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  1. Article ; Online: Protocol to identify fungal profile from fecal metagenomes in cancer patients prior to immunotherapy.

    Huang, Xiaowen / Li, Lingxi / Chen, Haoyan

    STAR protocols

    2024  Volume 5, Issue 1, Page(s) 102847

    Abstract: Identifying fungal profiles from metagenomes is challenging due to an incomplete fungal database and limitations in the understanding of software. Here, we describe a protocol for analyzing the fecal metagenome of cancer patients prior to immunotherapy. ... ...

    Abstract Identifying fungal profiles from metagenomes is challenging due to an incomplete fungal database and limitations in the understanding of software. Here, we describe a protocol for analyzing the fecal metagenome of cancer patients prior to immunotherapy. We describe steps for raw metagenomic sequencing data retrieval, human genome and contaminants elimination, and assigning taxonomy labels to fungal reads. We then detail measures for assessing fungal alpha diversity and beta diversity, along with differential analysis. For complete details on the use and execution of this protocol, please refer to Xiaowen Huang et al.
    MeSH term(s) Humans ; Metagenome/genetics ; Immunotherapy ; Databases, Factual ; Feces ; Genome, Human ; Neoplasms/genetics ; Neoplasms/therapy
    Language English
    Publishing date 2024-01-24
    Publishing country United States
    Document type Journal Article
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2024.102847
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  2. Article ; Online: Unveiling the hidden players: exploring the role of gut mycobiome in cancer development and treatment dynamics.

    Li, Lingxi / Huang, Xiaowen / Chen, Haoyan

    Gut microbes

    2024  Volume 16, Issue 1, Page(s) 2328868

    Abstract: The role of gut fungal species in tumor-related processes remains largely unexplored, with most studies still focusing on fungal infections. This review examines the accumulating evidence suggesting the involvement of commensal and pathogenic fungi in ... ...

    Abstract The role of gut fungal species in tumor-related processes remains largely unexplored, with most studies still focusing on fungal infections. This review examines the accumulating evidence suggesting the involvement of commensal and pathogenic fungi in cancer biological process, including oncogenesis, progression, and treatment response. Mechanisms explored include fungal influence on host immunity, secretion of bioactive toxins/metabolites, interaction with bacterial commensals, and migration to other tissues in certain types of cancers. Attempts to utilize fungal molecular signatures for cancer diagnosis and fungal-derived products for treatment are discussed. A few studies highlight fungi's impact on the responsiveness and sensitivity to chemotherapy, radiotherapy, immunotherapy, and fecal microbiota transplant. Given the limited understanding and techniques in fungal research, the studies on gut fungi are still facing great challenges, despite having great potentials.
    MeSH term(s) Humans ; Mycobiome ; Gastrointestinal Microbiome ; Fungi/genetics ; Carcinogenesis ; Cell Transformation, Neoplastic
    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2575755-6
    ISSN 1949-0984 ; 1949-0984
    ISSN (online) 1949-0984
    ISSN 1949-0984
    DOI 10.1080/19490976.2024.2328868
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  3. Article ; Online: Microbiome and cancer immunotherapies.

    Chen, Haoyan / Zitvogel, Laurence / Peng, Zhi / Yin, Xiaochen / McAllister, Florencia

    Cell reports. Medicine

    2024  Volume 5, Issue 4, Page(s) 101514

    Abstract: Here, we present 3 different perspectives on how the microbiome has impacted cancer patients, treatment, and clinical studies. We hear about the challenges of implementing microbiome analyses into the clinics, the impact these analyses might have on ... ...

    Abstract Here, we present 3 different perspectives on how the microbiome has impacted cancer patients, treatment, and clinical studies. We hear about the challenges of implementing microbiome analyses into the clinics, the impact these analyses might have on patients' care, and treatment in the future, specifically for gastric cancer treatment. These are a few of the many voices that are highlighting the role of the microbiome in cancer development, treatment, and clinical outcomes.
    MeSH term(s) Humans ; Microbiota ; Immunotherapy ; Stomach Neoplasms
    Language English
    Publishing date 2024-04-17
    Publishing country United States
    Document type Journal Article
    ISSN 2666-3791
    ISSN (online) 2666-3791
    DOI 10.1016/j.xcrm.2024.101514
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  4. Article ; Online: Research on Government Regulations, Cognition and Farmers’ Willingness of Straw-to-Field

    Hong Chen / Haoyan Wang / Yanqiu Li

    Sustainability, Vol 15, Iss 9823, p

    2023  Volume 9823

    Abstract: Contemporarily, the promotion and application of straw-to-field technology plays an important role in developing high-quality green agriculture, alleviating agricultural non-point source pollution and realizing the double carbon target. As the main ... ...

    Abstract Contemporarily, the promotion and application of straw-to-field technology plays an important role in developing high-quality green agriculture, alleviating agricultural non-point source pollution and realizing the double carbon target. As the main subject of straw-to-field, a farmers’ willingness directly determines their straw-to-field behavior. To explore the influencing factors of farmers’ straw-to-field willingness and to improve the comprehensive utilization level of straw, this paper researches the relationship between government regulation, farmers’ subject cognition and straw-to-field willingness based on the survey data of 733 farmers in Heilongjiang province, and it examines the mediating role of farmers’ cognition in the process of government regulation affecting farmers’ willingness of straw-to-field. The results evidence that policy incentives and administrative constraints affect farmers’ willingness of straw-to-field by influencing ecological and technical cognition. However, farmers’ cognition of the cost and benefit of straw-to-field is biased; thus, this factor cannot effectively transform the willingness of straw-to-field into action.
    Keywords straw-to-field ; path analysis ; cognition ; government regulation ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Subject code 620
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Farmers’ Cognition of and Satisfaction with Policy Affect Willingness of Returning Straw to Field

    Hong Chen / Haoyan Wang / Sishu Zhou

    Sustainability, Vol 15, Iss 21, p

    Based on Evolutionary Game Perspective

    2023  Volume 15227

    Abstract: As an important measure to promote the black soil protection strategy, returning straw to the fields is the choice of government policy to affect the decision-making behavior of farmers, and the policy implementation process is a dynamic game equilibrium ...

    Abstract As an important measure to promote the black soil protection strategy, returning straw to the fields is the choice of government policy to affect the decision-making behavior of farmers, and the policy implementation process is a dynamic game equilibrium process between farmers and the government. In order to explore the influence of policies on farmers’ straw-returning decision-making and stability processes, this paper used a logit model to analyze the influencing factors on farmers’ straw-returning decision-making behavior based on the survey data of 397 farmers in Hailun City, Heilongjiang Province. This study also constructs the evolutionary game model between farmers and government, carrying out a stability strategy analysis and numerical simulation. The results evidence that farmers’ cognition of fertilization technology, ecological protection, policy satisfaction and cognition of straw returning recipients have a significant negative influence on their willingness to return to the field, and the effect intensity decreases successively. What is more, cognition of crop disease resistance has a positive effect on the willingness of returning straw to the field. It is found that the game balancing process of farmers’ behavior and government straw returning policy evolution can be divided into three stages. At present, China’s straw returning policy is in the intermediate stage, and government needs to provide comprehensive compensation for returning straw to the field according to local conditions such as farmers’ willingness, crop conditions and so on.
    Keywords internal cognition ; satisfaction in policy ; willingness of straw to field ; evolutionary game ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Subject code 028
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Extraordinary Thermal Stability and Sinter Resistance of Sub-2 nm Platinum Nanoparticles Anchored to a Carbon Support by Selenium.

    Chen, Zitao / Cheng, Haoyan / Cao, Zhenming / Zhu, Jiawei / Blum, Thomas / Zhang, Qinyuan / Chi, Miaofang / Xia, Younan

    Nano letters

    2024  Volume 24, Issue 4, Page(s) 1392–1398

    Abstract: Nanoparticle sintering has long been a major challenge in developing catalytic systems for use at elevated temperatures. Here we report ... ...

    Abstract Nanoparticle sintering has long been a major challenge in developing catalytic systems for use at elevated temperatures. Here we report an
    Language English
    Publishing date 2024-01-16
    Publishing country United States
    Document type Journal Article
    ISSN 1530-6992
    ISSN (online) 1530-6992
    DOI 10.1021/acs.nanolett.3c04601
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  7. Book ; Online: Real spectra in 1D single-band non-Hermitian Hamiltonians

    Chen, Haoyan / Zhang, Yi

    2023  

    Abstract: In general, the energy spectrum of a non-Hermitian system turns out to be complex, which is not so satisfactory since the time evolution of eigenstates with complex eigenvalues is either exponentially growing or decaying. Here we provide a sufficient and ...

    Abstract In general, the energy spectrum of a non-Hermitian system turns out to be complex, which is not so satisfactory since the time evolution of eigenstates with complex eigenvalues is either exponentially growing or decaying. Here we provide a sufficient and necessary condition of the real spectrum under open boundary conditions for one-dimensional non-Hermitian tight-binding Hamiltonians. The necessity is directly related to the fact that the generalized Brillouin zone in one dimension is a closed loop with the origin in its interior. For some simple models, we demonstrate the sufficiency by analytically determining when the preimage of the characteristic polynomial contains a loop and showing that this loop is just the generalized Brillouin zone itself. For more complex models, the numerical results are shown. Our results indicate that real spectra are more common than one may have expected in non-Hermitian systems and are helpful for designing non-Hermitian models with real spectra.
    Keywords Condensed Matter - Materials Science ; Condensed Matter - Mesoscale and Nanoscale Physics
    Subject code 539
    Publishing date 2023-03-27
    Publishing country us
    Document type Book ; Online
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  8. Article ; Online: Steroidal saponins PPI/CCRIS/PSV induce cell death in pancreatic cancer cell through GSDME-dependent pyroptosis.

    Liu, Yang / Zhang, Weitao / Zhou, Haoyan / Chen, Jun

    Biochemical and biophysical research communications

    2023  Volume 673, Page(s) 51–58

    Abstract: Pancreatic cancer is highly aggressive and lethal, and treatment options for it are limited. Gasdermin E (GSDME) is highly expressed in pancreatic cancer and can induce pyroptosis. In this type of programmed cell death, cells swell and emit large gas ... ...

    Abstract Pancreatic cancer is highly aggressive and lethal, and treatment options for it are limited. Gasdermin E (GSDME) is highly expressed in pancreatic cancer and can induce pyroptosis. In this type of programmed cell death, cells swell and emit large gas bubbles through their plasma membranes. Hence, GSDME induction is potentially an efficacious therapeutic approach against pancreatic cancer. In the present study, we found that the steroidal saponins polyphyllin I (PPI), collettiside III (CCRIS), and paris saponin V (PSV) significantly inhibited PANC-1, AsPC-1, and BxPC-3 cell proliferation. PPI/CCRIS/PSV altered the morphology of PANC-1 cells and induced the release of lactate dehydrogenase (LDH) from them. Therefore, these three constituents caused PANC-1 cells to undergo pyroptosis. This conclusion was confirmed by propidium iodide (PI) staining and flow cytometry assays. The present work also revealed that PPI/CCRIS/PSV induced pyroptosis via GSDME rather than gasdermin D (GSDMD). Whereas PPI/CCRIS/PSV induced caspase-3 to cleave GSDME, it had no such effect on GSDMD. We also established a PANC-1 xenograft tumor model in BALB/c nude mice and administered CCRIS to them as this compound demonstrated the most substantial pyroptotic effect in the in vitro experiments. This treatment significantly inhibited tumor growth in the mice by activating GSDME-dependent pyroptosis. This research demonstrates demonstrate that pyroptosis induction by PPI/CCRIS/PSV has important implications in basic science and clinical medicine. Future investigations should endeavor to determine the benefits and risks associated with the administration of these steroidal saponins as anti-PDAC therapy.
    MeSH term(s) Saponins/pharmacology ; Saponins/therapeutic use ; Cell Proliferation/drug effects ; Humans ; Cell Line, Tumor ; Carcinoma, Pancreatic Ductal/drug therapy ; Carcinoma, Pancreatic Ductal/metabolism ; Carcinoma, Pancreatic Ductal/pathology ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/metabolism ; Pancreatic Neoplasms/pathology ; Lactate Dehydrogenases ; Gasdermins/metabolism ; Phosphate-Binding Proteins/metabolism ; Pyroptosis/drug effects ; Animals ; Mice ; Xenograft Model Antitumor Assays ; Mice, Inbred BALB C ; Female ; Diosgenin/pharmacology ; Diosgenin/therapeutic use
    Chemical Substances Saponins ; polyphyllin I ; Lactate Dehydrogenases (EC 1.1.-) ; GSDMD protein, human ; Gasdermins ; Phosphate-Binding Proteins ; Diosgenin (K49P2K8WLX)
    Language English
    Publishing date 2023-06-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2023.06.062
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  9. Article ; Online: Faecal microbiota transplantation, a promising way to treat colorectal cancer.

    Ma, Yanru / Chen, Haoyan

    EBioMedicine

    2019  Volume 49, Page(s) 13–14

    MeSH term(s) Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/therapy ; Fecal Microbiota Transplantation/methods ; Humans ; Treatment Outcome
    Language English
    Publishing date 2019-10-21
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2019.10.015
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7090: Show issues Location:
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  10. Article ; Online: Tanshinone IIA ameliorates energy metabolism dysfunction of pulmonary fibrosis using

    Shan, Baixi / Zhou, Haoyan / Guo, Congying / Liu, Xiaolu / Wu, Mingyu / Zhai, Rao / Chen, Jun

    Journal of pharmaceutical analysis

    2023  Volume 14, Issue 2, Page(s) 244–258

    Abstract: Evidence indicates that metabolic reprogramming characterized by the changes in cellular metabolic patterns contributes to the pathogenesis of pulmonary fibrosis (PF). It is considered as a promising therapeutic target anti-PF. The well-documented ... ...

    Abstract Evidence indicates that metabolic reprogramming characterized by the changes in cellular metabolic patterns contributes to the pathogenesis of pulmonary fibrosis (PF). It is considered as a promising therapeutic target anti-PF. The well-documented against PF properties of Tanshinone IIA (Tan IIA) have been primarily attributed to its antioxidant and anti-inflammatory potency. Emerging evidence suggests that Tan IIA may target energy metabolism pathways, including glycolysis and tricarboxylic acid (TCA) cycle. However, the detailed and advanced mechanisms underlying the anti-PF activities remain obscure. In this study, we applied [U-
    Language English
    Publishing date 2023-09-21
    Publishing country China
    Document type Journal Article
    ZDB-ID 2630174-X
    ISSN 2214-0883 ; 2095-1779
    ISSN (online) 2214-0883
    ISSN 2095-1779
    DOI 10.1016/j.jpha.2023.09.008
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