LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 268

Search options

  1. Book ; Online ; E-Book: Purifying and indexing technology for nucleic acids-based next generation storage medium

    Choi, Hansol

    (Springer Theses)

    2023  

    Author's details Hansol Choi
    Series title Springer Theses
    Keywords Nanobiotechnology ; Nucleic acids/Biotechnology ; Synthetic biology
    Subject code 620.5
    Language English
    Size 1 online resource (53 pages)
    Publisher Springer
    Publishing place Singapore
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 9789811942747 ; 9789811942730 ; 9811942749 ; 9811942730
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: MLL1 histone methyltransferase and UTX histone demethylase functionally cooperate to regulate the expression of NRF2 in response to ROS-induced oxidative stress.

    Choi, Janghyun / Lee, Hansol

    Free radical biology & medicine

    2024  Volume 217, Page(s) 48–59

    Abstract: The transcription factor NRF2 plays a pivotal role in maintaining redox and metabolic homeostasis by orchestrating oxidative stress-dependent transcription programs. Despite growing evidence implicating various cellular components in the regulation of ... ...

    Abstract The transcription factor NRF2 plays a pivotal role in maintaining redox and metabolic homeostasis by orchestrating oxidative stress-dependent transcription programs. Despite growing evidence implicating various cellular components in the regulation of NRF2 activity at the posttranslational stage, relatively less is known about the factors dictating the transcriptional activation of NRF2 in response to oxidative stress. In this study, we report the crucial roles of MLL1, an H3K4-specific methyltransferase, and UTX, an H3K27-specific histone demethylase, in the NRF2-dependent transcription program under oxidative stress. We find that the depletion of MLL1 or UTX results in increased susceptibility to oxidative stress, accompanied by higher intracellular ROS and the failed activation of antioxidant genes, including NRF2. In addition, MLL1 and UTX selectively target the NRF2 promoter, and exogenous FLAG-NRF2 expression increases the viability of MLL1-or UTX-depleted cells upon exposure to hydrogen peroxide. RNA-seq analysis demonstrates that depletion of MLL1 or UTX affects the changes in NRF2-dependent transcriptome in response to oxidative stress. Furthermore, ChIP and ChIP-seq analyses find that MLL1 and UTX functionally cooperate to establish a chromatin environment that favors active transcription at the H3K4me3/H3K27me3 bivalent NRF2 promoter in response to ROS-induced oxidative stress. Collectively, these findings provide a molecular mechanism underlying the cellular response to oxidative stress and highlight the importance of the chromatin structure and function in maintaining redox homeostasis.
    MeSH term(s) Histone Demethylases/genetics ; Histone Demethylases/metabolism ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; Reactive Oxygen Species ; Histone Methyltransferases/genetics ; Histone Methyltransferases/metabolism ; Methylation ; Chromatin ; Oxidative Stress
    Chemical Substances Histone Demethylases (EC 1.14.11.-) ; NF-E2-Related Factor 2 ; Reactive Oxygen Species ; Histone Methyltransferases (EC 2.1.1.-) ; Chromatin
    Language English
    Publishing date 2024-03-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 807032-5
    ISSN 1873-4596 ; 0891-5849
    ISSN (online) 1873-4596
    ISSN 0891-5849
    DOI 10.1016/j.freeradbiomed.2024.03.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2109: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: NFIB-MLL1 complex is required for the stemness and Dlx5-dependent osteogenic differentiation of C3H10T1/2 mesenchymal stem cells.

    Choi, Janghyun / Lee, Hansol

    The Journal of biological chemistry

    2023  Volume 299, Issue 10, Page(s) 105193

    Abstract: Despite significant progress in our understanding of the molecular mechanism of mesenchymal stem cell (MSC) differentiation, less is known about the factors maintaining the stemness and plasticity of MSCs. Here, we show that the NFIB-MLL1 complex plays ... ...

    Abstract Despite significant progress in our understanding of the molecular mechanism of mesenchymal stem cell (MSC) differentiation, less is known about the factors maintaining the stemness and plasticity of MSCs. Here, we show that the NFIB-MLL1 complex plays key roles in osteogenic differentiation and stemness of C3H10T1/2 MSCs. We find that depletion of either NFIB or MLL1 results in a severely hampered osteogenic potential and failed activation of key osteogenic transcription factors, such as Dlx5, Runx2, and Osx, following osteogenic stimuli. In addition, the NFIB-MLL1 complex binds directly to the promoter of Dlx5, and exogenous expression of Myc-Dlx5, but not the activation of either the BMP- or the Wnt-signaling pathway, is sufficient to restore the osteogenic potential of cells depleted of NFIB or MLL1. Moreover, chromatin immunoprecipitation (ChIP) and ChIP-sequencing analysis showed that the NFIB-MLL1 complex mediates the deposition of trimethylated histone H3K4 at both Dlx5 and Cebpa, key regulator genes that function at the early stages of osteogenic and adipogenic differentiation, respectively, in uncommitted C3H10T1/2 MSCs. Surprisingly, the depletion of either NFIB or MLL1 leads to decreased trimethylated histone H3K4 and results in elevated trimethylated histone H3K9 at those developmental genes. Furthermore, gene expression profiling and ChIP-sequencing analysis revealed lineage-specific changes in chromatin landscape and gene expression in response to osteogenic stimuli. Taken together, these data provide evidence for the hitherto unknown role of the NFIB-MLL1 complex in the maintenance and lineage-specific differentiation of C3H10T1/2 MSCs and support the epigenetic regulatory mechanism underlying the stemness and plasticity of MSCs.
    Language English
    Publishing date 2023-08-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1016/j.jbc.2023.105193
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.108: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: MOPSS: Toward high-fidelity oligonucleotides for clinical applications.

    Choi, Hansol / Kwon, Sunghoon / Ryu, Taehoon / Choi, Yeongjae

    Clinical and translational medicine

    2022  Volume 12, Issue 7, Page(s) e809

    MeSH term(s) Oligonucleotides/therapeutic use
    Chemical Substances Oligonucleotides
    Language English
    Publishing date 2022-07-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2697013-2
    ISSN 2001-1326 ; 2001-1326
    ISSN (online) 2001-1326
    ISSN 2001-1326
    DOI 10.1002/ctm2.809
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: MOPSS

    Hansol Choi / Sunghoon Kwon / Taehoon Ryu / Yeongjae Choi

    Clinical and Translational Medicine, Vol 12, Iss 7, Pp n/a-n/a (2022)

    Toward high‐fidelity oligonucleotides for clinical applications

    2022  

    Keywords Medicine (General) ; R5-920
    Language English
    Publishing date 2022-07-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: Corrugated Wood Fabricated Using Laser-Induced Graphitization for Salt-Resistant Solar Steam Generation.

    Jang, Hansol / Choi, Jihun / Lee, Hansol / Jeon, Sangmin

    ACS applied materials & interfaces

    2020  Volume 12, Issue 27, Page(s) 30320–30327

    Abstract: We developed a novel solar steam generator (SSG) with high solar conversion efficiency and excellent salt resistance. A ... ...

    Abstract We developed a novel solar steam generator (SSG) with high solar conversion efficiency and excellent salt resistance. A CO
    Language English
    Publishing date 2020-06-23
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.0c05138
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article: Corrugated Wood Fabricated Using Laser-Induced Graphitization for Salt-Resistant Solar Steam Generation

    Jang, Hansol / Choi, Jihun / Lee, Hansol / Jeon, Sangmin

    ACS applied materials & interfaces. 2020 June 09, v. 12, no. 27

    2020  

    Abstract: We developed a novel solar steam generator (SSG) with high solar conversion efficiency and excellent salt resistance. A CO₂ laser was used to convert the surface of basswood to graphitic carbon layers (GCL), and various grid patterns of GCL were created ... ...

    Abstract We developed a novel solar steam generator (SSG) with high solar conversion efficiency and excellent salt resistance. A CO₂ laser was used to convert the surface of basswood to graphitic carbon layers (GCL), and various grid patterns of GCL were created on wood. The low thermal conductivity of wood suppressed heat loss to bulk water, and the presence of the grooves in the grid increased the evaporation rate by increasing the surface area to absorb more sunlight. In addition, the supply of bulk water through the grooves endowed the SSG with salt resistance and self-regeneration properties. The salt resistance was maintained in a 20-wt % NaCl solution for the duration of the experiment (2 weeks), which indicates that the developed SSG can be used in saline water for long-term operation.
    Keywords carbon dioxide ; evaporation rate ; generators (equipment) ; graphene ; heat ; saline water ; sodium chloride ; solar radiation ; steam ; surface area ; thermal conductivity ; wood
    Language English
    Dates of publication 2020-0609
    Size p. 30320-30327.
    Publishing place American Chemical Society
    Document type Article
    ISSN 1944-8252
    DOI 10.1021/acsami.0c05138
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article: Evaluation of acute, 28-day, 13-week repeated dose oral toxicity and genotoxicity of a herbal extract (HemoHIM G) from

    Bak, Su-Bin / Choi, Hansol / Kim, Gyoung-Deuck / Kim, Ju Gyeong / Kwon, Da-Ae / Kim, Ha-Young / Son, Dong-Won / Jeong, Jang-Hun / Lee, Byung-Woo / An, Hyo-Jin / Lee, Hak Sung

    Toxicological research

    2024  Volume 40, Issue 2, Page(s) 297–311

    Abstract: HemoHIM G is a functional food ingredient composed of a triple herbal combination ... ...

    Abstract HemoHIM G is a functional food ingredient composed of a triple herbal combination of
    Language English
    Publishing date 2024-03-16
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 2727978-9
    ISSN 2234-2753 ; 1976-8257
    ISSN (online) 2234-2753
    ISSN 1976-8257
    DOI 10.1007/s43188-024-00227-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Histone demethylase KDM4D cooperates with NFIB and MLL1 complex to regulate adipogenic differentiation of C3H10T1/2 mesenchymal stem cells

    Jang Hyun Choi / Hansol Lee

    Scientific Reports, Vol 10, Iss 1, Pp 1-

    2020  Volume 13

    Abstract: Abstract The coordinated and sequential actions of lineage-specific transcription factors and epigenetic regulators are essential for the initiation and maintenance of cellular differentiation. We here report KDM4D histone demethylase as a key regulator ... ...

    Abstract Abstract The coordinated and sequential actions of lineage-specific transcription factors and epigenetic regulators are essential for the initiation and maintenance of cellular differentiation. We here report KDM4D histone demethylase as a key regulator of adipogenesis in C3H10T1/2 mesenchymal stem cells. The depletion of KDM4D results in impaired differentiation, which can be rescued by exogenous KDM4D, PPARγ, and C/EBPα, but not by C/EBPβ. In addition, KDM4D interacts physically and functionally with both NFIB and MLL1 complex to regulate C/EBPα and PPARγ expression upon adipogenic hormonal induction. Although KDM4D is dispensable for the binding of both NFIB and MLL1 complex to the target promoters, the demethylation of tri-methylated H3K9 by KDM4D is required for NFIB and MLL1 complex to deposit tri-methylated H3K4 and activate PPARγ and C/EBPα expression. Taken together, our data provide a molecular framework for lineage-specific transcription factor and histone modifiers to cooperate in adipogenic differentiation, in which KDM4D removes repressive histone marks at genes with a bivalent chromatin domain and allows NFIB and MLL1 complex to promote the expression of key adipogenic regulators.
    Keywords Medicine ; R ; Science ; Q
    Subject code 571
    Language English
    Publishing date 2020-02-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article ; Online: Protonated Organic Semiconductors: Origin of Water-Induced Charge-Trap Generation.

    Park, Sangsik / Choi, Wookjin / Kim, Seung Hyun / Lee, Hansol / Cho, Kilwon

    Advanced materials (Deerfield Beach, Fla.)

    2023  Volume 35, Issue 42, Page(s) e2303707

    Abstract: Despite dramatic improvements in the electronic characteristics of organic semiconductors, the low operational stability of organic field-effect transistors (OFETs) hinders their direct use in practical applications. Although the literature contains ... ...

    Abstract Despite dramatic improvements in the electronic characteristics of organic semiconductors, the low operational stability of organic field-effect transistors (OFETs) hinders their direct use in practical applications. Although the literature contains numerous reports on the effects of water on the operational stability of OFETs, the underlying mechanisms of trap generation induced by water remain unclear. Here, a protonation-induced trap generation of organic semiconductors is proposed as a possible origin of the operational instability in organic field-effect transistors. Spectroscopic and electronic investigation techniques combined with simulations reveal that the direct protonation of organic semiconductors by water during operation may be responsible for the trap generation induced by bias stress; this phenomenon is independent of the trap generation at an insulator surface. In addition, the same feature occurred in small-bandgap polymers with fused thiophene rings irrespective of their crystalline ordering, implying the generality of protonation induced trap generation in various polymer semiconductors with a small bandgap. The finding of the trap-generation process provides new perspectives for achieving greater operational stability of organic field-effect transistors.
    Language English
    Publishing date 2023-09-17
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1474949-X
    ISSN 1521-4095 ; 0935-9648
    ISSN (online) 1521-4095
    ISSN 0935-9648
    DOI 10.1002/adma.202303707
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top