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  1. Article ; Online: Pioneers in dermatology and venereology: an interview with Prof. Alberto Giannetti.

    Giannetti, A

    Journal of the European Academy of Dermatology and Venereology : JEADV

    2019  Volume 33, Issue 1, Page(s) 17–18

    MeSH term(s) Dermatology ; History, 20th Century ; History, 21st Century ; Humans ; Italy ; Venereology
    Language English
    Publishing date 2019-01-18
    Publishing country England
    Document type Historical Article ; Journal Article
    ZDB-ID 1128828-0
    ISSN 1468-3083 ; 0926-9959
    ISSN (online) 1468-3083
    ISSN 0926-9959
    DOI 10.1111/jdv.15376
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3492: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 413: Show issues

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  2. Article ; Online: A Spectroscopic and Molecular Dynamics Study on the Aggregation Properties of a Lipopeptide Analogue of Liraglutide, a Therapeutic Peptide against Diabetes Type 2.

    Giannetti, Micaela / Palleschi, Antonio / Ricciardi, Beatrice / Venanzi, Mariano

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 22

    Abstract: The pharmacokinetics of peptide drugs are strongly affected by their aggregation properties and the morphology of the nanostructures they form in their native state as well as in their therapeutic formulation. In this contribution, we analyze the ... ...

    Abstract The pharmacokinetics of peptide drugs are strongly affected by their aggregation properties and the morphology of the nanostructures they form in their native state as well as in their therapeutic formulation. In this contribution, we analyze the aggregation properties of a Liraglutide analogue (LG18), a leading drug against diabetes type 2. LG18 is a lipopeptide characterized by the functionalization of a lysine residue (K26) with an 18C lipid chain. To this end, spectroscopic experiments, dynamic light scattering measurements, and molecular dynamics simulations were carried out, following the evolution of the aggregation process from the small LG18 clusters formed at sub-micromolar concentrations to the mesoscopic aggregates formed by aged micromolar solutions. The critical aggregation concentration of LG18 in water (pH = 8) was found to amount to 4.3 μM, as assessed by the pyrene fluorescence assay. MD simulations showed that the LG18 nanostructures are formed by tetramer building blocks that, at longer times, self-assemble to form micrometric supramolecular architectures.
    MeSH term(s) Humans ; Aged ; Molecular Dynamics Simulation ; Lipopeptides/pharmacology ; Liraglutide/pharmacology ; Spectrometry, Fluorescence ; Diabetes Mellitus, Type 2/drug therapy
    Chemical Substances Lipopeptides ; Liraglutide (839I73S42A)
    Language English
    Publishing date 2023-11-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28227536
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  3. Article: Anti-inflammatory and biologic drugs for atopic dermatitis: a therapeutic approach in children and adolescents.

    Caffarelli, Carlo / Giannetti, Arianna / Giannì, Giuliana / Ricci, Giampaolo

    Frontiers in medicine

    2023  Volume 10, Page(s) 1214963

    Abstract: Atopic dermatitis (AD) is a chronic inflammatory disease with a heterogeneous pathogenesis correlated with dysregulation of the immune system and a prevalence of the T2-mediated immune pathway. Recent understanding of the pathogenesis of AD has allowed ... ...

    Abstract Atopic dermatitis (AD) is a chronic inflammatory disease with a heterogeneous pathogenesis correlated with dysregulation of the immune system and a prevalence of the T2-mediated immune pathway. Recent understanding of the pathogenesis of AD has allowed the development of new drugs targeting different mechanisms and cytokines that have changed the treatment approach. The aim of this review is to update knowledge on the standard of care and recent advancements in the control of skin inflammation. In light of recent guidelines, we report on the clinical efficacy of novel treatments, with special attention to situations where biologics and small molecules are involved.
    Language English
    Publishing date 2023-08-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1214963
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  4. Article: Predatory Abilities of Two Mediterranean Ants on the Eggs and Larvae of the Codling Moth

    Schifani, Enrico / Giannetti, Daniele / Grasso, Donato A

    Insects

    2023  Volume 14, Issue 2

    Abstract: The predatory ability of ants (Hymenoptera, Formicidae) against insect pests can offer an important service to agricultural activities and may sometimes be directly exploited in biological control strategies. The codling ... ...

    Abstract The predatory ability of ants (Hymenoptera, Formicidae) against insect pests can offer an important service to agricultural activities and may sometimes be directly exploited in biological control strategies. The codling moth
    Language English
    Publishing date 2023-01-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662247-6
    ISSN 2075-4450
    ISSN 2075-4450
    DOI 10.3390/insects14020097
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  5. Article ; Online: Modelling and Experimental Study of Power Losses in Toothed Wheels.

    Giannetti, Guglielmo / Meli, Enrico / Rindi, Andrea

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 12

    Abstract: In recent decades, the request for more efficient performances in the aeronautical sector moved researchers to pay particular attention to all the related mechanisms and systems, especially with respect to the saving of power. In this context, the ... ...

    Abstract In recent decades, the request for more efficient performances in the aeronautical sector moved researchers to pay particular attention to all the related mechanisms and systems, especially with respect to the saving of power. In this context, the bearing modeling and design, as well as gear coupling, play a fundamental role. Moreover, the need for low power losses also concerns the study and the implementation of advanced lubrication systems, especially for high peripheral speed. With the previous aims, this paper presents a new validated model for toothed gears, added to a bearing model; with the link of these different submodels, the whole model describes the system's dynamic behavior, taking into account the different kinds of power losses (windage losses, fluid dynamic losses, etc.) generated by the mechanical system parts (especially rolling bearings and gears). As the bearing model, the proposed model is characterized by high numerical efficiency and allows the investigation of different rolling bearings and gears with different lubrication conditions and frictions. A comparison between the experimental and simulated results is also presented in this paper. The analysis of the results is encouraging and shows a good agreement between experiments and model simulations, with particular attention to the power losses in the bearing and gears.
    Language English
    Publishing date 2023-06-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23125541
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  6. Article: Bacteria Living in Biofilms in Fluids: Could Chemical Antibiofilm Pretreatment of Culture Represent a Paradigm Shift in Diagnostics?

    Drago, Lorenzo / Fidanza, Andrea / Giannetti, Alessio / Ciuffoletti, Alessio / Logroscino, Giandomenico / Romanò, Carlo Luca

    Microorganisms

    2024  Volume 12, Issue 2

    Abstract: Biofilms are multicellular aggregates of bacteria immersed in an extracellular matrix that forms on various surfaces, including biological tissues and artificial surfaces. However, more and more reports point out the fact that even biological fluids and ... ...

    Abstract Biofilms are multicellular aggregates of bacteria immersed in an extracellular matrix that forms on various surfaces, including biological tissues and artificial surfaces. However, more and more reports point out the fact that even biological fluids and semifluid, such as synovial liquid, blood, urine, or mucus and feces, harbor "non-attached" biofilm aggregates of bacteria, which represent a significant phenomenon with critical clinical implications that remain to be fully investigated. In particular, biofilm aggregates in biological fluid samples have been shown to play a relevant role in bacterial count and in the overall accuracy of microbiological diagnosis. In line with these observations, the introduction in the clinical setting of fluid sample pretreatment with an antibiofilm chemical compound called dithiothreitol (DTT), which is able to dislodge microorganisms from their intercellular matrix without killing them, would effectively improve the microbiological yield and increase the sensitivity of cultural examination, compared to the current microbiological techniques. While other ongoing research continues to unveil the complexity of biofilm formation in biological fluids and its impact on infection pathogenesis and diagnosis, we here hypothesize that the routine use of a chemical antibiofilm pretreatment of fluid and semi-solid samples may lead to a paradigm shift in the microbiological approach to the diagnosis of biofilm-related infections and should be further investigated and eventually implemented in the clinical setting.
    Language English
    Publishing date 2024-01-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms12020259
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  7. Article ; Online: Fight and rescue or give up and flee? Behavioural responses of different ant species tending the mutualist walnut aphid

    Schifani, Enrico / Giannetti, Daniele / Castracani, Cristina / Spotti, Fiorenza A / Mori, Alessandra / Grasso, Donato A

    Bulletin of entomological research

    2024  Volume 113, Issue 6, Page(s) 858

    MeSH term(s) Humans ; Animals ; Juglans ; Aphids/physiology ; Coleoptera/physiology ; Symbiosis ; Ants
    Language English
    Publishing date 2024-01-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 280516-9
    ISSN 1475-2670 ; 0007-4853
    ISSN (online) 1475-2670
    ISSN 0007-4853
    DOI 10.1017/S000748532300055X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 514: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Percutaneous treatment of radial neck fractures in adult patients.

    Giannetti, Silvio / Smimmo, Alessandro / Torre, Guglielmo / Stancati, Andrea / Pagano, Ernesto / Santucci, Attilio

    European journal of orthopaedic surgery & traumatology : orthopedie traumatologie

    2024  Volume 34, Issue 3, Page(s) 1413–1418

    Abstract: Introduction: Radial neck fractures in adults are rare, but outcomes are often poor. Closed reduction and internal fixation (CRIF) technique has been advocated for the treatment of minimally displaced fractures in children, with a few reports on adult ... ...

    Abstract Introduction: Radial neck fractures in adults are rare, but outcomes are often poor. Closed reduction and internal fixation (CRIF) technique has been advocated for the treatment of minimally displaced fractures in children, with a few reports on adult subjects. The aim of the present paper is to investigate mid-term results of a CRIF technique in adults with retrograde intramedullary K-wires in Mason's type II and III fractures. The proposed technique yields to good anatomical reduction of displaced neck fractures, faster rehabilitation, and easier hardware removal after fracture consolidation.
    Material and methods: A consecutive series of 17 patients were treated with closed reduction and intramedullary osteosynthesis, and outcomes were retrospectively evaluated. Elbow X-ray (XR) and CT scan were obtained preoperatively. Objective assessment before surgery and at an average 36-month follow-up included active and passive elbow range of motion (ROM). Functional evaluation was carried out through the collection of the Mayo Elbow Performance Score (MEPS), the Disabilities of the Arm, Shoulder, and Hand (DASH) score, and Elbow Self-Assessment Score (ESAS). XR at last follow-up was evaluated.
    Results: The cohort included 10 males and seven females, with a mean age of 32 years. Patients returned for a follow-up evaluation at a mean of 36 months (range 6-43 m) form the surgery. The DASH score revealed good to excellent outcomes with a mean of 6.32 ± 10.24 points at last follow-up. The ESAS was 98.35 ± 1.89, indicating a non-restricted elbow function. Acceptable radiographic healing was achieved in all patients.
    Conclusions: The advocated technique is promising for obtaining good reduction and stabilization, and good to excellent satisfaction for patients. Given the challenging technique, the learning curve could be long and initial results unsatisfactory. More research with larger cohorts and improved study design could be carried out, comparing the technique with the current choice of treatment (ORIF, radial head resection).
    MeSH term(s) Male ; Adult ; Child ; Female ; Humans ; Elbow ; Radius Fractures/diagnostic imaging ; Radius Fractures/surgery ; Radius Fractures/etiology ; Retrospective Studies ; Radial Head and Neck Fractures ; Treatment Outcome ; Bone Nails ; Fracture Fixation, Intramedullary/adverse effects ; Fracture Fixation, Internal/methods ; Elbow Joint/diagnostic imaging ; Elbow Joint/surgery ; Range of Motion, Articular
    Language English
    Publishing date 2024-01-16
    Publishing country France
    Document type Journal Article
    ZDB-ID 1231084-0
    ISSN 1432-1068 ; 1633-8065 ; 0948-4817 ; 0940-3264
    ISSN (online) 1432-1068
    ISSN 1633-8065 ; 0948-4817 ; 0940-3264
    DOI 10.1007/s00590-023-03811-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3479: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: IPM Strategy to Control EFB in

    Mosca, Michela / Gyorffy, Andrea / Pietropaoli, Marco / Giannetti, Luigi / Cersini, Antonella / Fortugno, Luca / Formato, Giovanni

    Veterinary sciences

    2024  Volume 11, Issue 1

    Abstract: We tested an integrated pest management (IPM) strategy to control European foulbrood (EFB) in honey bees. Colonies affected by EFB were assigned to two homogenous groups: an oxytetracycline-treated group (1.5 g OTC/hive) that underwent partial shook ... ...

    Abstract We tested an integrated pest management (IPM) strategy to control European foulbrood (EFB) in honey bees. Colonies affected by EFB were assigned to two homogenous groups: an oxytetracycline-treated group (1.5 g OTC/hive) that underwent partial shook swarm (PSS) in combination with queen caging (QC) and an untreated group where only two beekeeping techniques, PSS and QC, were applied. The consumption of sucrose solution, the strength of the colonies, side effects of the mentioned techniques, clinical as well as subclinical relapses of EFB, and the amount of OTC residues in the honey were assessed over a 7-month-long monitoring period. Regarding the consumption of the sucrose solution, there was no significant difference between the OTC-treated and untreated groups. The strength of the untreated colonies was consistently but not significantly higher than those treated with OTC. PSS combined with QC resulted in various side effects in both groups: queen loss (52%), absconding (8%), and drone-laying queen (4%). Untreated colonies (16.7%) showed clinical EFB relapses 4 months after the application of PSS along with QC, while 15.4% of the OTC-treated colonies were confirmed EFB-positive by PCR. OTC residues were detected in the honey yielded in the cases of both groups. Two months after the PSS, the amount of OTC residues in the untreated group was 0.6 ± 0.2 µg/kg, while that in the OTC-treated group amounted to 5.8 ± 11.6 µg/kg; both results are below the maximum residue limit (MRL) of 100 ppb considered in the EU for cascade use.
    Language English
    Publishing date 2024-01-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2768971-2
    ISSN 2306-7381 ; 2306-7381
    ISSN (online) 2306-7381
    ISSN 2306-7381
    DOI 10.3390/vetsci11010028
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  10. Article: Natural History of Hazelnut Allergy and Current Approach to Its Diagnosis and Treatment.

    Giannetti, Arianna / Ruggi, Alessandro / Ricci, Giampaolo / Giannì, Giuliana / Caffarelli, Carlo

    Children (Basel, Switzerland)

    2023  Volume 10, Issue 3

    Abstract: Hazelnut allergy is the most prevalent type of nut allergy in Europe, with symptoms that can range from mild, such as hives and itching, to severe, such as anaphylaxis, particularly in patients who are sensitized to highly stable allergens, such as ... ...

    Abstract Hazelnut allergy is the most prevalent type of nut allergy in Europe, with symptoms that can range from mild, such as hives and itching, to severe, such as anaphylaxis, particularly in patients who are sensitized to highly stable allergens, such as storage proteins. Compared to other types of food allergies, allergies to tree nuts, including hazelnuts, tend to persist throughout life. Although symptoms can appear in early childhood, they often continue into adulthood, with a minority of cases improving during adolescence. Currently, there is no curative treatment available for hazelnut allergy, and patients must adhere to a restrictive diet and carry autoinjective epinephrine. However, oral allergen immunotherapy (AIT) is a promising treatment option. Patients can be categorized based on their risk for severe reactions using various clinical, in vivo, and in vitro tests, including component-resolved diagnosis and oral food challenge. This review aims to provide an overview of the current knowledge of the natural history of hazelnut allergy and new approaches for its diagnosis and management.
    Language English
    Publishing date 2023-03-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children10030585
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