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  1. Article: Skull Base Osteomyelitis from Otitis Media Presenting as the Collet-Sicard Syndrome.

    Low, Wong-Kein / Lhu, Hui-Ling

    Case reports in otolaryngology

    2018  Volume 2018, Page(s) 1407417

    Abstract: Skull base osteomyelitis can involve the jugular foramen and its associated cranial nerves resulting in specific clinical syndromes. The Collet-Sicard syndrome describes the clinical manifestations of palsies involving cranial nerves IX, X, XI, and XII. ... ...

    Abstract Skull base osteomyelitis can involve the jugular foramen and its associated cranial nerves resulting in specific clinical syndromes. The Collet-Sicard syndrome describes the clinical manifestations of palsies involving cranial nerves IX, X, XI, and XII. We present a rare atypical case of skull base osteomyelitis originating from infection of the middle ear and causing the Collet-Sicard syndrome. Caused by
    Language English
    Publishing date 2018-03-18
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2648756-1
    ISSN 2090-6773 ; 2090-6765
    ISSN (online) 2090-6773
    ISSN 2090-6765
    DOI 10.1155/2018/1407417
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Concomitant Obstructive Sleep Apnoea in Patients with Meniere's Disease: A Case Report and Literature Review.

    Low, Wong Kein / Lim, Esther Jiayi

    Case reports in otolaryngology

    2021  Volume 2021, Page(s) 5592611

    Abstract: Meniere's disease (MD) is a condition characterised by fluctuating and progressive hearing loss, aural fullness, tinnitus, and intermittent attacks of vertigo. The disabling vertigo symptoms can be controlled in most patients by lifestyle changes and ... ...

    Abstract Meniere's disease (MD) is a condition characterised by fluctuating and progressive hearing loss, aural fullness, tinnitus, and intermittent attacks of vertigo. The disabling vertigo symptoms can be controlled in most patients by lifestyle changes and medications such as diuretics. Should standard medical therapy fail, the patient may require surgery in order to control the disease, but such surgical procedures can be functionally destructive. Obstructive sleep apnoea syndrome (OSAS) is common, especially in people who are grossly overweight. Up to 15% of patients with MD may have concomitant OSA. Unless the OSA is well controlled, such patients may continue to experience MD symptoms despite receiving adequate standard medical therapy for MD. Moreover, MD patients may experience insomnia as a result of vertigo and/or tinnitus where sedatives are indicated. The use of sedatives with muscle relaxant properties may inadvertently further aggravate OSA resulting in a vicious cycle of symptoms. Symptoms suggestive of concomitant OSA must be proactively sought as these patients do not necessarily exhibit the obvious phenotypic features of OSA. This is especially so in Asians where OSAS is commonly observed in people who are not overly obese. We report a case of a female patient who presented with recalcitrant MD disease and was later found to have concomitant OSA. The relevant literature will be reviewed, and learning points will be discussed from the perspective of the otologist/neurotologist. The clinician must always be mindful of the existence of concomitant "silent" OSAS as this impacts the management of patients with MD.
    Language English
    Publishing date 2021-03-23
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2648756-1
    ISSN 2090-6773 ; 2090-6765
    ISSN (online) 2090-6773
    ISSN 2090-6765
    DOI 10.1155/2021/5592611
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  3. Article: Leprosy: face beyond the cranial nerves.

    Low, Wong-Kein

    Neurology India

    2006  Volume 54, Issue 3, Page(s) 249

    MeSH term(s) Cranial Nerve Diseases/epidemiology ; Cranial Nerve Diseases/microbiology ; Cranial Nerve Diseases/pathology ; Face/pathology ; Humans ; Leprosy/epidemiology ; Leprosy/microbiology ; Leprosy/pathology ; Mycobacterium/pathogenicity
    Language English
    Publishing date 2006-09
    Publishing country India
    Document type Journal Article
    ZDB-ID 415522-1
    ISSN 1998-4022 ; 0028-3886
    ISSN (online) 1998-4022
    ISSN 0028-3886
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 698: Show issues Location:
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  4. Article ; Online: Leprosy

    Low Wong-Kein

    Neurology India, Vol 54, Iss 3, Pp 249-

    Face beyond the cranial nerves

    2006  Volume 249

    Keywords Neurology. Diseases of the nervous system ; RC346-429 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Neurology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2006-01-01T00:00:00Z
    Publisher Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Facial palsy from metastatic nasopharyngeal carcinoma at various sites: three reports.

    Low, Wong-Kein

    Ear, nose, & throat journal

    2002  Volume 81, Issue 2, Page(s) 99–101

    Abstract: Nasopharyngeal carcinoma that causes clinically evident facial palsy is uncommon. This article describes and discusses a series of cases that illustrates how nasopharyngeal carcinoma caused facial palsy as a result of facial nerve involvement at three ... ...

    Abstract Nasopharyngeal carcinoma that causes clinically evident facial palsy is uncommon. This article describes and discusses a series of cases that illustrates how nasopharyngeal carcinoma caused facial palsy as a result of facial nerve involvement at three sites: the cerebellopontine angle, the middle ear, and the parotid. The maxim, "All that palsies is not Bell's," is particularly relevant with respect to patients who have previously been treated for advanced nasopharyngeal carcinoma. In these patients, recurrent or persistent nasopharyngeal carcinoma involving the cerebellopontine angle, temporal bone, or parotid should be excluded.
    MeSH term(s) Adult ; Carcinoma, Squamous Cell/complications ; Carcinoma, Squamous Cell/secondary ; Cerebellar Neoplasms/complications ; Cerebellar Neoplasms/secondary ; Cerebellopontine Angle ; Cranial Nerve Neoplasms/complications ; Cranial Nerve Neoplasms/secondary ; Facial Paralysis/etiology ; Fatal Outcome ; Humans ; Male ; Middle Aged ; Nasopharyngeal Neoplasms/pathology ; Parotid Neoplasms/complications ; Parotid Neoplasms/secondary ; Skull Neoplasms/complications ; Skull Neoplasms/secondary
    Language English
    Publishing date 2002-02
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 750153-5
    ISSN 1942-7522 ; 0145-5613
    ISSN (online) 1942-7522
    ISSN 0145-5613
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    In stock of ZB MED Cologne/Königswinter

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  6. Article ; Online: Management of major post-cochlear implant wound infections.

    Low, Wong-Kein / Rangabashyam, Mahalakshmi / Wang, Feifan

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2013  Volume 271, Issue 9, Page(s) 2409–2413

    Abstract: In post-cochlear implant (CI) wound infections, a commonly asked question is whether the device could be salvaged and if so, what the challenges were. The aim of this article is to study patients with major post-CI wound infections, identify the risk ... ...

    Abstract In post-cochlear implant (CI) wound infections, a commonly asked question is whether the device could be salvaged and if so, what the challenges were. The aim of this article is to study patients with major post-CI wound infections, identify the risk factors and discuss the management. The case records all CI recipients who developed post-CI wound infections that required parenteral antibiotics treatment or any form of surgery between Jan 1997 and Dec 2011 were retrospectively reviewed. Among the 432 CI surgeries performed by the senior author, 7 developed major post-CI wound infection (1.62 %). In children, the commonest etiology was from stitch abscesses. In four out of the five children who developed stitch abscesses, four were due to the use of non-absorbable polypropylene sutures, a technique which had since been discontinued. In adults, the cause was due to the late effects of prior radiotherapy for head and neck tumors. The commonest organism isolated from wound cultures was Staphylococcus aureus. Salvage surgery (complemented by antibiotics) was attempted in six out of eight patients managed. All were successfully salvaged with surgery entailing either skin flap reconstruction (2 patients), transposition of the CI body to new location (1 patient) or both (3 patients). Skin flap reconstruction surgery alone failed to control the infection in patients with a negative culture result and needed a subsequent transposition surgery of the device. Device transposition surgery was a consistently effective therapeutic approach, but carried a higher risk of iatrogenic damage to the electrode array as it might be embedded in new bone.
    MeSH term(s) Adult ; Anti-Bacterial Agents/therapeutic use ; Child ; Child, Preschool ; Cochlear Implantation/adverse effects ; Cochlear Implants/adverse effects ; Female ; Head and Neck Neoplasms/radiotherapy ; Humans ; Male ; Middle Aged ; Radiotherapy/adverse effects ; Retrospective Studies ; Risk Factors ; Surgical Wound Infection/epidemiology ; Surgical Wound Infection/microbiology ; Surgical Wound Infection/therapy
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2013-10-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-013-2732-5
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    In stock of ZB MED Cologne/Königswinter

    Ul II Zs.50: Show issues Location:
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  7. Article ; Online: Idiopathic sudden hearing loss: is there a role for complementary treatment?

    Low, Wong Kein

    Journal of alternative and complementary medicine (New York, N.Y.)

    2013  Volume 19, Issue 9, Page(s) 785–786

    MeSH term(s) Complementary Therapies ; Hearing Loss, Sensorineural/etiology ; Hearing Loss, Sensorineural/therapy ; Hearing Loss, Sudden/etiology ; Hearing Loss, Sudden/therapy ; Humans
    Language English
    Publishing date 2013-09
    Publishing country United States
    Document type Letter
    ZDB-ID 1237383-7
    ISSN 1557-7708 ; 1075-5535
    ISSN (online) 1557-7708
    ISSN 1075-5535
    DOI 10.1089/acm.2012.0960
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4366: Show issues Location:
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  8. Article: Is Electroacupuncture Treatment More Effective in Somatic Tinnitus Than in Nonsomatic Tinnitus?

    Low, Wong-Kein / Rangabashyam, Mahalakshmi Shetty / Cui, Shu Li / Dsouza, Vishal Deepak / Ong, Chun Suan / Teng, Siaw Wei / Li, Hui Hua

    Medical acupuncture

    2017  Volume 29, Issue 3, Page(s) 138–144

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2017-05-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2296110-0
    ISSN 1933-6594 ; 1933-6586
    ISSN (online) 1933-6594
    ISSN 1933-6586
    DOI 10.1089/acu.2017.1223
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  9. Article: Accidental Explantation of a Cochlear Implant in a Child Who Developed Cholesteatoma as a Late Complication of Cochlear Implantation.

    Low, Wong Kein / Pok, Wan Ni / Ng, Win Nie / Tan, Judy

    Case reports in otolaryngology

    2020  Volume 2020, Page(s) 6353706

    Abstract: Introduction: Although rare, cholesteatoma can develop as a late complication of cochlear implantation. The electrode array may then be exposed in the external auditory canal surrounded by cholesteatoma debris. : Conclusion: If aural toilet is ... ...

    Abstract Introduction: Although rare, cholesteatoma can develop as a late complication of cochlear implantation. The electrode array may then be exposed in the external auditory canal surrounded by cholesteatoma debris.
    Conclusion: If aural toilet is required in the implanted ear of a cochlear implant recipient, any complaint of hearing change, pain, or discharge should alert the clinician of the possibility of cholesteatoma developing. It warrants prompt evaluation by an experienced otologist in order to prevent accidental explantation.
    Language English
    Publishing date 2020-10-09
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2648756-1
    ISSN 2090-6773 ; 2090-6765
    ISSN (online) 2090-6773
    ISSN 2090-6765
    DOI 10.1155/2020/6353706
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  10. Article ; Online: Synergistic Ototoxicity of Gentamicin and Low-Dose Irradiation: Molecular Basis and Clinical Significance.

    Low, Wong Kein / Teng, Siaw Wei / Tan, Michelle G K

    Audiology & neuro-otology

    2019  Volume 25, Issue 3, Page(s) 111–119

    Abstract: ... the synergistic ototoxicity of combined gentamicin and low-dose irradiation treatment and identify the underlying ... low-dose irradiation, and their combination in the OC-k3 mouse cochlear cell line using cell viability ... of LC3b-II and SQSTM1/p62, suggesting an impairment of autophagic flux. Low-dose irradiation induced ...

    Abstract Background: Inner ear structures may be included in the radiation fields when irradiation is used to treat patients with head and neck cancers. These patients may also have concurrent infections that require gentamicin treatment. Radiation and gentamicin are both potentially ototoxic, and their combined use has been shown to result in synergistic ototoxicity in animals.
    Objective: We aimed to confirm the synergistic ototoxicity of combined gentamicin and low-dose irradiation treatment and identify the underlying molecular mechanisms using an in vitro model.
    Method: We compared the ototoxic effects of gentamicin, low-dose irradiation, and their combination in the OC-k3 mouse cochlear cell line using cell viability assay, live/dead stain, apoptosis detection assay, oxidative stress detection, and studied the molecular mechanisms involved using immunoblot analysis.
    Results: Combined treatment led to prolonged oxidative stress, reduced cell viability, and synergistic apoptosis. Gentamicin induced the concurrent accumulation of LC3b-II and SQSTM1/p62, suggesting an impairment of autophagic flux. Low-dose irradiation induced transient p53 phosphorylation and persistent Akt phosphorylation in response to DNA damage. In combined treatment, gentamicin attenuated irradiation-induced Akt activation.
    Conclusions: Besides increased oxidative stress, synergistic apoptosis observed in combined treatment could be attributed to gentamicin-induced perturbation of autophagic flux and attenuation of Akt phosphorylation, which led to an impairment of radiation-induced DNA repair response.
    MeSH term(s) Animals ; Apoptosis/drug effects ; Apoptosis/radiation effects ; Cell Line ; Cochlea/drug effects ; Cochlea/radiation effects ; Gentamicins/adverse effects ; Mice ; Ototoxicity/etiology ; Phosphorylation ; Radiotherapy/adverse effects
    Chemical Substances Gentamicins
    Language English
    Publishing date 2019-12-13
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1314086-3
    ISSN 1421-9700 ; 1420-3030
    ISSN (online) 1421-9700
    ISSN 1420-3030
    DOI 10.1159/000503133
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4518: Show issues Location:
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