Result 1 - 10 of total 755
J Thorac Oncol
| Keywords | covid19 |
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| Publisher | WHO |
| Document type | Article |
| Note | WHO #Covidence: #33195 |
| Database | COVID19 |
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Journal of personalized medicine
2024 Volume 14, Issue 3
Abstract: Personalized medicine is defined as a medical model using the characterization of individuals' phenotypes and genotypes (e [ ... ]. ...
| Abstract | Personalized medicine is defined as a medical model using the characterization of individuals' phenotypes and genotypes (e [...]. |
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| Language | English |
| Publishing date | 2024-03-05 |
| Publishing country | Switzerland |
| Document type | Editorial |
| ZDB-ID | 2662248-8 |
| ISSN | 2075-4426 |
| ISSN | 2075-4426 |
| DOI | 10.3390/jpm14030285 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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Psychological science in the public interest : a journal of the American Psychological Society
2023 Volume 24, Issue 1, Page(s) 15–73
Abstract: ... track hiring, (b) grant funding, (c) teaching ratings, (d) journal acceptances, (e) salaries, and (f ...
| Abstract | We synthesized the vast, contradictory scholarly literature on gender bias in academic science from 2000 to 2020. In the most prestigious journals and media outlets, which influence many people's opinions about sexism, bias is frequently portrayed as an omnipresent factor limiting women's progress in the tenure-track academy. Claims and counterclaims regarding the presence or absence of sexism span a range of evaluation contexts. Our approach relied on a combination of meta-analysis and analytic dissection. We evaluated the empirical evidence for gender bias in six key contexts in the tenure-track academy: (a) tenure-track hiring, (b) grant funding, (c) teaching ratings, (d) journal acceptances, (e) salaries, and (f) recommendation letters. We also explored the gender gap in a seventh area, journal productivity, because it can moderate bias in other contexts. We focused on these specific domains, in which sexism has most often been alleged to be pervasive, because they represent important types of evaluation, and the extensive research corpus within these domains provides sufficient quantitative data for comprehensive analysis. Contrary to the omnipresent claims of sexism in these domains appearing in top journals and the media, our findings show that tenure-track women are at parity with tenure-track men in three domains (grant funding, journal acceptances, and recommendation letters) and are advantaged over men in a fourth domain (hiring). For teaching ratings and salaries, we found evidence of bias against women; although gender gaps in salary were much smaller than often claimed, they were nevertheless concerning. Even in the four domains in which we failed to find evidence of sexism disadvantaging women, we nevertheless acknowledge that broad societal structural factors may still impede women's advancement in academic science. Given the substantial resources directed toward reducing gender bias in academic science, it is imperative to develop a clear understanding of when and where such efforts are justified and of how resources can best be directed to mitigate sexism when and where it exists. |
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| MeSH term(s) | Humans ; Male ; Female ; Sexism ; Salaries and Fringe Benefits ; Attitude ; Academies and Institutes |
| Language | English |
| Publishing date | 2023-04-26 |
| Publishing country | United States |
| Document type | Meta-Analysis ; Journal Article |
| ISSN | 2160-0031 |
| ISSN (online) | 2160-0031 |
| DOI | 10.1177/15291006231163179 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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2021 Volume 77, Issue 1, Page(s) 151
Abstract: Memorializes James (Jim) R. Flynn (1934-2020). Jim was one of psychology's most influential thinkers even though he was not a psychologist, receiving a PhD in 1958 in politics and moral philosophy at the University of Chicago. At the time of his death, ... ...
| Abstract | Memorializes James (Jim) R. Flynn (1934-2020). Jim was one of psychology's most influential thinkers even though he was not a psychologist, receiving a PhD in 1958 in politics and moral philosophy at the University of Chicago. At the time of his death, Jim was Emeritus Professor of Politics at the University of Otago in New Zealand. Over the course of his career, Jim amassed several high impact papers and books, including his two |
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| MeSH term(s) | Humans ; Male ; Morals ; Philosophy ; Politics ; Speech ; United States ; Universities |
| Language | English |
| Publishing date | 2021-11-18 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 209464-2 |
| ISSN | 1935-990X ; 0003-066X |
| ISSN (online) | 1935-990X |
| ISSN | 0003-066X |
| DOI | 10.1037/amp0000878 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 997: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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2022 Volume 34, Issue 6, Page(s) 606–613
Abstract: ... of BC patients.: Recent findings: Beside 2-deoxy-2-[ 18 F]-fluoro- d -glucose (FDG), new generation ...
| Abstract | Purpose of review: Nuclear medicine has the potential to explore and illuminate several pathways in breast cancer (BC) offering different radiopharmaceuticals for positron emission tomography (PET) designed to target specific tumor characteristics. The aim of this critical review is to give an overview about emerging opportunities in PET imaging, underlining the future potential contribution in the management of BC patients. Recent findings: Beside 2-deoxy-2-[ 18 F]-fluoro- d -glucose (FDG), new generation tracers for PET imaging have been recently proposed to investigate specific characteristics in breast cancer, both targeting tumor cells and the tumor micro-environment (TME). Summary: FDG-PET is a procedure that received extensive clinical validation. However, its role in BC is still suboptimal due to the low-FDG avidity of specific tumor subtypes. Human epidermal growth receptor-2 and integrin targeted PET radiotracers might provide useful information selecting patients more likely to respond to target therapy. FluoroEstradiol (FES) is a FDA-approved PET radiotracer targeting the estrogen receptor (ER), useful to investigate metastatic ER+ patients, to assess in vivo ER heterogeneity and to evaluate hormonal therapy efficacy. Inhibitors of the fibroblast activation protein (FAPi) targeting the cancer-associated fibroblast can explore the TME with PET imaging. FAPi is also proposed a theranostic agent for radio-ligand therapy. |
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| MeSH term(s) | Breast Neoplasms/drug therapy ; Female ; Fluorodeoxyglucose F18/therapeutic use ; Glucose ; Humans ; Integrins/therapeutic use ; Ligands ; Positron Emission Tomography Computed Tomography/methods ; Positron-Emission Tomography/methods ; Radiopharmaceuticals/therapeutic use ; Receptors, Estrogen/metabolism ; Tumor Microenvironment |
| Chemical Substances | Integrins ; Ligands ; Radiopharmaceuticals ; Receptors, Estrogen ; Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Glucose (IY9XDZ35W2) |
| Language | English |
| Publishing date | 2022-09-12 |
| Publishing country | United States |
| Document type | Journal Article ; Review |
| ZDB-ID | 1049384-0 |
| ISSN | 1531-703X ; 1040-8746 |
| ISSN (online) | 1531-703X |
| ISSN | 1040-8746 |
| DOI | 10.1097/CCO.0000000000000908 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 3046: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
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2022 Volume 39, Page(s) 47
Abstract: This corrects the article DOI: 10.1016/j.euros.2021.08.012.]. ...
| Abstract | [This corrects the article DOI: 10.1016/j.euros.2021.08.012.]. |
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| Language | English |
| Publishing date | 2022-04-04 |
| Publishing country | Netherlands |
| Document type | Published Erratum |
| ZDB-ID | 3040546-4 |
| ISSN | 2666-1683 ; 2058-4881 |
| ISSN (online) | 2666-1683 |
| ISSN | 2058-4881 |
| DOI | 10.1016/j.euros.2022.03.008 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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Frontiers in veterinary science
2023 Volume 10, Page(s) 1274466
Abstract: The safety of reclaimed urban wastewater (RUW) for the production of hydroponic barley forage (HBF) was evaluated in terms of effluent and forage characteristics, as well as the health and performance of lactating cows. The study was conducted on a dairy ...
| Abstract | The safety of reclaimed urban wastewater (RUW) for the production of hydroponic barley forage (HBF) was evaluated in terms of effluent and forage characteristics, as well as the health and performance of lactating cows. The study was conducted on a dairy farm equipped with two hydroponic chambers producing approximately 620 kg/d of HBF as fed. For experimental purposes, HBF was produced using RUW collected from an aqueduct plant processing urban wastewater in a membrane bioreactor treatment chain. A feeding trial was carried out with HBF derived from RUW. Sixty lactating cows were randomly assigned to two balanced groups fed a standard total mixed ration (TMR) or a TMR in which 10 kg of HBF replaced 1 kg of oat hay and 0.5 kg of maize. The experimental period lasted 7 weeks, including a 2-week adaptation period, during which each cow underwent a physical examination, BCS scoring, blood sampling for a complete blood count and biochemical panel, recording of body weight and milk yield and quality, including fatty acid composition and heavy metal content. Ruminal pH was continuously monitored by reticulorumen boluses, and nutrient digestibility and N balance were determined at week 7. RUW showed an acceptable microbial load and an overall good quality as irrigation water, even though the supply of N and P did not influence the yield and quality of HBF. The characteristics of HBF reflected the quality of RUW supplied to the hydroponic chambers and no anomalous components (i.e., high ion concentration) were found. Feeding RW-derived HBF to lactating cows had no major positive or negative effects on animal health and production, including milk quality, ruminal pH, |
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| Language | English |
| Publishing date | 2023-11-17 |
| Publishing country | Switzerland |
| Document type | Journal Article |
| ZDB-ID | 2834243-4 |
| ISSN | 2297-1769 |
| ISSN | 2297-1769 |
| DOI | 10.3389/fvets.2023.1274466 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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2023 Volume 12, Issue 7
Abstract: Microplastics are a ubiquitous pollutant whose spreading is a growing concern worldwide. They can pose a threat to food safety and consumer health as they are ingested through various foods. Bivalves are considered the most contaminated, as they filter ... ...
| Abstract | Microplastics are a ubiquitous pollutant whose spreading is a growing concern worldwide. They can pose a threat to food safety and consumer health as they are ingested through various foods. Bivalves are considered the most contaminated, as they filter large amounts of seawater and enter consumers' diet ingested whole. The aim of this study was to detect, quantify, identify and classify microplastics in mussels ( |
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| Language | English |
| Publishing date | 2023-04-02 |
| Publishing country | Switzerland |
| Document type | Journal Article |
| ZDB-ID | 2704223-6 |
| ISSN | 2304-8158 |
| ISSN | 2304-8158 |
| DOI | 10.3390/foods12071495 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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2023 Volume 10, Page(s) 1113460
Abstract: Introduction: Several new active substances (ASs) targeting neuroblastoma (NBL) are under study. We aim to describe the developmental and regulatory status of a sample of ASs targeting NBL to underline the existing regulatory gaps in product development ...
| Abstract | Introduction: Several new active substances (ASs) targeting neuroblastoma (NBL) are under study. We aim to describe the developmental and regulatory status of a sample of ASs targeting NBL to underline the existing regulatory gaps in product development and to discuss possible improvements. Methods: The developmental and regulatory statuses of the identified ASs targeting NBL were investigated by searching for preclinical studies, clinical trials (CTs), marketing authorizations, pediatric investigation plans (PIPs), waivers, orphan designations, and other regulatory procedures. Results: A total of 188 ASs were identified. Of these, 55 were considered 'not under development' without preclinical or clinical studies. Preclinical studies were found for 115 ASs, of which 54 were associated with a medicinal product. A total of 283 CTs (as monotherapy or in combination) were identified for 70 ASs. Of these, 52% were at phases 1, 1/2, and 2 aimed at PK/PD/dosing activity. The remaining ones also included efficacy. Phase 3 studies were limited. Studies were completed for 14 ASs and suspended for 11. The highest rate of ASs involved in CTs was observed in the RAS-MAPK-MEK and VEGF groups. A total of 37 ASs were granted with a PIP, of which 14 involved NBL, 41 ASs with a waiver, and 18 ASs with both PIPs and waivers, with the PIP covering pediatric indications different from the adult ones. In almost all the PIPs, preclinical studies were required, together with early-phase CTs often including efficacy evaluation. Two PIPs were terminated because of negative study results, and eight PIPs are in progress. Variations in the SmPC were made for larotrectinib sulfate/Vitrakvi Discussion: Several ASs entered early phase CTs but less than one out of four were included in a regulatory process, and only two were granted a pediatric indication extension. Our results confirm that it is necessary to identify a more efficient, less costly, and time-consuming "pediatric developmental model" integrating predictive preclinical study and innovative clinical study designs. Furthermore, stricter integration between scientific and regulatory efforts should be promoted. |
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| Language | English |
| Publishing date | 2023-07-14 |
| Publishing country | Switzerland |
| Document type | Journal Article |
| ZDB-ID | 2775999-4 |
| ISSN | 2296-858X |
| ISSN | 2296-858X |
| DOI | 10.3389/fmed.2023.1113460 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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2023 Volume 11, Issue 5
Abstract: Invasive lobular cancer (ILC) is the second most frequent histological type of breast cancer (BC) and includes a heterogeneous spectrum of diseases with unique characteristics, especially the infiltrative growth pattern and metastatic spread. [ ...
| Abstract | Invasive lobular cancer (ILC) is the second most frequent histological type of breast cancer (BC) and includes a heterogeneous spectrum of diseases with unique characteristics, especially the infiltrative growth pattern and metastatic spread. [ |
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| Language | English |
| Publishing date | 2023-05-03 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Review |
| ZDB-ID | 2720867-9 |
| ISSN | 2227-9059 |
| ISSN | 2227-9059 |
| DOI | 10.3390/biomedicines11051350 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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