Article ; Online: The T-cell Response to Epstein-Barr Virus-New Tricks From an Old Dog.
2019 Volume 10, Page(s) 2193
Abstract: Epstein-Barr virus (EBV) infects most people and establishes life-long infection controlled by the host's immune system. The genetic stability of the virus, deep understanding of the viral antigens and immune epitopes recognized by the host's T-cell ... ...
| Abstract | Epstein-Barr virus (EBV) infects most people and establishes life-long infection controlled by the host's immune system. The genetic stability of the virus, deep understanding of the viral antigens and immune epitopes recognized by the host's T-cell system and the fact that recent infection can be identified by the development of symptomatic infectious mononucleosis makes EBV a powerful system in which to study human immunology. The association between EBV and multiple cancers also means that the lessons learned have strong translational potential. Increasing evidence of a role for resident memory T-cells and non-conventional γδ T-cells in controlling EBV infection suggests new opportunities for research and means the virus will continue to provide exciting new insights into human biology and immunology into the future. |
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| MeSH term(s) | Antigens, Viral/immunology ; B-Lymphocytes/immunology ; B-Lymphocytes/pathology ; Epstein-Barr Virus Infections/immunology ; Epstein-Barr Virus Infections/pathology ; Herpesvirus 4, Human/immunology ; Humans ; Immunologic Memory ; Receptors, Antigen, T-Cell, gamma-delta/immunology ; T-Lymphocytes/immunology ; T-Lymphocytes/pathology |
| Chemical Substances | Antigens, Viral ; Receptors, Antigen, T-Cell, gamma-delta |
| Language | English |
| Publishing date | 2019-09-18 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Review |
| ZDB-ID | 2606827-8 |
| ISSN | 1664-3224 ; 1664-3224 |
| ISSN (online) | 1664-3224 |
| ISSN | 1664-3224 |
| DOI | 10.3389/fimmu.2019.02193 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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