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  1. Article ; Online: ASO Author Reflections: Late-Term Toxicity After Cytoreductive Surgery/Hyperthermic Intraperitoneal Chemotherapy for Desmoplastic Small Round Cell Tumor Underscores the Need for Novel Drug Development and Clinical Trial Design.

    Deneve, Jeremiah L

    Annals of surgical oncology

    2019  Volume 26, Issue Suppl 3, Page(s) 692–693

    MeSH term(s) Clinical Trials as Topic ; Cytoreduction Surgical Procedures ; Desmoplastic Small Round Cell Tumor ; Drug Development ; Humans ; Hyperthermia, Induced
    Language English
    Publishing date 2019-08-12
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-019-07712-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: ASO Author Reflections: Nodal Disease Burden in Patients with Gastrointestinal Stromal Tumor.

    Fleming, Andrew M / Stiles, Zachary E / Deneve, Jeremiah L

    Annals of surgical oncology

    2022  Volume 29, Issue 13, Page(s) 8649–8650

    MeSH term(s) Humans ; Gastrointestinal Stromal Tumors/surgery ; Transforming Growth Factor beta ; Cost of Illness
    Chemical Substances Transforming Growth Factor beta
    Language English
    Publishing date 2022-10-02
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-022-12591-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Management of malignant bowel obstruction - Authors' reply.

    Krouse, Robert S / Anderson, Garnet L / Arnold, Kathryn B / Sun, Virginia / Secord, Angeles Alvarez / Deutsch, Gary B / Deneve, Jeremiah L

    The lancet. Gastroenterology & hepatology

    2023  Volume 9, Issue 1, Page(s) 15

    Language English
    Publishing date 2023-12-05
    Publishing country Netherlands
    Document type Letter
    ISSN 2468-1253
    ISSN (online) 2468-1253
    DOI 10.1016/S2468-1253(23)00367-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Cholecystoappendiceal Fistula From Appendiceal Adenocarcinoma Requiring a Right Hemicolectomy With Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy.

    Doño, Angel / Schadt, Jennifer C / Hammond, William M / Muenyi, Clarisse S / Deneve, Jeremiah L / Altomar, Jonathan L / Foretia, Denis A

    The American surgeon

    2023  Volume 89, Issue 8, Page(s) 3605–3608

    Abstract: Bilioenteric fistulae are rare and difficult to manage complications of chronic cholecystitis. While cholecystoduodenal and cholecystocolic fistulae are more common, a cholecystoappendiceal fistula is an extremely rare finding. We report the presentation ...

    Abstract Bilioenteric fistulae are rare and difficult to manage complications of chronic cholecystitis. While cholecystoduodenal and cholecystocolic fistulae are more common, a cholecystoappendiceal fistula is an extremely rare finding. We report the presentation and operative management of a 59-year-old male with cholecystoappendiceal fistula and associated abscess in the gallbladder fossa. The patient was appropriately resuscitated, the abscess drained by interventional radiology, and after a complete workup, underwent a laparoscopic appendectomy and cholecystectomy. Pathology revealed moderately differentiated appendiceal adenocarcinoma requiring a right hemicolectomy with cytoreduction and hyperthermic intraperitoneal chemotherapy (HIPEC). He has recovered well postoperatively with no complications. This case highlights the importance of having a very high index of suspicion for underlying malignancy when managing a fistula of any kind. To the best of our understanding, this is only the second reported case of a cholecystoappendiceal fistula.
    MeSH term(s) Male ; Humans ; Middle Aged ; Hyperthermic Intraperitoneal Chemotherapy ; Cytoreduction Surgical Procedures ; Abscess/surgery ; Hyperthermia, Induced ; Peritoneal Neoplasms/pathology ; Appendiceal Neoplasms/complications ; Appendiceal Neoplasms/therapy ; Appendiceal Neoplasms/pathology ; Adenocarcinoma/therapy ; Adenocarcinoma/surgery ; Fistula/surgery ; Colectomy
    Language English
    Publishing date 2023-03-23
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 202465-2
    ISSN 1555-9823 ; 0003-1348
    ISSN (online) 1555-9823
    ISSN 0003-1348
    DOI 10.1177/00031348231167402
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Nationwide analysis of unplanned conversion during minimally invasive distal pancreatectomy for pancreatic adenocarcinoma.

    Stiles, Zachary E / Tolley, Elizabeth A / Dickson, Paxton V / Deneve, Jeremiah L / Kocak, Mehmet / Behrman, Stephen W

    HPB : the official journal of the International Hepato Pancreato Biliary Association

    2023  Volume 25, Issue 12, Page(s) 1566–1572

    Abstract: Background: Utilization of minimally-invasive distal pancreatectomy (MIDP) for pancreatic adenocarcinoma has increased. While unplanned conversion to an open procedure during MIDP is associated with inferior short-term outcomes, the long-term ... ...

    Abstract Background: Utilization of minimally-invasive distal pancreatectomy (MIDP) for pancreatic adenocarcinoma has increased. While unplanned conversion to an open procedure during MIDP is associated with inferior short-term outcomes, the long-term consequences of conversion have not been adequately examined.
    Methods: Patients with pancreatic adenocarcinoma undergoing MIDP were selected from the National Cancer Database (2010-2015) and subdivided based on the occurrence of unplanned conversion. Post-operative outcomes and overall survival (OS) were examined. Conversion was additionally compared to a matched group of planned open resections.
    Results: Among 592 patients undergoing attempted MIDP, unplanned conversion occurred in 23.1%. Despite increased 90-day mortality among patients experiencing conversion, there was no difference in median OS between groups (25.0 vs 27.8 months, p = 0.095). For patients undergoing conversion, post-operative outcomes and long-term survival were similar when compared to a propensity-matched group of patients undergoing planned open resection. On multivariable analysis, treatment at an academic facility (OR 0.63) and a robotic approach (OR 0.50) were both significantly associated with completed MIDP.
    Conclusion: Despite inferior post-operative outcomes compared to successful MIDP, unplanned conversion did not result in significantly reduced long term survival. MIDP can be attempted selectively but treatment at experienced centers via a robotic approach should be considered.
    MeSH term(s) Humans ; Pancreatic Neoplasms/pathology ; Pancreatectomy/adverse effects ; Pancreatectomy/methods ; Adenocarcinoma/surgery ; Treatment Outcome ; Robotic Surgical Procedures/adverse effects ; Robotic Surgical Procedures/methods ; Laparoscopy/methods ; Postoperative Complications/epidemiology ; Retrospective Studies ; Pancreatic Neoplasms
    Language English
    Publishing date 2023-08-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2131251-5
    ISSN 1477-2574 ; 1365-182X
    ISSN (online) 1477-2574
    ISSN 1365-182X
    DOI 10.1016/j.hpb.2023.08.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Pancreatic carcinosarcoma: An orthogonal analysis.

    Fleming, Andrew M / Hendrick, Leah E / Glazer, Evan S / Murphy, Andrew J / Dickson, Paxton V / Shibata, David / Yakoub, Danny / Deneve, Jeremiah L

    Surgery

    2023  Volume 174, Issue 4, Page(s) 907–915

    Abstract: Background: Pancreatic carcinosarcoma is a rare subtype of pancreatic cancer. There are no consensus guidelines regarding its treatment. The current study is an orthogonal analysis of multiple datasets to evaluate prognostic features.: Methods: A ... ...

    Abstract Background: Pancreatic carcinosarcoma is a rare subtype of pancreatic cancer. There are no consensus guidelines regarding its treatment. The current study is an orthogonal analysis of multiple datasets to evaluate prognostic features.
    Methods: A modified Preferred Reporting Items for Systematic reviews and Meta-Analyses 2020 systematic review was performed for reported cases of pancreatic carcinosarcoma. All cases of pancreatic carcinosarcoma in the National Cancer Database were identified for analysis. Analyses were compared to previously published data from the Surveillance, Epidemiology, and End Results database to increase validity.
    Results: Seventy-one cases of pancreatic carcinosarcoma were reported in the literature. Reports of pancreatic carcinosarcoma increased over time (P = .0075). Tumor size >5.0 cm, metastatic disease, and relapse were associated with decreased disease-specific survival (all log-rank P < .05). Ninety-nine cases of pancreatic carcinosarcoma were analyzed within the National Cancer Database. Pancreatic carcinosarcoma incidence increased over time (P = .0371). Resection + chemotherapy, pathologic lymph node examination, and treatment at an academic center were associated with improved overall survival (all log-rank P < .05), whereas harboring ≥2 positive lymph nodes was associated with decreased overall survival (log-rank P = .0171). Within a multivariable model adjusting for age, sex, comorbid disease, and disease stage, resection + chemotherapy was associated with a decreased hazard of death (hazard ratio .036; confidence Interval .004-.298; P = .0022). Published data from the Surveillance, Epidemiology, and End Results database supported the current analysis regarding the incidence of pancreatic carcinosarcoma, resection, lymph node evaluation, and the impact of metastatic disease.
    Conclusion: Pancreatic carcinosarcoma is exceedingly rare, with a poor prognosis. Long-term survival is possible with curative resection in the absence of relapse. The number of positive lymph nodes appears to impact prognosis.
    MeSH term(s) Humans ; Retrospective Studies ; Neoplasm Recurrence, Local/pathology ; Lymph Nodes/pathology ; Adenocarcinoma/pathology ; Prognosis ; Pancreatic Neoplasms/epidemiology ; Pancreatic Neoplasms/surgery ; Carcinosarcoma/diagnosis ; Carcinosarcoma/epidemiology ; Carcinosarcoma/surgery ; Neoplasm Staging ; Pancreatic Neoplasms
    Language English
    Publishing date 2023-07-29
    Publishing country United States
    Document type Systematic Review ; Journal Article
    ZDB-ID 202467-6
    ISSN 1532-7361 ; 0039-6060
    ISSN (online) 1532-7361
    ISSN 0039-6060
    DOI 10.1016/j.surg.2023.06.039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Impact of adjuvant therapies following surgery for anal melanoma.

    Wong, Denise L / Glazer, Evan S / Tsao, Miriam / Deneve, Jeremiah L / Fleming, Martin D / Shibata, David

    American journal of surgery

    2021  Volume 223, Issue 6, Page(s) 1132–1143

    Abstract: Background: Anal melanoma is rare. Surgery is standard of care for non-metastatic disease. There are limited data supporting adjuvant therapy. We sought to examine the impact of adjuvant radiation, chemotherapy and immunotherapy on survival.: Methods!# ...

    Abstract Background: Anal melanoma is rare. Surgery is standard of care for non-metastatic disease. There are limited data supporting adjuvant therapy. We sought to examine the impact of adjuvant radiation, chemotherapy and immunotherapy on survival.
    Methods: The National Cancer Database was queried. Factors associated with overall survival were examined by Kaplan-Meier and Cox proportional hazards analyses. Patients were grouped by treatment regimen.
    Results: 450 patients had complete treatment data: surgery alone (63.8%), surgery + radiation (14.9%), surgery + chemotherapy (7.6%), surgery + immunotherapy (9.6%) and non-surgical treatment (4.2%). Median survival was 27.2 months. Node-positive patients had worse survival than node-negative (22.4 vs. 36.8 months; p = 0.0002). Non-surgical treatment yielded worse survival than any surgery-inclusive regimen (10.4 vs. 27.8 months; p = 0.0002). No adjuvant modality conferred a survival advantage. By multivariate analysis, increasing age (HR/1 year = 1.02, p = 0.012) and node positivity (HR = 2.10, p = 0.0002) negatively impacted survival.
    Conclusion: Adjuvant therapy for non-metastatic anal melanoma does not appear to influence survival.
    MeSH term(s) Anus Neoplasms/surgery ; Chemotherapy, Adjuvant ; Combined Modality Therapy ; Humans ; Kaplan-Meier Estimate ; Melanoma/pathology ; Melanoma/surgery ; Neoplasm Staging ; Proportional Hazards Models ; Radiotherapy, Adjuvant ; Retrospective Studies ; Skin Neoplasms/pathology
    Language English
    Publishing date 2021-11-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2953-1
    ISSN 1879-1883 ; 0002-9610
    ISSN (online) 1879-1883
    ISSN 0002-9610
    DOI 10.1016/j.amjsurg.2021.10.041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Local Recurrence of Extremity Soft Tissue Sarcoma.

    Guerrero, Whitney M / Deneve, Jeremiah L

    The Surgical clinics of North America

    2016  Volume 96, Issue 5, Page(s) 1157–1174

    Abstract: The management of recurrent soft tissue sarcoma is a challenging problem for clinicians and has a significant physical, mental, emotional, and oncologic impact for the patient. Despite excellent limb-preservation therapies, approximately one-quarter of ... ...

    Abstract The management of recurrent soft tissue sarcoma is a challenging problem for clinicians and has a significant physical, mental, emotional, and oncologic impact for the patient. Despite excellent limb-preservation therapies, approximately one-quarter of patients may eventually develop recurrence of disease. How to most appropriately manage these patients is a matter of debate. Several treatment options exist, including surgical resection, irradiation, systemic chemotherapy, amputation, and regional therapies. This article highlights the management of recurrent extremity soft tissue sarcoma.
    MeSH term(s) Combined Modality Therapy ; Disease Management ; Extremities ; Humans ; Neoplasm Recurrence, Local/prevention & control ; Sarcoma/therapy
    Language English
    Publishing date 2016-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 215713-5
    ISSN 1558-3171 ; 0039-6109
    ISSN (online) 1558-3171
    ISSN 0039-6109
    DOI 10.1016/j.suc.2016.05.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Tumor Location in the Pancreatic Tail Is Associated with Decreased Likelihood of Receiving Chemotherapy for Pancreatic Adenocarcinoma.

    Drake, Justin A / Fleming, Andrew M / Behrman, Stephen W / Glazer, Evan S / Deneve, Jeremiah L / Yakoub, Danny / Tsao, Miriam W / Dickson, Paxton V

    Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

    2022  Volume 26, Issue 10, Page(s) 2136–2147

    Abstract: Background: Chemotherapy (CTX) is associated with improved survival for patients undergoing resection for pancreatic ductal adenocarcinoma (PDAC). The current study evaluated the influence of tumor location on receipt of CTX.: Methods: The NCDB (2006- ...

    Abstract Background: Chemotherapy (CTX) is associated with improved survival for patients undergoing resection for pancreatic ductal adenocarcinoma (PDAC). The current study evaluated the influence of tumor location on receipt of CTX.
    Methods: The NCDB (2006-2017) was queried to identify patients with clinical stage I-III PDAC. Predictors of receipt of CTX, sequencing of CTX, and overall survival (OS) were analyzed.
    Results: Among 14,557 patients who underwent resection for PDAC 3,453 (24%) did not receive CTX. On multivariable analysis, patients with tail tumors were 15% less likely to receive CTX (OR 0.85, 95% CI 0.747-0.968) and 58% less likely to receive neoadjuvant CTX (OR 0.42, 95% CI 0.351-0.509) relative to patients with head/neck tumors. For patients with body tumors, there was no difference in rates of administration or sequence of CTX. For patients with resected tail tumors, median OS was 29.9 vs 18.9 months (p < 0.001) between those who did and did not receive CTX. For patients with tail tumors, independent predictors of not receiving CTX, regardless of sequence, were increasing age (OR 0.95, 95% CI 0.935-0.965), increasing post-op length of stay (OR 0.95, 95% CI 0.932-0.968), and 30-day post-op readmission (OR 0.46, 95% CI 0.315-0.670).
    Conclusions: In patients with clinical stage I-III PDAC, tumor location within the tail was independently associated with not receiving CTX. Given the marked improvement in OS when CTX is administered, strategies aimed at increasing the number of these patients who receive CTX are necessary.
    MeSH term(s) Adenocarcinoma/drug therapy ; Adenocarcinoma/surgery ; Carcinoma, Pancreatic Ductal/drug therapy ; Carcinoma, Pancreatic Ductal/pathology ; Carcinoma, Pancreatic Ductal/surgery ; Chemotherapy, Adjuvant ; Humans ; Neoadjuvant Therapy ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/pathology ; Pancreatic Neoplasms/surgery ; Retrospective Studies
    Language English
    Publishing date 2022-06-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2012365-6
    ISSN 1873-4626 ; 1934-3213 ; 1091-255X
    ISSN (online) 1873-4626 ; 1934-3213
    ISSN 1091-255X
    DOI 10.1007/s11605-022-05381-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Lymph Node Metastases in Gastrointestinal Stromal Tumors: an Uncommon Event.

    Stiles, Zachary E / Fleming, Andrew M / Dickson, Paxton V / Tsao, Miriam / Glazer, Evan S / Shibata, David / Deneve, Jeremiah L

    Annals of surgical oncology

    2022  Volume 29, Issue 13, Page(s) 8641–8648

    Abstract: Background: Lymph node (LN) metastases are uncommon among gastrointestinal stromal tumors (GISTs), and their presence has not been utilized in disease prognostication. This study was designed to examine factors associated with GIST nodal metastases and ... ...

    Abstract Background: Lymph node (LN) metastases are uncommon among gastrointestinal stromal tumors (GISTs), and their presence has not been utilized in disease prognostication. This study was designed to examine factors associated with GIST nodal metastases and their impact on survival.
    Patients and methods: Patients undergoing surgical resection of GIST with nodal evaluation were selected from the National Cancer Database. Logistic regression was utilized to evaluate factors associated with LN metastases. Survival was assessed for patients with and without nodal involvement and Cox regression was used to evaluate the impact of LN metastases while adjusting for other prognostic factors.
    Results: Out of 5018 patients, 301 (6.0%) had LN involvement. Nodal metastases occurred most frequently among tumors of the stomach (49.5%), followed by the small bowel (43.2%), colorectum (6.0%), and esophagus (1.3%). On multivariable analysis, male sex (OR 1.34), high mitotic rate (OR 2.10), tumor size (OR 1.02), and a primary tumor located in the small bowel (OR 1.36) were all significantly associated with nodal metastases. LN metastases were significantly associated with decreased overall survival (OS) for tumors arising in the small bowel (log-rank p < 0.01) and the colorectum (log-rank p < 0.01). Within a multivariable model adjusting for established prognostic factors, LN metastases remained independently associated with decreased survival (HR 1.60, p < 0.001).
    Conclusions: For GISTs, LN metastases occur more often in males and were associated with tumor size and mitotic activity. Nodal involvement is associated with decreased survival, independent of other well-established prognostic factors.
    MeSH term(s) Humans ; Male ; Lymphatic Metastasis/pathology ; Gastrointestinal Stromal Tumors/surgery ; Gastrointestinal Stromal Tumors/pathology ; Lymph Nodes/surgery ; Lymph Nodes/pathology ; Stomach ; Prognosis ; Retrospective Studies
    Language English
    Publishing date 2022-10-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-022-12582-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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