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Article: Exercise-induced QTc prolongation and implications for military service members: A case series.

Pagani, Austin / Hellwig, Lydia D / Dobson, Craig P / Hughes, Brian N / Schacht, John P / Haigney, Mark

2023 Volume 9, Issue 10, Page(s) 759–763

Language	English
Publishing date	2023-08-09
Publishing country	United States
Document type	Case Reports
ZDB-ID	2834871-0
ISSN	2214-0271
ISSN	2214-0271
DOI	10.1016/j.hrcr.2023.07.023
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Paving the way for greater open science in sports and exercise medicine: navigating the barriers to adopting open and accessible data practices.

Bullock, Garrett S / Ward, Patrick / Kluzek, Stefan / Hughes, Tom / Shanley, Ellen / Arundale, Amelia Joanna Hanford / Ranson, Craig / Nimphius, Sophia / Riley, Richard D / Collins, Gary S / Impellizzeri, Franco M

British journal of sports medicine

2024 Volume 58, Issue 6, Page(s) 293–295

MeSH term(s)	Humans ; Sports ; Exercise ; Medicine
Language	English
Publishing date	2024-03-13
Publishing country	England
Document type	Editorial
ZDB-ID	600592-5
ISSN	1473-0480 ; 0306-3674
ISSN (online)	1473-0480
ISSN	0306-3674
DOI	10.1136/bjsports-2023-107225
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Article ; Online: 3-Methoxy-2-phenylimidazo[1,2-b]pyridazines highly active against Mycobacterium tuberculosis and Mycobacterium marinum.

Farrell, Kyle D / Gao, Yamin / Hughes, Deborah A / Henches, Robin / Tu, Zhengchao / Perkins, Michael V / Zhang, Tianyu / Francis, Craig L

European journal of medicinal chemistry

2023 Volume 259, Page(s) 115637

Abstract: A series of 3-methoxy-2-phenylimidazo[1,2-b]pyridazine derivatives which were highly active against autoluminescent Mycobacterium tuberculosis (Mtb) and Mycobacterium marinum (Mm) in an in vitro assay were identified. SAR analysis showed that the most ... ...

Abstract	A series of 3-methoxy-2-phenylimidazo[1,2-b]pyridazine derivatives which were highly active against autoluminescent Mycobacterium tuberculosis (Mtb) and Mycobacterium marinum (Mm) in an in vitro assay were identified. SAR analysis showed that the most active compounds, which included a phenyl group bearing fluoro substituent(s) at C2, a methoxy function at C3, and a benzyl-heteroatom moiety at C6, exhibited in vitro MIC
MeSH term(s)	Animals ; Mice ; Mycobacterium tuberculosis ; Antitubercular Agents/pharmacology ; Antitubercular Agents/chemistry ; Mycobacterium marinum ; Pyridazines/chemistry ; Microbial Sensitivity Tests
Chemical Substances	Antitubercular Agents ; Pyridazines
Language	English
Publishing date	2023-07-19
Publishing country	France
Document type	Journal Article
ZDB-ID	188597-2
ISSN	1768-3254 ; 0009-4374 ; 0223-5234
ISSN (online)	1768-3254
ISSN	0009-4374 ; 0223-5234
DOI	10.1016/j.ejmech.2023.115637
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Article ; Online: Immune checkpoint inhibitor therapy for advanced cutaneous squamous cell carcinoma in Australia: a retrospective real world cohort study.

McLean, Luke S / Lim, Annette M / Bressel, Mathias / Lee, Jenny / Ladwa, Rahul / Guminski, Alexander D / Hughes, Brett / Bowyer, Samantha / Briscoe, Karen / Harris, Samuel / Kukard, Craig / Zielinski, Rob / Alamgeer, Muhammad / Carlino, Matteo / Mo, Jeremy / Park, John J / Khattak, Muhammad A / Day, Fiona / Rischin, Danny

The Medical journal of Australia

2024 Volume 220, Issue 2, Page(s) 80–90

Abstract: Objectives: To review the outcomes of immune checkpoint inhibitor (ICI) treatment of advanced cutaneous squamous cell carcinoma (CSCC) outside clinical trials.: Study design: Retrospective observational study; review of patient records in fifteen ... ...

Abstract	Objectives: To review the outcomes of immune checkpoint inhibitor (ICI) treatment of advanced cutaneous squamous cell carcinoma (CSCC) outside clinical trials. Study design: Retrospective observational study; review of patient records in fifteen Australian institutions. Setting, participants: All Australian adults with locally advanced or metastatic CSCC not amenable to curative surgery or radiotherapy treated with ICIs, 5 May 2017 - 23 May 2022, through a cemiplimab compassionate access scheme (Therapeutic Goods Administration Special Access Scheme) or who personally covered the cost of pembrolizumab prior to the start of the access scheme. Main outcome measures: Best overall response rate (ORR) according to standardised assessment criteria using the hierarchy: Response Evaluation Criteria in Solid Tumors (RECIST 1.1), the modified World Health Organization clinical response criteria, and the Positron Emission Tomography Response Criteria (PERCIST 1.0); overall and progression-free survival. Results: A total of 286 people with advanced CSCC received ICI therapy during May 2017 - May 2022 (cemiplimab, 270; pembrolizumab, 16). Their median age was 75.2 years (range, 39.3-97.5 years) and 232 were men (81%); median follow-up time was 12.2 months (interquartile range, 5.5-20.5 months). Eighty-eight people (31%) were immunocompromised, 27 had autoimmune disease, and 59 of 277 (21%) had ECOG performance scores of 2 or 3. The ORR was 60% (166 of 278 evaluable patients): complete responses were recorded for 74 (27%) and partial responses for 92 patients (33%). Twelve-month overall survival was 78% (95% confidence interval [CI], 72-83%); progression-free survival was 65% (95% CI, 58-70%). Poorer ECOG performance status was associated with poorer overall survival (per unit: adjusted hazard ratio [aHR], 3.0; 95% CI, 2.0-4.3) and progression-free survival (aHR, 2.4; 95% CI, 1.8-3.3), as was being immunocompromised (overall: aHR, 1.8; 95% CI, 1.1-3.0; progression-free: aHR, 1.8; 95% CI, 1.2-2.7). Fifty-five people (19%) reported immune-related adverse events of grade 2 or higher; there were no treatment-related deaths. Conclusion: In our retrospective study, the effectiveness and toxicity of ICI therapy were similar to those determined in clinical trials. Our findings suggest that ICIs could be effective and well tolerated by people with advanced CSCC who are ineligible for clinical trials.
MeSH term(s)	Male ; Adult ; Humans ; Aged ; Female ; Skin Neoplasms/drug therapy ; Skin Neoplasms/pathology ; Carcinoma, Squamous Cell/drug therapy ; Carcinoma, Squamous Cell/pathology ; Retrospective Studies ; Immune Checkpoint Inhibitors/therapeutic use ; Cohort Studies ; Australia/epidemiology
Chemical Substances	Immune Checkpoint Inhibitors
Language	English
Publishing date	2024-01-11
Publishing country	Australia
Document type	Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	186082-3
ISSN	1326-5377 ; 0025-729X
ISSN (online)	1326-5377
ISSN	0025-729X
DOI	10.5694/mja2.52199
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Article ; Online: Mass-producible 2D-WS

Hughes, Jack P / Blanco, Felipe D / Banks, Craig E / Rowley-Neale, Samuel J

RSC advances

2019 Volume 9, Issue 43, Page(s) 25003–25011

Abstract: A screen-printable ink that contained varying percentage mass incorporations of two dimensional tungsten disulphide (2D- ... ...

Abstract	A screen-printable ink that contained varying percentage mass incorporations of two dimensional tungsten disulphide (2D-WS
Language	English
Publishing date	2019-08-12
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/c9ra05342e
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Article ; Online: Short-Term Efficacy of a Childhood Obesity Prevention Program Designed to Pair Feeding Content With Nutrition Education.

Hughes, Sheryl O / Power, Thomas G / Baker, Susan S / Barale, Karen V / Aragon, M Catalina / Lanigan, Jane D / Parker, Louise / Silva Garcia, Karina / Auld, Garry / Johnston, Craig A / Micheli, Nilda

Childhood obesity (Print)

2022 Volume 19, Issue 4, Page(s) 239–248

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Child ; Humans ; Child, Preschool ; Pediatric Obesity/prevention & control ; Health Education ; Parents/education ; Feeding Behavior ; Overweight/prevention & control
Language	English
Publishing date	2022-06-16
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2639910-6
ISSN	2153-2176 ; 2153-2168
ISSN (online)	2153-2176
ISSN	2153-2168
DOI	10.1089/chi.2022.0030
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Article: Mass-producible 2D-WS2 bulk modified screen printed electrodes towards the hydrogen evolution reaction

Hughes, Jack P / Blanco, Felipe D / Banks, Craig E / Rowley-Neale, Samuel J

RSC advances. 2019 Aug. 12, v. 9, no. 43

2019

Abstract: A screen-printable ink that contained varying percentage mass incorporations of two dimensional tungsten disulphide (2D-WS2) was produced and utilized to fabricate bespoke printed electrodes (2D-WS2-SPEs). These WS2-SPEs were then rigorously tested ... ...

Abstract	A screen-printable ink that contained varying percentage mass incorporations of two dimensional tungsten disulphide (2D-WS2) was produced and utilized to fabricate bespoke printed electrodes (2D-WS2-SPEs). These WS2-SPEs were then rigorously tested towards the Hydrogen Evolution Reaction (HER) within an acidic media. The mass incorporation of 2D-WS2 into the 2D-WS2-SPEs was found to critically affect the observed HER catalysis with the larger mass incorporations resulting in more beneficial catalysis. The optimal (largest possible mass of 2D-WS2 incorporation) was the 2D-WS2-SPE40%, which displayed a HER onset potential, Tafel slope value and Turn over Frequency (ToF) of −214 mV (vs. RHE), 51.1 mV dec−1 and 2.20 , respectively. These values significantly exceeded the HER catalysis of a bare/unmodified SPE, which had a HER onset and Tafel slope value of −459 mV (vs. RHE) and 118 mV dec−1, respectively. Clearly, indicating a strong electrocatalytic response from the 2D-WS2-SPEs. An investigation of the signal stability of the 2D-WS2-SPEs was conducted by performing 1000 repeat cyclic voltammograms (CVs) using a 2D-WS2-SPE10% as a representative example. The 2D-WS2-SPE10% displayed remarkable stability with no variance in the HER onset potential of ca. −268 mV (vs. RHE) and a 44.4% increase in the achievable current over the duration of the 1000 CVs. The technique utilized to fabricate these 2D-WS2-SPEs can be implemented for a plethora of different materials in order to produce large numbers of uniform and highly reproducible electrodes with bespoke electrochemical signal outputs.
Keywords	catalytic activity ; disulfides ; electrochemistry ; electrodes ; hydrogen production ; tungsten ; variance
Language	English
Dates of publication	2019-0812
Size	p. 25003-25011.
Publishing place	The Royal Society of Chemistry
Document type	Article
ISSN	2046-2069
DOI	10.1039/c9ra05342e
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Article ; Online: Combining information to estimate adherence in studies of pre-exposure prophylaxis for HIV prevention: Application to HPTN 067.

Hughes, James P / Williamson, Brian D / Krakauer, Chloe / Chau, Gordon / Ortiz, Brayan / Wakefield, Jon / Hendrix, Craig / Amico, K Rivet / Holtz, Timothy H / Bekker, Linda-Gail / Grant, Robert

Statistics in medicine

2022 Volume 41, Issue 6, Page(s) 1120–1136

Abstract: In trials of oral HIV pre-exposure prophylaxis (PrEP), multiple approaches have been used to measure adherence, including self-report, pill counts, electronic dose monitoring devices, and biological measures such as drug levels in plasma, peripheral ... ...

Abstract	In trials of oral HIV pre-exposure prophylaxis (PrEP), multiple approaches have been used to measure adherence, including self-report, pill counts, electronic dose monitoring devices, and biological measures such as drug levels in plasma, peripheral blood mononuclear cells, hair, and/or dried blood spots. No one of these measures is ideal and each has strengths and weaknesses. However, accurate estimates of adherence to oral PrEP are important as drug efficacy is closely tied to adherence, and secondary analyses of trial data within identified adherent/non-adherent subgroups may yield important insights into real-world drug effectiveness. We develop a statistical approach to combining multiple measures of adherence and show in simulated data that the proposed method provides a more accurate measure of true adherence than self-report. We then apply the method to estimate adherence in the ADAPT study (HPTN 067) in South African women.
MeSH term(s)	Anti-HIV Agents/therapeutic use ; Female ; HIV Infections/drug therapy ; HIV Infections/prevention & control ; Humans ; Leukocytes, Mononuclear ; Medication Adherence ; Pre-Exposure Prophylaxis
Chemical Substances	Anti-HIV Agents
Language	English
Publishing date	2022-01-25
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	843037-8
ISSN	1097-0258 ; 0277-6715
ISSN (online)	1097-0258
ISSN	0277-6715
DOI	10.1002/sim.9321
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Article ; Online: A Problem-Based Learning Session on Pregnancy Options, Counseling, and Abortion Care

Tali Pomerantz / Ashlee Bergin / Karen Hughes Miller / Craig H. Ziegler / Pradip D. Patel

MedEdPORTAL, Vol

2019 Volume 15

Abstract: Introduction Before their clinical rotations, medical students have limited exposure to women's health issues, particularly abortion. Methods We piloted a problem-based learning (PBL) module to introduce second-year medical students at the University of ... ...

Abstract	Introduction Before their clinical rotations, medical students have limited exposure to women's health issues, particularly abortion. Methods We piloted a problem-based learning (PBL) module to introduce second-year medical students at the University of Louisville School of Medicine to counseling patients about pregnancy options. Students were divided into groups of 10 and met for two 2-hour sessions. In the first session, learners were presented with a case about a woman diagnosed with Zika virus who was considering pregnancy termination. Students discussed the case and developed learning objectives to research. One week later, students reconvened and shared what they had learned individually. Students were asked to complete pre- and post-PBL surveys. PBL facilitators also completed a survey evaluating the module. Results Fifty-eight percent of students felt informed or very informed about abortion after the PBL, compared to 30% before (p < .001). Students' mean quiz score increased from 29% on the pretest to 40% on the posttest (p < .001). Ninety-three percent of facilitators believed this PBL provided students with tools to better counsel about abortion, but only 56% of faculty felt adequately trained to facilitate this discussion. Discussion Students appreciated this PBL as an opportunity to discuss pregnancy options counseling and to clarify their own values surrounding abortion provision. Despite their positive response to the module, students identified barriers that would prevent them from implementing knowledge learned from this module in practice.
Keywords	Counseling ; Abortion ; Professionalism ; Pregnancy ; Pregnancy Complications ; Problem-Based Learning ; Medicine (General) ; R5-920 ; Education ; L
Subject code	410
Language	English
Publishing date	2019-03-01T00:00:00Z
Publisher	Association of American Medical Colleges
Document type	Article ; Online
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Article: Short-Term Efficacy of a Childhood Obesity Prevention Program Designed to Pair Feeding Content with Nutrition Education

Hughes, Sheryl O. / Power, Thomas G. / Baker, Susan S. / Barale, Karen V. / Aragon, M. Catalina / Lanigan, Jane D. / Parker, Louise / Silva Garcia, Karina / Auld, Garry / Johnston, Craig A. / Micheli, Nilda

Childhood obesity. 2022 June 16,

2022

Abstract: Background: Family-based programs show considerable promise in preventing overweight and obesity in young children. However, dissemination is difficult because significant participant and staff involvement is required. This study examined the short-term ... ...

Abstract	Background: Family-based programs show considerable promise in preventing overweight and obesity in young children. However, dissemination is difficult because significant participant and staff involvement is required. This study examined the short-term efficacy of adding parental feeding content to a widely-used nutrition education curriculum for families in low-resourced communities comparing the influence of two delivery methods (in-class and online) on parents' feeding knowledge, practices, and styles. Methods: In this cluster randomized controlled trial, parents of 2- to 8-year-old children enrolled in the EFNEP (Expanded Food and Nutrition Education Program) in Colorado and Washington were randomly assigned to: in-class nutrition education only, in-class nutrition education with in-class feeding content, or in-class nutrition education with online feeding content. Data from the 382 participants who completed both pretest and posttest assessments are reported in this study. Results: Multilevel analyses showed empirical support for the influence of the program on parents' feeding knowledge, practices, and styles. Online and in-class methods were equally effective in delivering feeding content in low-resourced communities. Consistent effects were seen across the two delivery methods for encouraging children to try new foods (p < 0.05), use of child-centered feeding practices (i.e., greater responsiveness, p < 0.05), child involvement in food preparation (p < 0.05), and understanding the number of presentations often necessary for child acceptance of a new food (p < 0.001). Location and language differences were seen across some constructs. Conclusions: This study demonstrates the efficacy of in-class and online approaches to feeding highlighting the program's positive effects on promoting healthy feeding behaviors for parents of children in low-resourced families. ClinicalTrials.gov Identifier: NCT03170700.
Keywords	Expanded Food and Nutrition Education Program ; childhood obesity ; children ; curriculum ; food preparation ; nutrition education ; Colorado
Language	English
Dates of publication	2022-0616
Publishing place	Mary Ann Liebert, Inc.
Document type	Article
ZDB-ID	2639910-6
ISSN	2153-2176 ; 2153-2168
ISSN (online)	2153-2176
ISSN	2153-2168
DOI	10.1089/chi.2022.0030
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