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  1. Article ; Online: Enhancing diagnostic precision in liver lesion analysis using a deep learning-based system: opportunities and challenges.

    Lee, Jeong Min / Bae, Jae Seok

    Nature reviews. Clinical oncology

    2024  

    Language English
    Publishing date 2024-03-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2491410-1
    ISSN 1759-4782 ; 1759-4774
    ISSN (online) 1759-4782
    ISSN 1759-4774
    DOI 10.1038/s41571-024-00887-x
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6029: Show issues Location:
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    Zs.MG 103: Show issues

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  2. Article: Acquired antineutrophil cytoplasmic antibody-associated glomerulonephritis after COVID-19 infection.

    Lee, Jeong-Yeun / Hwang, Hyeon Seok

    Kidney research and clinical practice

    2023  Volume 42, Issue 3, Page(s) 405–408

    Language English
    Publishing date 2023-04-14
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2656420-8
    ISSN 2211-9132
    ISSN 2211-9132
    DOI 10.23876/j.krcp.22.261
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  3. Article ; Online: A patient with dyspnea and multiple pulmonary nodules.

    Jeong, Jae Seok / Park, Jun Hyung / Maeng, Ji In / Chung, Myoung Ja / Lee, Yong Chul

    The Korean journal of internal medicine

    2024  

    Language English
    Publishing date 2024-04-19
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 639023-7
    ISSN 2005-6648 ; 1226-3303
    ISSN (online) 2005-6648
    ISSN 1226-3303
    DOI 10.3904/kjim.2023.356
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 3028: Show issues Location:
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  4. Article ; Online: Comprehensive workflow encompassing discovery, verification, and quantification of indicator peptide in snail mucin using LC-quadrupole Orbitrap high-resolution tandem mass spectrometry.

    Moon, Sung-Kwon / Jeong, Eun-Jin / Tonog, Genevieve / Jin, Cheng-Min / Lee, Jeong-Seok / Kim, Hoon

    Food research international (Ottawa, Ont.)

    2024  Volume 180, Page(s) 114054

    Abstract: Peptidomics analysis was conducted using high-resolution tandem mass spectrometry ( ... ...

    Abstract Peptidomics analysis was conducted using high-resolution tandem mass spectrometry (MS
    MeSH term(s) Tandem Mass Spectrometry/methods ; Mucins ; Workflow ; Peptides/chemistry
    Chemical Substances Mucins ; Peptides
    Language English
    Publishing date 2024-01-28
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 1111695-x
    ISSN 1873-7145 ; 0963-9969
    ISSN (online) 1873-7145
    ISSN 0963-9969
    DOI 10.1016/j.foodres.2024.114054
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    In stock of ZB MED Bonn / Germany

    Z 2972: Show issues

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  5. Article ; Online: Prior respiratory syncytial viral infection contributes to severe COVID-19 illness: A nationwide cohort study.

    Lee, Hwan Jin / Kim, Min Ji / Kim, Jong Seung / Lee, Yong Chul / Jeong, Jae Seok

    Allergy

    2024  

    Language English
    Publishing date 2024-04-05
    Publishing country Denmark
    Document type Letter
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.16118
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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.150: Show issues Location:
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    Zs.MO 125: Show issues

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  6. Article ; Online: Mechanistic insight into human androgen receptor-mediated endocrine disrupting potential of cyclic depsipeptide mycotoxin, beauvericin, and influencing environmental factors for its biosynthesis in Fusarium oxysporum KFCC 11363P on rice cereal.

    Jeong, Da-Hyun / Jung, Da-Woon / You, Chaemin / Lee, Hee-Seok

    Ecotoxicology and environmental safety

    2024  Volume 274, Page(s) 116227

    Abstract: In current study, Fusarium mycotoxin, beauvericin (BEA), has endocrine disrupting potential through suppressing the exogenous androgen receptor (AR)-mediated transcriptional activation. BEA was classified as an AR antagonist, with ... ...

    Abstract In current study, Fusarium mycotoxin, beauvericin (BEA), has endocrine disrupting potential through suppressing the exogenous androgen receptor (AR)-mediated transcriptional activation. BEA was classified as an AR antagonist, with IC
    MeSH term(s) Humans ; Depsipeptides/toxicity ; Edible Grain/chemistry ; Fusarium/metabolism ; Mycotoxins/toxicity ; Oryza/chemistry ; Receptors, Androgen/drug effects ; Receptors, Androgen/metabolism ; Endocrine Disruptors/chemistry ; Endocrine Disruptors/toxicity
    Chemical Substances beauvericin (26S048LS2R) ; Depsipeptides ; Mycotoxins ; Receptors, Androgen ; Endocrine Disruptors
    Language English
    Publishing date 2024-03-16
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 436536-7
    ISSN 1090-2414 ; 0147-6513
    ISSN (online) 1090-2414
    ISSN 0147-6513
    DOI 10.1016/j.ecoenv.2024.116227
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1418: Show issues Location:
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  7. Article ; Online: Multiple treatments with human embryonic stem cell-derived mesenchymal progenitor cells preserved the fertility and ovarian function of perimenopausal mice undergoing natural aging.

    Shin, Eun-Young / Jeong, Suji / Lee, Jeoung Eun / Jeong, Dong Seok / Han, Dong Keun / Hong, Seok-Ho / Lee, Dong Ryul

    Stem cell research & therapy

    2024  Volume 15, Issue 1, Page(s) 58

    Abstract: Objectives: Currently, no approved stem cell-based therapies for preserving ovarian function during aging. To solve this problem, we developed a long-term treatment for human embryonic stem cell-derived mesenchymal progenitor cells (hESC-MPCs). We ... ...

    Abstract Objectives: Currently, no approved stem cell-based therapies for preserving ovarian function during aging. To solve this problem, we developed a long-term treatment for human embryonic stem cell-derived mesenchymal progenitor cells (hESC-MPCs). We investigated whether the cells retained their ability to resist ovarian aging, which leads to delayed reproductive senescence.
    Materials and methods: In a middle-aged female model undergoing natural aging, we analyzed whether hESC-MPCs benefit the long-term maintenance of reproductive fecundity and ovarian reservoirs and how their transplantation regulates ovarian function.
    Results: The number of primordial follicles and mice with regular estrous cycles were increased in perimenopausal mice who underwent multiple introductions of hESC-MPCs compared to age-matched controls. The estradiol levels in the hESC-MPCs group were restored to those in the young and adult groups. Embryonic development and live birth rates were higher in the hESC-MPC group than in the control group, suggesting that hESC-MPCs delayed ovarian senescence. In addition to their direct effects on the ovary, multiple-treatments with hESC-MPCs reduced ovarian fibrosis by downregulating inflammation and fibrosis-related genes via the suppression of myeloid-derived suppressor cells (MDSCs) produced in the bone marrow.
    Conclusions: Multiple introductions of hESC-MPCs could be a useful approach to prevent female reproductive senescence and that these cells are promising sources for cell therapy to postpone the ovarian aging and retain fecundity in perimenopausal women.
    MeSH term(s) Adult ; Pregnancy ; Middle Aged ; Female ; Humans ; Animals ; Mice ; Human Embryonic Stem Cells ; Perimenopause ; Fertility ; Aging ; Mesenchymal Stem Cells ; Fibrosis
    Language English
    Publishing date 2024-03-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2548671-8
    ISSN 1757-6512 ; 1757-6512
    ISSN (online) 1757-6512
    ISSN 1757-6512
    DOI 10.1186/s13287-024-03684-6
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  8. Article: Bone Substitute Options for Spine Fusion in Patients With Spine Trauma-Part II: The Role of rhBMP.

    Seok, Min Cheol / Koo, Hae-Won / Jeong, Je Hoon / Ko, Myeong Jin / Lee, Byung-Jou

    Korean journal of neurotrauma

    2024  Volume 20, Issue 1, Page(s) 35–44

    Abstract: In Part II, we focus on an important aspect of spine fusion in patients with spine trauma: the pivotal role of recombinant human bone morphogenetic protein-2 (rhBMP-2). Despite the influx of diverse techniques facilitated by technological advancements in ...

    Abstract In Part II, we focus on an important aspect of spine fusion in patients with spine trauma: the pivotal role of recombinant human bone morphogenetic protein-2 (rhBMP-2). Despite the influx of diverse techniques facilitated by technological advancements in spinal surgery, spinal fusion surgery remains widely used globally. The persistent challenge of spinal pseudarthrosis has driven extensive efforts to achieve clinically favorable fusion outcomes, with particular emphasis on the evolution of bone graft substitutes. Part II of this review aims to build upon the foundation laid out in Part I by providing a comprehensive summary of commonly utilized bone graft substitutes for spinal fusion in patients with spinal trauma. Additionally, it will delve into the latest advancements and insights regarding the application of rhBMP-2, offering an updated perspective on its role in enhancing the success of spinal fusion procedures.
    Language English
    Publishing date 2024-03-21
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 3028579-3
    ISSN 2288-2243 ; 2234-8999
    ISSN (online) 2288-2243
    ISSN 2234-8999
    DOI 10.13004/kjnt.2024.20.e13
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  9. Article ; Online: Single-Cell Genomics for Investigating Pathogenesis of Inflammatory Diseases.

    Jung, Seyoung / Lee, Jeong Seok

    Molecules and cells

    2023  Volume 46, Issue 2, Page(s) 120–129

    Abstract: Recent technical advances have enabled unbiased transcriptomic and epigenetic analysis of each cell, known as "single-cell analysis". Single-cell analysis has a variety of technical approaches to investigate the state of each cell, including mRNA levels ( ...

    Abstract Recent technical advances have enabled unbiased transcriptomic and epigenetic analysis of each cell, known as "single-cell analysis". Single-cell analysis has a variety of technical approaches to investigate the state of each cell, including mRNA levels (transcriptome), the immune repertoire (immune repertoire analysis), cell surface proteins (surface proteome analysis), chromatin accessibility (epigenome), and accordance with genome variants (eQTLs; expression quantitative trait loci). As an effective tool for investigating robust immune responses in coronavirus disease 2019 (COVID-19), many researchers performed single-cell analysis to capture the diverse, unbiased immune cell activation and differentiation. Despite challenges elucidating the complicated immune microenvironments of chronic inflammatory diseases using existing experimental methods, it is now possible to capture the simultaneous immune features of different cell types across inflamed tissues using various single-cell tools. In this review, we introduce patient-based and experimental mouse model research utilizing single-cell analyses in the field of chronic inflammatory diseases, as well as multi-organ atlas targeting immune cells.
    MeSH term(s) Animals ; Mice ; COVID-19 ; Cell Differentiation ; Chromatin ; Disease Models, Animal ; Genomics
    Chemical Substances Chromatin
    Language English
    Publishing date 2023-02-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1148964-9
    ISSN 0219-1032 ; 1016-8478
    ISSN (online) 0219-1032
    ISSN 1016-8478
    DOI 10.14348/molcells.2023.0002
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4713: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Risk Factors for a Narrow Safety Margin after Endoscopic Submucosal Dissection for Early Gastric Cancer.

    Yeo, Min Kyung / Kang, Sun Hyung / Lee, Hyun Seok / Eun, Hyuk Soo / Moon, Hee Seok / Lee, Eaum Seok / Kim, Seok Hyun / Sung, Jae Kyu / Lee, Byung Seok / Jeong, Hyun Yong

    Digestive diseases (Basel, Switzerland)

    2024  Volume 42, Issue 2, Page(s) 137–144

    Abstract: Introduction: A narrow safety margin (NSM) after endoscopic submucosal dissection (ESD) is a well-recognized risk factor for local recurrence in early gastric cancer (EGC). However, only a few studies have investigated the risk factors for the ... ...

    Abstract Introduction: A narrow safety margin (NSM) after endoscopic submucosal dissection (ESD) is a well-recognized risk factor for local recurrence in early gastric cancer (EGC). However, only a few studies have investigated the risk factors for the development of NSM.
    Methods: The medical records and pathologic specimens of patients with EGC who underwent ESD from January 2020 to December 2020 at a single tertiary hospital (Daejeon, South Korea) were reviewed.
    Results: A total of 218 patients were enrolled and 29 had NSM (<3 mm). When comparing the NSM and the control groups, the size of the lesion, the depth of invasion, and the operating endoscopist were found to be risk factors for the development of NSM. The increased length of the subepithelial spread of the lesion was associated with a narrower safety margin. Logistic regression analysis revealed that lesion size was a risk factor for NSM, and a marginally significant difference between endoscopists was found.
    Conclusions: Multiple factors may need to be considered during ESD, including lesion size, invasion depth, operating endoscopist, and subepithelial spread.
    MeSH term(s) Humans ; Stomach Neoplasms/surgery ; Stomach Neoplasms/pathology ; Endoscopic Mucosal Resection/adverse effects ; Retrospective Studies ; Gastric Mucosa/surgery ; Gastric Mucosa/pathology ; Risk Factors ; Treatment Outcome
    Language English
    Publishing date 2024-01-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 632798-9
    ISSN 1421-9875 ; 0257-2753
    ISSN (online) 1421-9875
    ISSN 0257-2753
    DOI 10.1159/000536053
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1853: Show issues Location:
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