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  1. Article ; Online: Long-term rhythm monitoring with an implantable loop recorder in patients after the first clinical atrial fibrillation episode. Towards an individualized management.

    Papakonstantinou, Panteleimon E / Simantirakis, Emmanuel N

    Minerva cardioangiologica

    2019  Volume 67, Issue 2, Page(s) 121–130

    Abstract: Although atrial fibrillation (AF) is an arrhythmia with a variable clinical profile (symptomatic and asymptomatic episodes), the first symptomatic episode leads to its initial diagnosis in most cases. Nowadays, continuous and remote long-term cardiac ... ...

    Abstract Although atrial fibrillation (AF) is an arrhythmia with a variable clinical profile (symptomatic and asymptomatic episodes), the first symptomatic episode leads to its initial diagnosis in most cases. Nowadays, continuous and remote long-term cardiac rhythm monitoring is feasible by the use of implantable loop recorders. The data concerning the AF recurrences and progression after the first electrocardiographic-documented clinical AF episode demonstrates that a high percentage of patients may not suffer any other AF recurrence, or may present a low recurrence rate of the arrhythmia in the future. The AF burden may play a key role in the management of the arrhythmia as far as the decision-making for anticoagulation, rate and/or rhythm control therapy is concerned. There is evidence that a higher AF burden is associated with a higher risk of ischemic stroke. Non-vitamin K antagonists (NOACs) anticoagulants are increasingly used in the management of AF, providing a more predictable effect with rapid onset and offset of their action. The use of these agents in combination with devices that provide a continuous remote rhythm monitoring capability has encouraged anticoagulation strategies based on the AF burden. Data from tailored anticoagulation studies in AF are in favor of the long-term rhythm monitoring, ensuring a patient-centered approach with a better evaluation and more individualized management of AF, especially in patients with intermediate thromboembolic risk and high bleeding risk. Further large randomized trials are needed, not only to evaluate such strategies but also to elucidate the long-term cardiac rhythm monitoring in the AF management.
    MeSH term(s) Anticoagulants/administration & dosage ; Anticoagulants/adverse effects ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/drug therapy ; Atrial Fibrillation/physiopathology ; Electrocardiography, Ambulatory/methods ; Equipment Design ; Hemorrhage/chemically induced ; Humans ; Recurrence ; Risk Factors ; Stroke/etiology ; Stroke/prevention & control ; Thromboembolism/etiology ; Thromboembolism/prevention & control
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2019-02-05
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 123583-7
    ISSN 1827-1618 ; 0026-4725
    ISSN (online) 1827-1618
    ISSN 0026-4725
    DOI 10.23736/S0026-4725.19.04883-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Obstructive Sleep Apnea and Sudden Cardiac Death: Is the Landscape Clear?

    Simantirakis, Emmanuel N / Papakonstantinou, Panteleimon E

    Cardiology

    2018  Volume 140, Issue 4, Page(s) 254–256

    MeSH term(s) Arrhythmias, Cardiac ; Death, Sudden, Cardiac ; Defibrillators, Implantable ; Humans ; Sleep Apnea Syndromes ; Sleep Apnea, Obstructive
    Language English
    Publishing date 2018-09-13
    Publishing country Switzerland
    Document type Journal Article ; Comment
    ZDB-ID 80092-2
    ISSN 1421-9751 ; 0008-6312
    ISSN (online) 1421-9751
    ISSN 0008-6312
    DOI 10.1159/000490882
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Optimizing the interventricular interval in biventricular pacing: When and how.

    Simantirakis, Emmanuel N / Papakonstantinou, Panteleimon E

    Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese

    2018  Volume 60, Issue 1, Page(s) 26–27

    MeSH term(s) Cardiac Resynchronization Therapy ; Follow-Up Studies ; Humans ; Systole ; Ventricular Dysfunction, Left
    Language English
    Publishing date 2018-11-07
    Publishing country Netherlands
    Document type Editorial ; Comment
    ZDB-ID 2215027-4
    ISSN 2241-5955 ; 1109-9666
    ISSN (online) 2241-5955
    ISSN 1109-9666
    DOI 10.1016/j.hjc.2018.10.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Left ventricular lead implantation in cardiac resynchronization therapy (CRT): A challenging procedure.

    Simantirakis, Emmanuel N / Papakonstantinou, Panteleimon E

    Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese

    2018  Volume 59, Issue 1, Page(s) 34–35

    MeSH term(s) Cardiac Resynchronization Therapy ; Cardiac Resynchronization Therapy Devices ; Heart Failure ; Heart Ventricles ; Treatment Outcome
    Language English
    Publishing date 2018-03-02
    Publishing country Netherlands
    Document type Editorial ; Comment
    ZDB-ID 2215027-4
    ISSN 2241-5955 ; 1109-9666
    ISSN (online) 2241-5955
    ISSN 1109-9666
    DOI 10.1016/j.hjc.2018.02.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Upgrading or downgrading a cardiac resynchronization therapy device (CRT) device? Gaps and dilemmas in current clinical practice.

    Simantirakis, Emmanuel N / Nakou, Eleni S / Vardas, Panos E

    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology

    2018  Volume 20, Issue 1, Page(s) 217–218

    MeSH term(s) Cardiac Resynchronization Therapy ; Cardiac Resynchronization Therapy Devices ; Defibrillators, Implantable ; Heart Failure ; Treatment Outcome
    Language English
    Publishing date 2018--01
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1449879-0
    ISSN 1532-2092 ; 1099-5129
    ISSN (online) 1532-2092
    ISSN 1099-5129
    DOI 10.1093/europace/eux266
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Obstructive Sleep Apnea and Sudden Cardiac Death: Is the Landscape Clear?

    Simantirakis, Emmanuel N. / Papakonstantinou, Panteleimon E.

    Cardiology

    2018  Volume 140, Issue 4, Page(s) 254–256

    Institution Department of Cardiology, University Hospital of Heraklion, School of Medicine, University of Crete, Heraklion, Crete, Greece
    Language English
    Publishing date 2018-09-13
    Publisher S. Karger AG
    Publishing place Basel, Switzerland
    Document type Article
    Note Editorial Comment
    ZDB-ID 80092-2
    ISSN 1421-9751 ; 0008-6312
    ISSN (online) 1421-9751
    ISSN 0008-6312
    DOI 10.1159/000490882
    Database Karger publisher's database

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  7. Article ; Online: Recurrence rate of atrial fibrillation after the first clinical episode: A prospective evaluation using continuous cardiac rhythm monitoring.

    Simantirakis, Emmanuel N / Papakonstantinou, Panteleimon E / Kanoupakis, Emmanuel / Chlouverakis, Gregory I / Tzeis, Stylianos / Vardas, Panos E

    Clinical cardiology

    2018  Volume 41, Issue 5, Page(s) 594–600

    Abstract: Background: Decision making regarding a patient who has experienced a first clinical episode of atrial fibrillation (AF) is challenging, and the AF recurrences should be a significant consideration. Continuous long-term rhythm monitoring via implantable ...

    Abstract Background: Decision making regarding a patient who has experienced a first clinical episode of atrial fibrillation (AF) is challenging, and the AF recurrences should be a significant consideration. Continuous long-term rhythm monitoring via implantable loop recorders (ILRs) has enabled us to evaluate the AF recurrence profile after the first clinical episode and to investigate clinical parameters associated with the course of the arrhythmia.
    Hypothesis: Continuous rhythm monitoring via ILRs in AF patients after the first clinical episode is of clinical significance and precisely evaluate the AF recurrence profile.
    Methods: Thirty consecutive patients with paroxysmal AF received an ILR after their first symptomatic episode. We evaluated the maximum duration of episodes and the recurrence rate of the arrhythmia during a follow-up period of 3 years.
    Results: Three patients (10%) had no AF recurrence, whereas 4 patients (13.3%) presented only 1 episode. Almost half of the patients (46.7%) had a low recurrence rate (<5 episodes/year), whereas the majority of patients (19/30) suffered from episodes with maximum duration ≤24 hours. Eleven patients (36.7%) presented either no episode or a low recurrence rate with episodes lasting ≤24 hours. The use of statins was greater in patients with a low recurrence rate (P = 0.025).
    Conclusions: A significant percentage of patients either suffer no AF recurrence after their first symptomatic episode or show a low recurrence rate. Most patients present episodes of short duration. If these findings are confirmed in larger studies, they could have clinical implications ensuring individualized management of the arrhythmia in the future.
    MeSH term(s) Action Potentials ; Aged ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/physiopathology ; Electrocardiography, Ambulatory/instrumentation ; Electrocardiography, Ambulatory/methods ; Female ; Heart Conduction System/physiopathology ; Heart Rate ; Humans ; Male ; Middle Aged ; Predictive Value of Tests ; Prospective Studies ; Recurrence ; Signal Processing, Computer-Assisted ; Telemetry/instrumentation ; Telemetry/methods ; Time Factors
    Language English
    Publishing date 2018-05-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391935-3
    ISSN 1932-8737 ; 0160-9289
    ISSN (online) 1932-8737
    ISSN 0160-9289
    DOI 10.1002/clc.22904
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: New developments in cardiac pacemakers.

    Vardas, Panos E / Simantirakis, Emmanuel N / Kanoupakis, Emmanuel M

    Circulation

    2013  Volume 127, Issue 23, Page(s) 2343–2350

    MeSH term(s) Arrhythmias, Cardiac/diagnosis ; Arrhythmias, Cardiac/physiopathology ; Arrhythmias, Cardiac/therapy ; Bradycardia/therapy ; Cardiac Pacing, Artificial/adverse effects ; Cardiac Pacing, Artificial/methods ; Cardiac Pacing, Artificial/trends ; Cardiomyopathies/therapy ; Double-Blind Method ; Electrocardiography/instrumentation ; Equipment Design ; Heart Block/complications ; Heart Block/physiopathology ; Heart Block/therapy ; Humans ; Meta-Analysis as Topic ; Monitoring, Physiologic/instrumentation ; Pacemaker, Artificial/trends ; Patient Selection ; Practice Guidelines as Topic ; Randomized Controlled Trials as Topic ; Reflex, Abnormal ; Sick Sinus Syndrome/physiopathology ; Sick Sinus Syndrome/therapy ; Software ; Syncope/etiology ; Syncope/physiopathology ; Syncope/prevention & control
    Language English
    Publishing date 2013-06-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.112.000086
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Impact of Sustained Cardiac Tachyarrhythmias Recorded in Coronary Intensive Care Unit on Short- and Long-Term Mortality and Duration of Hospitalization.

    Papakonstantinou, Panteleimon E / Malliou, Angelliki / Chlouverakis, Gregory / Kallergis, Eleftherios / Mavrakis, Hercules / Parthenakis, Frangiskos / Vardas, Panos E / Simantirakis, Emmanuel N

    Journal of intensive care medicine

    2020  Volume 36, Issue 7, Page(s) 775–782

    Abstract: Background: Studies conducted in coronary intensive care units (CICUs) have demonstrated that tachyarrhythmias are associated with increased mortality after acute coronary syndromes (ACSs). However, the data for tachyarrhythmias occurred in CICUs due to ...

    Abstract Background: Studies conducted in coronary intensive care units (CICUs) have demonstrated that tachyarrhythmias are associated with increased mortality after acute coronary syndromes (ACSs). However, the data for tachyarrhythmias occurred in CICUs due to a variety of cardiovascular disorders are limited.
    Methods: We conducted a single-center prospective observational study, which included consecutive CICU patients (January 1, 2014 to May 31, 2018). We recorded the ventricular arrhythmias (VAs), supraventricular tachycardias (SVTs), and days of CICU hospitalization. The patients were followed up for 6 months after CICU discharge.
    Results: A total of 943 patients (age: 66.37 ±15.4 years; 673 males [71.4%]) were included. Patients with tachyarrhythmias had higher in-CICU mortality (8.0% vs 4.1%,
    Conclusions: Tachyarrhythmias were associated with prolonged CICU hospitalization, while non-ACS cardiovascular disorders and the occurrence of VAs were associated with increased short- and long-term mortality.
    MeSH term(s) Acute Coronary Syndrome/complications ; Acute Coronary Syndrome/therapy ; Aged ; Hospitalization ; Humans ; Intensive Care Units ; Male ; Prognosis ; Retrospective Studies ; Tachycardia
    Language English
    Publishing date 2020-04-10
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 632828-3
    ISSN 1525-1489 ; 0885-0666
    ISSN (online) 1525-1489
    ISSN 0885-0666
    DOI 10.1177/0885066620918790
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Transient loss of consciousness: an ongoing challenge.

    Vardas, Panos E / Simantirakis, Emmanuel N

    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology

    2010  Volume 12, Issue 6, Page(s) 774–775

    MeSH term(s) Death, Sudden, Cardiac/epidemiology ; Emergency Medical Services/standards ; Emergency Medical Services/statistics & numerical data ; Guideline Adherence ; Humans ; Practice Guidelines as Topic ; Risk Factors ; Unconsciousness/diagnosis ; Unconsciousness/epidemiology
    Language English
    Publishing date 2010-06
    Publishing country England
    Document type Comment ; Editorial
    ZDB-ID 1449879-0
    ISSN 1532-2092 ; 1099-5129
    ISSN (online) 1532-2092
    ISSN 1099-5129
    DOI 10.1093/europace/euq139
    Database MEDical Literature Analysis and Retrieval System OnLINE

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