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  1. AU=Nixon G M
  2. AU="Di Girolamo, Nicola"
  3. AU="Fedina, Veronika"
  4. AU="Chao Xing"
  5. AU="Files, Megan"
  6. AU="Pietrzykowski, Łukasz"
  7. AU="Karimi, Poorya"
  8. AU="Mannava, Yamini"
  9. AU="Sangiovanni, Giuseppe"
  10. AU="Duff, John H."
  11. AU="Jin, Peng"
  12. AU="Bursill, Christina A"
  13. AU="Huchzermeyer, Cord"
  14. AU="Di Caprio, Simone"
  15. AU="Firl, Christina E M"
  16. AU="Davies, Jane" AU="Davies, Jane"
  17. AU="Srinivasan, Karpagam"
  18. AU="Pritam Banerjee"
  19. AU="Fried, Miriam"
  20. AU="Andita P. Newton"
  21. AU="Larsen, B. B."
  22. AU="McPheeters, D"

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  1. Artikel ; Online: Kangaroo mother care improves cardiorespiratory physiology in preterm infants: an observational study.

    Sehgal, Arvind / Yeomans, Emma J / Nixon, Gillian M

    Archives of disease in childhood. Fetal and neonatal edition

    2024  

    Abstract: ... of the cohort were 28.4±2.1 weeks and 1137±301 g, respectively. Dips in SpO: Conclusions: KMC improves ...

    Abstract Objectives: To evaluate whether kangaroo mother care (KMC) in preterm infants on non-invasive respiratory support improves indices of cardiorespiratory wellbeing.
    Study design: Prospective quasi-experimental observational study.
    Setting: Tertiary perinatal neonatal unit.
    Patients: 50 very preterm infants being managed with nasal continuous positive airway pressure.
    Interventions: Continuous high-resolution preductal pulse-oximetry recordings using Masimo Radical-7 oximeter for 1 hour (incubator care) followed by 1 hour during KMC performed on the same day.
    Main outcome measures: Measures of cardiorespiratory stability (dips in oxygen saturations (SpO
    Results: The gestational age and birth weight of the cohort were 28.4±2.1 weeks and 1137±301 g, respectively. Dips in SpO
    Conclusions: KMC improves cardiorespiratory stability in ventilated preterm infants. Regular KMC has the potential to improve clinical outcomes in this vulnerable cohort.
    Sprache Englisch
    Erscheinungsdatum 2024-03-27
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2007331-8
    ISSN 1468-2052 ; 1359-2998
    ISSN (online) 1468-2052
    ISSN 1359-2998
    DOI 10.1136/archdischild-2023-326748
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  2. Artikel ; Online: Mechanical scission of a knotted polymer.

    Zhang, Min / Nixon, Robert / Schaufelberger, Fredrik / Pirvu, Lucian / De Bo, Guillaume / Leigh, David A

    Nature chemistry

    2024  

    Abstract: Molecular knots and entanglements form randomly and spontaneously in both biological and synthetic polymer chains. It is known that macroscopic materials, such as ropes, are substantially weakened by the presence of knots, but until now it has been ... ...

    Abstract Molecular knots and entanglements form randomly and spontaneously in both biological and synthetic polymer chains. It is known that macroscopic materials, such as ropes, are substantially weakened by the presence of knots, but until now it has been unclear whether similar behaviour occurs on a molecular level. Here we show that the presence of a well-defined overhand knot in a polymer chain substantially increases the rate of scission of the polymer under tension (≥2.6× faster) in solution, because deformation of the polymer backbone induced by the tightening knot activates otherwise unreactive covalent bonds. The fragments formed upon severing of the knotted chain differ from those that arise from cleavage of a similar, but unknotted, polymer. Our solution studies provide experimental evidence that knotting can contribute to higher mechanical scission rates of polymers. It also demonstrates that entanglement design can be used to generate mechanophores that are among the most reactive described to date, providing opportunities to increase the reactivity of otherwise inert functional groups.
    Sprache Englisch
    Erscheinungsdatum 2024-04-22
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2464596-5
    ISSN 1755-4349 ; 1755-4330
    ISSN (online) 1755-4349
    ISSN 1755-4330
    DOI 10.1038/s41557-024-01510-3
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  3. Artikel ; Online: Prediction of obstructive sleep apnoea in children and adolescents with Down syndrome.

    Wijayaratne, P R / Williams, K / Davey, M J / Horne, R S C / Nixon, G M

    Journal of intellectual disability research : JIDR

    2023  Band 67, Heft 9, Seite(n) 880–892

    Abstract: Background: Obstructive sleep apnoea (OSA) is common in children and adolescents with Down syndrome (DS). Clinical guidelines recommend that all children with DS have polysomnography (PSG) for assessment of OSA by the age of 4 years, but access is ... ...

    Abstract Background: Obstructive sleep apnoea (OSA) is common in children and adolescents with Down syndrome (DS). Clinical guidelines recommend that all children with DS have polysomnography (PSG) for assessment of OSA by the age of 4 years, but access is limited and testing may be burdensome for children and families.
    Methods: The purpose of this prospective cross-sectional cohort study was to identify a model to predict OSA in this group that could be tested in an external population to triage children and adolescents with DS for PSG. These models were based on a comprehensive set of potential predictive demographic, anthropometric, quality of life and sleep-related variables.
    Results: The results of this study show the predictive power of a model based on the sleep disordered breathing subscale of the Pediatric Sleep Survey Instrument and sleep fragmentation quantified using actigraphy in determining moderate-severe OSA in children and adolescents with DS. This model exhibits high sensitivity (82%), specificity (80%), positive predictive value (75%) and negative predictive value (86%).
    Conclusions: We demonstrate the utility of a tool containing the sleep disordered breathing subscale of the Pediatric Sleep Survey Instrument and sleep fragmentation quantified using actigraphy in identifying children and adolescents with DS who have moderate/severe OSA.
    Mesh-Begriff(e) Child ; Child, Preschool ; Female ; Humans ; Male ; Actigraphy ; Cohort Studies ; Cross-Sectional Studies ; Down Syndrome/complications ; Likelihood Functions ; Quality of Life ; Regression Analysis ; Sensitivity and Specificity ; Sleep ; Sleep Apnea Syndromes ; Sleep Apnea, Obstructive/complications ; Sleep Apnea, Obstructive/diagnosis ; Sleep Apnea, Obstructive/physiopathology ; Sleep Deprivation ; Surveys and Questionnaires
    Sprache Englisch
    Erscheinungsdatum 2023-06-29
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1103832-9
    ISSN 1365-2788 ; 0964-2633
    ISSN (online) 1365-2788
    ISSN 0964-2633
    DOI 10.1111/jir.13065
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Optical polarization analogs in inelastic free-electron scattering.

    Bourgeois, Marc R / Nixon, Austin G / Chalifour, Matthieu / Masiello, David J

    Science advances

    2023  Band 9, Heft 51, Seite(n) eadj6038

    Abstract: Advances in the ability to manipulate free-electron phase profiles within the electron microscope have spurred development of quantum-mechanical descriptions of electron energy loss (EEL) processes involving transitions between phase-shaped transverse ... ...

    Abstract Advances in the ability to manipulate free-electron phase profiles within the electron microscope have spurred development of quantum-mechanical descriptions of electron energy loss (EEL) processes involving transitions between phase-shaped transverse states. Here, we elucidate an underlying connection between two ostensibly distinct optical polarization analogs identified in EEL experiments as manifestations of the same conserved scattering flux. Our work introduces a procedure for probing general tensorial target characteristics including global mode symmetries and local polarization.
    Sprache Englisch
    Erscheinungsdatum 2023-12-20
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.adj6038
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  5. Artikel ; Online: Validation of the Psychosocial Assessment Tool 2.0 for paediatric burn patients.

    Hocking, Phoebe / Broadhurst, Miriam / Nixon, Reginald D V / Gannoni, Anne

    Burns : journal of the International Society for Burn Injuries

    2023  Band 49, Heft 7, Seite(n) 1632–1642

    Abstract: ... Methods: Sixty-eight children aged between 6 months - 16 years (M = 4.40) admitted into hospital ... purposes (e.g., caregiver reports of family functioning, child emotional and behavioural problems ... g., posttraumatic stress and depression). Measures were completed within 3 weeks of child admission ...

    Abstract Objective: The Psychosocial Assessment Tool 2.0 (PAT-B) is an adaptation of an existing screening tool with the aim of the present study to examine its effectiveness and suitability to identify children and families at risk of emotional, behavioral, and social maladjustment following paediatric burns.
    Methods: Sixty-eight children aged between 6 months - 16 years (M = 4.40) admitted into hospital following paediatric burns, and their primary caregivers, were recruited. The PAT-B comprises several dimensions including family structure and resources, social support, as well as caregiver and child psychological difficulties. Caregivers completed the PAT-B and several standardized measures for validation purposes (e.g., caregiver reports of family functioning, child emotional and behavioural problems, caregiver distress). Children old enough to complete measures reported on their psychological functioning (e.g., posttraumatic stress and depression). Measures were completed within 3 weeks of child admission and then again at 3 months after burn.
    Results: The PAT-B demonstrated good construct validity, evidenced by moderate to strong correlations between the PAT-B Total and subscale scores and several criteria measures (family functioning, child behaviour and caregiver distress, child depressive symptoms, rs ranging from 0.33 -0.74). Preliminary support for criterion validity of the measure was observed when examined against the three tiers of the Paediatric Psychosocial Preventative Health Model. The proportion of families falling within these tiers of risk (Universal [low risk], 58.2%; Targeted, 31.3%; or Clinical range, 10.4%) was consistent with prior research. Sensitivity of the PAT-B to identify children and caregivers at high risk of psychological distress was 71% and 83%, respectively.
    Conclusion: The PAT-B appears to be a reliable and valid instrument for indexing psychosocial risk across families who have sustained a paediatric burn. However, further testing and replication using a larger sample size is recommended before the tool is integrated into routine clinical care.
    Mesh-Begriff(e) Humans ; Child ; Infant ; Burns ; Accidental Falls ; Emotions ; Family Structure ; Hospitalization ; Caregivers
    Sprache Englisch
    Erscheinungsdatum 2023-05-06
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 197308-3
    ISSN 1879-1409 ; 0305-4179
    ISSN (online) 1879-1409
    ISSN 0305-4179
    DOI 10.1016/j.burns.2023.05.002
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  6. Artikel ; Online: What does it mean to be an allied health professional working in rural Aotearoa New Zealand? A qualitative study.

    Walker, Sarah M / Blattner, Katharina / Nixon, Garry / Koroheke Rogers, Marara / Kennedy, Ewan

    The Australian journal of rural health

    2023  Band 32, Heft 1, Seite(n) 53–66

    Abstract: Objective: Building health services and workforce that are both well supported and fit for purpose is a key consideration for improving health outcomes in rural populations. Achieving this requires an understanding of the roles and practice ... ...

    Abstract Objective: Building health services and workforce that are both well supported and fit for purpose is a key consideration for improving health outcomes in rural populations. Achieving this requires an understanding of the roles and practice characteristic of each professional group, including allied health professionals. This study explores what it means to be an allied health professional practicing in rural Aotearoa New Zealand.
    Design: A qualitative study design was used, involving individual semi-structured interviews with 13 rural allied health professionals in the Otago and Northland regions. The interviews explored participants journey into rural practice, their experiences working rurally, and their views on rural practice.
    Findings: Four main themes were derived: Identity; Connectedness; Expectations; and Providing Care.
    Discussion: Proud of being rural, these allied health professionals are immersed within their community, intertwining their professional and personal identities. The unique nature of this dual identity while empowering for some, can also isolate rural allied health professionals from their professional bodies and urban peers. This leads to a sense of vulnerability and feeling undervalued and invisible. In response, rural allied health professionals choose to form strong connections to their local interprofessional team and their community. The connections they forge, and the breadth of their skills cumulate to enable allied health professionals to provide dynamic and responsive health services for their rural communities.
    Conclusion: This study provides the first insight into experiences and perspectives of allied health professionals within rural Aotearoa New Zealand. Despite the challenges, a sense of pride is associated with practicing rurally for allied health professionals.
    Mesh-Begriff(e) Humans ; Rural Population ; Rural Health Services ; New Zealand ; Allied Health Personnel ; Qualitative Research
    Sprache Englisch
    Erscheinungsdatum 2023-11-14
    Erscheinungsland Australia
    Dokumenttyp Journal Article
    ZDB-ID 2069573-1
    ISSN 1440-1584 ; 1038-5282
    ISSN (online) 1440-1584
    ISSN 1038-5282
    DOI 10.1111/ajr.13061
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  7. Artikel ; Online: Bleeding self-assessments by patients with immune thrombocytopenia (ITP): An agreement study.

    Clerici, Bianca / Masood, Sahrish / Nazy, Ishac / Tang, Ngan / Cranstone, Madison / Liu, Yang / Hadzi-Tosev, Milena / Nixon, Joanne / St John, Melanie / Shirinzadeh, Maryam / Jamula, Erin / Kelton, John G / Arnold, Donald M

    American journal of hematology

    2024  Band 99, Heft 6, Seite(n) 1184–1186

    Abstract: We designed anagreement study to compare the results of bleeding assessments done in tandem by ITP patients and trained research staff. We used a modified version of the ITP Bleeding Scale, which captured the patients' worst bleeding event at any of nine ...

    Abstract We designed anagreement study to compare the results of bleeding assessments done in tandem by ITP patients and trained research staff. We used a modified version of the ITP Bleeding Scale, which captured the patients' worst bleeding event at any of nine anatomical sites since the time of the last assessment. Interrater agreement was determined using the 2-way kappa for the assessment of severe vs. non-severe bleeds. We analyzed 108 consecutive patients with ITP from the McMaster ITP Registry who had duplicate bleeding assessments. Two-way agreement was excellent for gynecological (k = 0.86, 95% CI 0.71-1.02), gastrointestinal (k = 1), genitourinary (k = 1), pulmonary (k = 1) and intracranial (k = 1) bleeds; good for skin (k = 0.68, 95% CI, 0.54-0.82), oral (k = 0.76, 95% CI, 0.53-0.98) and ocular (k = 0.66, 95% CI, 0.04-1-28) bleeds; and moderate for epistaxis (k = 0.58, 95% CI, 0.21-0.95). Bleeding self-assessments by ITP patients were similar to trained research staff, but disagreements in severity grades were more frequent with skin bleeds, oral bleeds and epistaxis. Bleeding self-assessments could simplify bleeding assessments in clinical trials.
    Mesh-Begriff(e) Humans ; Purpura, Thrombocytopenic, Idiopathic/complications ; Female ; Male ; Hemorrhage/etiology ; Middle Aged ; Adult ; Aged
    Sprache Englisch
    Erscheinungsdatum 2024-03-27
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Letter
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.27298
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    Zs.A 1251: Hefte anzeigen Standort:
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  8. Artikel ; Online: Retrospective Hair Cortisol Concentrations from Pretreatment to Early Recovery in Alcohol Use Disorder.

    Price, Julianne L / Nixon, Sara Jo

    Alcohol and alcoholism (Oxford, Oxfordshire)

    2020  Band 56, Heft 2, Seite(n) 181–184

    Abstract: Cortisol profiles are known to vary across phases of alcohol use disorder (AUD; e.g. chronic use ... significantly lower than both the distal (M∆ = 0.200, P = 0.004) and mid (M∆ = 0.175, P < 0.001) segments ...

    Abstract Cortisol profiles are known to vary across phases of alcohol use disorder (AUD; e.g. chronic use, withdrawal and early/sustained recovery). These patterns have largely been established through between-subjects contrasts. Using a segmental hair cortisol concentrations (HCC) approach, retrospective longitudinal analyses are feasible. Here, we examine monthly cortisol secretion in treatment-seekers with AUD from alcohol use to abstinence. At ~6 weeks of recovery we collected hair samples from individuals with moderate-to-severe AUD. We examined HCC from three consecutive segments; proximal to the scalp representing the most recent month (sustained abstinence from alcohol), the midsegment representing the previous month in which abstinence was attained, and the distal segment representing 2 months prior during active drinking. Analyses examined main and interactive effects of segment and sex, controlling for monthly alcohol consumption. Best fit by a quadratic shape, within-subject change was significant (F1,15 = 5.27, P = 0.04, ηpartial2 = 0.26). The distal and midsegments did not differ from one another (P = 0.51). The proximal segment was significantly lower than both the distal (M∆ = 0.200, P = 0.004) and mid (M∆ = 0.175, P < 0.001) segments. An effect of sex approached significance suggesting women had modestly higher HCC than men (MWOMEN = 1.37 vs. MMEN = 1.02, P = 0.10). Consistent with previous cross-sectional reports, these data confirm nonlinear patterns of cortisol accumulation with elevations apparent during periods of alcohol consumption and a decrease in abstinence. Capturing these within-subject patterns via HCC trajectories may serve as a valuable resource in identifying profiles associated with increased risk and post-treatment outcomes.
    Mesh-Begriff(e) Adult ; Alcohol Abstinence ; Alcoholism/rehabilitation ; Female ; Hair/chemistry ; Humans ; Hydrocortisone/analysis ; Male ; Middle Aged ; Recovery of Function ; Retrospective Studies
    Chemische Substanzen Hydrocortisone (WI4X0X7BPJ)
    Sprache Englisch
    Erscheinungsdatum 2020-12-05
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 604956-4
    ISSN 1464-3502 ; 0309-1635 ; 0735-0414
    ISSN (online) 1464-3502
    ISSN 0309-1635 ; 0735-0414
    DOI 10.1093/alcalc/agaa127
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  9. Artikel ; Online: Superficial soft tissue sarcomas: 10‑year survival outcomes.

    Tolia, Maria / Gkantaifi, Areti / Hayward, Larry / Gupta, Girish / Kyriazoglou, Anastasios / Mauri, Davide / Nixon, Ioanna

    Oncology letters

    2023  Band 25, Heft 3, Seite(n) 96

    Abstract: Cutaneous sarcomas comprise a broad group of rare, heterogeneous mesenchymal tumours. The present report describes a single centre experience regarding the management and the outcomes of patients with superficial soft tissue sarcomas (SSTS). Key ... ...

    Abstract Cutaneous sarcomas comprise a broad group of rare, heterogeneous mesenchymal tumours. The present report describes a single centre experience regarding the management and the outcomes of patients with superficial soft tissue sarcomas (SSTS). Key prognostic factors in predicting overall survival (OS) and local relapse-free survival were determined. Data from 66 patients with SSTS treated surgically within Edinburgh and Lothian were collected in the context of a service evaluation. Patient demographics, tumour specifics and treatment, as well as 5-year OS and local recurrence, were analysed. Kaplan-Meier analysis was applied for survival curves, and mortality rate estimation and Cox regression were used to establish independent predictors. The mean estimated OS time was 57.2 months, with a 95% CI between 55.0 and 59.5 months. The median OS time could not be estimated because there is no time point during which the survival function has a value <50%. The death risk for a person with SSTS was increased by 7.3% (odds ratio, 1.073; 95% CI, 1.012-1.138) for every additional year of life. The estimated mean local relapse time was 58.5 months, with a 95% CI between 56 and 61 months. The median local relapse time could not be estimated since there is no time point during which the local recurrence function has a value <50%. In conclusion, out of all independent variables considered, none could statistically significantly explicate local relapse recurrence time. It is important that these rare tumours are treated in the context of a multidisciplinary team with consensus guidelines to assist decision-making.
    Sprache Englisch
    Erscheinungsdatum 2023-01-27
    Erscheinungsland Greece
    Dokumenttyp Journal Article
    ZDB-ID 2573196-8
    ISSN 1792-1082 ; 1792-1074
    ISSN (online) 1792-1082
    ISSN 1792-1074
    DOI 10.3892/ol.2023.13682
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  10. Artikel ; Online: The allied health workforce of rural Aotearoa New Zealand: a scoping review.

    Walker, Sarah M / Kennedy, Ewan / Nixon, Garry / Blattner, Katharina

    Journal of primary health care

    2022  Band 14, Heft 3, Seite(n) 259–267

    Abstract: Introduction The allied health workforce is a crucial, if at times poorly visible, component of modern healthcare systems. The services provided by allied health professionals may be particularly important for underserved populations, including rural and ...

    Abstract Introduction The allied health workforce is a crucial, if at times poorly visible, component of modern healthcare systems. The services provided by allied health professionals may be particularly important for underserved populations, including rural and remote communities. Aim To determine what is currently known through research about the allied health workforce in rural Aotearoa New Zealand. Method A scoping review of diverse sources of literature from Aotearoa New Zealand was obtained from seven databases (July 2011-July 2021). Results Eighty-nine articles were identified, of which 10 met the inclusion criteria; nine empirical studies and one narrative review. The included research fell into two main categories: geographic workforce distribution (n  = 8), and the role of the rural allied health workforce (n  = 2). Discussion The paucity of research that meets the criteria for inclusion makes it difficult to draw conclusions about the allied health workforce in rural Aotearoa New Zealand. There is a focus in both the international rural allied health literature and the Aotearoa New Zealand rural medical and nursing literature on: measuring geographic workforce distribution; and rural-specific training. This suggests that these issues are important to the rural workforce. Similar research is needed in Aotearoa New Zealand to inform policy and ensure the rural allied health workforce reaches its full potential in improving health outcomes for rural New Zealanders.
    Mesh-Begriff(e) Allied Health Personnel ; Health Workforce ; Humans ; New Zealand ; Rural Health Services ; Rural Population
    Sprache Englisch
    Erscheinungsdatum 2022-09-30
    Erscheinungsland Australia
    Dokumenttyp Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2572943-3
    ISSN 1172-6156 ; 1172-6156
    ISSN (online) 1172-6156
    ISSN 1172-6156
    DOI 10.1071/HC22055
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