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  1. Article ; Online: Wen-Yi and Chinese medicine: Why we need to pay attention?

    Xiong, Yibai / Bao, Linlin / Ma, Yan / Zhang, Ling / Qin, Chuan / Huang, Luqi

    Science bulletin

    2024  

    Language English
    Publishing date 2024-03-30
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2816140-3
    ISSN 2095-9281 ; 2095-9273
    ISSN (online) 2095-9281
    ISSN 2095-9273
    DOI 10.1016/j.scib.2024.03.059
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Ethnobotanical study of medicinal plants used by the Yi people in Mile, Yunnan, China.

    Li, Hongrui / Huang, Caiwen / Li, Yanhong / Wang, Pujing / Sun, Jingxian / Bi, Zizhen / Xia, Shisheng / Xiong, Yong / Bai, Xishan / Huang, Xiangzhong

    Journal of ethnobiology and ethnomedicine

    2024  Volume 20, Issue 1, Page(s) 22

    Abstract: Background: The Yi people are a sociolinguistic group living in Mile City, which is their typical ... settlement in southeastern Yunnan, China. Over the long history of using medicinal plants, the Yi people have ... commonly used by the Yi people. This study provides fundamental data for the development and application ...

    Abstract Background: The Yi people are a sociolinguistic group living in Mile City, which is their typical settlement in southeastern Yunnan, China. Over the long history of using medicinal plants, the Yi people have accumulated and developed a wealth of traditional medicinal knowledge, which has played a vital role in their health care. However, only a few studies have been performed to systematically document the medicinal plants commonly used by the Yi people. This study provides fundamental data for the development and application of ethnomedicine as well as supports the conservation of the traditional medical knowledge of the Yi people.
    Methods: This study was conducted from May 2020 to August 2022 and involved five townships in Mile. Information regarding medicinal plants was obtained through semistructured interviews, key informant interviews, and participatory observation. The collected voucher specimens were identified using the botanical taxonomy method and deposited in the herbarium. Ethnobotanical data were analyzed using informant consensus factor, relative frequency of citation, and fidelity level.
    Results: In total, 114 informants distributed in five townships of Mile were interviewed. The Yi people used 267 medicinal plant species belonging to 232 genera and 104 families to treat various diseases. Asteraceae, Lamiaceae, and Fabaceae were the most commonly used plant families by the Yi people. In addition, herbs were most commonly used by the Yi people. Whole plants and roots were the preferred medicinal parts. Decoctions were the most common method of herbal medicine preparation. There are 49 different recorded diseases treated by Yi medicinal plants, and among them, respiratory diseases, rheumatism, traumatic injury, fractures, and digestive system diseases have the largest number of species used. A quantitative analysis demonstrated that plants such as Zingiber officinale, Lycopodium japonicum, Aconitum carmichaelii, Panax notoginseng, Cyathula officinalis, and Leonurus japonicus played crucial roles in disease prevention and treatment.
    Conclusion: Traditional knowledge of medicinal plants is closely associated with the social culture of the local Yi people. The medicinal plants used for health care in the study area were diverse. Local healers were skilled at using medicinal plants to treat various diseases. Their treatment methods were convenient and unique, exhibiting distinctive regional characteristics. However, the inheritance of their traditional medicinal knowledge and protection of wild medicinal plant resources are facing serious challenges, including the decreasing number of local healers, aging of healers, lack of successors, and excessive harvesting of medicinal plant resources. This ethnobotanical survey provides a useful reference for the sustainable utilization and protection of medicinal plant resources in Mile and the inheritance of traditional medicinal knowledge of the Yi people.
    MeSH term(s) Humans ; Plants, Medicinal ; China ; Ethnobotany/methods ; Medicine, Traditional/methods ; Phytotherapy/methods ; Plant Preparations ; Southeast Asian People
    Chemical Substances Plant Preparations
    Language English
    Publishing date 2024-02-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2202544-3
    ISSN 1746-4269 ; 1746-4269
    ISSN (online) 1746-4269
    ISSN 1746-4269
    DOI 10.1186/s13002-024-00656-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Identification of Active Compounds From Yi Nationality Herbal Formula

    Zhang, Ji-Zhong / Chen, Xiao-Yi / Wu, You-Jiao / Li, Li-Min / Huang, Li / Yin, Qiao-Zhi / Luo, Pei / Liu, Yuan

    Frontiers in pharmacology

    2020  Volume 11, Page(s) 568585

    Abstract: The Yi nationality herbal formula ...

    Abstract The Yi nationality herbal formula
    Language English
    Publishing date 2020-11-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2020.568585
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Analysis of potential risks of clinical application of Yi Dian Hong and its proprietary Chinese medicines: A review.

    Chen, Gongzhen / Mao, Leiming / Xia, Huyan / Zhu, Lei / Huang, Jiamin / Lu, Yingmin / Liu, Xin / Tang, Ting

    Medicine

    2024  Volume 103, Issue 4, Page(s) e36860

    Abstract: Yi Dian Hong, belonging to the Asteraceae family, finds widespread use ... swelling, and cooling the blood. Modern medical research has revealed that Yi Dian Hong and its proprietary ... regulating immune-related molecules. However, studies have identified that the primary component of Yi Dian ...

    Abstract Yi Dian Hong, belonging to the Asteraceae family, finds widespread use in traditional Chinese medicine for its effectiveness in clearing heat, detoxifying, promoting blood circulation, reducing swelling, and cooling the blood. Modern medical research has revealed that Yi Dian Hong and its proprietary Chinese medicines possess biological functions such as inhibiting tumor-specific angiogenesis and regulating immune-related molecules. However, studies have identified that the primary component of Yi Dian Hong contains pyrrolizidine alkaloids (PAs), a toxic substance with potential risks to the liver, lungs, genes, and a propensity for carcinogenicity. Many countries impose strict controls on the content of PAs in herbal medicines and products. Unfortunately, China currently lacks relevant content standards, thereby introducing greater clinical application risks. To ensure the safety of clinical use of Yi Dian Hong, this review will analyze the risk associated with Yi Dian Hong and its proprietary Chinese medicines in clinical applications based on the PAs content in these medicines and provide recommendations.
    MeSH term(s) Humans ; Medicine, Chinese Traditional/adverse effects ; Drugs, Chinese Herbal/adverse effects ; Plants, Medicinal ; China ; Pyrrolizidine Alkaloids
    Chemical Substances Drugs, Chinese Herbal ; Pyrrolizidine Alkaloids
    Language English
    Publishing date 2024-01-26
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000036860
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Integrated serum pharmacochemistry and network pharmacology to explore the mechanism of Yi-Shan-Hong formula in alleviating chronic liver injury.

    Zhao, Xinyi / Su, Hua / Chen, Haiyan / Tang, Xiusong / Li, Wenling / Huang, An / Fang, Gang / Chen, Qing / Luo, Yudong / Pang, Yuzhou

    Phytomedicine : international journal of phytotherapy and phytopharmacology

    2024  Volume 128, Page(s) 155439

    Abstract: ... interventions. The Yi-Shan-Hong (YSH) formula is an empirically derived remedy that has shown effectiveness and ...

    Abstract Background: Chronic liver injury (CLI) is a complex condition that requires effective therapeutic interventions. The Yi-Shan-Hong (YSH) formula is an empirically derived remedy that has shown effectiveness and safety in the management of chronic liver damage. However, the bioactive components and multifaceted mechanisms of YSH remain inadequately understood.
    Purpose: To examine the bioactive compounds and functional processes that contribute to the therapeutic benefits of YSH against CLI.
    Methods: Serum pharmacochemistry and network pharmacology were employed to identify active compounds and possible targets of YSH in CLI. In addition, YSH was also given in three doses to
    Results: The analysis of serum samples successfully detected 25 compounds from YSH. Searches on the databases resulted in 277 genes as being correlated with chemicals in YSH, and 397 genes associated with CLI. In vivo experiments revealed that YSH displayed a notable therapeutic impact on liver injury caused by
    Conclusion: These findings provide preclinical evidence of YSH's therapeutic value in CLI and highlight its hepatoprotective action via the PI3K/AKT signaling pathway.
    MeSH term(s) Animals ; Drugs, Chinese Herbal/pharmacology ; Network Pharmacology ; Male ; Oxidative Stress/drug effects ; Rats, Sprague-Dawley ; Rats ; Liver/drug effects ; Galactosamine ; Chemical and Drug Induced Liver Injury, Chronic/drug therapy ; Signal Transduction/drug effects
    Chemical Substances Drugs, Chinese Herbal ; Galactosamine (7535-00-4)
    Language English
    Publishing date 2024-02-09
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1205240-1
    ISSN 1618-095X ; 0944-7113
    ISSN (online) 1618-095X
    ISSN 0944-7113
    DOI 10.1016/j.phymed.2024.155439
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: [ZHENG Wenzhuo's Yi gu (

    Zheng, H J / Huang, Z Z

    Zhonghua yi shi za zhi (Beijing, China : 1980)

    2018  Volume 47, Issue 5, Page(s) 303–306

    Abstract: Yi gu ...

    Abstract Yi gu
    MeSH term(s) Books/history ; History, 19th Century ; Medicine, Chinese Traditional
    Language Chinese
    Publishing date 2018-06-03
    Publishing country China
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 1052411-3
    ISSN 0255-7053
    ISSN 0255-7053
    DOI 10.3760/cma.j.issn.0255-7053.2017.05.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Exploring the potential mechanisms of Yi-Yi-Fu-Zi-Bai-Jiang-San therapy on the immune-inflamed phenotype of colorectal cancer via combined network pharmacology and bioinformatics analyses.

    Liu, Yong / Liang, Youcheng / Su, Yongjian / Hu, Jiaqi / Sun, Jianbo / Zheng, Mingbin / Huang, Zunnan

    Computers in biology and medicine

    2023  Volume 166, Page(s) 107432

    Abstract: ... will help increase knowledge regarding the characteristics of TME infiltration. Yi-Yi-Fu-Zi-Bai-Jiang-San ...

    Abstract Background: The development and progression of colorectal cancer (CRC) is closely associated with its complex tumor microenvironment (TME). Assessment of the modified pattern of immune cell infiltration (ICI) will help increase knowledge regarding the characteristics of TME infiltration. Yi-Yi-Fu-Zi-Bai-Jiang-San (YYFZBJS) has been shown to have positive effects on the regulation of the immune microenvironment of CRC. However, its pharmacological targets and molecular mechanisms remain to be elucidated.
    Methods: Network pharmacological analysis was used to identify the target of YYFZBJS in the TME of CRC. Patients with the immune-inflamed phenotype (IIP) were identified using CRC samples from The Cancer Genome Atlas (TCGA) database. Consensus genes were identified by intersecting YYFZBJS targets, CRC disease targets and differentially expressed genes in the CRC microenvironment. Then, least absolute shrinkage and selection operator (LASSO) Cox analyses were used to identify a prognostic signature from the consensus genes. Cytoscape software was further used to build a unique herb-compound-target network diagram of the important components of YYFZBJS and prognostic gene targets. In addition, Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis was performed using the prognostic gene sets to explore the molecular mechanism of the prognostic genes in drug therapy for CRC IIP patients. Finally, single-cell analysis was performed to validate the expression of the prognostic genes in the TME of CRC using the TISCH2 database.
    Results: A total of 284 IIP patients were identified from 480 patients with CRC. A total of 35 consensus genes were identified as targets of YYFZBJS in the TME of CRC patients. An eleven-gene prognostic signature, including PIK3CG, C5AR1, PRF1, CAV1, HPGDS, PTGS2, SERPINE1, IDO1, TGFB1, CXCR2 and MMP9, was identified from the consensus genes, with areas under the receiver operating characteristic (ROC) curve (AUCs) values of 0.84 and 0.793 for the training and test cohorts, respectively. In the herb-compound-target network, twenty-four compounds were shown to interact with the 11 prognostic genes, which were significantly enriched in the IL-17 signaling, arachidonic acid metabolism and metabolic pathways. Single-cell analysis of the prognostic genes confirmed that their abnormal expression was associated with the TME of CRC.
    Conclusion: This study organically integrated network pharmacology and bioinformatics analyses to identify prognostic genes in CRC IIP patients from the targets of YYFZBJS. Although this data mining work was limited to the study of mechanisms related to prognosis based on the immune microenvironment, the methodology provides new perspectives in the search for novel therapeutic targets of traditional Chinese medicines (TCMs) and accurate diagnostic indicators of cancers targeted by TCMs.
    Language English
    Publishing date 2023-08-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 127557-4
    ISSN 1879-0534 ; 0010-4825
    ISSN (online) 1879-0534
    ISSN 0010-4825
    DOI 10.1016/j.compbiomed.2023.107432
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Effect of Yi Jin Jing exercise plus Elastic Band Resistance exercise on overall bone mineral density in postmenopausal women.

    Li, Jingyuan / Gu, Qing / Li, Ruixue / Wang, Ru / Cai, Yanwei / Huang, Yunda / Wang, Shasha / Wang, Suijun / Liu, Xiangyun

    Journal of science and medicine in sport

    2023  Volume 26, Issue 2, Page(s) 87–92

    Abstract: Objectives: This work aimed to study the effects of Yi Jin Jing plus Elastic Band Resistance ... their lifestyle behaviors unaltered, whereas the exercise group received  Yi Jin Jing plus Elastic Band Resistance ... Conclusions: The results suggested that Yi Jin Jing plus Elastic Band Resistance exercise could delay ...

    Abstract Objectives: This work aimed to study the effects of Yi Jin Jing plus Elastic Band Resistance exercise on bone mineral density at all parts of the body and bone metabolism index levels in postmenopausal women.
    Design: Randomized controlled trial.
    Methods: Forty postmenopausal women were randomly assigned equally to the exercise or to the control group. The control group maintained their lifestyle behaviors unaltered, whereas the exercise group received  Yi Jin Jing plus Elastic Band Resistance exercise. The primary outcome was overall bone mineral density at each part, and the secondary one was bone metabolism indicator levels and bone mineral density on both sides.
    Results: The results after six months showed increased bone mineral density at all parts of the body in the exercise group (spine, P = 0.002; thighs, lumbar, and whole body, P < 0.05) and decreased bone mineral density in the control group (trunk, pelvis, and spine, P < 0.01). In particular, the decrease and increase were greater on the non-preferred (left) side than on the right side. As for bone metabolism indexes, β-Crosslaps levels reduced (P = 0.016) and a significant increase in 1,25-(OH)2-D3 (P < 0.001) can be observed in the exercise group.
    Conclusions: The results suggested that Yi Jin Jing plus Elastic Band Resistance exercise could delay the overall decrease of bone mineral density in postmenopausal women, especially on the non-preferred side. It also increased bone formation metabolite levels and inhibited bone resorption metabolite levels.
    MeSH term(s) Humans ; Female ; Bone Density ; Postmenopause ; Resistance Training ; Exercise ; Spine
    Language English
    Publishing date 2023-01-14
    Publishing country Australia
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 1437829-2
    ISSN 1878-1861 ; 1440-2440
    ISSN (online) 1878-1861
    ISSN 1440-2440
    DOI 10.1016/j.jsams.2023.01.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Jian-Pi-Yi-Shen formula restores iron metabolism from dysregulation in anemic rats with adenine-induced nephropathy.

    Li, Changhui / Huang, Haipiao / Wang, Rui / Zhang, Chi / Huang, Shiying / Wu, Jinru / Mo, Pingli / Yu, Huimin / Li, Shunmin / Chen, Jianping

    Journal of ethnopharmacology

    2023  Volume 312, Page(s) 116526

    Abstract: Ethnopharmacological relevance: Jian-Pi-Yi-Shen (JPYS) is a herbal decoction being used to relieve ...

    Abstract Ethnopharmacological relevance: Jian-Pi-Yi-Shen (JPYS) is a herbal decoction being used to relieve the symptoms of chronic kidney disease (CKD) and its complications, including anemia, for over twenty years. Nonetheless, it is unclear how JPYS influences renal anemia and iron metabolism.
    Aim of the study: An analysis of network pharmacology, chemical profiling, and in vivo experiments was conducted to identify the impact of JPYS on JAK2-STAT3 pathway and iron utilization in renal anemia and CKD.
    Materials and methods: The chemical properties of JPYS and its exposed ingredients were detected in vivo. And based on the aforesaid chemical compounds, the potential targets and signaling pathways of JPYS for renal anemia treatment were predicted by network pharmacology. Afterward, an adenine-feeding animal model of CKD-related anemia was developed to verify the mechanism by which JPYS modulates iron recycling to treat renal anemia. Renal injury was estimated by serum creatinine (Scr), blood urea nitrogen (BUN), histopathological examinations and fibrosis degree. Western blot, enzyme-linked immunosorbent assay (ELISA), quantitative real-time polymerase chain reaction (qPCR) and immunohistochemistry approaches were utilized to assess the levels of JAK2, STAT3 and iron metabolism-related factors.
    Results: There were 164 active ingredients identified in JPYS, including prototypes and metabolites in vivo were identified in JPYS, and 21 core targets were found through network pharmacology based on topological characteristics. Combined with the core targets and pathway enrichment analysis, the majority of the candidate targets were associated with the JAK2-STAT3 signaling pathways. Experimental results indicated that JPYS treatment significantly decreased the expression of BUN and Scr, restored renal pathological damage, down-regulated fibrosis degree, and improved hematological parameters such as red blood cell, hemoglobin and hematocrit in CKD rats. Furthermore, JPYS significantly restored iron metabolism from dysregulation by increasing the levels of iron and ferritin in the serum, inhibiting the production of hepcidin in liver and serum, and regulating transferrin receptor 1 in bone marrow. Meanwhile, the expression of JAK2 and STAT3 was suppressed by JPYS treatment.
    Conclusions: Based on these results, JPYS reduces hepcidin levels by inhibiting the activation of JAK2-STAT3 signaling, thereby protecting against iron deficiency anemia.
    MeSH term(s) Rats ; Animals ; Hepcidins/metabolism ; Adenine ; Anemia/drug therapy ; Iron ; Renal Insufficiency, Chronic/chemically induced ; Renal Insufficiency, Chronic/drug therapy ; Fibrosis
    Chemical Substances Hepcidins ; Adenine (JAC85A2161) ; Iron (E1UOL152H7)
    Language English
    Publishing date 2023-04-23
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2023.116526
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Jian-Pi-Yi-Shen formula alleviates renal fibrosis by restoring NAD+ biosynthesis

    Gao, Liwen / Huang, Xi / Deng, Ruyu / Wu, Shanshan / Peng, Yu / Xiong, Guoliang / Lu, Jiandong / Liu, Xinhui

    Aging

    2023  Volume 16, Issue 1, Page(s) 106–128

    Abstract: Background: Patients with chronic kidney disease (CKD) lack efficacious treatment. Jian-Pi-Yi-Shen ...

    Abstract Background: Patients with chronic kidney disease (CKD) lack efficacious treatment. Jian-Pi-Yi-Shen formula (JPYSF) has demonstrated significant clinical efficacy in treating CKD for decades. However, its renoprotective mechanism has not been fully elucidated. This study aimed to determine whether JPYSF could delay renal fibrosis progression in CKD by restoring nicotinamide adenine dinucleotide (NAD+) biosynthesis.
    Methods: Adenine-diet feeding was used to model CKD in C57BL/6 mice. JPYSF was orally administered for 4 weeks. Human proximal tubular epithelial cells (HK-2) cells were stimulated with transforming growth factor-β1 (TGF-β1) with or without JPYSF treatment. Renal function of mice was assessed by serum creatinine and blood urea nitrogen levels. Renal histopathological changes were assessed using Periodic acid-Schiff and Masson's trichrome staining. Cell viability was assessed using a cell counting kit-8 assay. NAD+ concentrations were detected by a NAD+/NADH assay kit. Western blotting, immunohistochemistry, and immunofluorescence were employed to examine fibrosis-related proteins and key NAD+ biosynthesis enzymes expression in the CKD kidney and TGF-β1-induced HK-2 cells.
    Results: JPYSF treatment could not only improve renal function and pathological injury but also inhibit renal fibrosis in CKD mice. Additionally, JPYSF reversed fibrotic response in TGF-β1-induced HK-2 cells. Moreover, JPYSF rescued the decreased NAD+ content in CKD mice and TGF-β1-induced HK-2 cells through restoring expression of key enzymes in NAD+ biosynthesis, including quinolinate phosphoribosyltransferase, nicotinamide mononucleotide adenylyltransferase 1, and nicotinamide riboside kinase 1.
    Conclusions: JPYSF alleviated renal fibrosis in CKD mice and reversed fibrotic response in TGF-β1-induced HK-2 cells, which may be related to the restoration of NAD+ biosynthesis.
    MeSH term(s) Animals ; Humans ; Mice ; Fibrosis ; Kidney/pathology ; Mice, Inbred C57BL ; NAD/biosynthesis ; Renal Insufficiency, Chronic/metabolism ; Transforming Growth Factor beta1/metabolism
    Chemical Substances NAD (0U46U6E8UK) ; Transforming Growth Factor beta1
    Language English
    Publishing date 2023-12-28
    Publishing country United States
    Document type Journal Article
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.205352
    Database MEDical Literature Analysis and Retrieval System OnLINE

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