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  1. Article: Evaluation of a new reagent for anti-cytomegalovirus and anti-Epstein-Barr virus immunoglobulin G.

    Gutierrez, J / Maroto, M D / Piédrola, G

    Journal of clinical microbiology

    1994  Volume 32, Issue 10, Page(s) 2603–2605

    Abstract: The Enzygnost alpha method was tested against the complement fixation test and anti-VCA immunofluorescence to determine the respective titers of anti-cytomegalovirus and anti-Epstein-Barr virus immunoglobulin G antibodies. For cytomegalovirus, the ... ...

    Abstract The Enzygnost alpha method was tested against the complement fixation test and anti-VCA immunofluorescence to determine the respective titers of anti-cytomegalovirus and anti-Epstein-Barr virus immunoglobulin G antibodies. For cytomegalovirus, the Enzygnost results showed 97.99% agreement with the readings obtained by the alternative method, with 100% sensitivity and 93.7% specificity. For Epstein-Barr virus, Enzygnost showed 97.71% agreement, 100% sensitivity, and 91.11% specificity.
    MeSH term(s) Adult ; Antibodies, Viral/analysis ; Child, Preschool ; Cytomegalovirus/immunology ; Enzyme-Linked Immunosorbent Assay ; Female ; Herpesvirus 4, Human/immunology ; Humans ; Immunoglobulin G/analysis ; Male
    Chemical Substances Antibodies, Viral ; Immunoglobulin G
    Language English
    Publishing date 1994-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/jcm.32.10.2603-2605.1994
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1188: Show issues Location:
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  2. Article: Clinical utility of a competitive ELISA to detect antibodies against Treponema pallidum.

    Gutiérrez, J / Vergara, M J / Soto, M J / Piédrola, G / Maroto, M d

    Journal of clinical laboratory analysis

    2000  Volume 14, Issue 2, Page(s) 83–86

    Abstract: Screening for Treponema pallidum infection is carried out on a large human population. To reduce costs, fewer tests which still offer adequate sensitivity and specificity could be performed. We studied the reliability of a novel indirect ELISA method to ... ...

    Abstract Screening for Treponema pallidum infection is carried out on a large human population. To reduce costs, fewer tests which still offer adequate sensitivity and specificity could be performed. We studied the reliability of a novel indirect ELISA method to test for this infection. Several panels of sera were used that corresponded to 40 primary infections (group 1), 13 recurrences (group 2), 348 latent infections (group 3), 5 samples with anticardiolipin antibodies (group 4), 15 samples from patients with Lyme borreliosis (group 5), and 400 samples from blood donors and healthy pregnant women (group 6). The ELISA showed a global sensitivity and specificity of 100 and 99.5%, respectively. Our evaluation shows that Enzygnost Syphilis is a sensitive, specific, and simple test to screen for this infection.
    MeSH term(s) Adult ; Aged ; Antibodies, Anticardiolipin/blood ; Antibodies, Bacterial/blood ; Binding, Competitive ; Enzyme-Linked Immunosorbent Assay/methods ; Female ; Humans ; Lyme Disease/immunology ; Pregnancy ; Recurrence ; Sensitivity and Specificity ; Syphilis/diagnosis ; Treponema pallidum/immunology
    Chemical Substances Antibodies, Anticardiolipin ; Antibodies, Bacterial
    Language English
    Publishing date 2000
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645095-7
    ISSN 1098-2825 ; 0887-8013
    ISSN (online) 1098-2825
    ISSN 0887-8013
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    Zs.A 2471: Show issues Location:
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  3. Article: Morbilidad en pacientes transexuales con autotratamiento hormonal para cambio de sexo.

    Becerra Fernández, A / de Luis Román, D A / Piédrola Maroto, G

    Medicina clinica

    1999  Volume 113, Issue 13, Page(s) 484–487

    Abstract: Background: The demand for sex reassignment in transsexual patients has increased as have the number of treatments. However, these patients run into troubles to be treated in Spanish public hospitals and the patients usually make use of self-therapy, ... ...

    Title translation Morbidity in transsexual patients with cross-gender hormone self-treatment.
    Abstract Background: The demand for sex reassignment in transsexual patients has increased as have the number of treatments. However, these patients run into troubles to be treated in Spanish public hospitals and the patients usually make use of self-therapy, without medical control, by suffering frequent side effects. In this paper, we have analysed these effects.
    Patients and methods: Cross-sectional and descriptive study of the side effects of cross-gender hormone self-administration in 57 transsexuals, aged (median [SD]) 30(7) years.
    Results: Combined treatment with estrogen and cyproterone acetate in 31 male-to-female transsexuals was associated with hyperprolactinemia in 24/31 patients (77.4%) and elevation of liver enzymes in 4/31 (12.9%). Androgen treatment in 26 female-to-male transsexuals was associated with hyperprolactinemia in 10/26 patients (38.5%), elevation of liver enzymes in 5/26 (19.2%). The levels of total cholesterol, LDL-cholesterol and triglycerides were higher in female-to-male that in male-to-female transsexuals (197.3 [40.2] vs 160.6 [38.0] mg/dl, p = 0.033; 131.4 [29.4] vs 104.8 [26.4] mg/dl, p = 0.049; and 131.3 [62.7] vs 67.4 [25.6], p = 0.001, respectively). Total cholesterol/HDL-cholesterol and LDL-cholesterol/HDL-cholesterol ratios were higher in female-to-male that in male-to-female transsexuals, too (4.94 [1.20] vs 3.32 [0.71], p = 0.006; and 3.20 [0.87] vs 2.04 [0.63], p = 0.003, respectively).
    Conclusions: The alteration of the cardiovascular risk, the presence of hyperprolactinemia and the elevation of liver enzymes must be taken into account in transsexual patients with hormone treatment.
    MeSH term(s) Adolescent ; Adult ; Cholesterol/blood ; Cross-Sectional Studies ; Cyproterone/therapeutic use ; Disorders of Sex Development ; Enzymes/metabolism ; Estrogens/therapeutic use ; Female ; Gonadal Steroid Hormones/therapeutic use ; Humans ; Hyperprolactinemia/diagnosis ; Liver/enzymology ; Male ; Morbidity ; Prevalence ; Retrospective Studies ; Self Administration ; Self Medication/adverse effects ; Spain/epidemiology ; Transsexualism/drug therapy ; Transsexualism/epidemiology
    Chemical Substances Enzymes ; Estrogens ; Gonadal Steroid Hormones ; Cholesterol (97C5T2UQ7J) ; Cyproterone (E61Q31EK2F)
    Language Spanish
    Publishing date 1999-10-23
    Publishing country Spain
    Document type Comparative Study ; English Abstract ; Journal Article
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
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  4. Article ; Online: Resultado funcional de las miringoplastias.

    Piédrola Maroto, David / Escalona Gutiérrez, Juan José / Conde Jiménez, Manuel / Casado Morente, Juan Carlos / Povedano Rodríguez, Valerio / Benítez-Parejo, Nicolás

    Acta otorrinolaringologica espanola

    2010  Volume 61, Issue 2, Page(s) 94–99

    Abstract: Goal: The aim of this study was to assess hearing improvement after myringoplasty.: Material and methods: We present a retrospective study with a total of 119 cases undergoing myringoplasty at our Department analyzing the air conduction thresholds ... ...

    Title translation Functional results in myringoplasties.
    Abstract Goal: The aim of this study was to assess hearing improvement after myringoplasty.
    Material and methods: We present a retrospective study with a total of 119 cases undergoing myringoplasty at our Department analyzing the air conduction thresholds before and 6 months after surgery. We conducted an analysis of variance for the different variables and contrasted hypotheses using Student's T-test.
    Results: We obtained a hearing improvement at all frequencies, except at 8.000 Hz, at which surgery noticeably worsens hearing. The lower the frequency, the higher the hearing improvement, with the best results at 250 Hz, where the mean hearing improvement reached 13.49 dB.
    Conclusions: Myringoplasty is an effective technique in the recovery of hearing thresholds secondary to a tympanic membrane perforation.
    MeSH term(s) Adolescent ; Adult ; Aged ; Audiometry ; Child ; Female ; Humans ; Male ; Middle Aged ; Myringoplasty ; Recovery of Function ; Retrospective Studies ; Treatment Outcome ; Tympanic Membrane Perforation/surgery ; Young Adult
    Language Spanish
    Publishing date 2010-03
    Publishing country Spain
    Document type English Abstract ; Journal Article
    ZDB-ID 730022-0
    ISSN 1988-3013 ; 0001-6519
    ISSN (online) 1988-3013
    ISSN 0001-6519
    DOI 10.1016/j.otorri.2009.09.007
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  5. Article ; Online: Effectiveness of lanreotide autogel 120 mg at extended dosing intervals for acromegaly.

    Bernabéu, Ignacio / Fajardo, Carmen / Marazuela, Mónica / Cordido, Fernando / Venegas, Eva María / de Pablos-Velasco, Pedro / Maroto, Gonzalo Piedrola / Olvera, María Pilar / de Paz, Isabel Pavón / Carvalho, Davide / Romero, Carme / De la Cruz, Guillermo / Escolá, Cristina Álvarez

    Endocrine

    2020  Volume 70, Issue 3, Page(s) 575–583

    Abstract: Purpose: Recent data indicate that extended dosing intervals (EDIs) with lanreotide autogel 120 mg are effective and well-received among patients with acromegaly who have achieved biochemical control with monthly injections of long-acting somatostatin ... ...

    Abstract Purpose: Recent data indicate that extended dosing intervals (EDIs) with lanreotide autogel 120 mg are effective and well-received among patients with acromegaly who have achieved biochemical control with monthly injections of long-acting somatostatin analogues (SSAs). We further evaluated the effectiveness of lanreotide autogel 120 mg delivered at EDIs (>4 weeks) in routine clinical practice.
    Methods: Cross-sectional, multicentre, observational study conducted to determine the effectiveness-measured by control of serum insulin-like growth factor 1 (IGF-1)-of lanreotide autogel 120 mg at dosing intervals >4 weeks for ≥6 months in selected patients with acromegaly treated in routine clinical practice (NCT02807233). Secondary assessments included control of growth hormone (GH) levels, treatment adherence, patient satisfaction, and quality of life (QoL) using validated questionnaires (EQ-5D, AcroQoL, and TSQM-9). Patients who received radiotherapy within the last 6 months were excluded.
    Results: Among 109 patients evaluated, mean (SD) age was 59.1 (13.2) years. IGF-1 values were normal (mean [SD]: 175.0 [74.5], 95% CI: 160.8 -189.1) in 91.7% of cases and normal in 91.4% of patients without previous radiotherapy treatment (n = 81). GH levels were ≤2.5 and ≤1 ng/mL, respectively, in 80.6% and 58.3%. Most patients were treated either every 5-6 (57.8%) or 7-8 weeks (38.5%), with 2.8% treated greater than every 8 weeks. The mean AcroQoL score was 63.0 (20.1). The mean global treatment satisfaction score (TSQM-9) was 75.1 (16.6). Treatment adherence (defined as no missed injections) was 94.5%.
    Conclusion: Lanreotide autogel 120 mg at intervals of >4 weeks provided IGF-1 control in more than 90% of patients with acromegaly. Treatment satisfaction and adherence were good. These findings support use of extended dosing intervals in patients who have achieved good biochemical control with long-acting SSAs.
    MeSH term(s) Acromegaly/drug therapy ; Cross-Sectional Studies ; Delayed-Action Preparations/therapeutic use ; Human Growth Hormone/therapeutic use ; Humans ; Insulin-Like Growth Factor I ; Middle Aged ; Peptides, Cyclic/therapeutic use ; Quality of Life ; Somatostatin/analogs & derivatives
    Chemical Substances Delayed-Action Preparations ; Peptides, Cyclic ; lanreotide (0G3DE8943Y) ; Human Growth Hormone (12629-01-5) ; Somatostatin (51110-01-1) ; Insulin-Like Growth Factor I (67763-96-6)
    Language English
    Publishing date 2020-07-28
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 1194484-5
    ISSN 1559-0100 ; 1355-008X ; 0969-711X
    ISSN (online) 1559-0100
    ISSN 1355-008X ; 0969-711X
    DOI 10.1007/s12020-020-02424-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3884: Show issues Location:
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  6. Article: Situación actual de las resistencias a antibióticos en infecciones amigdalares.

    Piédrola Maroto, D / Montiel Quezel, N / López Rodríguez, I / Monje Vega, E / Casado Morente, J C / Povedano Rodríguez, V / Fernández Ruiz, E / Conde Jiménez, M

    Acta otorrinolaringologica espanola

    2006  Volume 57, Issue 4, Page(s) 171–175

    Abstract: Objective: To obtain the main responsible organisms, its sensitivity and resistances to antibiotics in tonsillitis.: Material and methods: We have studied the post-surgical tonsils, carrying out a microbiologic study, its culture and sensitivity.: ... ...

    Title translation Present situation of antibiotic resistances in tonsillar infections.
    Abstract Objective: To obtain the main responsible organisms, its sensitivity and resistances to antibiotics in tonsillitis.
    Material and methods: We have studied the post-surgical tonsils, carrying out a microbiologic study, its culture and sensitivity.
    Results: The most frequent isolated organisms were Staphylococcus aureus (29.3%), followed by Streptococcus pyogenes (23.4%), and Haemophilus influenzae (12.1%). The highest resistances were for the S. aureus (penicillin 91%, erythromycin 18% and 5% to the rest of the beta-lactams), followed by H. influenzae (50% clarithromycin, 30% amoxyciIlin and 2% cephalosporins) and S. pyogenes (28% erytromycin, 10% clindamycin and 3% penicillin).
    Conclusions: We noticed the minimal resistance found to cephalosporins, and for this reason they appear to be the safest option, except in children under five years old, in which amoxicillin is still the first line treatment, because the causative agent is S. pyogenes, sensitive to that antibiotic.
    MeSH term(s) Adolescent ; Adult ; Age Distribution ; Anti-Bacterial Agents/therapeutic use ; Bacterial Infections/complications ; Bacterial Infections/drug therapy ; Cephalosporins/therapeutic use ; Child ; Child, Preschool ; Drug Resistance, Bacterial/physiology ; Drug Resistance, Fungal ; Erythromycin/therapeutic use ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; Penicillin Resistance/physiology ; Tonsillitis/drug therapy ; Tonsillitis/epidemiology ; Tonsillitis/microbiology
    Chemical Substances Anti-Bacterial Agents ; Cephalosporins ; Erythromycin (63937KV33D)
    Language Spanish
    Publishing date 2006-05-02
    Publishing country Spain
    Document type English Abstract ; Journal Article
    ZDB-ID 730022-0
    ISSN 0001-6519
    ISSN 0001-6519
    DOI 10.1016/s0001-6519(06)78686-1
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  7. Article: Degloving medio-facial en un plasmocitoma extramedular con invasión orbitaria.

    Casado Morente, J C / Povedano Rodríguez, V / Piédrola Maroto, D / Conde Jiménez, M / Jurado Ramos, A

    Acta otorrinolaringologica espanola

    2000  Volume 51, Issue 1, Page(s) 71–75

    Abstract: Extramedullary solitary plasmacytoma is a rare plasmatic cell tumor occurring in the head and neck. We report the case of a patient with a mass that arose from the sphenoidal base, extended toward the right paranasal sinuses, and invaded the orbit. The ... ...

    Title translation Mediofacial degloving in extramedullary plasmacytoma with orbital invasion.
    Abstract Extramedullary solitary plasmacytoma is a rare plasmatic cell tumor occurring in the head and neck. We report the case of a patient with a mass that arose from the sphenoidal base, extended toward the right paranasal sinuses, and invaded the orbit. The clinical characteristics, diagnostic criteria, and therapeutic problems are discussed and reviewed in the literature, with special attention to an alternative therapeutic approach, midfacial degloving.
    MeSH term(s) Adult ; Female ; Humans ; Neoplasm Invasiveness ; Orbital Neoplasms/diagnostic imaging ; Orbital Neoplasms/pathology ; Orbital Neoplasms/surgery ; Paranasal Sinus Neoplasms/diagnostic imaging ; Paranasal Sinus Neoplasms/pathology ; Paranasal Sinus Neoplasms/surgery ; Plasmacytoma/diagnostic imaging ; Plasmacytoma/pathology ; Plasmacytoma/surgery ; Skull Neoplasms/diagnostic imaging ; Skull Neoplasms/pathology ; Skull Neoplasms/surgery ; Sphenoid Bone/diagnostic imaging ; Sphenoid Bone/pathology ; Sphenoid Bone/surgery ; Surgical Procedures, Operative/methods ; Tomography, X-Ray Computed
    Language Spanish
    Publishing date 2000-01
    Publishing country Spain
    Document type Case Reports ; Journal Article
    ZDB-ID 730022-0
    ISSN 0001-6519
    ISSN 0001-6519
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  8. Article: Coste anual de las pruebas inmunológicas microbianas de individuos VIH-positivos en un centro hospitalario.

    Maroto, M C / Piédrola, D / Quirós, E / García, F / Bernal, M C

    Enfermedades infecciosas y microbiologia clinica

    1992  Volume 10, Issue 8, Page(s) 462–465

    Abstract: The goal of this study is to increase the knowledge of the AIDS cost in a hospital. We have studied the HIV patients diagnosed during a year in our hospital and the charges of the serological tests performed to them. 20.8% of the tests were to study ... ...

    Title translation Annual cost of microbial immunological tests for HIV-positive individuals in a hospital center.
    Abstract The goal of this study is to increase the knowledge of the AIDS cost in a hospital. We have studied the HIV patients diagnosed during a year in our hospital and the charges of the serological tests performed to them. 20.8% of the tests were to study antibodies against HIV (only 20% were positive). After patient distribution between extra or intrahospital origin, we highlight that 61% of the charges are attributed to patients who do not belong to the hospital but to its catchment area. We emphasize the problem that AIDS patients are creating to hospital, being necessary that personal select only useful tests honestly.
    MeSH term(s) AIDS Serodiagnosis/economics ; AIDS Serodiagnosis/utilization ; Acquired Immunodeficiency Syndrome/economics ; Antibodies/analysis ; Catchment Area (Health) ; Costs and Cost Analysis ; HIV Antibodies/analysis ; HIV Seropositivity/complications ; HIV Seropositivity/diagnosis ; Hospitals, University/economics ; Humans ; Immunologic Tests/economics ; Immunologic Tests/utilization ; Infection/complications ; Infection/diagnosis ; Prisons ; Substance Abuse Treatment Centers
    Chemical Substances Antibodies ; HIV Antibodies
    Language Spanish
    Publishing date 1992-10
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 1070941-1
    ISSN 1578-1852 ; 0213-005X
    ISSN (online) 1578-1852
    ISSN 0213-005X
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  9. Article: Cierre endoscópico de fístulas nasales de líquido cefalorraquídeo. Nuestra experiencia.

    Casado Morente, J / Povedano Rodríguez, V / Piédrola Maroto, D / Conde Jiménez, M / Jurado Ramos, A

    Acta otorrinolaringologica espanola

    1999  Volume 50, Issue 8, Page(s) 607–611

    Abstract: Unlabelled: Cerebrospinal fluid (SCF) rhinorrea results from a breakdown of the dura and supporting structures of the skull base. Trauma is responsible for 81 to 90 percent of the cases of SCF rhinorrea, and it occurs in approximately 2 percent of all ... ...

    Title translation Endoscopic closure of nasal fistulas leaking cerebrospinal fluid. Our experience.
    Abstract Unlabelled: Cerebrospinal fluid (SCF) rhinorrea results from a breakdown of the dura and supporting structures of the skull base. Trauma is responsible for 81 to 90 percent of the cases of SCF rhinorrea, and it occurs in approximately 2 percent of all head injuries. This is a retrospective review of 5 patients who underwent endoscopic treatment of CSF rhinorrea during 1997 in our hospital. The aetiology of leaks was: iatrogenic in two cases (by transphenoidal hypophysectomies), traumatic in two cases (by head injuries) and spontaneous in one (nasal encephalocele).
    Conclusion: we recommend endoscopic approach as the first line in managing CSF rhinorrea because it avoids an external incision, requires less cumbersome instrumentation and in our hands in the safest and most successful. Furthermore, we prefer the autogenous mocuperiosteum of the inferior turbinate glued over the fistula offers several advantages: it is readily available in sufficient size for the closure of most defects, only minor surgery for graft harvesting is necessary and, the texture of the mucoperiostium permits a good secure seal.
    MeSH term(s) Cerebrospinal Fluid Rhinorrhea/etiology ; Cerebrospinal Fluid Rhinorrhea/surgery ; Endoscopy ; Humans ; Nose Diseases/complications ; Nose Diseases/surgery ; Respiratory Tract Fistula/complications ; Respiratory Tract Fistula/surgery ; Retrospective Studies
    Language Spanish
    Publishing date 1999-11
    Publishing country Spain
    Document type English Abstract ; Journal Article
    ZDB-ID 730022-0
    ISSN 0001-6519
    ISSN 0001-6519
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Implantación de la cirugía endoscópica nasosinusal en España.

    Piédrola Maroto, D / Jiménez Puente, A / Bandera Florido, A / Conde Jiménez, M / Perea-Milla López, E / Casado Morente, J C / Povedano Rodríguez, V

    Acta otorrinolaringologica espanola

    2004  Volume 55, Issue 4, Page(s) 165–170

    Abstract: The purpose of this study is to find out more about the implementation of functional endoscopic sinus surgery (FESS) in our country. To do that, we designed a survey which was sent to 160 public hospitals (June 2002). We received the answers of 111 ... ...

    Title translation The implementation of endoscopic sinus surgery in Spain.
    Abstract The purpose of this study is to find out more about the implementation of functional endoscopic sinus surgery (FESS) in our country. To do that, we designed a survey which was sent to 160 public hospitals (June 2002). We received the answers of 111 hospitals. 82.9% of hospitals and 58% of surgeons performed FESS, with some differences among autonomic regions. The percentage of surgeons who performed FESS was higher in small hospitals and their mean experience time was 6.2 years. We consider the implementation of endoscopic sinus surgery very high, this can reflect that there are evident advantages for those who specialists who use it.
    MeSH term(s) Endoscopy/methods ; Humans ; Nasal Polyps/surgery ; Otolaryngology/organization & administration ; Paranasal Sinus Diseases/surgery ; Sinusitis/surgery ; Spain
    Language Spanish
    Publishing date 2004-08-23
    Publishing country Spain
    Document type English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 730022-0
    ISSN 0001-6519
    ISSN 0001-6519
    DOI 10.1016/s0001-6519(04)78502-7
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