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  1. Article: Erratum: Yuan, W., et al. Genome-Wide Identification of Banana

    Yuan, Weina / Liu, Jing / Takáč, Tomáš / Chen, Houbin / Li, Xiaoquan / Meng, Jian / Tan, Yehuan / Ning, Tong / He, Zhenting / Yi, Ganjun / Xu, Chunxiang

    Plants (Basel, Switzerland)

    2021  Volume 10, Issue 4

    Abstract: The authors wish to make the following corrections to this paper [ ... ]. ...

    Abstract The authors wish to make the following corrections to this paper [...].
    Language English
    Publishing date 2021-03-30
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants10040654
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Assembly and comparative analysis of the first complete mitochondrial genome of a traditional Chinese medicine Angelica biserrata (Shan et Yuan) Yuan et Shan.

    Wang, Le / Liu, Xue / Xu, Yuanjiang / Zhang, Zhiwei / Wei, Yongsheng / Hu, Ying / Zheng, Changbing / Qu, Xianyou

    International journal of biological macromolecules

    2023  Volume 257, Issue Pt 1, Page(s) 128571

    Abstract: Duhuo, a member of the Angelica family, is widely used to treat ailments such as rheumatic pain. It possesses a diverse array of bioactivities, including anti-tumor, anti-inflammatory, and analgesic properties, as recent pharmacological research has ... ...

    Abstract Duhuo, a member of the Angelica family, is widely used to treat ailments such as rheumatic pain. It possesses a diverse array of bioactivities, including anti-tumor, anti-inflammatory, and analgesic properties, as recent pharmacological research has revealed. Nevertheless, the mtDNA of Angelica species remains relatively unexplored. To address this gap, we sequenced and assembled the mtDNA of A. biserrata to shed light on its genetic mechanisms and evolutionary pathways. Our investigation indicated a distinctive multi-branched conformation in the A. biserrata mtDNA. A comprehensive analysis of protein-coding sequences (PCGs) across six closely related species revealed the presence of 11 shared genes in their mitochondrial genomes. Intriguingly, positive selection emerged as a significant factor in the evolution of the atp4, matR, nad3, and nad7 genes. In addition, our data highlighted a recurring trend of homologous fragment migration between chloroplast and mitochondrial organelles. We identified 13 homologous fragments spanning both chloroplast and mitochondrial genomes. The phylogenetic tree established a close relationship between A. biserrata and Saposhnikovia divaricata. To sum up, our research would contribute to the application of population genetics and evolutionary studies in the genus Acanthopanax and other genera in the Araliaceae family.
    MeSH term(s) Medicine, Chinese Traditional ; Angelica/genetics ; Phylogeny ; Genome, Mitochondrial/genetics ; DNA, Mitochondrial
    Chemical Substances DNA, Mitochondrial
    Language English
    Publishing date 2023-12-03
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2023.128571
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Online: Yuan 1.0

    Wu, Shaohua / Zhao, Xudong / Yu, Tong / Zhang, Rongguo / Shen, Chong / Liu, Hongli / Li, Feng / Zhu, Hong / Luo, Jiangang / Xu, Liang / Zhang, Xuanwei

    Large-Scale Pre-trained Language Model in Zero-Shot and Few-Shot Learning

    2021  

    Abstract: ... into model architecture design. With this method, Yuan 1.0, the current largest singleton language model ... Few-Shot performance, and steady improvement is observed on the accuracy of various tasks. Yuan 1.0 ...

    Abstract Recent work like GPT-3 has demonstrated excellent performance of Zero-Shot and Few-Shot learning on many natural language processing (NLP) tasks by scaling up model size, dataset size and the amount of computation. However, training a model like GPT-3 requires huge amount of computational resources which makes it challengeable to researchers. In this work, we propose a method that incorporates large-scale distributed training performance into model architecture design. With this method, Yuan 1.0, the current largest singleton language model with 245B parameters, achieves excellent performance on thousands GPUs during training, and the state-of-the-art results on NLP tasks. A data processing method is designed to efficiently filter massive amount of raw data. The current largest high-quality Chinese corpus with 5TB high quality texts is built based on this method. In addition, a calibration and label expansion method is proposed to improve the Zero-Shot and Few-Shot performance, and steady improvement is observed on the accuracy of various tasks. Yuan 1.0 presents strong capacity of natural language generation, and the generated articles are difficult to distinguish from the human-written ones.
    Keywords Computer Science - Computation and Language ; Computer Science - Artificial Intelligence
    Subject code 004
    Publishing date 2021-10-10
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  4. Article: Response to Comment on Yuan et al: The use of external fixation for the management of acute and chronic Monteggia fractures in children.

    Yuan, Zhe / Xu, HongWen / Liu, YuanZhong / Li, YiQiang / Li, JingChun / Canavese, Federico

    Journal of children's orthopaedics

    2020  Volume 14, Issue 2, Page(s) 152–153

    Language English
    Publishing date 2020-04-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2279410-4
    ISSN 1863-2548 ; 1863-2521
    ISSN (online) 1863-2548
    ISSN 1863-2521
    DOI 10.1302/1863-2548.14.200031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6613: Show issues Location:
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  5. Article: Yuan-Zhi decoction in the treatment of Alzheimer's disease: An integrated approach based on chemical profiling, network pharmacology, molecular docking and experimental evaluation.

    Wu, Qiong / Li, Xiang / Jiang, Xiao-Wen / Yao, Dong / Zhou, Li-Jun / Xu, Zi-Hua / Wang, Nan / Zhao, Qing-Chun / Zhang, Zhou

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 893244

    Abstract: Yuan-Zhi Decoction (YZD) is a traditional Chinese medical formulation with demonstrated clinical ...

    Abstract Yuan-Zhi Decoction (YZD) is a traditional Chinese medical formulation with demonstrated clinical benefits in Alzheimer's disease (AD). We used liquid chromatography coupled with mass spectrometry to identify 27 unique chemical components of YZD. Analyzing these using network pharmacology and molecular docking models identified 34 potential interacting molecular targets involved in 26 biochemical pathways. When tested in an animal model of AD, the APP/PS1 transgenic mice showed measurable improvements in spatial orientation and memory after the administration of YZD. These improvements coincided with significantly reduced deposition of Aβ plaques and tau protein in the hippocampi in the treated animals. In addition, a decreased BACE1 and beta-amyloid levels, a downregulation of the p-GSK-3β/GSK-3β, and an upregulation of the PI3K and p-AKT/AKT pathway was seen in YZD treated animals. These
    Language English
    Publishing date 2022-08-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.893244
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: [Comparative study on the academic thought of bloodletting for expelling pathogens between Jin-Yuan Dynasties and Ming-Qing Dynasties].

    Chen, Hao / She, Yan-Fen / Gao, Ya-Yu / Song, Xiao-Dan / Fan, Xi-Sheng / Shi, Xu-Liang / Dong, Shang-Pu / Lv, Jing

    Zhongguo zhen jiu = Chinese acupuncture & moxibustion

    2021  Volume 41, Issue 7, Page(s) 813–817

    Abstract: ... of the medical representative scholars in Jin-Yuan Dynasties and Ming-Qing Dynasties respectively to construct ... the databases of bloodletting for expelling pathogens of Jin-Yuan Dynasties and Ming-Qing Dynasties. Using ... that the three-edge needle is the most commonly used device for bloodletting in Jin-Yuan Dynasties and Ming-Qing ...

    Abstract The relevant provisions of bloodletting for expelling pathogens are collected from the works of the medical representative scholars in Jin-Yuan Dynasties and Ming-Qing Dynasties respectively to construct the databases of bloodletting for expelling pathogens of Jin-Yuan Dynasties and Ming-Qing Dynasties. Using frequency analysis, the bloodletting device, bloodletting location, bloodletting volume, the related pathogens and indications are compared between these two times so that the evidences could be provided for the inheritance and development of the academic thought of bloodletting for expelling pathogens. It is found that the three-edge needle is the most commonly used device for bloodletting in Jin-Yuan Dynasties and Ming-Qing Dynasties and
    MeSH term(s) Acupuncture Points ; Bloodletting ; China ; Medicine, Chinese Traditional ; Meridians ; Needles
    Language Chinese
    Publishing date 2021-07-14
    Publishing country China
    Document type Journal Article
    ISSN 0255-2930
    ISSN 0255-2930
    DOI 10.13703/j.0255-2930.20200609-k0002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A randomized, placebo-controlled, double-blind trial to evaluate efficacy and safety of Shen-Yuan-Dan capsules, a traditional Chinese medicine, for treatment of peri-procedure myocardial injury following percutaneous coronary intervention.

    Li, Xiang / Zhang, Ying / Liu, Hong-Xu / Shang, Ju-Ju / Zhou, Qi / Li, Ai-Yong / Lai, Xiao-Lei / Xing, Wen-Long / Jia, Si-Han

    Complementary therapies in medicine

    2022  Volume 69, Page(s) 102841

    Abstract: ... research have shown that Shen-Yuan-Dan (SYD) capsules, a traditional Chinese medicine, can potentially ...

    Abstract Background: Peri-procedural myocardial injury (PMI) is a common complication of percutaneous coronary intervention (PCI), which cannot be entirely avoided using available treatments. The findings of earlier research have shown that Shen-Yuan-Dan (SYD) capsules, a traditional Chinese medicine, can potentially alleviating PMI. This study aimed to confirm further this hypothesis in a rigorous, well-designed randomized controlled study.
    Methods: Our clinical trial was randomized, double-blinded, and placebo-controlled. A total of 181 patients with unstable angina (UA) undergoing elective PCI were randomized to pretreatment with SYD or a placebo under the basis of conventional treatment; 87 patients were pretreated with SYD (4 capsules, 3 times a day, with a further 4 capsules 2 h before PCI) 3 days before the procedure, and 94 patients were given a placebo. No patients received reloading statins before PCI, and SYD or placebo was maintained for 1 month after PCI. The primary endpoint was the incidence of PMI. The secondary endpoint was calculating the incidence rate of all 30-day major adverse cardiovascular events (all-cause mortality, non-fatal myocardial infarction, unplanned revascularization). The safety outcomes, including abnormalities in electrocardiogram and serum biochemical examinations caused by drug use, were also tested.
    Results: The levels of creatine kinase-myocardial band (CK-MB) in both the SYD and placebo groups were increased at 4 h and 24 h after PCI compared with before the procedure (P < 0.05). The incidence rate of PMI in the SYD group (10.3 %) was lower than that in the placebo group (34 %) (absolute difference, 23.7 % [95 % CI, 11.7-34.8 %], P < 0.01). After taking SYD, the relative risk reduction (RRR) and absolute risk reduction (ARR) were 69.7 % and 24.3 %, respectively; further, number needed to treat (NNT) was 4.2. The 30-day major adverse cardiovascular event (MACE) rate was not statistically different between the SYD and placebo groups (6.9 % vs. 9.6 %, P = 0.352). There were no abnormal situations during the trial.
    Conclusion: These findings showed that pretreatment with SYD could safely reduce the incidence rate of PMI in patients with UA undergoing elective PCI. Further study on the effects of SYD and how it can improve adverse cardiovascular events outcomes is needed.
    MeSH term(s) Double-Blind Method ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Medicine, Chinese Traditional ; Myocardial Infarction/drug therapy ; Percutaneous Coronary Intervention/adverse effects ; Percutaneous Coronary Intervention/methods ; Treatment Outcome
    Chemical Substances Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Language English
    Publishing date 2022-05-25
    Publishing country Scotland
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 1155895-7
    ISSN 1873-6963 ; 0965-2299
    ISSN (online) 1873-6963
    ISSN 0965-2299
    DOI 10.1016/j.ctim.2022.102841
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3726: Show issues Location:
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  8. Article: Repair of Adult Mammalian Heart After Damages by Oral Intake of Gu Ben Pei Yuan San.

    Cui, Baiping / Zheng, Yufan / Zhou, Xinyan / Zhu, Jiaqi / Zhuang, Jiexian / Liang, Qianqian / Xu, Chen / Sheng, Wei / Huang, Guoying / Luan, Lina / Sun, Ning

    Frontiers in physiology

    2019  Volume 10, Page(s) 607

    Abstract: ... concoction named Gu Ben Pei Yuan San (GBPYS), which is composed of ...

    Abstract Adult mammalian heart repair after myocardial damage is highly inefficient due to the post-mitotic nature of cardiomyocytes. Interestingly, in traditional Chinese medicine (TCM), there are reported effective treatments of myocardial infarction (MI) and heart failure in adult humans by oral intake of a TCM concoction named Gu Ben Pei Yuan San (GBPYS), which is composed of
    Language English
    Publishing date 2019-05-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2019.00607
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book: Yi yuan zhen cang

    Xu, Hongtao

    Taizhou Shi ren min yi yuan = Hospital collection : Taizhou People's Hospital

    2013  

    Title variant Hospital collection :
    Institution Taizhou Shi ren min yi yuan
    Author's details Xu Hongtao zhu bian
    MeSH term(s) Hospitals, Community
    Language Chinese
    Size 4, 219 pages :, illustrations
    Edition Di 1 ban.
    Document type Book
    ISBN 9787550602830 ; 7550602832
    Database Catalogue of the US National Library of Medicine (NLM)

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  10. Book: Kong zi xue yuan

    Xu, Lin

    The story so far

    2012  

    Author's details Xu lin zong bian
    Language Chinese
    Size 513 p, col. ill.
    Publisher Guo jia han ban
    Publishing place s.l.
    Document type Book
    Database Former special subject collection: coastal and deep sea fishing

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