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Article ; Online: On the need to harmonize nephrological terminology in Ibero-American countries.

Sánchez-Alvarez, J Emilio / Ferreiro-Fuentes, Alejandro / González-Bedat, María Carlota / Rosa Díez, Guillermo Javier / Lombardi, Raúl / Lugón, Jocemir / Mira, Filipe / Mastroianni, Gianna

Nefrologia

2022 Volume 41, Issue 6, Page(s) 700–701

MeSH term(s)	Humans ; Nephrology ; Terminology as Topic
Language	English
Publishing date	2022-01-14
Publishing country	Spain
Document type	Letter
ZDB-ID	2837917-2
ISSN	2013-2514 ; 2013-2514
ISSN (online)	2013-2514
ISSN	2013-2514
DOI	10.1016/j.nefroe.2021.01.002
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Article ; Online: Pelvic organ prolapse in women with autosomal dominant polycystic kidney disease under tolvaptan treatment.

Sango, Cristina / Merino Bueno, María Del Carmen / Gallardo Pérez, Anna / Pérez Martinez, Noelia / Gutiérrez González, Jaime / Ruiz-Zorrilla, Carlos / de la Torre-Fernández, Miguel / Suárez Laurés, Ana María / Sánchez-Álvarez, Emilio

Nefrologia

2023 Volume 43, Issue 6, Page(s) 791–792

MeSH term(s)	Humans ; Female ; Tolvaptan/therapeutic use ; Polycystic Kidney, Autosomal Dominant/complications ; Polycystic Kidney, Autosomal Dominant/drug therapy ; Antidiuretic Hormone Receptor Antagonists/therapeutic use ; Glomerular Filtration Rate ; Pelvic Organ Prolapse
Chemical Substances	Tolvaptan (21G72T1950) ; Antidiuretic Hormone Receptor Antagonists
Language	English
Publishing date	2023-10-23
Publishing country	Spain
Document type	Letter
ZDB-ID	2837917-2
ISSN	2013-2514 ; 2013-2514
ISSN (online)	2013-2514
ISSN	2013-2514
DOI	10.1016/j.nefroe.2021.09.011
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Article: Prevalence and severity of pruritus in Spanish patients with chronic kidney disease and impact on quality of life: a cross-sectional study.

Aresté, Nuria / Sanchez-Alvarez, J Emilio / Prieto-Velasco, Mario / Molina, Pablo / Esteve-Simó, Vicent / Ojeda, Raquel / Buades, Juan Manuel / Goicoechea, Marian / Sanchez-Villanueva, Rafael / Bezhold, Guillermo Alcalde / Pérez-Morales, Rosa Elena / Santos, Ana Blanco / Peiró-Jordan, Roser / Arenas, María Dolores

Clinical kidney journal

2023 Volume 16, Issue 6, Page(s) 1035–1037

Language	English
Publishing date	2023-03-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2655800-2
ISSN	2048-8513 ; 2048-8505
ISSN (online)	2048-8513
ISSN	2048-8505
DOI	10.1093/ckj/sfac246
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Article ; Online: An uncommon cause of spontaneous hemoperitoneum in a peritoneal dialysis patient.

Hidalgo-Ordoñez, Carlos / Sánchez-Alvarez, J Emilio / Rodríguez-Suárez, Carmen

Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia

2016 Volume 36, Issue 1, Page(s) 80–81

MeSH term(s)	Hemoperitoneum/etiology ; Humans ; Peritoneal Dialysis
Language	Spanish
Publishing date	2016
Publishing country	Spain
Document type	Case Reports ; Letter
ZDB-ID	632512-9
ISSN	1989-2284 ; 0211-6995
ISSN (online)	1989-2284
ISSN	0211-6995
DOI	10.1016/j.nefro.2015.08.010
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Article ; Online: Risk factors associated with valvular calcification in patients with chronic kidney disease. Analysis of NEFRONA study.

Martínez Fernández, Lidia / Sánchez-Alvarez, J Emilio / Morís de la Tassa, César / Bande Fernández, José Joaquín / María, Virtudes / Fernández, Elvira / Valdivielso, Jose M / Betriu, Angels

Nefrologia

2021 Volume 41, Issue 3, Page(s) 337–346

Abstract: Introduction: Patients with chronic kidney disease (CKD) are at high risk of cardiovascular morbidity and mortality. Subclinical cardiac structural alterations have prognostic value in these patients. The aim was to analyse the prevalence of valvular ... ...

Abstract	Introduction: Patients with chronic kidney disease (CKD) are at high risk of cardiovascular morbidity and mortality. Subclinical cardiac structural alterations have prognostic value in these patients. The aim was to analyse the prevalence of valvular calcification, the evolution and the relationship with different risk factors. Material and methods: Part of the sample of the NEFRONA study was randomly selected. Aortic and mitral valve calcification were analysed in echocardiograms performed at the baseline visit and at 24 months. Results: We included 397 patients, the estimated basal glomerular filtrate (eGFR) was 33 ml/min with significant decrease to 30.9 ml/min. There was an increase in the area of carotid and femoral plaque, as well as an increase in patients with aortic and mitral calcification at 24 months. A positive association of mitral calcification at 24 months with age, ankle-brachial index (ABI) and calcium-phosphorus product (CaxP) at baseline visit was observed, without association with eGFR. Aortic calcification at 24 months was positively associated with age, phosphorous and total carotid plaque area at baseline, with no relationship to eGFR. Conclusions: A significant prevalence of valvular calcification was observed in patients with CKD without known cardiovascular disease.Two-year progression was observed independently of the eGFR. Patients with higher risk of mitral valve calcification were those with older age, higher ABI and CaxP product. Patients with a higher risk of aortic calcification were those with older age, higher phosphorous levels and larger area of carotid plaque. Identifying these higher risk patients would help to avoid future cardiovascular events intensifying follow-ups.
MeSH term(s)	Calcinosis/epidemiology ; Calcinosis/etiology ; Calcium ; Heart Valve Diseases/complications ; Heart Valve Diseases/epidemiology ; Humans ; Phosphorus ; Plaque, Atherosclerotic ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/epidemiology ; Risk Factors
Chemical Substances	Phosphorus (27YLU75U4W) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2021-09-06
Publishing country	Spain
Document type	Journal Article
ZDB-ID	2837917-2
ISSN	2013-2514 ; 2013-2514
ISSN (online)	2013-2514
ISSN	2013-2514
DOI	10.1016/j.nefroe.2021.08.002
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Article: Proteinuria-Lowering Effects of Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors in Chronic Kidney Disease Patients: A Real-World Multicentric Study.

Muñoz Ramos, Patricia / Gil Giraldo, Yohana / Álvarez-Chiva, Vicente / Arroyo, David / Sango Merino, Cristina / Moncho Francés, Francesc / Ocaña, Javier / Reque, Javier / Sánchez-Álvarez, Emilio / Górriz, José Luis / Quiroga, Borja

Metabolites

2021 Volume 11, Issue 11

Abstract: Control of dyslipidemia in chronic kidney disease (CKD) is not always guaranteed with statins and/or ezetimibe. Proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) have opened up a new era in lipid control, but their effect on renal ... ...

Abstract	Control of dyslipidemia in chronic kidney disease (CKD) is not always guaranteed with statins and/or ezetimibe. Proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) have opened up a new era in lipid control, but their effect on renal function and proteinuria in real life have not yet been evaluated. The aim of the present study was to analyze the evolution of renal function and proteinuria in a cohort of CKD patients treated with PCSK9i. This retrospective multicentric cohort study included CKD patients treated with PCSK9i. Baseline epidemiological data, comorbidities and laboratory findings (including estimated glomerular filtration rate [eGFR], proteinuria and lipid profile) were collected. The evolution of renal function, proteinuria and lipid profile was analyzed during the 1-year follow-up. The cohort included 76 patients (68% male, mean age 66 ± 10 years). The mean baseline creatinine was 1.55 ± 0.77 mg/dL, and the mean eGFR was 52 ± 22 mL/min/1.73 m
Language	English
Publishing date	2021-11-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662251-8
ISSN	2218-1989
ISSN	2218-1989
DOI	10.3390/metabo11110760
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Article ; Online: Global Dialysis Perspective: Spain.

Roca-Tey, Ramon / Ibeas, Jose / Sánchez Alvarez, J Emilio

Kidney360

2020 Volume 2, Issue 2, Page(s) 344–349

MeSH term(s)	Hemodialysis, Home ; Humans ; Peritoneal Dialysis ; Renal Dialysis ; Spain
Language	English
Publishing date	2020-12-30
Publishing country	United States
Document type	Journal Article
ISSN	2641-7650
ISSN (online)	2641-7650
DOI	10.34067/KID.0005722020
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Article ; Online: Factores de riesgo asociados a la calcificación valvular en pacientes con enfermedad renal crónica. Análisis del Estudio Nefrona.

Martínez Fernández, Lidia / Sánchez-Alvarez, J Emilio / Morís de la Tassa, César / Bande Fernández, José Joaquín / María, Virtudes / Fernández, Elvira / Valdivielso, José M / Betriu, Angels

Nefrologia

2020 Volume 41, Issue 3, Page(s) 337–346

Title translation	Risk factors associated with valvular calcification in patients with chronic kidney disease. Analysis of NEFRONA Study.
Abstract	Introduction: Patients with chronic kidney disease (CKD) are at high risk of cardiovascular morbidity and mortality. Subclinical cardiac structural alterations have prognostic value in these patients. The aim was to analyse the prevalence of valvular calcification, the evolution and the relationship with different risk factors. Material and methods: Part of the sample of the NEFRONA study was randomly selected. Aortic and mitral valve calcification were analysed in echocardiograms performed at the baseline visit and at 24 months. Results: We included 397 patients, the estimated basal glomerular filtrate (eGFR) was 33ml/min with significant decrease to 30.9ml/min. There was an increase in the area of carotid and femoral plaque, as well as an increase in patients with aortic and mitral calcification at 24 months. A positive association of mitral calcification at 24 months with age, ankle-brachial index (ABI) and calcium-phosphorus product (CaxP) at baseline visit was observed, without association with eGFR. Aortic calcification at 24 months was positively associated with age, phosphorous and total carotid plaque area at baseline, with no relationship to eGFR. Conclusions: A significant prevalence of valvular calcification was observed in patients with CKD without known cardiovascular disease.Two-year progression was observed independently of the eGFR. Patients with higher risk of mitral valve calcification were those with older age, higher ABI and CaxP product. Patients with a higher risk of aortic calcification were those with older age, higher phosphorous levels and larger area of carotid plaque. Identifying these higher risk patients would help to avoid future cardiovascular events intensifying follow-ups.
MeSH term(s)	Aged ; Calcinosis/epidemiology ; Calcinosis/etiology ; Female ; Heart Valve Diseases/etiology ; Humans ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/epidemiology ; Male ; Middle Aged ; Mitral Valve ; Prevalence ; Retrospective Studies ; Risk Factors
Language	Spanish
Publishing date	2020-12-25
Publishing country	Spain
Document type	Journal Article ; Observational Study
ZDB-ID	2837917-2
ISSN	2013-2514 ; 2013-2514
ISSN (online)	2013-2514
ISSN	2013-2514
DOI	10.1016/j.nefro.2020.08.012
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Article ; Online: Efficacy and safety of sucroferric oxyhydroxide in the treatment of hyperphosphataemia in chronic kidney disease in Asturias. FOSFASTUR study.

Sanchez-Alvarez, J Emilio / Astudillo Cortés, Elena / Seras Mozas, Miguel / García Castro, Raúl / Hidalgo Ordoñez, Carlos Miguel / Andrade López, Ana Cristina / Ulloa Clavijo, Catalina / Gallardo Pérez, Anna / Rodríguez Suarez, Carmen

Nefrologia

2021 Volume 41, Issue 1, Page(s) 45–52

Abstract: Alterations in bone and mineral metabolism are very common in chronic kidney disease (CKD). The increase in phosphate levels leads to bone disease, risk of calcification and greater mortality, so any strategy aimed at reducing them should be welcomed. ... ...

Abstract	Alterations in bone and mineral metabolism are very common in chronic kidney disease (CKD). The increase in phosphate levels leads to bone disease, risk of calcification and greater mortality, so any strategy aimed at reducing them should be welcomed. The latest drug incorporated into the therapeutic arsenal to treat hyperphosphataemia in CKD is Sucroferric Oxyhydroxide (SFO). Objective: To analyse the efficacy and safety of OSF in three cohorts of patients, one with advanced chronic kidney disease not on dialysis (CKD-NoD), another on peritoneal dialysis (PD) and the last on haemodialysis (HD), followed for six months. Methods: A prospective, observational, multicentre study in clinical practice. Clinical and epidemiological variables were analysed. The evolution of parameters relating to alterations in bone and mineral metabolism and anaemia was analysed. Results: Eighty-five patients were included in the study (62 ± 12 years, 64% male, 34% diabetic), 25 with CKD-NoD, 25 on PD and lastly, 35 on HD. In 66 patients (78%), SFO was the first phosphate binder; in the other 19, SFO replaced a previous phosphate binder due to poor tolerance or efficacy. The initial dose of SFO was 964 ± 323 mg/day. Overall, serum phosphate levels saw a significant reduction at three months of treatment (19.6%, P < 0.001). There were no differences in the efficacy of the drug when the different populations analysed were compared. Over the course of the study, there were no changes to levels of calcium, PTHi, ferritin, or the transferrin and haemoglobin saturation indices, although there was a tendency for the last two to increase. Twelve patients (14%) withdrew from follow-up, ten due to gastrointestinal adverse effects (primarily diarrhoea) and two were lost to follow-up (kidney transplant). The mean dose of the drug that the patients received increased over time, up to 1147 ± 371 mg/day. Conclusions: SFO is an effective option for the treatment of hyperphosphataemia in patients with CKD both in the advanced phases of the disease and on dialysis. We found similar efficacy across the three groups analysed. The higher their baseline phosphate level, the greater the reduction in the serum levels. A notable reduction in phosphate levels can be achieved with doses of around 1000 mg/day. Diarrhoea was the most common side effect, although it generally was not significant.
Language	English
Publishing date	2021-03-01
Publishing country	Spain
Document type	Journal Article
ZDB-ID	2837917-2
ISSN	2013-2514 ; 2013-2514
ISSN (online)	2013-2514
ISSN	2013-2514
DOI	10.1016/j.nefroe.2021.02.005
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Article ; Online: Situación de la infección por SARS-CoV-2 en pacientes en tratamiento renal sustitutivo. Informe del Registro COVID-19 de la Sociedad Española de Nefrología (SEN).

Sánchez-Álvarez, J Emilio / Pérez Fontán, Miguel / Jiménez Martín, Carlos / Blasco Pelícano, Miquel / Cabezas Reina, Carlos Jesús / Sevillano Prieto, Ángel M / Melilli, Edoardo / Crespo Barrios, Marta / Macía Heras, Manuel / Del Pino Y Pino, María Dolores

Nefrologia

2020 Volume 40, Issue 3, Page(s) 272–278

Abstract: Introduction: The recent appearance of the SARS-CoV-2 coronavirus pandemic has had a significant impact on the general population. Patients on renal replacement therapy (RRT) have not been unaware of this situation and due to their characteristics they ... ...

Title translation	SARS-CoV-2 infection in patients on renal replacement therapy. Report of the COVID-19 Registry of the Spanish Society of Nephrology (SEN).
Abstract	Introduction: The recent appearance of the SARS-CoV-2 coronavirus pandemic has had a significant impact on the general population. Patients on renal replacement therapy (RRT) have not been unaware of this situation and due to their characteristics they are especially vulnerable. We present the results of the analysis of the COVID-19 Registry of the Spanish Society of Nephrology. Material and methods: The Registry began operating on March 18th, 2020. It collects epidemiological variables, contagion and diagnosis data, signs and symptoms, treatments and outcomes. It is an online registry. Patients were diagnosed with SARS-CoV-2 infection based on the results of the PCR of the virus, carried out both in patients who had manifested compatible symptoms or had suspicious signs, as well as in those who had undergone screening after some contact acquainted with another patient. Results: As of April 11, the Registry had data on 868 patients, from all the Autonomous Communities. The most represented form of RRT is in-center hemodialysis (ICH) followed by transplant patients. Symptoms are similar to the general population. A very high percentage (85%) required hospital admission, 8% in intensive care units. The most used treatments were hydroxychloroquine, lopinavir-ritonavir, and steroids. Mortality is high and reaches 23%; deceased patients were more frequently on ICH, developed pneumonia more frequently, and received less frequently lopinavir-ritonavir and steroids. Age and pneumonia were independently associated with the risk of death. Conclusions: SARS-CoV-2 infection already affects a significant number of Spanish patients on RRT, mainly those on ICH, hospitalization rates are very high and mortality is high; age and the development of pneumonia are factors associated with mortality.
MeSH term(s)	Age Factors ; Aged ; Betacoronavirus ; COVID-19 ; Chi-Square Distribution ; Coronavirus Infections/drug therapy ; Coronavirus Infections/epidemiology ; Coronavirus Infections/mortality ; Female ; Hemodialysis Units, Hospital/statistics & numerical data ; Humans ; Intensive Care Units/statistics & numerical data ; Male ; Middle Aged ; Nephrology/statistics & numerical data ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/mortality ; Registries/statistics & numerical data ; Renal Replacement Therapy/statistics & numerical data ; SARS-CoV-2 ; Societies, Medical ; Spain/epidemiology ; Statistics, Nonparametric ; Symptom Assessment/statistics & numerical data ; Transplant Recipients/statistics & numerical data
Keywords	covid19
Language	Spanish
Publishing date	2020-04-16
Document type	Journal Article
ZDB-ID	2837917-2
ISSN	2013-2514 ; 2013-2514
ISSN (online)	2013-2514
ISSN	2013-2514
DOI	10.1016/j.nefro.2020.04.002
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