0031-4005
    ISSN (online) 1098-4275
    ISSN 0031-4005
    DOI 10.1542/peds.2019-3202
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    Um IV Zs.131: Show issues Location:
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    Zs.MO 357: Show issues

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  8. Article ; Online: Study protocol for the epigenetic characterization of angor pectoris according to the affected coronary compartment: Global and comprehensive assessment of the relationship between invasive coronary physiology and microRNAs.

    Matute-Blanco, Lucía / Fernández-Rodríguez, Diego / Casanova-Sandoval, Juan / Belmonte, Thalía / Benítez, Iván D / Rivera, Kristian / Garcia-Guimaraes, Marcos / Cortés Villar, Carlos / Peral Disdier, Vicente / Millán Segovia, Raúl / Barriuso, Ignacio / de Gonzalo-Calvo, David / Barbé, Ferran / Worner, Fernando

    PloS one

    2023  Volume 18, Issue 5, Page(s) e0283097

    Abstract: Background: MicroRNAs (miRNAs) are noncoding RNAs involved in post-transcriptional genetic regulation with a proposed role in intercellular communication. miRNAs are considered promising biomarkers in ischemic heart disease. Invasive physiological ... ...

    Abstract Background: MicroRNAs (miRNAs) are noncoding RNAs involved in post-transcriptional genetic regulation with a proposed role in intercellular communication. miRNAs are considered promising biomarkers in ischemic heart disease. Invasive physiological evaluation allows a precise assessment of each affected coronary compartment. Although some studies have associated the expression of circulating miRNAs with invasive physiological indexes, their global relationship with coronary compartments has not been assessed. Here, we will evaluate circulating miRNAs profiles according to the coronary pattern of the vascular compartment affectation.
    Study and design: This is an investigator-initiated, multicentre, descriptive study to be conducted at three centres in Spain (NCT05374694). The study will include one hundred consecutive patients older than 18 years with chest pain of presumed coronary cause undergoing invasive physiological evaluation, including fractional flow reserve (FFR) and index of microvascular resistance (IMR). Patients will be initially classified into four groups, according to FFR and IMR: macrovascular and microvascular affectation (FFR≤0.80 / IMR≥25), isolated macrovascular affectation (FFR≤0.80 / IMR<25), isolated microvascular affectation (FFR>0.80 / IMR ≥25) and normal coronary indexes (FFR>0.80 / IMR<25). Patients with isolated microvascular affectation or normal indexes will also undergo the acetylcholine test and may be reclassified as a fifth group in the presence of spasm. A panel of miRNAs previously associated with molecular mechanisms linked to chronic coronary syndrome will be analysed using RT-qPCR.
    Conclusions: The results of this study will identify miRNA profiles associated with patterns of coronary affectation and will contribute to a better understanding of the mechanistic pathways of coronary pathology.
    MeSH term(s) Humans ; Angina Pectoris ; Coronary Angiography ; Coronary Artery Disease ; Coronary Stenosis ; Coronary Vessels ; Epigenesis, Genetic ; Fractional Flow Reserve, Myocardial/physiology ; Microcirculation/physiology ; MicroRNAs/genetics ; Predictive Value of Tests ; Vascular Resistance/physiology
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2023-05-11
    Publishing country United States
    Document type Clinical Study ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0283097
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  9. Article ; Online: Derrame pericárdico severo recurrente y amiloidosis cardíaca senil: utilidad de la pericardiotomía con balón.

    Matute-Blanco, Lucía / Casanova-Sandoval, Juan / Rivera, Kristian / Fernández-Rodríguez, Diego

    Revista espanola de geriatria y gerontologia

    2021  Volume 56, Issue 5, Page(s) 320–322

    Title translation Recurrent severe pericardial effusion and senile cardiac amyloidosis: Usefulness of balloon pericardiotomy.
    MeSH term(s) Amyloidosis/complications ; Humans ; Pericardial Effusion/etiology ; Pericardiectomy ; Recurrence
    Language Spanish
    Publishing date 2021-03-26
    Publishing country Spain
    Document type Case Reports ; Journal Article
    ZDB-ID 605609-x
    ISSN 1578-1747 ; 0211-139X
    ISSN (online) 1578-1747
    ISSN 0211-139X
    DOI 10.1016/j.regg.2021.02.009
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    Zs.B 2677: Show issues Location:
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  10. Article ; Online: Screening for modulators of the cellular composition of gut epithelia via organoid models of intestinal stem cell differentiation.

    Mead, Benjamin E / Hattori, Kazuki / Levy, Lauren / Imada, Shinya / Goto, Norihiro / Vukovic, Marko / Sze, Daphne / Kummerlowe, Conner / Matute, Juan D / Duan, Jinzhi / Langer, Robert / Blumberg, Richard S / Ordovas-Montanes, Jose / Yilmaz, Ömer H / Karp, Jeffrey M / Shalek, Alex K

    Nature biomedical engineering

    2022  Volume 6, Issue 4, Page(s) 476–494

    Abstract: The cellular composition of barrier epithelia is essential to organismal homoeostasis. In particular, within the small intestine, adult stem cells establish tissue cellularity, and may provide a means to control the abundance and quality of specialized ... ...

    Abstract The cellular composition of barrier epithelia is essential to organismal homoeostasis. In particular, within the small intestine, adult stem cells establish tissue cellularity, and may provide a means to control the abundance and quality of specialized epithelial cells. Yet, methods for the identification of biological targets regulating epithelial composition and function, and of small molecules modulating them, are lacking. Here we show that druggable biological targets and small-molecule regulators of intestinal stem cell differentiation can be identified via multiplexed phenotypic screening using thousands of miniaturized organoid models of intestinal stem cell differentiation into Paneth cells, and validated via longitudinal single-cell RNA-sequencing. We found that inhibitors of the nuclear exporter Exportin 1 modulate the fate of intestinal stem cells, independently of known differentiation cues, significantly increasing the abundance of Paneth cells in the organoids and in wild-type mice. Physiological organoid models of the differentiation of intestinal stem cells could find broader utility for the screening of biological targets and small molecules that can modulate the composition and function of other barrier epithelia.
    MeSH term(s) Animals ; Cell Differentiation ; Intestines ; Mice ; Organoids ; Paneth Cells/physiology ; Stem Cells
    Language English
    Publishing date 2022-03-21
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2157-846X
    ISSN (online) 2157-846X
    DOI 10.1038/s41551-022-00863-9
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