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  1. Article ; Online: Judith Campisi (1948-2024).

    Verdin, Eric

    Cell metabolism

    2024  Volume 36, Issue 4, Page(s) 649–650

    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2176834-1
    ISSN 1932-7420 ; 1550-4131
    ISSN (online) 1932-7420
    ISSN 1550-4131
    DOI 10.1016/j.cmet.2024.03.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Judith Campisi (1948-2024).

    Verdin, Eric

    Cell

    2024  Volume 187, Issue 6, Page(s) 1358–1359

    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2024.02.017
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  3. Article ; Online: Paolo Sassone-Corsi (1956-2020).

    Verdin, Eric

    Science (New York, N.Y.)

    2020  Volume 370, Issue 6516, Page(s) 532

    MeSH term(s) Epigenomics/history ; History, 20th Century ; History, 21st Century ; Italy ; Molecular Biology/history ; United States
    Language English
    Publishing date 2020-10-26
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article ; Portrait
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.abe9149
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 27: Show issues Location:
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  4. Book: Histone deacetylases

    Verdin, Eric

    transcriptional regulation and other cellular functions

    (Cancer drug discovery and development)

    2006  

    Author's details ed. by Eric Verdin
    Series title Cancer drug discovery and development
    Keywords Histone Deacetylases / physiology ; Histone Deacetylases / antagonists & inhibitors ; Enzyme Repression / physiology ; Cell Cycle / drug effects ; Neoplasms / drug therapy ; Sirtuins / physiology
    Language English
    Size XI, 340 S., [4] Bl. : Ill., graph. Darst.
    Publisher Humana Press
    Publishing place Totowa, NJ
    Publishing country United States
    Document type Book
    HBZ-ID HT014565835
    ISBN 1-58829-499-4 ; 978-1-58829-499-9
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2006 A 1569 order for loan Magazin

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  5. Article ; Online: How inflammaging diminishes adaptive immunity.

    Kasler, Herbert / Verdin, Eric

    Nature aging

    2021  Volume 1, Issue 1, Page(s) 24–25

    MeSH term(s) Humans ; Monocytes ; Aging/immunology ; Adaptive Immunity/immunology
    Language English
    Publishing date 2021-10-07
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2662-8465
    ISSN (online) 2662-8465
    DOI 10.1038/s43587-020-00021-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: HIV

    Battivelli, Emilie / Verdin, Eric

    Bio-protocol

    2021  Volume 8, Issue 20

    Abstract: While able to suppress HIV replication in HIV infected individuals, combination antiretroviral therapy (ART) fails to eliminate viral latent reservoir, which consists in integrated transcriptional silenced HIV provirus. So far, identification of latently- ...

    Abstract While able to suppress HIV replication in HIV infected individuals, combination antiretroviral therapy (ART) fails to eliminate viral latent reservoir, which consists in integrated transcriptional silenced HIV provirus. So far, identification of latently-infected cells has relied on activating cells to induce expression of HIV proteins which can then be detected. Unfortunately, this activation significantly changed the cell phenotype. We developed a novel HIV reporter, named HIV
    Language English
    Publishing date 2021-02-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2833269-6
    ISSN 2331-8325 ; 2331-8325
    ISSN (online) 2331-8325
    ISSN 2331-8325
    DOI 10.21769/bioprotoc.3050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: NAD⁺ in aging, metabolism, and neurodegeneration.

    Verdin, Eric

    Science (New York, N.Y.)

    2015  Volume 350, Issue 6265, Page(s) 1208–1213

    Abstract: Nicotinamide adenine dinucleotide (NAD(+)) is a coenzyme found in all living cells. It serves both as a critical coenzyme for enzymes that fuel reduction-oxidation reactions, carrying electrons from one reaction to another, and as a cosubstrate for other ...

    Abstract Nicotinamide adenine dinucleotide (NAD(+)) is a coenzyme found in all living cells. It serves both as a critical coenzyme for enzymes that fuel reduction-oxidation reactions, carrying electrons from one reaction to another, and as a cosubstrate for other enzymes such as the sirtuins and poly(adenosine diphosphate-ribose) polymerases. Cellular NAD(+) concentrations change during aging, and modulation of NAD(+) usage or production can prolong both health span and life span. Here we review factors that regulate NAD(+) and discuss how supplementation with NAD(+) precursors may represent a new therapeutic opportunity for aging and its associated disorders, particularly neurodegenerative diseases.
    MeSH term(s) Aging/drug effects ; Aging/genetics ; Aging/metabolism ; Biosynthetic Pathways ; DNA Damage ; Diabetes Mellitus, Type 2/metabolism ; Fatty Liver/metabolism ; Humans ; Mitochondria/metabolism ; NAD/metabolism ; Neurodegenerative Diseases/drug therapy ; Neurodegenerative Diseases/metabolism ; Obesity/metabolism ; Oxidation-Reduction ; Poly(ADP-ribose) Polymerases/metabolism ; Sirtuins/metabolism
    Chemical Substances NAD (0U46U6E8UK) ; Poly(ADP-ribose) Polymerases (EC 2.4.2.30) ; Sirtuins (EC 3.5.1.-)
    Language English
    Publishing date 2015-12-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.aac4854
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Viral gene drive in herpesviruses.

    Walter, Marius / Verdin, Eric

    Nature communications

    2020  Volume 11, Issue 1, Page(s) 4884

    Abstract: Gene drives are genetic modifications designed to propagate in a population with high efficiency. Current gene drive strategies rely on sexual reproduction and are thought to be restricted to sexual organisms. Here, we report on a gene drive system that ... ...

    Abstract Gene drives are genetic modifications designed to propagate in a population with high efficiency. Current gene drive strategies rely on sexual reproduction and are thought to be restricted to sexual organisms. Here, we report on a gene drive system that allows the spread of an engineered trait in populations of DNA viruses and, in particular, herpesviruses. We describe the successful transmission of a gene drive sequence between distinct strains of human cytomegalovirus (human herpesvirus 5) and show that gene drive viruses can efficiently target and replace wildtype populations in cell culture experiments. Moreover, by targeting sequences necessary for viral replication, our results indicate that a viral gene drive can be used as a strategy to suppress a viral infection. Taken together, this work offers a proof of principle for the design of a gene drive in viruses.
    MeSH term(s) Cell Line ; Cytomegalovirus/genetics ; Cytomegalovirus/physiology ; DNA, Viral/genetics ; Gene Drive Technology/methods ; Gene Editing ; Herpesviridae/genetics ; Herpesviridae/physiology ; Humans ; Virus Replication
    Chemical Substances DNA, Viral
    Language English
    Publishing date 2020-09-28
    Publishing country England
    Document type Evaluation Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-020-18678-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Clinical Evidence for Targeting NAD Therapeutically.

    Radenkovic, Dina / Reason / Verdin, Eric

    Pharmaceuticals (Basel, Switzerland)

    2020  Volume 13, Issue 9

    Abstract: Nicotinamide adenine dinucleotide (NAD) pharmacology is a promising class of treatments for age-related conditions that are likely to have a favorable side effect profile for human use, given the widespread use of the NAD precursor vitamin B3 supplements. ...

    Abstract Nicotinamide adenine dinucleotide (NAD) pharmacology is a promising class of treatments for age-related conditions that are likely to have a favorable side effect profile for human use, given the widespread use of the NAD precursor vitamin B3 supplements. However, despite several decades of active investigation and numerous possible biochemical mechanisms of action suggested, only a small number of randomized and adequately powered clinical trials of NAD upregulation as a therapeutic strategy have taken place. We conducted a systematic review of the literature, following the PRISMA guidelines, in an attempt to determine whether or not the human clinical trials performed to date support the potential benefits of NAD supplementation in a range of skin, metabolic and age-related conditions. In addition, we sought medical indications that have yielded the most promising results in the limited studies to date. We conclude that promising, yet still speculative, results have been reported for the treatment of psoriasis and enhancement of skeletal muscle activity. However, further trials are required to determine the optimal method of raising NAD levels, identifying the target conditions, and comparisons to the present standard of care for these conditions. Lastly, pharmacological methods that increase NAD levels should also be directly compared to physiological means of raising NAD levels, such as exercise programs and dietary interventions that are tailored to older individuals, and which may be more effective.
    Keywords covid19
    Language English
    Publishing date 2020-09-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph13090247
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The many faces of sirtuins: Coupling of NAD metabolism, sirtuins and lifespan.

    Verdin, Eric

    Nature medicine

    2014  Volume 20, Issue 1, Page(s) 25–27

    MeSH term(s) Aging/physiology ; Humans ; Longevity/physiology ; Models, Biological ; NAD/metabolism ; NAD/pharmacology ; Sirtuins/metabolism
    Chemical Substances NAD (0U46U6E8UK) ; Sirtuins (EC 3.5.1.-)
    Language English
    Publishing date 2014-01-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/nm.3447
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