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Article: Resilience processes among Ukrainian youth preparing to build resilience with peers during the Ukraine-Russia war.

Giordano, Francesca / Lipscomb, Shannon / Jefferies, Philip / Kwon, Kyong-Ah / Giammarchi, Marianna

2024 Volume 15, Page(s) 1331886

Abstract: The war in Ukraine significantly impacts the mental health and well-being of its youth. Like other communities affected by war, Ukraine's youth are at risk of developing psychopathological symptoms, and there is a shortage of mental health and ... ...

Abstract	The war in Ukraine significantly impacts the mental health and well-being of its youth. Like other communities affected by war, Ukraine's youth are at risk of developing psychopathological symptoms, and there is a shortage of mental health and psychosocial support services to address this. Resilience-building initiatives present an alternative approach to supporting the well-being of young people by promoting protective processes to enhance the likelihood of positive development in the context of adversity. Emerging research findings suggest that young people themselves can serve as powerful facilitators of such initiatives with one another. Yet, evidence about culturally and contextually relevant protective processes is needed to guide such interventions, especially among young people experiencing the war and working to boost resilience within their communities. In this study, we identified key protective processes Ukrainian youth depend on as they adapt to the conflict while also preparing to implement a resilience-building intervention as a facilitator. Through thematic analysis of transcripts of three training sessions with Ukrainian youth (
Language	English
Publishing date	2024-02-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2024.1331886
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Article ; Online: Meta-Analyses Do Not Establish Improved Mortality With Ivermectin Use in COVID-19.

Rothrock, Steven G / Weber, Kurt D / Giordano, Philip A / Barneck, Mitchell D

American journal of therapeutics

2022 Volume 29, Issue 2, Page(s) e237–e244

MeSH term(s)	COVID-19/drug therapy ; COVID-19/mortality ; Humans ; Ivermectin/therapeutic use ; Meta-Analysis as Topic ; Treatment Outcome
Chemical Substances	Ivermectin (70288-86-7)
Language	English
Publishing date	2022-02-10
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	1280786-2
ISSN	1536-3686 ; 1075-2765
ISSN (online)	1536-3686
ISSN	1075-2765
DOI	10.1097/MJT.0000000000001477
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Article: Genomic amplifications identified by circulating tumor DNA analysis guide prognosis in metastatic castration-resistant prostate cancer.

Dincman, Toros A / Karam, Joseph A Q / Giordano, Antonio / Li, Hong / Drusbosky, Leylah M / Gourdin, Theodore S / Howe, Philip H / Lilly, Michael B

Frontiers in oncology

2024 Volume 13, Page(s) 1202277

Abstract: Purpose: Analysis of circulating tumor DNA (ctDNA) in patients with metastatic prostate cancer (mPC) provides an opportunity to identify and monitor genomic alterations during a patient's treatment course. We evaluated whether the presence of specific ... ...

Abstract	Purpose: Analysis of circulating tumor DNA (ctDNA) in patients with metastatic prostate cancer (mPC) provides an opportunity to identify and monitor genomic alterations during a patient's treatment course. We evaluated whether the presence of specific gene amplifications (GAs) and plasma copy number (PCN) alterations are associated with disease features. Methods: This is a single-institution retrospective study of patients with mPC who underwent ctDNA profiling using Guardant360 Results: The presence of liver and/or lung metastases was associated with GAs of Conclusions: The association of select GAs with survival provides an additional tool for assessing mCRPC prognosis and informing management. Serial monitoring of ctDNA GAs is also useful to guide prognosis and therapeutic response.
Language	English
Publishing date	2024-02-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1202277
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Article ; Online: Pituitary metastasis arising from hepatocellular carcinoma: a case report and update of the literature.

Rodriguez, Isaac / Vogel, Lena / Dreher, Constantin / Cherkezov, Asan / Giordano, Frank / Frölich, Matthias / Ebert, Matthias Philip / Teufel, Andreas / Boda-Heggemann, Judit

Zeitschrift fur Gastroenterologie

2024

Abstract: Hepatocellular carcinoma (HCC) is the sixth most common neoplasia and the third leading cause of cancer-associated deaths worldwide. Most cases arise in patients with cirrhosis, and early detection through periodic screening can make it potentially ... ...

Title translation	Hypophysenmetastase bei hepatozellulärem Karzinom: Ein Case Report und Aktualisierung der Literatur.
Abstract	Hepatocellular carcinoma (HCC) is the sixth most common neoplasia and the third leading cause of cancer-associated deaths worldwide. Most cases arise in patients with cirrhosis, and early detection through periodic screening can make it potentially curable. The presence of extrahepatic metastases (EHM) affects treatment decisions and curability. The lungs are the most common site for EHM, followed by lymph nodes, bones, and the adrenal glands. Interestingly, approximately only 15 cases of HCC metastasizing to the pituitary gland have been reported so far.The most common symptoms of pituitary metastasis (PM) arising from HCC are nerve palsies affecting the third, fourth, and sixth cranial nerves. Other symptoms, such as diabetes insipidus or pituitary insufficiencies, are present in a minority of cases. Detecting PM is difficult given its rarity. Gold-standard treatments for these patients have not yet been established, but the prognosis is dismal, with a median overall survival of only 4.5 months. In this paper, we present an interesting case of PM as the first symptom of an HCC in a 75-year-old female. We also present an overview of all cases reported to date with emphasis on symptom presentation and survival after diagnosis.Given the improvement of systemic therapy, more cases are diagnosed in both oligometastatic and palliative conditions. Therefore, better approaches and treatment modalities for extrahepatic metastases due to HCC should be defined.
Language	English
Publishing date	2024-01-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	201387-3
ISSN	1439-7803 ; 0172-8504 ; 0044-2771
ISSN (online)	1439-7803
ISSN	0172-8504 ; 0044-2771
DOI	10.1055/a-2225-5057
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Article ; Online: Meta-Analyses Do Not Establish Improved Mortality With Ivermectin Use in COVID-19.

Rothrock, Steven G / Weber, Kurt D / Giordano, Philip A / Barneck, Mitchell D

American journal of therapeutics

2021 Volume 29, Issue 1, Page(s) e87–e94

MeSH term(s)	Antiparasitic Agents/therapeutic use ; COVID-19 ; Humans ; Ivermectin ; SARS-CoV-2 ; Treatment Outcome
Chemical Substances	Antiparasitic Agents ; Ivermectin (70288-86-7)
Language	English
Publishing date	2021-12-07
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	1280786-2
ISSN	1536-3686 ; 1075-2765
ISSN (online)	1536-3686
ISSN	1075-2765
DOI	10.1097/MJT.0000000000001461
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Article: A Case of Brown Widow Envenomation in Central Florida.

Earwood, Ryan C / Ladde, Jay / Giordano, Philip A

Cureus

2020 Volume 12, Issue 7, Page(s) e9165

Abstract: Latrodectus geometricus, also known as the brown widow or brown button spider, is an unrenowned relative of the American black widow. While brown widow envenomation is generally thought of as mild, it does have the potential to lead to moderate or severe ...

Abstract	Latrodectus geometricus, also known as the brown widow or brown button spider, is an unrenowned relative of the American black widow. While brown widow envenomation is generally thought of as mild, it does have the potential to lead to moderate or severe features similar to black widow bites. We report a case of brown widow envenomation that led to a moderate reaction including rash, local pain, pain radiating proximally in the extremity and nausea. Poison control was consulted for aid in spider identification. The patient was treated for pain control and muscle relaxation and monitored for eight hours. After proper tetanus prophylaxis, the patient was successfully discharged home with well-controlled, but continued mild symptoms. This case highlights a little-known, but clinically relevant species of widow spider with a wide distribution. Expeditious identification and treatment of brown widow bites can increase patient comfort, satisfaction, and discharge rates.
Language	English
Publishing date	2020-07-13
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.9165
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Article: Social-Ecological Resilience Moderates the Effectiveness of Avoidant Coping in Children Exposed to Adversity: An Exploratory Study in Lithuania.

Giordano, Francesca / Caravita, Simona C S / Jefferies, Philip

Frontiers in psychology

2020 Volume 11, Page(s) 536353

Abstract: Background: Against the high prevalence of adverse childhood experiences in Lithuania, the government testified a lack of effective ways to address the problem. A crucial endeavor for intervention planners is to identify the risk and protective factors ... ...

Abstract	Background: Against the high prevalence of adverse childhood experiences in Lithuania, the government testified a lack of effective ways to address the problem. A crucial endeavor for intervention planners is to identify the risk and protective factors whose interaction may lead at risk children to achieve greater levels of functioning. Internal qualities and external resources can act independently or interactively to reduce the damaging effects of adversities, and to enhance resilience process. In particular, both coping strategies and social resources have been shown to have a consistent influence on trauma-related outcomes. Objective: The aim of this study was to investigate the potential interaction of coping strategies with external resources in predicting trauma-related outcomes in children exposed to adversities. Participants and setting: A sample of 372 Lithuanian children (mean age = 13.03; range: 7-17) with a history of traumatic experiences has been involved. Methods: The Child and Youth Resilience Measure-Revised (CYRM-R), the Children Coping Strategy Checklist (CCSC), and the Trauma Symptom Checklist for Children (TSCC) have been administered to participants. A moderation analysis was performed to test whether social-ecological resilience moderate the relationship between each coping strategy and trauma-related outcomes. Results: When controlling for sex, age, other coping strategies, and social-ecological resilience, only active coping was found to significantly predict each of the trauma-related symptoms. Furthermore, social-ecological resilience has a negatively moderating effect on the relationship between avoidant coping strategies and depression. Conclusion: MHPSS professionals who design and implement interventions to enhance the likelihood of resilience among vulnerable children, should take in considerations the multiple interaction between social-ecological resilience and avoidant coping strategies in the children adjustment.
Language	English
Publishing date	2020-10-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2020.536353
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Article ; Online: Sex differences in time course and diagnostic accuracy of GFAP and UCH-L1 in trauma patients with mild traumatic brain injury.

Papa, Linda / Brophy, Gretchen M / Alvarez, Wilmer / Hirschl, Robert / Cress, Marshall / Weber, Kurt / Giordano, Philip

Scientific reports

2023 Volume 13, Issue 1, Page(s) 11833

Abstract: Glial Fibrillary Acidic Protein (GFAP) and Ubiquitin C-terminal hydrolase (UCH-L1) have been FDA-approved for clinical use in mild and moderate traumatic brain injury (TBI). Understanding sex differences in their diagnostic accuracy over time will help ... ...

Abstract	Glial Fibrillary Acidic Protein (GFAP) and Ubiquitin C-terminal hydrolase (UCH-L1) have been FDA-approved for clinical use in mild and moderate traumatic brain injury (TBI). Understanding sex differences in their diagnostic accuracy over time will help inform clinical practice. We sought to evaluate the sex differences in the temporal profile of GFAP and UCH-L1 in a large cohort of trauma patients presenting to the emergency department. To compare the biomarkers' diagnostic accuracy in male versus female patients for detecting mild TBI (MTBI), and traumatic intracranial lesions on head CT. This prospective cohort study enrolled female and male adult trauma patients presenting to a Level 1 Trauma Center. All patients underwent rigorous screening to determine whether or not they had experienced a MTBI. Of 3025 trauma patients assessed, 1030 met eligibility criteria and 446 declined. Initial blood samples were obtained in 584 patients enrolled within 4 h of injury. Repeated blood sampling was conducted at 4, 8, 12, 16, 24, 36, 48, 60, 72, 84, 96, 108, 120, 132, 144, 156, 168, and 180-h post-injury. The main outcomes included the diagnostic accuracy in detection of MTBI and traumatic intracranial lesions on head CT scan. A total of 1831 samples were drawn in 584 patients over 7 days, 362 (62%) were male and 222 (38%) were female. The pattern of elevation was similar in both sexes. Although the pattern of elevation was similar between male and female for both biomarkers, male patients had significantly higher concentrations of UCH-L1 compared to female patients at several timepoints post-injury, particularly within 24 h of injury. There were no significant differences in diagnostic accuracy for detecting MTBI or for detecting CT lesions between male and female patients at any timepoint for both GFAP and UCH-L1. Although patterns of GFAP and UCH-L1 release in trauma patients over a week post-injury was similar between the sexes, there were significantly higher concentrations of UCH-L1 in males at several timepoints post-injury. Despite this, the overall diagnostic accuracies of both GFAP and UCH-L1 over time for detecting MTBI and CT lesions were not significantly different between male and female trauma patients.
MeSH term(s)	Humans ; Male ; Female ; Young Adult ; Adult ; Middle Aged ; Adolescent ; Aged ; Aged, 80 and over ; Sex Characteristics ; Brain Concussion/diagnosis ; Biomarkers
Chemical Substances	GFAP protein, human ; UCHL1 protein, human ; Biomarkers
Language	English
Publishing date	2023-07-22
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-38804-4
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Article: Pituitary metastasis arising from hepatocellular carcinoma: a case report and update of the literature

Rodriguez, Isaac / Vogel, Lena / Dreher, Constantin / Cherkezov, Asan / Giordano, Frank / Frölich, Matthias / Ebert, Matthias Philip / Teufel, Andreas / Boda-Heggemann, Judit

Zeitschrift für Gastroenterologie

2024

Abstract	Hepatocellular carcinoma (HCC) is the sixth most common neoplasia and the third leading cause of cancer-associated deaths worldwide. Most cases arise in patients with cirrhosis, and early detection through periodic screening can make it potentially curable. The presence of extrahepatic metastases (EHM) affects treatment decisions and curability. The lungs are the most common site for EHM, followed by lymph nodes, bones, and the adrenal glands. Interestingly, approximately only 15 cases of HCC metastasizing to the pituitary gland have been reported so far. The most common symptoms of pituitary metastasis (PM) arising from HCC are nerve palsies affecting the third, fourth, and sixth cranial nerves. Other symptoms, such as diabetes insipidus or pituitary insufficiencies, are present in a minority of cases. Detecting PM is difficult given its rarity. Gold-standard treatments for these patients have not yet been established, but the prognosis is dismal, with a median overall survival of only 4.5 months. In this paper, we present an interesting case of PM as the first symptom of an HCC in a 75-year-old female. We also present an overview of all cases reported to date with emphasis on symptom presentation and survival after diagnosis. Given the improvement of systemic therapy, more cases are diagnosed in both oligometastatic and palliative conditions. Therefore, better approaches and treatment modalities for extrahepatic metastases due to HCC should be defined.
Keywords	Hepatocellular Carcinoma ; Pituitary metastasis ; Radiotherapy ; Extrahepatic metastasis ; Oligometastasis ; hepatozelluläres Karzinom ; hypophysäre Metastasen ; Radiotherapie ; extrahepatische Metastasen ; Oligometastase
Language	English
Publishing date	2024-01-15
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	201387-3
ISSN	1439-7803 ; 0044-2771 ; 0172-8504
ISSN (online)	1439-7803
ISSN	0044-2771 ; 0172-8504
DOI	10.1055/a-2225-5057
Database	Thieme publisher's database

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Article ; Online: Analysis of Pooled Phase III Efficacy Data for Delafloxacin in Acute Bacterial Skin and Skin Structure Infections.

Giordano, Philip A / Pogue, Jason M / Cammarata, Sue

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2019 Volume 68, Issue Suppl 3, Page(s) S223–S232

Abstract: Background: Delafloxacin is an oral or intravenous (IV) antibiotic indicated for the treatment of acute bacterial skin and skin structure infections (ABSSSI), including both gram-positive (including methicillin-resistant Staphylococcus aureus [MRSA]) ... ...

Abstract	Background: Delafloxacin is an oral or intravenous (IV) antibiotic indicated for the treatment of acute bacterial skin and skin structure infections (ABSSSI), including both gram-positive (including methicillin-resistant Staphylococcus aureus [MRSA]) and gram-negative organisms. Chemically distinct from other quinolones, delafloxacin exhibits enhanced potency, particularly against gram-positive pathogens. The integration of efficacy data across the Phase III ABSSSI studies is presented here and allows for additional examination of results across subgroups. Methods: Results of 2 multicenter, randomized, double-blind trials of 1510 adults with ABSSSI were pooled for this analysis. Subjects in the vancomycin arm received 15 mg/kg, plus 1-2 g of aztreonam every 12 hours. Delafloxacin was dosed at 300 mg IV every 12 hours in Study 302; dosing in Study 303 was 300 mg IV every 12 hours for 3 days, with a mandatory, blinded switch to delafloxacin at 450 mg orally every 12 hours. The primary endpoint was objective response (OR), defined as a ≥20% reduction of lesion spread of erythema area at the primary infection site at 48 to 72 hours (±2 hours), in the absence of clinical failure. Investigator-assessed response, based on the resolution of signs and symptoms at follow-up (FU; Day 14 ± 1) and late follow-up (LFU; Day 21- 28), were secondary endpoints. Results: In the intent-to-treat analysis set, the OR was 81.3% in the delafloxacin arm and 80.7% in the comparator arm (mean treatment difference 0.8%, 95% confidence interval -3.2% to 4.7). Results for OR in the defined subgroups showed delafloxacin to be comparable to vancomycin/aztreonam. Investigator-assessed success was similar at FU (84.7% versus 84.1%) and LFU (82.0% versus 81.7%). Delafloxacin was comparable to vancomycin/aztreonam in the eradication of MRSA, at 98.1% versus 98.0%, respectively, at FU. The frequencies of treatment-emergent adverse events between the groups were similar. Conclusions: Overall, IV/oral delafloxacin fixed-dose monotherapy was non-inferior to IV vancomycin/aztreonam combination therapy and was well tolerated in each Phase III study, as well as in the pooled analysis, regardless of endpoint or analysis population.
MeSH term(s)	Administration, Intravenous ; Administration, Oral ; Aged ; Aged, 80 and over ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Drug Therapy, Combination ; Female ; Fluoroquinolones/pharmacology ; Fluoroquinolones/therapeutic use ; Humans ; Male ; Middle Aged ; Skin Diseases, Bacterial/drug therapy ; Skin Diseases, Bacterial/microbiology ; Soft Tissue Infections/drug therapy ; Soft Tissue Infections/microbiology ; Treatment Outcome
Chemical Substances	Anti-Bacterial Agents ; Fluoroquinolones ; delafloxacin (6315412YVF)
Language	English
Publishing date	2019-04-24
Publishing country	United States
Document type	Clinical Trial, Phase III ; Journal Article ; Multicenter Study ; Randomized Controlled Trial
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciz006
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