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  1. Article: Dysregulation of cell state dynamics during early stages of serous endometrial carcinogenesis.

    Flesken-Nikitin, Andrea / Pirtz, Matalin G / Ashe, Christopher S / Ellenson, Lora H / Cosgrove, Benjamin D / Nikitin, Alexander Yu

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Serous endometrial carcinoma (SEC) constitutes about 10% of endometrial carcinomas and is one of the most aggressive and lethal types of uterine cancer. Due to the rapid progression of SEC, early detection of this disease is of utmost importance. However, ...

    Abstract Serous endometrial carcinoma (SEC) constitutes about 10% of endometrial carcinomas and is one of the most aggressive and lethal types of uterine cancer. Due to the rapid progression of SEC, early detection of this disease is of utmost importance. However, molecular and cellular dynamics during the pre-dysplastic stage of this disease remain largely unknown. Here, we provide a comprehensive census of cell types and their states for normal, pre-dysplastic, and dysplastic endometrium in a mouse model of SEC. This model is associated with inactivation of tumor suppressor genes
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.03.15.585274
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Predictors of persistent opioid use in bladder cancer patients undergoing radical cystectomy: A SEER-Medicare analysis.

    Staniorski, Christopher J / Yu, Michelle / Sharbaugh, Danielle / Stencel, Michael G / Myrga, John M / Davies, Benjamin J / Yabes, Jonathan G / Jacobs, Bruce

    Urologic oncology

    2024  

    Abstract: ... Opioid exposure was identified before and after cystectomy using Medicare Part D data ...

    Abstract Purpose: To evaluate patient and provider characteristics that predict persistent opioid use following radical cystectomy for bladder cancer including non-opioid naïve patients.
    Methods: Patients undergoing cystectomy between July 2007 and December 2015 were identified using the SEER-Medicare database. Opioid exposure was identified before and after cystectomy using Medicare Part D data. Multivariable analyses were used to identify predictors of the primary outcomes: persistent opioid use (prescription 3-6 months after surgery) and postoperative opioid prescriptions (within 30 days of surgery). Secondary outcomes included physician prescribing practices and rates of persistent opioid use in their patient cohorts.
    Results: A total of 1,774 patients were included; 29% had prior opioid exposure. Compared to opioid-naïve patients, non-opioid naïve patients were more frequently younger, Black, and living in less educated communities. The percentage of persistent postoperative use was 10% overall and 24% in non-opioid naïve patients. Adjusting for patient factors, opioid naïve individuals were less likely to develop persistent use (OR 0.23) while a 50-unit increase in oral morphine equivalent per day prescribed following surgery nearly doubled the likelihood of persistent use (OR 1.98). Practice factors such as hospital size, teaching affiliation, and hospital ownership failed to predict persistent use. 29% of patients filled an opioid prescription postoperatively. Opioid naïve patients (OR 0.13) and those cared for at government hospitals (OR 0.59) were less likely to fill an opioid script along with those residing in the Northeast. Variability between physicians was seen in prescribing practices and rates of persistent use.
    Conclusions: Non-opioid naïve patients have higher rates of post-operative opioid prescription than opioid-naïve patients. Physician prescribing practices play a role in persistent use, as initial prescription amount predicts persistent use even in non-opioid naïve patients. Significant physician variation in both prescribing practices and rates of persistent use suggest a role for standardizing practices.
    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1336505-8
    ISSN 1873-2496 ; 1078-1439
    ISSN (online) 1873-2496
    ISSN 1078-1439
    DOI 10.1016/j.urolonc.2024.03.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4817: Show issues Location:
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  3. Article ; Online: Endoscopic enucleation and clinicopathologic correlation of a small choroidal melanoma hiding massive extrascleral extension.

    Yu, Michael D / Chiang, Bryce / Pasricha, Malini Veerappan / Erickson, Benjamin P / Mruthyunjaya, Prithvi

    American journal of ophthalmology case reports

    2023  Volume 29, Page(s) 101797

    Abstract: Purpose: To report the unusual case of a previously stable choroidal nevus, closely followed for over 15 years, which underwent malignant transformation into small choroidal melanoma with massive extrascleral extension.: Observations: A 67-year-old ... ...

    Abstract Purpose: To report the unusual case of a previously stable choroidal nevus, closely followed for over 15 years, which underwent malignant transformation into small choroidal melanoma with massive extrascleral extension.
    Observations: A 67-year-old Caucasian female was referred to the Stanford Ocular Oncology Service with concern for malignant transformation of a previously stable choroidal nevus in her left eye. Her funduscopic examination demonstrated a dome-shaped choroidal lesion with overlying associated lipofuscin and subretinal fluid, consistent with a diagnosis of small choroidal melanoma. By B-scan ultrasonography, the lesion measured 8.0 × 6.0 mm in base and 2.1 mm in thickness. B-scan ultrasonography also disclosed an associated retroscleral mass, which appeared contiguous with the intraocular melanoma and was confirmed on subsequent orbital magnetic resonance imaging. A decision was made to proceed with enucleation. Under direct endoscopic visualization, the globe and extrascleral mass were fully isolated, mobilized, and removed
    Conclusions/importance: This case describes a small choroidal melanoma hiding massive extrascleral extension, underscoring the value of B-scan ultrasonography. This case also describes the unique management of choroidal melanoma with extrascleral extension using endoscopic enucleation. Performing enucleation under direct endoscopic visualization ensures complete resection and prevents inadvertent transection of the extrascleral component.
    Language English
    Publishing date 2023-01-16
    Publishing country United States
    Document type Case Reports
    ISSN 2451-9936
    ISSN (online) 2451-9936
    DOI 10.1016/j.ajoc.2023.101797
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  4. Article ; Online: Molecular characterization of canine parvovirus type 2 (CPV2) reveals a high prevalence of the CPV2c genotype among dogs suffering from diarrhea

    Sajid Umar / Di Gao / Semin Kim / Yixi Cheng / Zhenkun Fang / Qiu Zhongqi / Weidong Yu / Benjamin D. Anderson

    Animal Diseases, Vol 4, Iss 1, Pp 1-

    2024  Volume 9

    Abstract: Abstract Canine parvovirus 2 (CPV-2) is a highly contagious virus in dogs that typically causes hemorrhagic enteritis and a high mortality rate in unvaccinated puppies. The genetic variability and antigenic diversity of CPV-2 hinder its effective ... ...

    Abstract Abstract Canine parvovirus 2 (CPV-2) is a highly contagious virus in dogs that typically causes hemorrhagic enteritis and a high mortality rate in unvaccinated puppies. The genetic variability and antigenic diversity of CPV-2 hinder its effective prevention of infection by vaccination. To investigate the epidemiology and genetic characteristics of CPV-2 in China, rectal swabs from affected dogs were collected from different animal clinics in Kunshan from 2022 to 2023. Preliminary detection and capsid gene sequencing of CPV-2 were performed using previously described primers and protocols. The overall detection rate for CPV-2 was 16.5% (33/200). A significant association was found between the CPV-2-positivity and clinical signs, age, breed and vaccination status. Sequence analysis revealed the presence of CPV-2c genotypes in all positive samples, which were genetically similar to other Asian CPV-2c strains. Notably, four key mutations (A5G, F267Y, Y324I and Q370R) were detected in all isolates, and one novel mutation (I447M) was detected in three CPV-2 isolates. These mutations in the CPV-2 strains could impact vaccine efficacy and the effectiveness of the virus immune evasion. Surprisingly, no recombination events were observed between the identified CPV-2c strains and reference strains from China. Our data revealed that amino acid residues 324, 426 and 440 of VP2 may under strong selection pressure. This pattern of genetic variation in the CPV-2 lineage warrants continuous laboratory-based surveillance programs in other parts of China to better understand the pattern of seasonal distribution and association between emerging genotypes and the intensity of disease severity.
    Keywords Canine parvovirus ; Dogs ; Epidemiology ; Genetic diversity ; Phylogenetic analysis ; Veterinary medicine ; SF600-1100 ; Public aspects of medicine ; RA1-1270
    Subject code 630
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Does a Kegel Exercise Program Prior to Resistance Training Reduce the Risk of Stress Urinary Incontinence?

    Cross, Donelle / Kirshbaum, Marilynne N / Wikander, Lolita / Tan, Jing-Yu Benjamin / Moss, Simon / Gahreman, Daniel

    International journal of environmental research and public health

    2023  Volume 20, Issue 2

    Abstract: ... were large (d = 1.50 and d = 1.17 respectively). A two-way ANOVA indicated a statistically significant ...

    Abstract This comparative pre-post intervention study investigated the feasibility and benefits of Kegel exercises amongst incontinent women, prior to commencing resistance training (RT), to reduce the risk of stress urinary incontinence (SUI) compared to a group of women without prior Kegel exercises (KE). Incontinence severity index (ISI) score, pelvic floor muscle strength (PFMS), and body composition (such as body mass index (BMI), fat, and muscle mass), were obtained pre and post intervention. Results demonstrated that RT reduced SUI to a significantly greater extent only if preceded by KE as was observed in the Kegel exercise plus RT group (KE + RT) over time. The improvements in total ISI in both the KE + RT and RT groups were large (d = 1.50 and d = 1.17 respectively). A two-way ANOVA indicated a statistically significant improvement in average PFMS within the KE + RT group over time and between the two groups. A positive correlation was found between the average strength of pelvic floor muscles and SUI. Participants in KE + RT group demonstrated a significant increase in muscle mass (
    MeSH term(s) Female ; Humans ; Urinary Incontinence, Stress/prevention & control ; Resistance Training ; Pelvic Floor ; Exercise Therapy/methods ; Urinary Incontinence ; Treatment Outcome
    Language English
    Publishing date 2023-01-13
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph20021481
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  6. Article ; Online: Microglial P2Y

    Umpierre, Anthony D / Li, Bohan / Ayasoufi, Katayoun / Simon, Whitney L / Zhao, Shunyi / Xie, Manling / Thyen, Grace / Hur, Benjamin / Zheng, Jiaying / Liang, Yue / Bosco, Dale B / Maynes, Mark A / Wu, Zhaofa / Yu, Xinzhu / Sung, Jaeyun / Johnson, Aaron J / Li, Yulong / Wu, Long-Jun

    Neuron

    2024  

    Abstract: Microglial calcium signaling is rare in a baseline state but strongly engaged during early epilepsy development. The mechanism(s) governing microglial calcium signaling are not known. By developing an in vivo uridine diphosphate (UDP) fluorescent sensor, ...

    Abstract Microglial calcium signaling is rare in a baseline state but strongly engaged during early epilepsy development. The mechanism(s) governing microglial calcium signaling are not known. By developing an in vivo uridine diphosphate (UDP) fluorescent sensor, GRAB
    Language English
    Publishing date 2024-04-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 808167-0
    ISSN 1097-4199 ; 0896-6273
    ISSN (online) 1097-4199
    ISSN 0896-6273
    DOI 10.1016/j.neuron.2024.03.017
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    In stock of ZB MED Cologne/Königswinter

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    Zs.MG 92: Show issues

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  7. Article ; Online: Mild-Temperature Supercritical Water Confined in Hydrophobic Metal-Organic Frameworks.

    Merchiori, Sebastiano / Le Donne, Andrea / Littlefair, Josh D / Lowe, Alexander Rowland / Yu, Jiang-Jing / Wu, Xu-Dong / Li, Mian / Li, Dan / Geppert-Rybczyńska, Monika / Scheller, Lukasz / Trump, Benjamin A / Yakovenko, Andrey A / Zajdel, Paweł / Chorążewski, Mirosław / Grosu, Yaroslav / Meloni, Simone

    Journal of the American Chemical Society

    2024  

    Abstract: Fluids under extreme confinement show characteristics significantly different from those of their bulk counterpart. This work focuses on water confined within the complex cavities of highly hydrophobic metal-organic frameworks (MOFs) at high pressures. A ...

    Abstract Fluids under extreme confinement show characteristics significantly different from those of their bulk counterpart. This work focuses on water confined within the complex cavities of highly hydrophobic metal-organic frameworks (MOFs) at high pressures. A combination of high-pressure intrusion-extrusion experiments with molecular dynamic simulations and synchrotron data reveals that supercritical transition for MOF-confined water takes place at a much lower temperature than in bulk water, ∼250 K below the reference values. This large shifting of the critical temperature (
    Language English
    Publishing date 2024-05-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.4c01226
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 4' 55/32: Show issues
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  8. Article: Elizabethkingia anophelis

    Chen, Shicheng / Johnson, Benjamin K / Yu, Ting / Nelson, Brooke N / Walker, Edward D

    Frontiers in microbiology

    2020  Volume 11, Page(s) 804

    Abstract: In this study, we investigated the global gene expression responses ... ...

    Abstract In this study, we investigated the global gene expression responses of
    Language English
    Publishing date 2020-05-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2020.00804
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  9. Article: Microglial P2Y

    Umpierre, Anthony D / Li, Bohan / Ayasoufi, Katayoun / Zhao, Shunyi / Xie, Manling / Thyen, Grace / Hur, Benjamin / Zheng, Jiaying / Liang, Yue / Wu, Zhaofa / Yu, Xinzhu / Sung, Jaeyun / Johnson, Aaron J / Li, Yulong / Wu, Long-Jun

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Microglial calcium signaling is rare in a baseline state but shows strong engagement during early epilepsy development. The mechanism and purpose behind microglial calcium signaling is not known. By developing ... ...

    Abstract Microglial calcium signaling is rare in a baseline state but shows strong engagement during early epilepsy development. The mechanism and purpose behind microglial calcium signaling is not known. By developing an
    Language English
    Publishing date 2023-06-13
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.06.12.544691
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: High-dose budesonide for early COVID-19 - Authors' reply.

    Hobbs, F D Richard / Yu, Ly-Mee / Saville, Benjamin R / Bafadhel, Mona / Butler, Christopher C

    Lancet (London, England)

    2021  Volume 398, Issue 10317, Page(s) 2147–2148

    MeSH term(s) Anti-Asthmatic Agents ; Budesonide ; COVID-19 ; Formoterol Fumarate ; Humans ; SARS-CoV-2
    Chemical Substances Anti-Asthmatic Agents ; Budesonide (51333-22-3) ; Formoterol Fumarate (W34SHF8J2K)
    Language English
    Publishing date 2021-12-02
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(21)02449-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.5: Show issues Location:
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