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Article ; Online: Letter to the editor: Exploiting the anatomy of the anterior abdominal wall when raising a permanent stoma.

Sams, Emily / Stephenson, Brian M

2024

Language	English
Publishing date	2024-02-28
Publishing country	United States
Document type	Letter
ZDB-ID	202467-6
ISSN	1532-7361 ; 0039-6060
ISSN (online)	1532-7361
ISSN	0039-6060
DOI	10.1016/j.surg.2023.12.028
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Article ; Online: Food Marketing and Power: Teen-Identified Indicators of Targeted Food Marketing.

Elliott, Charlene / Truman, Emily / Stephenson, Nikki

International journal of environmental research and public health

2022 Volume 19, Issue 13

Abstract: Food marketing is powerful and prevalent, influencing young people's food attitudes, preferences, and dietary habits. Teenagers are aggressively targeted by unhealthy food marketing messages across a range of platforms, prompting recognition of the need ... ...

Abstract	Food marketing is powerful and prevalent, influencing young people's food attitudes, preferences, and dietary habits. Teenagers are aggressively targeted by unhealthy food marketing messages across a range of platforms, prompting recognition of the need to monitor such marketing. To monitor, criteria for what counts as teen-targeted food marketing content (i.e., persuasive techniques) must first be established. This exploratory study engaged teenagers to explore the "power" of food marketing by identifying what they consider to be teen-targeted marketing techniques within various food marketing examples. Fifty-four teenagers (ages 13-17) participated in a tagging exercise of 19 pre-selected food/beverage advertisements. Assessed in light of age and gender, the results showed clear consistency with what indicators the participants identified when it comes to selecting "teen-targeted" ads-with advertisements most frequently chosen as "teen-targeted" containing humor (particularly irony) and celebrities. When it comes to specific indicators used by teenagers, visual style dominated, standing as the marketing technique with the most "power" for teenagers. The findings shed much needed insight into the elements of power-and more precisely, the specific marketing techniques persuasive to teenagers-which are necessary to inform monitoring efforts and to create evidence-based policy.
MeSH term(s)	Adolescent ; Advertising/methods ; Beverages ; Food ; Food Industry ; Food Preferences ; Humans ; Marketing/methods ; Television
Language	English
Publishing date	2022-06-25
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph19137815
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Article ; Online: Implementing a Statewide Speakers Bureau to Address Maternal Morbidity and Mortality.

Stephenson, Emily / Newnam, Katherine / Barker, Brenda / Brewer, Tracy

Nursing for women's health

2022 Volume 26, Issue 3, Page(s) 194–204

Abstract: Objective: To implement a speakers bureau to educate providers, health caregivers, and staff practicing within Tennessee hospitals on evidence-based practice recommendations related to opioid use disorder in pregnancy, postpartum hemorrhage, maternal ... ...

Abstract	Objective: To implement a speakers bureau to educate providers, health caregivers, and staff practicing within Tennessee hospitals on evidence-based practice recommendations related to opioid use disorder in pregnancy, postpartum hemorrhage, maternal hypertension, and implicit bias. Design: Quality improvement project. Setting/local problem: Multiple health care facilities throughout Tennessee, where rates of pregnancy-related mortality are greater than the national average and where Black women are three times as likely as White women to die of pregnancy complications. Participants: Speakers (n = 47) included obstetricians, advanced practice providers, and nurses. Program attendees (n = 369) included providers and caregivers representing five health care facilities. Intervention/measurements: Speakers were provided standardized training to disseminate best practice methods. Current evidence-based presentations regarding the top maternal mortality concerns were formatted for educational events at five Tennessee health care facilities. Independent outcome measures using electronic survey instruments were collected for speakers and audience participants. Speakers evaluated training methods, and participants evaluated the quality and efficacy of the information provided. Results: Based on speaker evaluations, 70.59% rated the quality of training as 5 of 5, and 76.47% rated the relevance of training as 5 of 5. Overall, 16 of 17 (94.1%) speakers stated that adequate training was provided. Analysis of participant evaluations reported that 57.5% were very confident (5/5) that the information learned through the speakers bureau will improve their care of pregnant and postpartum people. Additionally, 71% were very likely (5/5) to apply the information to their practice. Conclusion: This project showed the dissemination of best practices by promoting knowledge, supporting practice change, and improving retained information in maternity providers and caregiver participants. Implementation of speakers bureaus to educate providers and caregivers within health care facilities has the potential to influence practice change and decrease maternal morbidity and mortality rates in the state of Tennessee.
MeSH term(s)	Female ; Humans ; Maternal Mortality ; Postpartum Hemorrhage ; Pre-Eclampsia ; Pregnancy ; Pregnancy Complications ; Quality Improvement
Language	English
Publishing date	2022-05-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2275619-X
ISSN	1751-486X ; 1751-4851
ISSN (online)	1751-486X
ISSN	1751-4851
DOI	10.1016/j.nwh.2022.03.004
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Article ; Online: Food Marketing and Power

Charlene Elliott / Emily Truman / Nikki Stephenson

International Journal of Environmental Research and Public Health, Vol 19, Iss 7815, p

Teen-Identified Indicators of Targeted Food Marketing

2022 Volume 7815

Abstract: Food marketing is powerful and prevalent, influencing young people’s food attitudes, preferences, and dietary habits. Teenagers are aggressively targeted by unhealthy food marketing messages across a range of platforms, prompting recognition of the need ... ...

Abstract	Food marketing is powerful and prevalent, influencing young people’s food attitudes, preferences, and dietary habits. Teenagers are aggressively targeted by unhealthy food marketing messages across a range of platforms, prompting recognition of the need to monitor such marketing. To monitor, criteria for what counts as teen-targeted food marketing content (i.e., persuasive techniques) must first be established. This exploratory study engaged teenagers to explore the “power” of food marketing by identifying what they consider to be teen-targeted marketing techniques within various food marketing examples. Fifty-four teenagers (ages 13–17) participated in a tagging exercise of 19 pre-selected food/beverage advertisements. Assessed in light of age and gender, the results showed clear consistency with what indicators the participants identified when it comes to selecting “teen-targeted” ads—with advertisements most frequently chosen as “teen-targeted” containing humor (particularly irony) and celebrities. When it comes to specific indicators used by teenagers, visual style dominated, standing as the marketing technique with the most “power” for teenagers. The findings shed much needed insight into the elements of power—and more precisely, the specific marketing techniques persuasive to teenagers—which are necessary to inform monitoring efforts and to create evidence-based policy.
Keywords	food ; marketing ; advertising ; youth ; teenager ; adolescent ; Medicine ; R
Subject code	360
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article: Location, location, location: mapping the lymphoma tumor microenvironment using spatial transcriptomics.

Pickard, Keir / Stephenson, Emily / Mitchell, Alex / Jardine, Laura / Bacon, Chris M

Frontiers in oncology

2023 Volume 13, Page(s) 1258245

Abstract: Lymphomas are a heterogenous group of lymphoid neoplasms with a wide variety of clinical presentations. Response to treatment and prognosis differs both between and within lymphoma subtypes. Improved molecular and genetic profiling has increased our ... ...

Abstract	Lymphomas are a heterogenous group of lymphoid neoplasms with a wide variety of clinical presentations. Response to treatment and prognosis differs both between and within lymphoma subtypes. Improved molecular and genetic profiling has increased our understanding of the factors which drive these clinical dynamics. Immune and non-immune cells within the lymphoma tumor microenvironment (TME) can both play a key role in antitumor immune responses and conversely also support lymphoma growth and survival. A deeper understanding of the lymphoma TME would identify key lymphoma and immune cell interactions which could be disrupted for therapeutic benefit. Single cell RNA sequencing studies have provided a more comprehensive description of the TME, however these studies are limited in that they lack spatial context. Spatial transcriptomics provides a comprehensive analysis of gene expression within tissue and is an attractive technique in lymphoma to both disentangle the complex interactions between lymphoma and TME cells and improve understanding of how lymphoma cells evade the host immune response. This article summarizes current spatial transcriptomic technologies and their use in lymphoma research to date. The resulting data has already enriched our knowledge of the mechanisms and clinical impact of an immunosuppressive TME in lymphoma and the accrual of further studies will provide a fundamental step in the march towards personalized medicine.
Language	English
Publishing date	2023-10-04
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1258245
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Article ; Online: The Impact of the COVID-19 Pandemic on Demand for Emergency Ambulances in Victoria, Australia.

Andrew, Emily / Nehme, Ziad / Stephenson, Michael / Walker, Tony / Smith, Karen

Prehospital emergency care

2021 , Page(s) 1–7

Abstract: Objective: ...

Abstract	Objective:
Language	English
Publishing date	2021-07-16
Publishing country	England
Document type	Journal Article
ZDB-ID	1461751-1
ISSN	1545-0066 ; 1090-3127
ISSN (online)	1545-0066
ISSN	1090-3127
DOI	10.1080/10903127.2021.1944409
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Article ; Online: Multiomics uncovers developing immunological lineages in human.

Stephenson, Emily / Webb, Simone / Haniffa, Muzlifah

European journal of immunology

2021 Volume 51, Issue 4, Page(s) 764–772

Abstract: The development of the human immune system during embryonic and fetal life has historically been difficult to research due to limited access to human tissue. Experimental animal models have been widely used to study development but cellular and molecular ...

Abstract	The development of the human immune system during embryonic and fetal life has historically been difficult to research due to limited access to human tissue. Experimental animal models have been widely used to study development but cellular and molecular programmes may not be conserved across species. The advent of multiomic single-cell technologies and an increase in human developmental tissue biobank resources have facilitated single-cell multiomic studies focused on human immune development. A critical question in the near future is "How do we best reconcile scientific findings across multiple omic modalities, developmental time, and organismic space?" In this review, we discuss the application of single-cell multiomic technologies to unravel the major cellular lineages in the prenatal human immune system. We also identify key areas where the combined power of multiomics technologies can be leveraged to address specific immunological gaps in our current knowledge and explore new research horizons in human development.
MeSH term(s)	Cell Lineage/genetics ; Cell Lineage/immunology ; Embryo, Mammalian/embryology ; Embryo, Mammalian/immunology ; Embryo, Mammalian/metabolism ; Embryonic Development/genetics ; Embryonic Development/immunology ; Epigenomics/methods ; Gene Expression Profiling/methods ; Genomics/methods ; High-Throughput Nucleotide Sequencing/methods ; Humans ; Proteomics/methods ; Single-Cell Analysis/methods
Language	English
Publishing date	2021-03-10
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	120108-6
ISSN	1521-4141 ; 0014-2980
ISSN (online)	1521-4141
ISSN	0014-2980
DOI	10.1002/eji.202048769
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Article ; Online: Treatment of Legacy Nitrogen as a Compliance Option to Meet Chesapeake Bay TMDL Requirements.

Stephenson, Kurt / Ferris, William / Bock, Emily / Easton, Zachary M

Environmental science & technology

2021 Volume 55, Issue 20, Page(s) 13593–13601

Abstract: In efforts to combat eutrophication, the U.S. Environmental Protection Agency has established aggressive nitrogen, phosphorus, and sediment reduction goals for states and regulated dischargers within the Chesapeake Bay watershed. Chesapeake Bay ... ...

Abstract	In efforts to combat eutrophication, the U.S. Environmental Protection Agency has established aggressive nitrogen, phosphorus, and sediment reduction goals for states and regulated dischargers within the Chesapeake Bay watershed. Chesapeake Bay jurisdictions are struggling to meet the nutrient (N, P) reduction goals. This paper evaluates the efficacy of removing legacy N from groundwater as a compliance strategy for three potential classes of "buyers" of N reductions in the Chesapeake Bay watershed: permitted point sources, permitted municipal stormwater systems (called MS4s), and state nonpoint source (NPS) managers. We compare denitrifying spring bioreactors with conventional agricultural and urban NPS removal technologies using evaluative criteria important to each of these buyers. Results indicate that spring bioreactors compare favorably to other N removal technologies based on cost effectiveness, administrative costs, and certainty of N removal performance. Most conventional NPS technologies provide greater ancillary benefits. On balance, denitrifying spring bioreactors add a valuable compliance option to those tasked with achieving Bay N reduction goals.
MeSH term(s)	Agriculture ; Bays ; Nitrogen/analysis ; Phosphorus/analysis ; Water Quality
Chemical Substances	Phosphorus (27YLU75U4W) ; Nitrogen (N762921K75)
Language	English
Publishing date	2021-10-06
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	1520-5851
ISSN (online)	1520-5851
DOI	10.1021/acs.est.1c04022
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Functional and multi-omics signatures of mitapivat efficacy upon activation of pyruvate kinase in red blood cells from patients with sickle cell disease.

D'Alessandro, Angelo / Le, Kang / Lundt, Maureen / Li, Quan / Dunkelberger, Emily B / Cellmer, Troy / Worth, Andrew J / Patil, Spurthi / Huston, Chris / Grier, Abby / Dzieciatkowska, Monika / Stephenson, Daniel / Eaton, William A / Thein, Swee Lay

Haematologica

2024

Abstract: Mitapivat, a pyruvate kinase (PK) activator, shows great potential as a sickle cell disease (SCD)- modifying therapy. Safety and efficacy of mitapivat as a long-term maintenance therapy is currently being evaluated in two open-label studies. Here we ... ...

Abstract	Mitapivat, a pyruvate kinase (PK) activator, shows great potential as a sickle cell disease (SCD)- modifying therapy. Safety and efficacy of mitapivat as a long-term maintenance therapy is currently being evaluated in two open-label studies. Here we apply a comprehensive multi-omics approach to investigate the impact of activating PK on red blood cells (RBCs) from 15 SCD patients. HbSS patients were enrolled in one of the open label, extended studies (NCT04610866). Leuko-depleted RBCs obtained from fresh whole blood at baseline (visit 1, V1), prior to drug initiation and longitudinal time points over the course of the study were processed for multiomics through a stepwise extraction of metabolites, lipids and proteins. Mitapivat therapy had significant effects on the metabolome, lipidome and proteome of SCD RBCs. Mitapivat decreased 2,3-diphosphoglycerate (DPG) levels, increased adenosine triphosphate (ATP) levels, and improved hematologic and sickling parameters in patients with SCD. Agreement between omics measurements and clinical measurements confirmed the specificity of mitapivat on targeting late glycolysis, with glycolytic metabolites ranking as the top correlates to parameters of hemoglobin S (HbS) oxygen affinity (p50) and sickling kinetics (t50) during treatment. Mitapivat markedly reduced levels of proteins of mitochondrial origin within 2 weeks of initiation of drug treatment, with minimal changes in the reticulocyte counts. The first six months of treatment also witnessed transient elevation of lysophosphatidylcholines and oxylipins with depletion in free fatty acids, suggestive of an effect on membrane lipid remodeling. Multi-omics analysis of RBCs identified benefits for glycolysis, as well as activation of the Lands cycle.
Language	English
Publishing date	2024-03-07
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2333-4
ISSN	1592-8721 ; 0017-6567 ; 0390-6078
ISSN (online)	1592-8721
ISSN	0017-6567 ; 0390-6078
DOI	10.3324/haematol.2023.284831
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Article ; Online: Changing intra‐ and interspecific interactions across sedimentary and environmental stress gradients

Douglas, Emily J. / Hewitt, Judi / Lohrer, A. M. / Stephenson, F.

Ecosphere. 2023 Jan., v. 14, no. 1 p.e4373-

2023

Abstract: Intensifying land use and accelerated erosion has resulted in increased delivery and deposition of fine terrestrially derived sediment to coastal ecosystems, increasing sediment mud content in estuarine ecosystems. This change in the sedimentary ... ...

Abstract	Intensifying land use and accelerated erosion has resulted in increased delivery and deposition of fine terrestrially derived sediment to coastal ecosystems, increasing sediment mud content in estuarine ecosystems. This change in the sedimentary environment is known to have negative consequences for ecosystem functioning. Yet indirect and cyclical relationships between species and the environment are rarely investigated, despite being crucial for understanding ecosystem resilience. We investigate changes in intra‐ and inter‐specific interactions between two key intertidal species (Austrovenus stutchburyi and Macomona liliana) with different but overlapping environmental preferences. We use a large dataset spanning 29 estuaries and 0%–87% mud content to predict the effects of increases in mud. We observed important changes in feedback loops between Austrovenus recent recruits, older individuals, and sediment shell content, and between Macomona and chlorophyll with increasing stress (mud). These loops show different characteristics in the high and low mud content ecosystems and are not apparent in moderate mud. Increases in the number of paths and weaker/more variable relationships between low and moderate mud also occurred. Thus, our moderate (12%–25%) mud content model may be encompassing a transition point in ecosystem dynamics where interaction networks break down and shift to an alternate state.
Keywords	accelerated erosion ; chlorophyll ; data collection ; ecological resilience ; ecosystems ; estuaries ; land use ; littoral zone ; models ; sediments
Language	English
Dates of publication	2023-01
Publishing place	John Wiley & Sons, Inc.
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	2572257-8
ISSN	2150-8925
ISSN	2150-8925
DOI	10.1002/ecs2.4373
Database	NAL-Catalogue (AGRICOLA)

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