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Article ; Online: Clinical potential of fasting in type 1 diabetes.

Varady, Krista A / Runchey, Mary-Claire / Reutrakul, Sirimon / Vidmar, Alaina P / Chow, Lisa S

Trends in endocrinology and metabolism: TEM

2024

Abstract: Most adults with type 1 diabetes (T1DM) are either overweight or obese. As such, dietary management is recommended as an adjunct to insulin treatment to improve glycemic control and facilitate weight loss in these patients. Time-restricted eating (TRE) ... ...

Abstract	Most adults with type 1 diabetes (T1DM) are either overweight or obese. As such, dietary management is recommended as an adjunct to insulin treatment to improve glycemic control and facilitate weight loss in these patients. Time-restricted eating (TRE) is a form of intermittent fasting that offers a simplified approach to treating obesity in T1DM. TRE typically involves restricting eating to 6 to 10 h per day, with water and medications allowed outside the eating window. This review examines the efficacy of TRE and other fasting protocols in improving weight and glycemic control in patients with obesity and T1DM. This review will also evaluate the safety of these regimens and provide advice to clinicians on implementing intermittent fasting in T1DM.
Language	English
Publishing date	2024-02-07
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1042384-9
ISSN	1879-3061 ; 1043-2760
ISSN (online)	1879-3061
ISSN	1043-2760
DOI	10.1016/j.tem.2024.01.007
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Article ; Online: The microenvironment matters: the secret life of intramuscular lipid droplets.

Chow, Lisa S / Mashek, Douglas G

The Journal of physiology

2020 Volume 598, Issue 6, Page(s) 1117–1118

MeSH term(s)	Diet ; Humans ; Lipid Droplets ; Muscle, Skeletal ; Perilipin-1 ; Perilipin-5 ; Triglycerides
Chemical Substances	Perilipin-1 ; Perilipin-5 ; Triglycerides
Language	English
Publishing date	2020-02-28
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	3115-x
ISSN	1469-7793 ; 0022-3751
ISSN (online)	1469-7793
ISSN	0022-3751
DOI	10.1113/JP279583
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Uc I Zs.65: Show issues

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Article ; Online: How Significant Is Severe Hypoglycemia in Older Adults With Diabetes?

Chow, Lisa / Seaquist, Elizabeth R

Diabetes care

2020 Volume 43, Issue 3, Page(s) 512–514

MeSH term(s)	Aged ; Cardiovascular Diseases ; Diabetes Mellitus, Type 2 ; Humans ; Hypoglycemia ; Hypoglycemic Agents
Chemical Substances	Hypoglycemic Agents
Language	English
Publishing date	2020-02-19
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	441231-x
ISSN	1935-5548 ; 0149-5992
ISSN (online)	1935-5548
ISSN	0149-5992
DOI	10.2337/dci19-0069
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Zs.A 1434: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 365: Show issues

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Article ; Online: A Leg to Stand On: Working With Marginal Decision-making Capacity in a Patient With a Severe Leg Infection and Schizophrenia.

Kichler, Zoe / Andermann, Lisa / Chow, Wendy / Gnanapragasam, Gesland / Law, Samuel

Journal of psychiatric practice

2023 Volume 29, Issue 2, Page(s) 154–159

Abstract: Assessment of a patient's capacity to make treatment decisions and working with the wishes of a patient with mental illness against the best medically indicated plan is a complex and dynamic task. It is particularly challenging when the course of ... ...

Abstract	Assessment of a patient's capacity to make treatment decisions and working with the wishes of a patient with mental illness against the best medically indicated plan is a complex and dynamic task. It is particularly challenging when the course of deterioration of the illness is meandering and slow, and the time horizon for recovery is uncertain, providing no clear point of entry for definitive crisis intervention. High-impact decisions concerning body integrity, such as the amputation of a leg, further complicate the task. To highlight these challenges and complexities, we present the case of a man who suffered from schizophrenia, with a worsening diabetic foot ulcer and suboptimal acceptance of proper wound care. The patient died as a result of his refusal of a proposed amputation to address his life-threatening infection. Medical system and cultural issues are also considered.
MeSH term(s)	Male ; Humans ; Schizophrenia/complications ; Schizophrenia/diagnosis ; Schizophrenia/therapy ; Leg
Language	English
Publishing date	2023-03-01
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2022726-7
ISSN	1538-1145 ; 1527-4160
ISSN (online)	1538-1145
ISSN	1527-4160
DOI	10.1097/PRA.0000000000000692
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Zs.A 4753: Show issues

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Article ; Online: A teenage girl with altered mental status and paraparesis.

Miyakawa, Ryo / Louie, Janice / Keh, Chris / Chen, Lisa / Javid, Babak / Ernst, Joel D / Goswami, Neela / Chow, Felicia C

Journal of clinical tuberculosis and other mycobacterial diseases

2024 Volume 35, Page(s) 100425

Abstract: A teenage girl presented with fever and altered mental status. MRI showed diffuse leptomeningeal enhancement of the brain and spine. She was diagnosed by a positive cerebrospinal fluid (CSF) culture with tuberculous (TB) meningitis and was started on ... ...

Abstract	A teenage girl presented with fever and altered mental status. MRI showed diffuse leptomeningeal enhancement of the brain and spine. She was diagnosed by a positive cerebrospinal fluid (CSF) culture with tuberculous (TB) meningitis and was started on anti-TB medications and corticosteroids. Her mental status improved, but she was noted to have proximal weakness of the lower extremities. In the course of tapering corticosteroids at week 11 of anti-TB therapy, she became acutely confused and febrile. MRI demonstrated interval development of tuberculomas in the brain and a mass lesion in the thoracic spine causing cord compression. Given the clinical picture was suggestive of a paradoxical reaction, the dose of corticosteroids was increased. Infliximab was added when repeat MRI revealed enlargement of the mass lesion in the spine with worsening cord compression. She was successfully tapered off of corticosteroids. Over several months, the patient's motor function recovered fully, and she returned to ambulating without assistance.
Language	English
Publishing date	2024-03-01
Publishing country	England
Document type	Case Reports
ISSN	2405-5794
ISSN (online)	2405-5794
DOI	10.1016/j.jctube.2024.100425
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Article ; Online: The longitudinal association of adipose-to-lean ratio with incident cardiometabolic morbidity: The CARDIA study.

Booker, Robert / Wong, Mandy / Bancks, Michael P / Carnethon, Mercedes R / Chow, Lisa S / Lewis, Cora E / Schreiner, Pamela J / Alexandria, Shaina J

Journal of diabetes and its complications

2024 Volume 38, Issue 5, Page(s) 108725

Abstract: Aim: To assess the association of adipose-to-lean ratio (ALR) with incident type 2 diabetes mellitus (T2DM), hypertension, and dyslipidemia in middle adulthood.: Method: Black and White Coronary Artery Risk Development in Young Adults participants ... ...

Abstract	Aim: To assess the association of adipose-to-lean ratio (ALR) with incident type 2 diabetes mellitus (T2DM), hypertension, and dyslipidemia in middle adulthood. Method: Black and White Coronary Artery Risk Development in Young Adults participants without T2DM, hypertension, or dyslipidemia in 2005-06 (baseline) were included. Baseline adipose and lean mass were assessed via dual-energy X-ray absorptiometry. ALR was calculated as adipose divided by lean mass and then standardized within sex strata. Single time-point incident morbidity was assessed every five years from baseline through 2016. Cox proportional hazards regression was used to estimate hazard ratios (HR) for morbidity over 10 years per 1-SD increment in ALR adjusted for cardiovascular risk factors. Result: The cumulative incidence of T2DM was 7.9 % (129 events/N = 1643; 16,301 person-years), 26.7 % (485 events/N = 1819; 17,895 person-years) for hypertension, and 49.1 % (435 events/N = 855, 8089 person-years) for dyslipidemia. In the adjusted models, ALR was positively associated with a risk of T2DM (HR [95 % CI]; 1.69 [1.31, 2.19]) and hypertension (1.23 [1.08, 1.40]). There was no significant interaction between ALR and sex for any morbidity. Conclusion: ALR in middle adulthood is associated with incident T2DM and hypertension. The extent to which localized body composition measures might inform morbidity risk merits further investigation.
MeSH term(s)	Humans ; Male ; Female ; Adult ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/complications ; Incidence ; Longitudinal Studies ; Hypertension/epidemiology ; Hypertension/complications ; Young Adult ; Dyslipidemias/epidemiology ; Dyslipidemias/complications ; Adiposity/physiology ; Adolescent ; Middle Aged ; Body Composition ; Adipose Tissue ; Cardiovascular Diseases/epidemiology ; United States/epidemiology ; Cardiometabolic Risk Factors ; Absorptiometry, Photon
Language	English
Publishing date	2024-03-20
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1105840-7
ISSN	1873-460X ; 1056-8727
ISSN (online)	1873-460X
ISSN	1056-8727
DOI	10.1016/j.jdiacomp.2024.108725
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Zs.A 2225: Show issues

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Article ; Online: Development and Validation of an Electronic Health Record-Based Risk Assessment Tool for Hypoglycemia in Patients With Type 2 Diabetes Mellitus.

Ma, Sisi / Alvear, Alison / Schreiner, Pamela J / Seaquist, Elizabeth R / Kirsh, Thomas / Chow, Lisa S

Journal of diabetes science and technology

2023 , Page(s) 19322968231184497

Abstract: Background: The recent availability of high-quality data from clinical trials, together with machine learning (ML) techniques, presents exciting opportunities for developing prediction models for clinical outcomes.: Methods: As a proof-of-concept, we ...

Abstract	Background: The recent availability of high-quality data from clinical trials, together with machine learning (ML) techniques, presents exciting opportunities for developing prediction models for clinical outcomes. Methods: As a proof-of-concept, we translated a hypoglycemia risk model derived from the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study into the HypoHazardScore, a risk assessment tool applicable to electronic health record (EHR) data. To assess its performance, we conducted a 16-week clinical study at the University of Minnesota where participants (N = 40) with type 2 diabetes mellitus (T2DM) had hypoglycemia assessed prospectively by continuous glucose monitoring (CGM). Results: The HypoHazardScore combines 16 risk factors commonly found within the EHR. The HypoHazardScore successfully predicted (area under the curve [AUC] = 0.723) whether participants experienced least one CGM-assessed hypoglycemic event (glucose <54 mg/dL for ≥15 minutes from two CGMs) while significantly correlating with frequency of CGM-assessed hypoglycemic events (r = 0.38) and percent time experiencing CGM-assessed hypoglycemia (r = 0.39). Compared to participants with a low HypoHazardScore (N = 19, score <4, median score of 4), participants with a high HypoHazardScore (N = 21, score ≥4) had more frequent CGM-assessed hypoglycemic events (high: 1.6 ± 2.2 events/week; low: 0.3 ± 0.5 events/week) and experienced more CGM-assessed hypoglycemia (high: 1.4% ± 2.0%; low: 0.2% ± 0.4% time) during the 16-week follow-up. Conclusions: We demonstrated that a hypoglycemia risk model can be successfully adapted from the ACCORD data to the EHR, with validation by a prospective study using CGM-assessed hypoglycemia. The HypoHazardScore represents a significant advancement toward implementing an EHR-based decision support system that can help reduce hypoglycemia in patients with T2DM.
Language	English
Publishing date	2023-06-28
Publishing country	United States
Document type	Journal Article
ISSN	1932-2968
ISSN (online)	1932-2968
DOI	10.1177/19322968231184497
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Article ; Online: Characterizing Dermal Transcriptional Change in the Progression from Sun-Protected Skin to Actinic Keratosis.

LaFleur, Bonnie / Curiel-Lewandrowski, Clara / Tapia, Edgar / Parker, Joel / White, Lisa / Chow, H-H Sherry / South, Andrew P

The Journal of investigative dermatology

2023 Volume 143, Issue 7, Page(s) 1299–1302.e3

MeSH term(s)	Humans ; Keratosis, Actinic/genetics ; Skin ; Skin Neoplasms/genetics
Language	English
Publishing date	2023-01-26
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	80136-7
ISSN	1523-1747 ; 0022-202X
ISSN (online)	1523-1747
ISSN	0022-202X
DOI	10.1016/j.jid.2022.12.021
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Article ; Online: Partial Sequence Labeling With Structured Gaussian Processes.

Lu, Xiaolei / Chow, Tommy W S

IEEE transactions on neural networks and learning systems

2024 Volume 35, Issue 2, Page(s) 2783–2792

Abstract: Existing partial sequence labeling models mainly focus on a max-margin framework that fails to provide an uncertainty estimation of the prediction. Furthermore, the unique ground-truth disambiguation strategy employed by these models may include wrong ... ...

Abstract	Existing partial sequence labeling models mainly focus on a max-margin framework that fails to provide an uncertainty estimation of the prediction. Furthermore, the unique ground-truth disambiguation strategy employed by these models may include wrong label information for parameter learning. In this article, we propose structured Gaussian processes for partial sequence labeling (SGPPSL), which encodes uncertainty in the prediction and does not need extra effort for model selection and hyperparameter learning. The model employs factor-as-piece approximation that divides the linear-chain graph structure into the set of pieces, which preserves the basic Markov random field structure and effectively avoids handling a large number of candidate output sequences generated by partially annotated data. Then, confidence measure is introduced in the model to address different contributions of candidate labels, which enables the ground-truth label information to be utilized in parameter learning. Based on the derived lower bound of the variational lower bound of the proposed model, variational parameters and confidence measures are estimated in the framework of alternating optimization. Moreover, a weighted Viterbi algorithm is proposed to incorporate confidence measures to sequence prediction, which considers label ambiguity arose from multiple annotations in the training data and thus helps improve the performance. SGPPSL is evaluated on several sequence labeling tasks and the experimental results show the effectiveness of the proposed model.
Language	English
Publishing date	2024-02-05
Publishing country	United States
Document type	Journal Article
ISSN	2162-2388
ISSN (online)	2162-2388
DOI	10.1109/TNNLS.2022.3191726
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Article: Gender-based heterogeneity of FAHFAs in trained runners.

Nelson, Alisa B / Chow, Lisa S / Dengel, Donald R / Pan, Meixia / Hughey, Curtis C / Han, Xianlin / Puchalska, Patrycja / Crawford, Peter A

bioRxiv : the preprint server for biology

2023

Abstract: Fatty acid esters of hydroxy fatty acid (FAHFA) are anti-diabetic and anti-inflammatory lipokines. Recently FAHFAs were also found to predict cardiorespiratory fitness in trained runners. Here we compared the association between circulating FAHFA ... ...

Abstract	Fatty acid esters of hydroxy fatty acid (FAHFA) are anti-diabetic and anti-inflammatory lipokines. Recently FAHFAs were also found to predict cardiorespiratory fitness in trained runners. Here we compared the association between circulating FAHFA baseline concentrations and body composition, determined by dual x-ray absorptiometry, in female runners who were lean (BMI < 25 kg/m
Language	English
Publishing date	2023-06-08
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.06.07.543941
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