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  1. Article ; Online: The Missing Link in Sleep and Substance Use Research.

    Morgan, Peter T

    Biological psychiatry

    2022  Volume 92, Issue 11, Page(s) 832–833

    MeSH term(s) Humans ; Sleep ; Sleep Wake Disorders ; Substance-Related Disorders
    Language English
    Publishing date 2022-11-03
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 209434-4
    ISSN 1873-2402 ; 0006-3223
    ISSN (online) 1873-2402
    ISSN 0006-3223
    DOI 10.1016/j.biopsych.2022.09.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 720: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Book ; Online ; E-Book: Pathology of the placenta

    Khong, T. Yee / Mooney, Eoghan E. / Nikkels, Peter G. J. / Morgan, Terry K. / Gordijn, Sanne J.

    a practical guide

    2019  

    Author's details T. Yee Khong, Eoghan E. Mooney, Peter G. J. Nikkels, Terry K. Morgan, Sanne J. Gordijn editors
    Keywords Pathology ; Obstetrics ; Epidemiology ; Pediatrics
    Subject code 616.07
    Language English
    Size 1 Online-Ressource (XVI, 395 Seiten), Illustrationen
    Publisher Springer International Publishing
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021323381
    ISBN 978-3-319-97214-5 ; 9783319972138 ; 3-319-97214-6 ; 3319972138
    DOI 10.1007/978-3-319-97214-5
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Ketamine and Sleep: Bridging the Gap in the Treatment of Depressive Illness.

    Morgan, Peter T

    Biological psychiatry

    2017  Volume 82, Issue 5, Page(s) 309–311

    Language English
    Publishing date 2017-09-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209434-4
    ISSN 1873-2402 ; 0006-3223
    ISSN (online) 1873-2402
    ISSN 0006-3223
    DOI 10.1016/j.biopsych.2017.07.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 720: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: The Image-to-Physical Liver Registration Sparse Data Challenge: comparison of state-of-the-art using a common dataset.

    Heiselman, Jon S / Collins, Jarrod A / Ringel, Morgan J / Peter Kingham, T / Jarnagin, William R / Miga, Michael I

    Journal of medical imaging (Bellingham, Wash.)

    2024  Volume 11, Issue 1, Page(s) 15001

    Abstract: Purpose: Computational methods for image-to-physical registration during surgical guidance frequently rely on sparse point clouds obtained over a limited region of the organ surface. However, soft tissue deformations complicate the ability to accurately ...

    Abstract Purpose: Computational methods for image-to-physical registration during surgical guidance frequently rely on sparse point clouds obtained over a limited region of the organ surface. However, soft tissue deformations complicate the ability to accurately infer anatomical alignments from sparse descriptors of the organ surface. The Image-to-Physical Liver Registration Sparse Data Challenge introduced at SPIE Medical Imaging 2019 seeks to characterize the performance of sparse data registration methods on a common dataset to benchmark and identify effective tactics and limitations that will continue to inform the evolution of image-to-physical registration algorithms.
    Approach: Three rigid and five deformable registration methods were contributed to the challenge. The deformable approaches consisted of two deep learning and three biomechanical boundary condition reconstruction methods. These algorithms were compared on a common dataset of 112 registration scenarios derived from a tissue-mimicking phantom with 159 subsurface validation targets. Target registration errors (TRE) were evaluated under varying conditions of data extent, target location, and measurement noise. Jacobian determinants and strain magnitudes were compared to assess displacement field consistency.
    Results: Rigid registration algorithms produced significant differences in TRE ranging from
    Conclusions: The choice of registration algorithm significantly impacts registration accuracy and variability of deformation fields. Among current sparse data driven image-to-physical registration algorithms, biomechanical simulations that incorporate task-specific insight into boundary conditions seem to offer best performance.
    Language English
    Publishing date 2024-01-08
    Publishing country United States
    Document type Journal Article
    ISSN 2329-4302
    ISSN 2329-4302
    DOI 10.1117/1.JMI.11.1.015001
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  5. Article ; Online: Dual-probe fluorescence spectroscopy for sensitive quantitation of Alzheimer's amyloid pathology.

    Stepanchuk, Anastasiia A / Morgan, Megan L / Joseph, Jeffrey T / Stys, Peter K

    Acta neuropathologica communications

    2022  Volume 10, Issue 1, Page(s) 153

    Abstract: Protein misfolding is a prominent pathological hallmark of neurodegenerative disorders, including Alzheimer's disease (AD). Studies have shown that the diversity of β sheet-rich protein deposits (such as amyloid β plaques and neurofibrillary tangles), ... ...

    Abstract Protein misfolding is a prominent pathological hallmark of neurodegenerative disorders, including Alzheimer's disease (AD). Studies have shown that the diversity of β sheet-rich protein deposits (such as amyloid β plaques and neurofibrillary tangles), present across different brain regions, might underlie different disease phenotypes and only certain types of aggregates might be associated with cognitive decline. Conformationally sensitive fluorescent amyloid probes have the ability to report different structures of protein aggregates by virtue of their shifting emission spectra. Here we defined the binding affinity of the fluorescent amyloid probes BSB and MCAAD to disease-relevant protein aggregates, and combined the two probes to examine formalin-fixed paraffin-embedded mouse and human brain samples. Coupled with quantitative spectral phasor analysis, the dual-probe staining approach revealed remarkable heterogeneity of protein aggregates across the samples. Distinct emission spectra were consistent with certain types of deposits present in the mouse and human brain sections. The sensitivity of this staining, imaging and analysis approach outperformed conventional immunohistochemistry with the detected spectral differences between the greater parenchyma of cognitively normal and AD cases indicating a subtle yet widespread proteopathy associated with disease. Our method offers more sensitive, objective, and quantitative examination of protein misfolding pathology using conventional tissue sections.
    MeSH term(s) Animals ; Humans ; Mice ; Amyloid beta-Peptides/metabolism ; Alzheimer Disease/pathology ; tau Proteins/metabolism ; Protein Aggregates ; Spectrometry, Fluorescence ; Plaque, Amyloid/pathology ; Amyloid/metabolism ; Brain/pathology ; Amyloidosis/pathology ; Fluorescent Dyes/metabolism
    Chemical Substances Amyloid beta-Peptides ; tau Proteins ; Protein Aggregates ; Amyloid ; Fluorescent Dyes
    Language English
    Publishing date 2022-10-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2715589-4
    ISSN 2051-5960 ; 2051-5960
    ISSN (online) 2051-5960
    ISSN 2051-5960
    DOI 10.1186/s40478-022-01456-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Acute resistance exercise training does not augment mitochondrial remodelling in master athletes or untrained older adults.

    Marshall, Ryan Neil / McKendry, James / Smeuninx, Benoit / Seabright, Alex Peter / Morgan, Paul T / Greig, Carolyn / Breen, Leigh

    Frontiers in physiology

    2023  Volume 13, Page(s) 1097988

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-01-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2022.1097988
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  7. Article ; Online: Systematic conservation planning for Antarctic research stations.

    Brooks, Shaun T / Jabour, Julia / Hughes, Kevin A / Morgan, Fraser / Convey, Peter / Polymeropoulos, Elias T / Bergstrom, Dana M

    Journal of environmental management

    2023  Volume 351, Page(s) 119711

    Abstract: The small ice-free areas of Antarctica are essential locations for both biodiversity and scientific research but are subject to considerable and expanding human impacts, resulting primarily from station-based research and support activities, and local ... ...

    Abstract The small ice-free areas of Antarctica are essential locations for both biodiversity and scientific research but are subject to considerable and expanding human impacts, resulting primarily from station-based research and support activities, and local tourism. Awareness by operators of the need to conserve natural values in and around station and visitor site footprints exists, but the cumulative nature of impacts often results in reactive rather than proactive management. With human activity spread across many isolated pockets of ice-free ground, the pathway to the greatest reduction of human impacts within this natural reserve is through better management of these areas, which are impacted the most. Using a case study of Australia's Casey Station, we found significant natural values persist within the immediate proximity (<10 m) of long-term station infrastructure, but encroachment by physical disturbance results in ongoing pressures. Active planning to better conserve such values would provide a direct opportunity to enhance protection of Antarctica's environment. Here we introduce an approach to systematic conservation planning, tailored to Antarctic research stations, to help managers improve the conservation of values surrounding their activity locations. Use of this approach provides a potential mechanism to balance the need for scientific access to the continent with international obligations to protect its environment. It may also facilitate the development of subordinate conservation tools, including management plans and natural capital accounting. By proactively minimising and containing their station footprints, national programs can also independently demonstrate their commitment to protecting Antarctica's environment.
    MeSH term(s) Humans ; Antarctic Regions ; Conservation of Natural Resources ; Biodiversity ; Human Activities ; Anthropogenic Effects
    Language English
    Publishing date 2023-12-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 184882-3
    ISSN 1095-8630 ; 0301-4797
    ISSN (online) 1095-8630
    ISSN 0301-4797
    DOI 10.1016/j.jenvman.2023.119711
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 7556: Show issues

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  8. Article: IBD barriers across the continents: a continent-specific analysis - Australasia.

    Elford, Alexander T / Leong, Rupert W / Halmos, Emma P / Morgan, Manal / Kilpatrick, Kate / Lewindon, Peter J / Gearry, Richard B / Christensen, Britt

    Therapeutic advances in gastroenterology

    2023  Volume 16, Page(s) 17562848231197509

    Abstract: Australasia, encompassing Australia, New Zealand, and Papua New Guinea, has some of the highest prevalence's of inflammatory bowel disease (IBD) in the world. The way IBD medicine is practiced varies between and within these countries. There are numerous ...

    Abstract Australasia, encompassing Australia, New Zealand, and Papua New Guinea, has some of the highest prevalence's of inflammatory bowel disease (IBD) in the world. The way IBD medicine is practiced varies between and within these countries. There are numerous shared issues of IBD care between Australia and New Zealand, whereas Papua New Guinea has its' own unique set of circumstances. This review looks to explore some of the barriers to IBD care across the continent from the perspective of local IBD healthcare professionals. Barriers to IBD care that are explored include access to IBD multidisciplinary teams, provision of nutritional-based therapies, the prevalence and engagement of IBD-associated mental health disorders, access to medicine, access to endoscopy, rural barriers to care, Indigenous IBD care and paediatric issues. We look to highlight areas where improvements to IBD care across Australasia could be made as well as address research needs.
    Language English
    Publishing date 2023-09-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2440710-0
    ISSN 1756-2848 ; 1756-283X
    ISSN (online) 1756-2848
    ISSN 1756-283X
    DOI 10.1177/17562848231197509
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  9. Article: Reported Rates of Intraocular Inflammation with Intravitreal Aflibercept Administered via Pre-Filled Syringe or from Vials in Clinical Practice Between 2012 and 2022.

    Schmidt-Ott, Ursula / Fitzpatrick, Scott / Hasanbasic, Zoran / Leal, Sergio / Morgan-Warren, Peter / Zhang, Xin / Johnson, Kristian T

    Clinical ophthalmology (Auckland, N.Z.)

    2023  Volume 17, Page(s) 385–390

    Abstract: Purpose: To determine the reported rates of intraocular inflammation (IOI) in patients treated with intravitreal aflibercept (IVT-AFL) 2 mg in routine clinical practice (ie, outside interventional studies), across all indications and within all ... ...

    Abstract Purpose: To determine the reported rates of intraocular inflammation (IOI) in patients treated with intravitreal aflibercept (IVT-AFL) 2 mg in routine clinical practice (ie, outside interventional studies), across all indications and within all countries (excluding the United States), with access to either the vial presentation or pre-filled syringe (PFS).
    Patients and methods: A search was conducted using the Bayer EYLEA
    Results: With more than 10 years of post-marketing experience with the IVT-AFL vial presentation (>25 million sold units), and over 2 years of experience with the PFS of IVT-AFL (>6.7 million sold units) the rate of any IOI, including endophthalmitis, outside the United States was 0.3 events per 10,000 units for the PFS and 1.2 events per 10,000 units for the vial presentation. The event rates specifically for endophthalmitis were 0.1 per 10,000 units for the IVT-AFL PFS and 0.6 per 10,000 units for the IVT-AFL vial presentation.
    Conclusion: In patients with retinal diseases treated in routine clinical practice with IVT-AFL either from a vial or the PFS, medically important adverse events of IOI, and in particular, endophthalmitis, are infrequently reported events. Numerically, reported rates of IOI and endophthalmitis are low for the vial presentation and even lower for the PFS.
    Language English
    Publishing date 2023-01-26
    Publishing country New Zealand
    Document type Journal Article
    ISSN 1177-5467
    ISSN 1177-5467
    DOI 10.2147/OPTH.S393519
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  10. Article ; Online: Durability of Thermal Pulmonary Vein Isolation in Persistent Atrial Fibrillation Assessed by Mandated Repeat Invasive Study.

    Calvert, Peter / Ding, Wern Yew / Mills, Mark T / Snowdon, Richard / Borbas, Zoltan / Modi, Simon / Hall, Mark / Morgan, Maureen / Clarkson, Nichola / Chackochen, Sijimole / Barton, Janet / Kemp, Ian / Luther, Vishal / Gupta, Dhiraj

    Heart rhythm

    2024  

    Abstract: Background: No study has assessed durability of pulmonary vein isolation (PVI) with radiofrequency (RF) and Cryoballoon (CB) in patients with persistent AF. These data are especially lacking for those with significantly diseased left atria (LA).: ... ...

    Abstract Background: No study has assessed durability of pulmonary vein isolation (PVI) with radiofrequency (RF) and Cryoballoon (CB) in patients with persistent AF. These data are especially lacking for those with significantly diseased left atria (LA).
    Objective: To assess PVI durability in patients with significant LA disease and compare reconnection rates between RF and CB.
    Methods: 44 Patients (mean age 63, 77% male, median time since AF diagnosis 22.5 months, median indexed LA volume 36 ml/m
    Results: 38 patients underwent both procedures (n=17 CB, n=21 RF). Index RF procedures were longer (median 158 vs 97min; p<0.001) but required less fluoroscopy (9.5 vs 23min; p<0.001). At the index RF procedure, median 47% of LA myocardium had voltage <0.5mV, suggesting half of the mapped LA comprised scar. PV reconnection was observed in 73/152 (48.0%) PVs and was more frequent with CB (58.8%) vs RF (39.3%), p=0.022. Reconnection of at least 1 PV was detected in >75% of patients. Significantly more ablation was required at redo to reisolate PVs in the CB arm (median 10.8 vs 1.2min; p<0.001).
    Conclusion: PVI durability may be poor in those with significant LA scarring and dilatation, even with modern thermal ablation technologies. RF resulted in significantly better PVI durability than CB in this complex population.
    Clinical trial registration: NCT04111731.
    Language English
    Publishing date 2024-04-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2229357-7
    ISSN 1556-3871 ; 1547-5271
    ISSN (online) 1556-3871
    ISSN 1547-5271
    DOI 10.1016/j.hrthm.2024.04.061
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6278: Show issues Location:
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