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Article ; Online: Authors' response to Das R and Neumann P. Re: Resnick NM, Perera S, Tadic S, Organist L, Riley MA, Schaefer W, Griffiths D. What predicts and what mediates response of urge urinary incontinence to biofeedback? Neurourol Urodyn. 2013 Jun;32(5):408-15.

Resnick, Neil M / Griffiths, Derek

2014 Volume 33, Issue 8, Page(s) 1280

MeSH term(s)	Biofeedback, Psychology ; Female ; Humans ; Pelvic Floor/innervation ; Urinary Bladder, Overactive/therapy ; Urinary Incontinence, Urge/therapy
Language	English
Publishing date	2014-11
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	604904-7
ISSN	1520-6777 ; 0733-2467
ISSN (online)	1520-6777
ISSN	0733-2467
DOI	10.1002/nau.22527
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Zs.A 1828: Show issues

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Article: Fractal Electronics for Stimulating and Sensing Neural Networks: Enhanced Electrical, Optical, and Cell Interaction Properties.

Moslehi, S / Rowland, C / Smith, J H / Watterson, W J / Griffiths, W / Montgomery, R D / Philliber, S / Marlow, C A / Perez, M-T / Taylor, R P

Advances in neurobiology

2024 Volume 36, Page(s) 849–875

Abstract: Imagine a world in which damaged parts of the body - an arm, an eye, and ultimately a region of the brain - can be replaced by artificial implants capable of restoring or even enhancing human performance. The associated improvements in the quality of ... ...

Abstract	Imagine a world in which damaged parts of the body - an arm, an eye, and ultimately a region of the brain - can be replaced by artificial implants capable of restoring or even enhancing human performance. The associated improvements in the quality of human life would revolutionize the medical world and produce sweeping changes across society. In this chapter, we discuss several approaches to the fabrication of fractal electronics designed to interface with neural networks. We consider two fundamental functions - stimulating electrical signals in the neural networks and sensing the location of the signals as they pass through the network. Using experiments and simulations, we discuss the favorable electrical performances that arise from adopting fractal rather than traditional Euclidean architectures. We also demonstrate how the fractal architecture induces favorable physical interactions with the cells they interact with, including the ability to direct the growth of neurons and glia to specific regions of the neural-electronic interface.
MeSH term(s)	Humans ; Fractals ; Brain/physiology ; Neural Networks, Computer ; Electronics ; Neurons
Language	English
Publishing date	2024-03-12
Publishing country	United States
Document type	Journal Article
ISSN	2190-5215
ISSN	2190-5215
DOI	10.1007/978-3-031-47606-8_43
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Article ; Online: Rapid Detection of Hepatitis A Virus in Foods Using a Bioluminescent Assay in Real-Time (BART) and Reverse Transcription Loop-Mediated Isothermal Amplification (RT-LAMP) Technology.

Wu, Ruiqin / Meng, Baozhong / Corredig, Milena / Griffiths, Mansel W

Food and environmental virology

2023 Volume 15, Issue 2, Page(s) 144–157

Abstract: Foodborne hepatitis A infections have been considered as a major threat for public health worldwide. Increased incidences of hepatitis A virus (HAV) infection has been associated with growing global trade of food products. Rapid and sensitive detection ... ...

Abstract	Foodborne hepatitis A infections have been considered as a major threat for public health worldwide. Increased incidences of hepatitis A virus (HAV) infection has been associated with growing global trade of food products. Rapid and sensitive detection of HAV in foods is very essential for investigating the outbreaks. Real-time RT-PCR has been most widely used for the detection of HAV by far. However, the technology relies on fluorescence determination of the amplicon and requires sophisticated, high-cost instruments and trained personnel, limiting its use in low resource settings. In this study, a robust, affordable, and simple assay, reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay in combination with a bioluminescence-based determination of amplification in real-time (BART), was developed for the detection of HAV in different food matrices, including green onion, strawberry, mussel, and milk. The efficiencies of a one-step RT-LAMP-BART and a two-step RT-LAMP-BART were investigated for the detection of HAV in different food matrices and was compared with that of real-time RT-PCR. The sensitivity of the RT-LAMP-BART assay was significantly affected by Mg
MeSH term(s)	Reverse Transcription ; Hepatitis A virus ; Nucleic Acid Amplification Techniques ; Luminescent Measurements/methods ; Technology ; Sensitivity and Specificity
Language	English
Publishing date	2023-01-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2487173-4
ISSN	1867-0342 ; 1867-0334
ISSN (online)	1867-0342
ISSN	1867-0334
DOI	10.1007/s12560-022-09548-7
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Article ; Online: ASO Author Reflections: Challenges in the Management of Gastroesophageal Junctional Adenocarcinoma.

Kamarajah, Sivesh K / Phillips, Alexander W / Markar, Sheraz R / Griffiths, Ewen A

Annals of surgical oncology

2021 Volume 28, Issue 13, Page(s) 8495–8496

MeSH term(s)	Adenocarcinoma/therapy ; Esophageal Neoplasms/therapy ; Humans
Language	English
Publishing date	2021-08-14
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	1200469-8
ISSN	1534-4681 ; 1068-9265
ISSN (online)	1534-4681
ISSN	1068-9265
DOI	10.1245/s10434-021-10397-0
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Article ; Online: The Neural Bases of Action-Outcome Learning in Humans.

Morris, Richard W / Dezfouli, Amir / Griffiths, Kristi R / Le Pelley, Mike E / Balleine, Bernard W

The Journal of neuroscience : the official journal of the Society for Neuroscience

2022 Volume 42, Issue 17, Page(s) 3636–3647

Abstract: From an associative perspective the acquisition of new goal-directed actions requires the encoding of specific action-outcome (AO) associations and, therefore, sensitivity to the validity of an action as a predictor of a specific outcome relative to ... ...

Abstract	From an associative perspective the acquisition of new goal-directed actions requires the encoding of specific action-outcome (AO) associations and, therefore, sensitivity to the validity of an action as a predictor of a specific outcome relative to other events. Although competitive architectures have been proposed within associative learning theory to achieve this kind of identity-based selection, whether and how these architectures are implemented by the brain is still a matter of conjecture. To investigate this issue, we trained human participants to encode various AO associations while undergoing functional neuroimaging (fMRI). We then degraded one AO contingency by increasing the probability of the outcome in the absence of its associated action while keeping other AO contingencies intact. We found that this treatment selectively reduced performance of the degraded action. Furthermore, when a signal predicted the unpaired outcome, performance of the action was restored, suggesting that the degradation effect reflects competition between the action and the context for prediction of the specific outcome. We used a Kalman filter to model the contribution of different causal variables to AO learning and found that activity in the medial prefrontal cortex (mPFC) and the dorsal anterior cingulate cortex (dACC) tracked changes in the association of the action and context, respectively, with regard to the specific outcome. Furthermore, we found the mPFC participated in a network with the striatum and posterior parietal cortex to segregate the influence of the various competing predictors to establish specific AO associations.
MeSH term(s)	Animals ; Corpus Striatum ; Gyrus Cinguli ; Humans ; Learning ; Magnetic Resonance Imaging ; Parietal Lobe ; Prefrontal Cortex ; Problem-Based Learning
Language	English
Publishing date	2022-03-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604637-x
ISSN	1529-2401 ; 0270-6474
ISSN (online)	1529-2401
ISSN	0270-6474
DOI	10.1523/JNEUROSCI.1079-21.2022
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Article ; Online: Is Running Power a Useful Metric? Quantifying Training Intensity and Aerobic Fitness Using Stryd Running Power Near the Maximal Lactate Steady State.

van Rassel, Cody R / Ajayi, Oluwatimilehin O / Sales, Kate M / Griffiths, James K / Fletcher, Jared R / Edwards, W Brent / MacInnis, Martin J

Sensors (Basel, Switzerland)

2023 Volume 23, Issue 21

Abstract: We sought to determine the utility of Stryd, a commercially available inertial measurement unit, to quantify running intensity and aerobic fitness. Fifteen (eight male, seven female) runners (age = 30.2 [4.3] years; V· ... ...

Abstract	We sought to determine the utility of Stryd, a commercially available inertial measurement unit, to quantify running intensity and aerobic fitness. Fifteen (eight male, seven female) runners (age = 30.2 [4.3] years; V·O
MeSH term(s)	Male ; Humans ; Female ; Adult ; Lactic Acid ; Reproducibility of Results ; Exercise ; Running ; Oxygen Consumption ; Exercise Test
Chemical Substances	Lactic Acid (33X04XA5AT)
Language	English
Publishing date	2023-10-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23218729
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Article ; Online: The therapeutic alliance between study participants and intervention facilitators is associated with acute effects and clinical outcomes in a psilocybin-assisted therapy trial for major depressive disorder.

Levin, Adam W / Lancelotta, Rafaelle / Sepeda, Nathan D / Gukasyan, Natalie / Nayak, Sandeep / Wagener, Theodore L / Barrett, Frederick S / Griffiths, Roland R / Davis, Alan K

PloS one

2024 Volume 19, Issue 3, Page(s) e0300501

Abstract: ... predicted depression scores at 4 weeks (r = -.65, p = .002), 6 months (r = -.47, p = .036), and 12 months (r ... correlated with higher peak ratings of mystical experiences (r = .49, p = .027) and psychological insight (r ... with depression scores at 4 weeks (r = -.45, p = .030 for mystical; r = -.75, p < .001 for insight). Stronger ...

Abstract	We examined if the therapeutic alliance between study participants and intervention facilitators in a psilocybin-assisted therapy (PAT) trial changed over time and whether there were relationships between alliance, acute psilocybin experiences, and depression outcomes. In a randomized, waiting list-controlled clinical trial for major depressive disorder in adults (N = 24), participants were randomized to an immediate (N = 13) or delayed (N = 11) condition with two oral doses of psilocybin (20mg/70kg and 30mg/70kg). Ratings of therapeutic alliance significantly increased from the final preparation session to one-week post-intervention (p = .03, d = .43). A stronger total alliance at the final preparation session predicted depression scores at 4 weeks (r = -.65, p = .002), 6 months (r = -.47, p = .036), and 12 months (r = -.54, p = .014) post-intervention. A stronger total alliance in the final preparation session was correlated with higher peak ratings of mystical experiences (r = .49, p = .027) and psychological insight (r = .52, p = .040), and peak ratings of mystical experience and psychological insight were correlated with depression scores at 4 weeks (r = -.45, p = .030 for mystical; r = -.75, p < .001 for insight). Stronger total alliance one week after the final psilocybin session predicted depression scores at 4 weeks (r = -.85, p < .001), 3 months (r = -.52, p = .010), 6 months (r = -.77, p < .001), and 12 months (r = -.61, p = .001) post-intervention. These findings highlight the importance of the therapeutic relationship in PAT. Future research should explore therapist and participant characteristics which maximize the therapeutic alliance and evaluate its relationship to treatment outcomes. Trial registration: Registration: Clinicaltrials.gov NCT03181529. https://classic.clinicaltrials.gov/ct2/show/NCT03181529.
MeSH term(s)	Adult ; Humans ; Psilocybin/therapeutic use ; Depressive Disorder, Major/drug therapy ; Therapeutic Alliance ; Treatment Outcome
Chemical Substances	Psilocybin (2RV7212BP0)
Language	English
Publishing date	2024-03-14
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0300501
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Article ; Online: Long and Short-Term Impact of Papers in Applied Spectroscopy.

Griffiths, Peter R / Blades, Michael W

Applied spectroscopy

2018 Volume 72, Issue 1_suppl, Page(s) 27–33

Abstract: In 1955, Eugene Garfield introduced the concept of a journal impact factor as a metric for measuring the importance or influence of scholarly journals. These days a journal's fate is often tied strongly to the impact factor. It is a topic that comes up ... ...

Abstract	In 1955, Eugene Garfield introduced the concept of a journal impact factor as a metric for measuring the importance or influence of scholarly journals. These days a journal's fate is often tied strongly to the impact factor. It is a topic that comes up regularly and a source of concern for the journal because of the slavish focus on metrics in the publishing world and in the academic community. From our perspective, the impact factor is shown to be a poor metric for illustrating the long-term significance of papers published in Applied Spectroscopy. The five-year impact factor is a better indicator for the short-term impact of the papers published in this journal, while the cited half-life and the citing half-life both provide a better measure of the long-term impact of papers published in Applied Spectroscopy. Of the most highly cited papers published in this journal, those that describe innovative data processing techniques have been cited more than papers that describe specific applications of a given technique such as infrared (IR), Raman, or laser-induced breakdown spectroscopy (LIBS).
Language	English
Publishing date	2018-09-28
Publishing country	United States
Document type	Journal Article
ISSN	1943-3530
ISSN (online)	1943-3530
DOI	10.1177/0003702818791928
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Article ; Online: Subjective features of the psilocybin experience that may account for its self-administration by humans: a double-blind comparison of psilocybin and dextromethorphan.

Carbonaro, Theresa M / Johnson, Matthew W / Griffiths, Roland R

Psychopharmacology

2020 Volume 237, Issue 8, Page(s) 2293–2304

Abstract: Rationale: Although both psilocybin and dextromethorphan (DXM) produce psychedelic-like subjective effects, rates of non-medical use of psilocybin are consistently greater than DXM.: Objective: New data are presented from a study of psilocybin and ... ...

Abstract	Rationale: Although both psilocybin and dextromethorphan (DXM) produce psychedelic-like subjective effects, rates of non-medical use of psilocybin are consistently greater than DXM. Objective: New data are presented from a study of psilocybin and DXM relevant to understanding the features of psilocybin subjective effects that may account for its higher rates of non-medical use. Methods: Single, acute oral doses of psilocybin (10, 20, 30 mg/70 kg), DXM (400 mg/70 kg), and placebo were administered under double-blind conditions to 20 healthy participants with histories of hallucinogen use. Results: High doses of both drugs produced similar time courses and increases in participant ratings of peak overall drug effect strength. Nine subjective effect domains are proposed to be related to the reinforcing effects of psilocybin: liking, visual effects, positive mood, insight, positive social effects, increased awareness of beauty (both visual and music), awe/amazement, meaningfulness, and mystical experience. For most ratings, (1) psilocybin and DXM both produced effects significantly greater than placebo; (2) psilocybin showed dose-related increases; 3, DXM was never significantly higher than psilocybin; (4) the two highest psilocybin doses were significantly greater than DXM. These differences were consistent with two measures of desire to take the drug condition again. Conclusions: This analysis provides new information about domains of psilocybin subjective effects proposed to be related to its reinforcing effects (alternatively described as the "motivation" to use). Observed differences on these domains between psilocybin and DXM are consistent with the relative rates of non-medical use of psilocybin and DXM.
MeSH term(s)	Adult ; Affect/drug effects ; Affect/physiology ; Dextromethorphan/administration & dosage ; Dose-Response Relationship, Drug ; Double-Blind Method ; Excitatory Amino Acid Antagonists/administration & dosage ; Female ; Follow-Up Studies ; Hallucinogens/administration & dosage ; Humans ; Male ; Motivation/drug effects ; Motivation/physiology ; Music/psychology ; Psilocybin/administration & dosage ; Reinforcement, Psychology ; Retrospective Studies ; Self Administration/psychology ; Young Adult
Chemical Substances	Excitatory Amino Acid Antagonists ; Hallucinogens ; Psilocybin (2RV7212BP0) ; Dextromethorphan (7355X3ROTS)
Language	English
Publishing date	2020-06-05
Publishing country	Germany
Document type	Comparative Study ; Journal Article
ZDB-ID	130601-7
ISSN	1432-2072 ; 0033-3158
ISSN (online)	1432-2072
ISSN	0033-3158
DOI	10.1007/s00213-020-05533-9
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Ui I Zs.240: Show issues

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Article ; Online: Three-Dimensional Human Neural Stem Cell Models to Mimic Heparan Sulfate Proteoglycans and the Neural Niche.

Peall, Ian W / Okolicsanyi, Rachel K / Griffiths, Lyn R / Haupt, Larisa M

Seminars in thrombosis and hemostasis

2021 Volume 47, Issue 3, Page(s) 308–315

Abstract: Heparan sulfate proteoglycans (HSPGs) are a diverse family of polysaccharides, consisting of a core protein with glycosaminoglycan (GAG) side chains attached. The heterogeneous GAG side-chain carbohydrates consist of repeating disaccharides, with each ... ...

Abstract	Heparan sulfate proteoglycans (HSPGs) are a diverse family of polysaccharides, consisting of a core protein with glycosaminoglycan (GAG) side chains attached. The heterogeneous GAG side-chain carbohydrates consist of repeating disaccharides, with each side chain possessing a specific sulfation pattern. It is the variable sulfation pattern that allows HSPGs to interact with numerous ligands including growth factors, cytokines, chemokines, morphogens, extracellular matrix (ECM) glycoproteins, collagens, enzymes, and lipases. HSPGs are classified according to their localization within an individual cell, and include the membrane bound syndecans (SDCs) and glypicans (GPCs), with perlecan, agrin, and type-XVIII collagen secreted into the ECM. The stem cell niche is defined as the environment that circumscribes stem cells when they are in their naïve state, and includes the ECM, which provides a complex contribution to various biological processes during development and throughout life. These contributions include facilitating cell adhesion, proliferation, migration, differentiation, specification, and cell survival. In contrast, HSPGs play an anticoagulant role in thrombosis through being present on the luminal surface of cells, while also playing roles in the stimulation and inhibition of angiogenesis, highlighting their varied and systemic roles in cellular control. To fully understand the complexities of cell-cell and cell-matrix interactions, three-dimensional (3D) models such as hydrogels offer researchers exciting opportunities, such as controllable 3D in vitro environments, that more readily mimic the in vivo
MeSH term(s)	Cell Differentiation ; Heparan Sulfate Proteoglycans/metabolism ; Humans ; Neural Stem Cells/metabolism ; Stem Cell Niche/genetics
Chemical Substances	Heparan Sulfate Proteoglycans
Language	English
Publishing date	2021-04-01
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	196901-8
ISSN	1098-9064 ; 0094-6176
ISSN (online)	1098-9064
ISSN	0094-6176
DOI	10.1055/s-0041-1724117
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