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Article ; Online: Multicenter PET image harmonization using generative adversarial networks.

Haberl, David / Spielvogel, Clemens P / Jiang, Zewen / Orlhac, Fanny / Iommi, David / Carrió, Ignasi / Buvat, Irène / Haug, Alexander R / Papp, Laszlo

European journal of nuclear medicine and molecular imaging

2024

Abstract: Purpose: To improve reproducibility and predictive performance of PET radiomic features in multicentric studies by cycle-consistent generative adversarial network (GAN) harmonization approaches.: Methods: GAN-harmonization was developed to harmonize ... ...

Abstract	Purpose: To improve reproducibility and predictive performance of PET radiomic features in multicentric studies by cycle-consistent generative adversarial network (GAN) harmonization approaches. Methods: GAN-harmonization was developed to harmonize whole-body PET scans to perform image style and texture translation between different centers and scanners. GAN-harmonization was evaluated by application to two retrospectively collected open datasets and different tasks. First, GAN-harmonization was performed on a dual-center lung cancer cohort (127 female, 138 male) where the reproducibility of radiomic features in healthy liver tissue was evaluated. Second, GAN-harmonization was applied to a head and neck cancer cohort (43 female, 154 male) acquired from three centers. Here, the clinical impact of GAN-harmonization was analyzed by predicting the development of distant metastases using a logistic regression model incorporating first-order statistics and texture features from baseline Results: Image quality remained high (structural similarity: left kidney Conclusions: GANs are capable of performing image harmonization and increase reproducibility and predictive performance of radiomic features derived from different centers and scanners.
Language	English
Publishing date	2024-05-02
Publishing country	Germany
Document type	Journal Article
ZDB-ID	8236-3
ISSN	1619-7089 ; 0340-6997 ; 1619-7070
ISSN (online)	1619-7089
ISSN	0340-6997 ; 1619-7070
DOI	10.1007/s00259-024-06708-8
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Article ; Online: Direct Axillary Artery Cannulation for Aortic Surgery: Lessons From Contemporary Experiences.

Ohira, Suguru / Kai, Masashi / Goldberg, Joshua B / Malekan, Ramin / Lansman, Steven L / Spielvogel, David

The Annals of thoracic surgery

2022 Volume 114, Issue 4, Page(s) 1341–1347

Abstract: Background: This study seeks to assess the outcomes of direct axillary artery (AX) cannulation for thoracic aortic surgery.: Methods: From October 2009 to November 2021 direct AX cannulation was planned in 515 patients for thoracic aortic pathology. ... ...

Abstract	Background: This study seeks to assess the outcomes of direct axillary artery (AX) cannulation for thoracic aortic surgery. Methods: From October 2009 to November 2021 direct AX cannulation was planned in 515 patients for thoracic aortic pathology. An important aspect of our technique is that the cannula is not inserted deeper than 3 cm. AX cannulation-related events included shift of cannulation site from the initial site, vascular injury, and iatrogenic dissection. Results: Half of the patients had acute type A dissection (ATAD). An angled cannula was used in 442 patients and a straight cannula in 73 patients (14.2%) after August 2020. A previously cannulated AX was reused in 36 patients (7.0%). Mortality and stroke rates were 5.4% (ATAD vs non-ATAD: 8.0% vs 2.8%, P = .008) and 2.7% (ATAD vs non-ATAD: 4.6% vs 0.8%, P = .034), respectively. AX cannulation-related events were observed in 2.7% of patients. There was no difference in the vascular injury rate between ATAD and non-ATAD cases (1.6% vs 0.4%, respectively; P = .385), between different cannula types (angled vs straight: 0.9% vs 1.4%, P = 1.00), or between primary and redo AX cannulation cases (0.8% vs 2.8%, respectively; P = .791). On multidetector computed tomography analysis using automated 3-dimensional images, the mean distance from the thoracoacromial artery to the vertebral artery on the right and left sides was 8.70 cm and 8.69 cm, respectively. Conclusions: Direct AX cannulation for thoracic aortic repair is safe and carries a low rate of vascular injury, especially in elective cases. Our direct cannulation technique, which includes not inserting a cannula deeper than 3 cm, seems to be safe in not occluding the vertebral artery.
MeSH term(s)	Aorta, Thoracic/diagnostic imaging ; Aorta, Thoracic/surgery ; Axillary Artery ; Cannula ; Cardiopulmonary Bypass ; Catheterization/methods ; Humans ; Retrospective Studies ; Treatment Outcome ; Vascular System Injuries/etiology
Language	English
Publishing date	2022-03-12
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	211007-6
ISSN	1552-6259 ; 0003-4975
ISSN (online)	1552-6259
ISSN	0003-4975
DOI	10.1016/j.athoracsur.2022.02.048
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Zs.A 252: Show issues

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Article ; Online: Clinical data classification with noisy intermediate scale quantum computers.

Moradi, S / Brandner, C / Spielvogel, C / Krajnc, D / Hillmich, S / Wille, R / Drexler, W / Papp, L

Scientific reports

2022 Volume 12, Issue 1, Page(s) 1851

Abstract: Quantum machine learning has experienced significant progress in both software and hardware development in the recent years and has emerged as an applicable area of near-term quantum computers. In this work, we investigate the feasibility of utilizing ... ...

Abstract	Quantum machine learning has experienced significant progress in both software and hardware development in the recent years and has emerged as an applicable area of near-term quantum computers. In this work, we investigate the feasibility of utilizing quantum machine learning (QML) on real clinical datasets. We propose two QML algorithms for data classification on IBM quantum hardware: a quantum distance classifier (qDS) and a simplified quantum-kernel support vector machine (sqKSVM). We utilize these different methods using the linear time quantum data encoding technique ([Formula: see text]) for embedding classical data into quantum states and estimating the inner product on the 15-qubit IBMQ Melbourne quantum computer. We match the predictive performance of our QML approaches with prior QML methods and with their classical counterpart algorithms for three open-access clinical datasets. Our results imply that the qDS in small sample and feature count datasets outperforms kernel-based methods. In contrast, quantum kernel approaches outperform qDS in high sample and feature count datasets. We demonstrate that the [Formula: see text] encoding increases predictive performance with up to + 2% area under the receiver operator characteristics curve across all quantum machine learning approaches, thus, making it ideal for machine learning tasks executed in Noisy Intermediate Scale Quantum computers.
Language	English
Publishing date	2022-02-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-05971-9
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Article ; Conference proceedings: A Machine Learning Approach to Identify Patients at Risk for Long-Term Consequences after Pulmonary Embolism

Nopp, S. / Spielvogel, C. / Bikdeli, B. / Francisco, I. / Hernández-Blasco, L. / Peris, L. / Otero, R. / Jiménez, D. / Monreal, M. / Ay, C.

Hämostaseologie

2024 Volume 44, Issue S 01

Event/congress	GTH Congress 2024 - 68th Annual Meeting of the Society of Thrombosis and Haemostasis Research - Building Bridges in Coagulation, Vienna, Austria, 2024-03-27
Language	English
Publishing date	2024-02-01
Publisher	Georg Thieme Verlag
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	801512-0
ISSN	2567-5761 ; 0720-9355
ISSN (online)	2567-5761
ISSN	0720-9355
DOI	10.1055/s-0044-1779064
Database	Thieme publisher's database

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Zs.A 1631: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Error mitigation enables PET radiomic cancer characterization on quantum computers.

Moradi, S / Spielvogel, Clemens / Krajnc, Denis / Brandner, C / Hillmich, S / Wille, R / Traub-Weidinger, T / Li, X / Hacker, M / Drexler, W / Papp, L

European journal of nuclear medicine and molecular imaging

2023 Volume 50, Issue 13, Page(s) 3826–3837

Abstract: Background: Cancer is a leading cause of death worldwide. While routine diagnosis of cancer is performed mainly with biopsy sampling, it is suboptimal to accurately characterize tumor heterogeneity. Positron emission tomography (PET)-driven radiomic ... ...

Abstract	Background: Cancer is a leading cause of death worldwide. While routine diagnosis of cancer is performed mainly with biopsy sampling, it is suboptimal to accurately characterize tumor heterogeneity. Positron emission tomography (PET)-driven radiomic research has demonstrated promising results when predicting clinical endpoints. This study aimed to investigate the added value of quantum machine learning both in simulator and in real quantum computers utilizing error mitigation techniques to predict clinical endpoints in various PET cancer patients. Methods: Previously published PET radiomics datasets including 11C-MET PET glioma, 68GA-PSMA-11 PET prostate and lung 18F-FDG PET with 3-year survival, low-vs-high Gleason risk and 2-year survival as clinical endpoints respectively were utilized in this study. Redundancy reduction with 0.7, 0.8, and 0.9 Spearman rank thresholds (SRT), followed by selecting 8 and 16 features from all cohorts, was performed, resulting in 18 dataset variants. Quantum advantage was estimated by Geometric Difference (GD Results: On average, QML outperformed CML in simulator environments with 16-features (BACC 70% and 69%, respectively), while with 8-features, CML outperformed QML with + 1%. The highest average QML advantage was + 4%. The GD Conclusions: We demonstrated that with error mitigation, quantum advantage can be achieved in real existing quantum computers when predicting clinical endpoints in clinically relevant PET cancer cohorts. Quantum advantage can already be achieved in simulator environments in these cohorts when relying on QML.
MeSH term(s)	Male ; Humans ; Fluorodeoxyglucose F18 ; Positron-Emission Tomography/methods ; Lung Neoplasms/pathology ; Lung/pathology ; Computers ; Positron Emission Tomography Computed Tomography/methods ; Retrospective Studies
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2023-08-04
Publishing country	Germany
Document type	Journal Article
ZDB-ID	8236-3
ISSN	1619-7089 ; 0340-6997 ; 1619-7070
ISSN (online)	1619-7089
ISSN	0340-6997 ; 1619-7070
DOI	10.1007/s00259-023-06362-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1227: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Conference proceedings: Prognose und Screening nach kardialer Amyloidose in der Knochenszintigrafie durch künstliche Intelligenz: Eine internationale, multizentrische, Tracer-übergreiffende Studie

Spielvogel, C. P. / Haberl, D. / Ning, J. / Kluge, K. / Traub-Weidinger, T. / Nakuz, T. / Göllner, A. / Amareller, D. / Zhao, M. / Ma, X. / Calabretta, R. / Haug, A. R. / Sciagra, R. / Menezes, L. / Treibel, T. A. / Hacker, M. / Nitsche, C.

Nuklearmedizin - NuclearMedicine

2024 Volume 63, Issue 02

Event/congress	62. Jahrestagung der Deutschen Gesellschaft für Nuklearmedizin, Leipzig, 2024-04-10
Language	German
Publishing date	2024-03-01
Publisher	Georg Thieme Verlag
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	2030804-8
ISSN	2567-6407 ; 0029-5566
ISSN (online)	2567-6407
ISSN	0029-5566
DOI	10.1055/s-0044-1782271
Database	Thieme publisher's database

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Article ; Online: Quantifying Variations in Metal-Ligand Cooperative Binding Strength with Cyclic Voltammetry and Redox-Active Ligands.

Spielvogel, Kyle D / Stumme, Nathan C / Fetrow, Taylor V / Wang, Li / Luna, Javier A / Keith, Jason M / Shaw, Scott K / Daly, Scott R

Inorganic chemistry

2022 Volume 61, Issue 5, Page(s) 2391–2401

Abstract: Metal-ligand cooperativity (MLC), a phenomenon that leverages reactive ligands to promote synergistic reactions with metals, has proven to be a powerful approach to achieving new and unprecedented chemical transformations with metal complexes. While many ...

Abstract	Metal-ligand cooperativity (MLC), a phenomenon that leverages reactive ligands to promote synergistic reactions with metals, has proven to be a powerful approach to achieving new and unprecedented chemical transformations with metal complexes. While many examples of MLC are known with a wide range of substrates, experimentally quantifying how ligand modifications affect MLC binding strength remains a challenge. Here we describe how cyclic voltammetry (CV) was used to quantify differences in MLC binding strength in a series of square-pyramidal Ru complexes. This method relies on using multifunctional ligands (those capable of both MLC and ligand-centered redox activity) as electrochemical reporters of MLC binding strength. The synthesis and characterization of Ru complexes with three different redox-active tetradentate ligands and two different ancillary phosphines (PPh
Language	English
Publishing date	2022-01-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	1484438-2
ISSN	1520-510X ; 0020-1669
ISSN (online)	1520-510X
ISSN	0020-1669
DOI	10.1021/acs.inorgchem.1c03014
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The timing of HIV-1 infection of cells that persist on therapy is not strongly influenced by replication competency or cellular tropism of the provirus.

Joseph, Sarah B / Abrahams, Melissa-Rose / Moeser, Matthew / Tyers, Lynn / Archin, Nancie M / Council, Olivia D / Sondgeroth, Amy / Spielvogel, Ean / Emery, Ann / Zhou, Shuntai / Doolabh, Deelan / Ismail, Sherazaan D / Karim, Salim Abdool / Margolis, David M / Pond, Sergei Kosakovsky / Garrett, Nigel / Swanstrom, Ronald / Williamson, Carolyn

PLoS pathogens

2024 Volume 20, Issue 2, Page(s) e1011974

Abstract: People with HIV-1 (PWH) on antiretroviral therapy (ART) can maintain undetectable virus levels, but a small pool of infected cells persists. This pool is largely comprised of defective proviruses that may produce HIV-1 proteins but are incapable of ... ...

Abstract	People with HIV-1 (PWH) on antiretroviral therapy (ART) can maintain undetectable virus levels, but a small pool of infected cells persists. This pool is largely comprised of defective proviruses that may produce HIV-1 proteins but are incapable of making infectious virus, with only a fraction (~10%) of these cells harboring intact viral genomes, some of which produce infectious virus following ex vivo stimulation (i.e. inducible intact proviruses). A majority of the inducible proviruses that persist on ART are formed near the time of therapy initiation. Here we compared proviral DNA (assessed here as 3' half genomes amplified from total cellular DNA) and inducible replication competent viruses in the pool of infected cells that persists during ART to determine if the original infection of these cells occurred at comparable times prior to therapy initiation. Overall, the average percent of proviruses that formed late (i.e. around the time of ART initiation, 60%) did not differ from the average percent of replication competent inducible viruses that formed late (69%), and this was also true for proviral DNA that was hypermutated (57%). Further, there was no evidence that entry into the long-lived infected cell pool was impeded by the ability to use the CXCR4 coreceptor, nor was the formation of long-lived infected cells enhanced during primary infection, when viral loads are exceptionally high. We observed that infection of cells that transitioned to be long-lived was enhanced among people with a lower nadir CD4+ T cell count. Together these data suggest that the timing of infection of cells that become long-lived is impacted more by biological processes associated with immunodeficiency before ART than the replication competency and/or cellular tropism of the infecting virus or the intactness of the provirus. Further research is needed to determine the mechanistic link between immunodeficiency and the timing of infected cells transitioning to the long-lived pool, particularly whether this is due to differences in infected cell clearance, turnover rates and/or homeostatic proliferation before and after ART.
MeSH term(s)	Humans ; Proviruses/genetics ; HIV-1/genetics ; Anti-Retroviral Agents/pharmacology ; Anti-Retroviral Agents/therapeutic use ; HIV Infections/drug therapy ; CD4-Positive T-Lymphocytes ; DNA, Viral/genetics ; DNA, Viral/metabolism ; Viral Load ; Tropism
Chemical Substances	Anti-Retroviral Agents ; DNA, Viral
Language	English
Publishing date	2024-02-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2205412-1
ISSN	1553-7374 ; 1553-7374
ISSN (online)	1553-7374
ISSN	1553-7374
DOI	10.1371/journal.ppat.1011974
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Article ; Online: Axillary artery cannulation for veno-arterial extracorporeal membrane oxygenation support in cardiogenic shock.

Ohira, Suguru / Malekan, Ramin / Goldberg, Joshua B / Lansman, Steven L / Spielvogel, David / Kai, Masashi

JTCVS techniques

2020 Volume 5, Page(s) 62–71

Abstract: Objective: To review the outcomes of axillary artery (AX) and femoral artery (FA) cannulation for veno-arterial extracorporeal membraneous oxygenation (VA-ECMO).: Methods: From 2009 to 2019, 371 patients who were supported with VA-ECMO for ... ...

Abstract	Objective: To review the outcomes of axillary artery (AX) and femoral artery (FA) cannulation for veno-arterial extracorporeal membraneous oxygenation (VA-ECMO). Methods: From 2009 to 2019, 371 patients who were supported with VA-ECMO for cardiogenic shock were compared based on the arterial cannulation site: AX (n = 218) versus FA (n = 153). Results: Patients in the AX group were older (61 years vs 58 years, Conclusions: AX cannulation for VA-ECMO is a safe and effective alternative to FA cannulation. It can be considered especially for patients with limited groin access, peripheral vascular disease, or for primary graft failure after heart transplant.
Language	English
Publishing date	2020-11-03
Publishing country	United States
Document type	Journal Article
ISSN	2666-2507
ISSN (online)	2666-2507
DOI	10.1016/j.xjtc.2020.10.035
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Zone 2 arch repair for acute type A dissection: Evolution from arch-first to proximal-first repair.

Ohira, Suguru / Gregory, Vasiliki / Goldberg, Joshua B / Malekan, Ramin / Laskowski, Igor / De La Pena, Corazon / Lansman, Steven L / Spielvogel, David / Kai, Masashi

JTCVS techniques

2023 Volume 21, Page(s) 7–17

Abstract: Objective: With growing experience of acute type A aortic dissection repair, Zone 2 arch repair has been advocated. The aim of this study is to compare the outcome between "proximal-first" and "arch-first" Zone 2 repair.: Methods: From January 2015 ... ...

Abstract	Objective: With growing experience of acute type A aortic dissection repair, Zone 2 arch repair has been advocated. The aim of this study is to compare the outcome between "proximal-first" and "arch-first" Zone 2 repair. Methods: From January 2015 to March 2023, 45 patients underwent Zone 2 arch repair out of 208 acute type A aortic dissection repairs: arch-first, N = 19, and proximal-first technique, N = 26, since January 2021. Indications were aortic arch or descending tear, complex dissection in neck vessels, cerebral malperfusion, or aneurysm of the aortic arch. Results: The lowest bladder temperature was higher in the proximal-first technique (24.9 °C vs 19.7 °C, Conclusions: Zone 2 arch repair using the proximal-first technique for acute type A aortic dissection repair yields shorter lower-body ischemic time with a warmer core temperature, resulting in shorter cardiopulmonary bypass time, less blood product use, and fewer morbidities when compared with the arch-first technique.
Language	English
Publishing date	2023-07-08
Publishing country	United States
Document type	Journal Article
ISSN	2666-2507
ISSN (online)	2666-2507
DOI	10.1016/j.xjtc.2023.06.012
Database	MEDical Literature Analysis and Retrieval System OnLINE

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