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  1. Article ; Online: Cutaneous thigh abscess secondary to melioidosis: a rare cause for a common presentation.

    Hughes, Sam / Loughenbury, Faye / Richards, Alexander / Easom, Nicholas

    BMJ case reports

    2021  Volume 14, Issue 3

    MeSH term(s) Abscess/diagnostic imaging ; Abscess/drug therapy ; Abscess/etiology ; Anti-Bacterial Agents/therapeutic use ; Burkholderia pseudomallei ; Humans ; Melioidosis/complications ; Melioidosis/diagnosis ; Melioidosis/drug therapy ; Skin ; Thigh
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2021-03-24
    Publishing country England
    Document type Journal Article ; Case Reports
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2020-240965
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Subacute thyroiditis following Mpox infection in a patient with human immunodeficiency virus.

    Ssemmondo, Emmanuel / Idris, Mohamed Akasha / Mawer, Damian / Easom, Nicholas / Thow, Jonathan

    Endocrinology, diabetes & metabolism case reports

    2023  Volume 2023, Issue 3

    Abstract: Summary: Mpox (MPX) formerly known as monkeypox was declared a public health emergency of international concern, following an outbreak that commenced in May 2022. We report a case of subacute thyroiditis following MPX infection. To our knowledge, it is ... ...

    Abstract Summary: Mpox (MPX) formerly known as monkeypox was declared a public health emergency of international concern, following an outbreak that commenced in May 2022. We report a case of subacute thyroiditis following MPX infection. To our knowledge, it is the first documented incidence of this complication in humans. A 51-year-old male, with a well-controlled human immunodeficiency virus (HIV) infection on antiretroviral therapy, was reviewed 3 weeks after a positive test for MPX. The acute skin lesions and initial systemic symptoms had resolved, but he described significant neck discomfort, fatigue, weight loss and night sweats. Blood tests showed a raised C-reactive protein, free T4 and suppressed thyroid-stimulating hormone. His thyroid antibodies were negative. He was treated initially with carbimazole and propranolol, pending exclusion of any other intercurrent infection. A chest radiograph was normal; blood cultures and a combined nose and throat swab for respiratory virus PCR testing were negative. Following this, he commenced a 2-week course of prednisolone; his symptoms resolved completely within 24 h of starting. He subsequently developed hypothyroidism, which was treated with levothyroxine. The clinical features, abnormal thyroid function, raised CRP and negative thyroid antibodies 3 weeks post-MPX positive test was consistent with viral subacute thyroiditis. This case demonstrates that, as described following other viral infections, MPX can cause subacute thyroiditis, which follows a similar course to the classic form of subacute thyroiditis. Clinicians should be aware of this potential endocrine complication when attending to patients with MPX.
    Learning points: Subacute thyroiditis can present following mpox virus infection. Its course is similar to the classic form of subacute thyroiditis and steroids are effective. It is important to exclude other concurrent infections prior to starting steroids, especially for patients who are immunosuppressed or in other high-risk groups.
    Language English
    Publishing date 2023-08-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2785530-2
    ISSN 2052-0573
    ISSN 2052-0573
    DOI 10.1530/EDM-23-0034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Stakeholder perspectives of piloting pre-hospital COVID-19 lateral flow testing and direct admissions pathway: exploring why well-received ideas have low uptake.

    Sampson, Fiona C / Bell, Fiona / Coster, Joanne E / Miller, Elisha / Easom, Nicholas

    British paramedic journal

    2022  Volume 7, Issue 3, Page(s) 15–25

    Abstract: Introduction: In January 2021, Yorkshire Ambulance Service and Hull University Teaching Hospitals implemented a pilot COVID-19 lateral flow testing (LFT) and direct admissions pathway to assess the feasibility of using pre-hospital LFTs to bypass the ... ...

    Abstract Introduction: In January 2021, Yorkshire Ambulance Service and Hull University Teaching Hospitals implemented a pilot COVID-19 lateral flow testing (LFT) and direct admissions pathway to assess the feasibility of using pre-hospital LFTs to bypass the emergency department. Due to lower than anticipated uptake of the pilot among paramedics, we undertook a process evaluation to assess reasons for low uptake and perceived potential benefits and risks associated with the pilot.
    Methods: We undertook semi-structured telephone interviews with 12 paramedics and hospital staff. We aimed to interview paramedics who had taken part in the pilot, those who had received the project information but not taken part and ward staff receiving patients from the pilot. We transcribed interviews verbatim and analysed data using thematic analysis.
    Results: Participation in the pilot appeared to be positively influenced by high personal capacity for undertaking research (being 'research-keen') and negatively influenced by 'COVID-19 exhaustion', electronic information overload and lack of time for training. Barriers to use of the pathway related to 'poor timing' of the pilot, restrictive patient eligibility and inclusion criteria. The rapid rollout meant that paramedics had limited knowledge or awareness of the pilot, and pilot participants reported poor understanding of the pilot criteria or the rationale for the criteria. Participants who were involved in the pilot were overwhelmingly positive about the intervention, which they perceived as having limited risks and high potential benefits to the health service, patients and themselves, and supported future roll-out.
    Conclusions: Ambulance clinician involvement in rapid research pilots may be improved by using multiple recruitment methods (electronic and other), providing protected time for training and increased direct support for paramedics with lower personal capacity for research. Improved communication (including face-to-face approaches) may help understanding of eligibility criteria and increase appropriate recruitment.
    Language English
    Publishing date 2022-11-24
    Publishing country England
    Document type Journal Article
    ISSN 1478-4726
    ISSN (online) 1478-4726
    DOI 10.29045/14784726.2022.12.7.3.15
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Acute Epstein-Barr infection presenting as cholecystitis with ascites.

    Teopoulos Lamprianidis, Konstantinos / Easom, Nicholas / Patch, Emma / Thomas, Sherine

    BMJ case reports

    2020  Volume 13, Issue 1

    Abstract: A young female patient presented with features of ascites and cholecystitis. She was subsequently diagnosed with an acute Epstein-Barr virus infection. This is a rare presentation of a common infection. The patient was managed conservatively and the ... ...

    Abstract A young female patient presented with features of ascites and cholecystitis. She was subsequently diagnosed with an acute Epstein-Barr virus infection. This is a rare presentation of a common infection. The patient was managed conservatively and the illness resolved within 6 weeks.
    MeSH term(s) Acalculous Cholecystitis/diagnostic imaging ; Acalculous Cholecystitis/virology ; Ascites/diagnostic imaging ; Ascites/virology ; Epstein-Barr Virus Infections/complications ; Epstein-Barr Virus Infections/diagnostic imaging ; Female ; Humans ; Ultrasonography ; Young Adult
    Language English
    Publishing date 2020-01-08
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2019-232562
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Lessons for managing high-consequence infections from first COVID-19 cases in the UK.

    Moss, Peter / Barlow, Gavin / Easom, Nicholas / Lillie, Patrick / Samson, Anda

    Lancet (London, England)

    2020  Volume 395, Issue 10227, Page(s) e46

    MeSH term(s) Betacoronavirus/isolation & purification ; COVID-19 ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/transmission ; Disease Outbreaks ; Humans ; Infection Control/methods ; Patient Isolation ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/transmission ; SARS-CoV-2 ; State Medicine ; United Kingdom/epidemiology
    Keywords covid19
    Language English
    Publishing date 2020-02-27
    Publishing country England
    Document type Letter
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(20)30463-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Significantly lower 30 day/inpatient mortality observed in people who inject drugs (PWID) compared to non-PWID with Staphylococcus aureus bacteraemia.

    Mortimer, Isabel / Drury, Katie / Lowe, Shakeel / Akhtar, Marium / Barlow, Gavin D / Easom, Nicholas / Lillie, Patrick J

    The Journal of infection

    2022  Volume 85, Issue 4, Page(s) 436–480

    MeSH term(s) Bacteremia/complications ; Drug Users ; Humans ; Inpatients ; Staphylococcal Infections ; Staphylococcus aureus ; Substance Abuse, Intravenous/complications
    Language English
    Publishing date 2022-06-18
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2022.06.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Misdiagnoses in the Context of Suspected Pandemic Influenza or Coronavirus Disease 2019: A Systematic Review.

    Bray, Lucy / Meznikova, Katerina / James, Daniel / Rislan, Razan / Shah, Rahul / Mason, Pavan / Staniland, Tim / Lillie, Patrick / Barlow, Gavin / Easom, Nicholas

    Open forum infectious diseases

    2022  Volume 9, Issue 11, Page(s) ofac515

    Abstract: There have been numerous reports of patients initially misdiagnosed in the 2009 H1N1 influenza and coronavirus disease 2019 (COVID-19) pandemics within the literature. A systematic review was undertaken to collate misdiagnoses during the H1N1 and COVID- ... ...

    Abstract There have been numerous reports of patients initially misdiagnosed in the 2009 H1N1 influenza and coronavirus disease 2019 (COVID-19) pandemics within the literature. A systematic review was undertaken to collate misdiagnoses during the H1N1 and COVID-19 pandemics and identify which cognitive biases may contribute to this. MEDLINE, Embase, Cochrane and MedRxiv databases were searched for misdiagnoses or cognitive biases resulting in misdiagnosis, occurring during the H1N1 or COVID-19 virus pandemics. Eligible studies were assessed for quality using JBI criteria; primary outcome was the final diagnosis. Sixty-nine studies involving 2551 participants were included. We identified 686 cases of misdiagnosis, categorized as viral respiratory infection, other respiratory infection, non-respiratory infection, and non-infective. Misdiagnoses are listed and relevant investigations are offered. No article described prospective assessment of decision making in the pandemic setting or debiasing diagnostic thinking. Further research is required to understand why misdiagnoses occur and harm arises and how clinicians can be assisted in their decision making in a pandemic context.
    Language English
    Publishing date 2022-10-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofac515
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Lessons for managing high-consequence infections from first COVID-19 cases in the UK

    Moss, Peter / Barlow, Gavin / Easom, Nicholas / Lillie, Patrick / Samson, Anda

    The Lancet

    2020  Volume 395, Issue 10227, Page(s) e46

    Keywords General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/s0140-6736(20)30463-3
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: First Dose of BNT162b2 mRNA Vaccine in a Healthcare Worker Cohort Is Associated With Reduced Symptomatic and Asymptomatic Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection.

    Lillie, Patrick J / O'Brien, Paul / Lawtie, Michelle / Jessop, Steve / Easom, Nicholas J W / Patmore, Russell

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2021  Volume 73, Issue 10, Page(s) 1906–1908

    Abstract: Over the first 2 months of 2021, vaccination coverage of staff at Hull Teaching Hospitals with BNT162b2 increased from 8.3% to 82.5% and was associated with a significant reduction in symptomatic and asymptomatic severe acute respiratory syndrome ... ...

    Abstract Over the first 2 months of 2021, vaccination coverage of staff at Hull Teaching Hospitals with BNT162b2 increased from 8.3% to 82.5% and was associated with a significant reduction in symptomatic and asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cases. The proportion of positive lateral flow tests from asymptomatic screening was maintained over this period.
    MeSH term(s) BNT162 Vaccine ; COVID-19 ; COVID-19 Vaccines ; Health Personnel ; Humans ; RNA, Messenger ; SARS-CoV-2 ; Vaccines
    Chemical Substances COVID-19 Vaccines ; RNA, Messenger ; Vaccines ; BNT162 Vaccine (N38TVC63NU)
    Language English
    Publishing date 2021-04-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciab351
    Database MEDical Literature Analysis and Retrieval System OnLINE

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