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  1. AU=Ryan C F
  2. AU="Perez, F."
  3. AU="Durán, Mercedes"
  4. AU="Wilne, Sophie"
  5. AU="Changjin Lee"
  6. AU="Hyunsoo Lee"
  7. AU=Sinha Ian
  8. AU="Bird, M F"

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  1. Artikel: Acetolactate Synthase-Inhibitor Resistance in Monochoria vaginalis (Burm. f.) C. Presl from Indonesia

    Widianto, Ryan / Kurniadie, Denny / Widayat, Dedi / Umiyati, Uum / Nasahi, Ceppy / Sari, Santika / Juraimi, Abdul Shukor / Kato-Noguchi, Hisashi

    Plants. 2022 Jan. 31, v. 11, no. 3

    2022  

    Abstract: Monochoria vaginalis (Burm. f.) C. Presl, belonging to the family Pontederiaceae, is an aquatic ...

    Abstract Monochoria vaginalis (Burm. f.) C. Presl, belonging to the family Pontederiaceae, is an aquatic herbaceous plant, native to temperate and tropical Asia. The species often occurs in paddy fields as a noxious weed in East Asia, and in the USA, and causes a significant reduction in rice production. The objective of the present research was the evaluation of the resistance levels of M. vaginalis against three chemical groups of acetolactate synthase (ALS)-inhibitor herbicides and other two different groups of herbicides, and the investigation of the mutations in the ALS gene of the resistant biotype of M. vaginalis. Herbicide dose–response experiments showed that the resistant biotype of M. vaginalis was highly resistant to bensulfuron-methyl, moderately resistant to bispyribac-sodium, had low resistance to penoxsulam and 2,4-D dimethyl ammonium, and was susceptible to sulfentrazone. The nucleotide sequences of the ALS gene of resistant and susceptible biotypes showed 14 base substitutions, which caused two amino acid substitutions: Val-143-Ile and Val-148-Ile. It is the first report of the substitutions of amino acids Val-143-Ile and Val-148-Ile in ALS protein. Those mutations may give different resistance spectra against three ALS-inhibitor herbicides: bensulfuron-methyl, bispyribac-sodium, and penoxsulam. Further research is needed to elucidate the molecular basis of target-site resistance mechanisms such as the transformation of the ALS gene of M. vaginalis. It is also necessary to evaluate herbicide mixtures and/or the rotation of herbicide sites of action to control the resistant biotype of M. vaginalis.
    Schlagwörter 2,4-D ; Monochoria vaginalis ; acetolactate synthase ; amino acids ; ammonium ; bensulfuron-methyl ; biotypes ; bispyribac-sodium ; dose response ; genes ; herbaceous plants ; noxious weeds ; paddies ; rice ; sulfentrazone ; Indonesia
    Sprache Englisch
    Erscheinungsverlauf 2022-0131
    Erscheinungsort Multidisciplinary Digital Publishing Institute
    Dokumenttyp Artikel
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants11030400
    Datenquelle NAL Katalog (AGRICOLA)

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  2. Artikel: Palladium-catalysed C-F alumination of fluorobenzenes: mechanistic diversity and origin of selectivity.

    Rekhroukh, Feriel / Chen, Wenyi / Brown, Ryan K / White, Andrew J P / Crimmin, Mark R

    Chemical science

    2020  Band 11, Heft 30, Seite(n) 7842–7849

    Abstract: A palladium pre-catalyst, [Pd( ... ...

    Abstract A palladium pre-catalyst, [Pd(PCy
    Sprache Englisch
    Erscheinungsdatum 2020-07-21
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/d0sc01915a
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Reply to P.F. Pinsky, C.P. Crum, and M.W. McIntosh et al.

    Menon, Usha / Kalsi, Jatinderpal K / Gentry-Maharaj, Aleksandra / Ryan, Andy / Burnell, Matthew / Parmar, Max / Fallowfield, Lesley / Campbell, Stuart / McGuire, Alistair / Skates, Steven / Jacobs, Ian

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2015  Band 34, Heft 2, Seite(n) 201–202

    Mesh-Begriff(e) Biomarkers, Tumor/blood ; Early Detection of Cancer/methods ; Female ; Humans ; Ovarian Neoplasms/blood
    Chemische Substanzen Biomarkers, Tumor
    Sprache Englisch
    Erscheinungsdatum 2015-11-16
    Erscheinungsland United States
    Dokumenttyp Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.2015.64.1365
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Scleral depressed vitreous shaving, 360 laser, and perfluoropropane (C 3 F 8 ) for retinal detachment

    Vivek Chaturvedi / Ryan P Basham / Kourous A Rezaei

    Indian Journal of Ophthalmology, Vol 62, Iss 7, Pp 804-

    2014  Band 808

    Abstract: ... peripheral endolaser, and 14% perfluoropropane (C 3 F 8 ) was conducted. Patients with less than 3 months ... shaving, 360 degree peripheral endolaser, and 14% C 3 F 8 leads to successful anatomical reattachment ...

    Abstract Purpose : To review the characteristics and outcomes of patients who underwent pars plana vitrectomy (PPV) with scleral depressed vitreous shaving, 360 degree peripheral endolaser, and 14% C3F8 gas for rhegmatogenous retinal detachment (RRD). Materials and Methods : A retrospective review of a consecutive series of patients who underwent primary repair of RRD by PPV with scleral depressed vitreous shaving, 360 degree peripheral endolaser, and 14% perfluoropropane (C 3 F 8 ) was conducted. Patients with less than 3 months follow-up, previous retinal surgery, and higher than grade B proliferative vitreoretinopathy were excluded. Results : Ninety-one eyes were included in the study. The mean age was 60.1 years. The mean follow-up was 13.7 months. The macula was detached in 63% (58/91) of the eyes. The reattachment rate after one surgical procedure was 95% (86/91) while overall reattachment rate was 100%. There was no statistically significant difference between reattachment rates of superior, nasal/temporal, or inferior RRDs. The mean final best corrected visual acuity (BCVA) was 20/40. Of all the patients, 66% of patients with macula-off RRDs had a final BCVA of 20/40 or better. Conclusions: PPV with scleral depressed vitreous shaving, 360 degree peripheral endolaser, and 14% C 3 F 8 leads to successful anatomical reattachment with visual improvement in patients with primary RRD.
    Schlagwörter Bevacizumab ; intravitreal ; neovascular age related macular degeneration ; systemic ; systematic review ; systematic review of reviews ; Hydrophillic nanogels ; ophthalmic drug delivery ; nanosponges ; solid lipid nanoparticles ; Adult strabismus ; personality ; psychosocial impact ; quality of life ; squint ; Maculopathy ; optic pit ; spectral domain optical coherence tomography ; Corneal hysteresis ; corneal resistance factor ; exfoliative glaucoma ; primary open angle glaucoma ; A-constant ; biometry ; individualized ; intraocular lenses ; personal ; Tecnis ; E-learning ; medical education ; methodology ; Chronic macular hole ; macular hole duration ; macular hole size ; macular hole surgery ; Adult strabismus-20 ; functional ; psychosocial ; strabismus ; surgery ; Retinal detachment ; vitreous shaving ; gas ; Ophthalmology ; RE1-994 ; Medicine ; R
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2014-01-01T00:00:00Z
    Verlag Medknow Publications
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Re: Decision Support with the Personal Patient Profile-Prostate: A Multicenter Randomized Trial: D. L. Berry, F. Hong, T. M. Blonquist, B. Halpenny, C. P. Filson, V. A. Master, M. G. Sanda, P. Chang, G. W. Chien, R. A. Jones, T. L. Krupski, S. Wolpin, L. Wilson, J. H. Hayes, Q.-D. Trinh, M. Sokoloff and P. Somayaji J Urol 2018;199:89-97.

    Vickers, Andrew / Weber, Ryan

    The Journal of urology

    2018  Band 199, Heft 6, Seite(n) 1632–1633

    Mesh-Begriff(e) Humans ; Male ; Prostate
    Sprache Englisch
    Erscheinungsdatum 2018-03-16
    Erscheinungsland United States
    Dokumenttyp Letter ; Comment
    ZDB-ID 3176-8
    ISSN 1527-3792 ; 0022-5347
    ISSN (online) 1527-3792
    ISSN 0022-5347
    DOI 10.1016/j.juro.2017.12.064
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  6. Artikel: Fluorinase mediated C-(18)F bond formation, an enzymatic tool for PET labelling.

    Deng, Hai / Cobb, Steven L / Gee, Antony D / Lockhart, Andrew / Martarello, Laurent / McGlinchey, Ryan P / O'Hagan, David / Onega, Mayca

    Chemical communications (Cambridge, England)

    2006  , Heft 6, Seite(n) 652–654

    Abstract: The fluorinase enzyme from S. cattleya is applied as a catalyst for the efficient incorporation of [18F]-fluoride into [18F]-5'-fluoro-5'-deoxyadenosine, [18F]-5'-fluoro-5'-deoxyinosine and [18F]-5-fluoro-5-deoxyribose for positron emission tomography ( ... ...

    Abstract The fluorinase enzyme from S. cattleya is applied as a catalyst for the efficient incorporation of [18F]-fluoride into [18F]-5'-fluoro-5'-deoxyadenosine, [18F]-5'-fluoro-5'-deoxyinosine and [18F]-5-fluoro-5-deoxyribose for positron emission tomography (PET) applications.
    Mesh-Begriff(e) Bacterial Proteins/chemistry ; Carbon/chemistry ; Catalysis ; Deoxyadenosines/chemistry ; Fluorine Radioisotopes/chemistry ; Inosine/analogs & derivatives ; Inosine/chemistry ; Models, Chemical ; Oxidoreductases/chemistry ; Positron-Emission Tomography/methods ; Ribosemonophosphates/chemistry ; Staining and Labeling ; Streptomyces/enzymology ; Time Factors
    Chemische Substanzen 5'-fluoro-5'-deoxyadenosine ; 5'-fluoro-5-deoxyinosine ; 5-fluoro-5-deoxy-D-ribose-1-phosphate ; Bacterial Proteins ; Deoxyadenosines ; Fluorine Radioisotopes ; Ribosemonophosphates ; Inosine (5A614L51CT) ; Carbon (7440-44-0) ; Oxidoreductases (EC 1.-) ; fluorinase (EC 1.-)
    Sprache Englisch
    Erscheinungsdatum 2006-01-18
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/b516861a
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: Influence of bovine respiratory syncytial virus F glycoprotein N-linked glycans on in vitro expression and on antibody responses in BALB/c mice.

    Klink, Holly A / Brady, Ryan P / Topliff, Christina L / Eskridge, Kent M / Srikumaran, Subramaniam / Kelling, Clayton L

    Vaccine

    2006  Band 24, Heft 16, Seite(n) 3388–3395

    Abstract: ... their expression in cell culture, and potential to induce anti-BRSV F antibody responses in BALB/c mice. Four ... encoding single or multiple N-glycosylation-site deletion BRSV fusion (F) proteins, and evaluate ... and Gly1/2/3/4. Each of the N-glycosylation-site deletion BRSV F proteins were expressed in COS-7 ...

    Abstract Bovine respiratory syncytial virus (BRSV) is an etiological component of the bovine respiratory tract disease complex. Infection with BRSV following vaccination, or re-infection following natural infection is common since protection is incomplete. The objectives of this study were to create plasmid DNA constructs encoding single or multiple N-glycosylation-site deletion BRSV fusion (F) proteins, and evaluate their expression in cell culture, and potential to induce anti-BRSV F antibody responses in BALB/c mice. Four plasmid DNAs were constructed, each encoding 1-4 N-glycosylation-site deletions: Gly4, Gly2/4, Gly1/2/4 and Gly1/2/3/4. Each of the N-glycosylation-site deletion BRSV F proteins were expressed in COS-7 cells following transfection with plasmid DNA. Inoculation of BALB/c mice with plasmid DNA, resulted in a significant anti-BRSV F IgG response to the wild-type (WT) F and glycosylation-site deletion protein Gly2/4. Gly2/4 elicited a higher antibody titer than the fully glycosylated WT F protein. Significant neutralizing antibody titers were detected following immunization with the Gly2/4 plasmid DNA. These glycosylation-site deletion BRSV F proteins will be useful to characterize the effects of glycosylation on immunogenicity in the natural host, and may lead to a new approach for the generation of BRSV vaccines.
    Mesh-Begriff(e) Animals ; Antibodies, Viral/blood ; Cattle ; Cell Line ; Cercopithecus aethiops ; Enzyme-Linked Immunosorbent Assay ; Female ; Glycosylation ; Immunoglobulin G/blood ; Mice ; Mice, Inbred BALB C ; Models, Animal ; Neutralization Tests ; Polysaccharides/chemistry ; Polysaccharides/immunology ; Protein Processing, Post-Translational ; Respiratory Syncytial Virus, Bovine/immunology ; Vaccines, DNA/immunology ; Viral Fusion Proteins/biosynthesis ; Viral Fusion Proteins/chemistry ; Viral Fusion Proteins/genetics ; Viral Fusion Proteins/immunology ; Viral Vaccines/immunology
    Chemische Substanzen Antibodies, Viral ; Immunoglobulin G ; Polysaccharides ; Vaccines, DNA ; Viral Fusion Proteins ; Viral Vaccines
    Sprache Englisch
    Erscheinungsdatum 2006-04-12
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2005.12.067
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: The synthesis and preclinical evaluation in rhesus monkey of [¹⁸F]MK-6577 and [¹¹C]CMPyPB glycine transporter 1 positron emission tomography radiotracers.

    Hamill, Terence G / Eng, Waisi / Jennings, Andrew / Lewis, Richard / Thomas, Steven / Wood, Suzanne / Street, Leslie / Wisnoski, David / Wolkenberg, Scott / Lindsley, Craig / Sanabria-Bohórquez, Sandra M / Patel, Shil / Riffel, Kerry / Ryan, Christine / Cook, Jacquelynn / Sur, Cyrille / Burns, H Donald / Hargreaves, Richard

    Synapse (New York, N.Y.)

    2011  Band 65, Heft 4, Seite(n) 261–270

    Abstract: ... using [¹¹C]MeI, and [¹⁸F]MK-6577 was synthesized by a nucleophilic aromatic substitution reaction using ... 11 or fluorine-18. [¹¹C]CMPyPB was synthesized by the alkylation of a 3-hydroxypyridine precursor ... matter of the frontal cortex. In vivo blockade and chase studies of [¹⁸F]MK-6577 showed a large specific ...

    Abstract Two positron emission tomography radiotracers for the glycine transporter 1 (GlyT1) are reported here. Each radiotracer is a propylsulfonamide-containing benzamide and was labeled with either carbon-11 or fluorine-18. [¹¹C]CMPyPB was synthesized by the alkylation of a 3-hydroxypyridine precursor using [¹¹C]MeI, and [¹⁸F]MK-6577 was synthesized by a nucleophilic aromatic substitution reaction using a 2-chloropyridine precursor. Each tracer shows good uptake into rhesus monkey brain with the expected distribution of highest uptake in the pons, thalamus, and cerebellum and lower uptake in the striatum and gray matter of the frontal cortex. In vivo blockade and chase studies of [¹⁸F]MK-6577 showed a large specific signal and reversible binding. In vitro autoradiographic studies with [¹⁸F]MK-6577 showed a large specific signal in both rhesus monkey and human brain slices and a distribution consistent with the in vivo results and those reported in the literature. In vivo metabolism studies in rhesus monkeys demonstrated that only more-polar metabolites are formed for each tracer. Of these two tracers, [¹⁸F]MK-6577 was more extensively characterized and is a promising clinical positron emission tomography tracer for imaging GlyT1 and for measuring GlyT1 occupancy of therapeutic compounds.
    Mesh-Begriff(e) Animals ; Benzamides/blood ; Benzamides/chemical synthesis ; Carbon Radioisotopes/blood ; Cell Line ; Drug Evaluation, Preclinical/methods ; Fluorine Radioisotopes/blood ; Glycine Plasma Membrane Transport Proteins/blood ; Glycine Plasma Membrane Transport Proteins/metabolism ; Humans ; Macaca mulatta ; Positron-Emission Tomography/methods ; Pyridines/blood ; Pyridines/chemical synthesis ; Sulfonamides/blood ; Sulfonamides/chemical synthesis
    Chemische Substanzen Benzamides ; Carbon Radioisotopes ; Fluorine Radioisotopes ; Glycine Plasma Membrane Transport Proteins ; MK-6577 ; Pyridines ; Sulfonamides ; 3-hydroxypyridine (4KBE4P5B6S) ; 2-chloropyridine (8HMD45AYEJ)
    Sprache Englisch
    Erscheinungsdatum 2011-04
    Erscheinungsland United States
    Dokumenttyp Comparative Study ; Journal Article
    ZDB-ID 639061-4
    ISSN 1098-2396 ; 0885-8276 ; 0887-4476
    ISSN (online) 1098-2396
    ISSN 0885-8276 ; 0887-4476
    DOI 10.1002/syn.20842
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  9. Artikel ; Online: Position Statement: Expert Witness Qualifications and Ethical Guidelines for Emergency Medical Services Litigation.

    Maggiore, W Ann Winnie / Jacobsen, Ryan C / Kupas, Douglas F

    Prehospital emergency care

    2024  Band 28, Heft 4, Seite(n) 666–667

    Mesh-Begriff(e) Expert Testimony/ethics ; Expert Testimony/legislation & jurisprudence ; Humans ; Emergency Medical Services/ethics ; Emergency Medical Services/legislation & jurisprudence ; Emergency Medical Services/standards ; United States ; Malpractice/legislation & jurisprudence
    Sprache Englisch
    Erscheinungsdatum 2024-03-28
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1461751-1
    ISSN 1545-0066 ; 1090-3127
    ISSN (online) 1545-0066
    ISSN 1090-3127
    DOI 10.1080/10903127.2024.2325634
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  10. Artikel ; Online: Defining the Shape of the Mylohyoid Muscle: A Morphometric Imaging Study.

    Magaña, Linda C / Branstetter, Barton F / Soose, Ryan J

    The Laryngoscope

    2024  Band 134, Heft 6, Seite(n) 2970–2975

    Abstract: Objectives: Implantable hypoglossal nerve stimulation (HNS) therapy is an evolving therapeutic alternative for patients with refractory obstructive sleep apnea (OSA). The muscular anatomy of this region has implications for surgical access through this ... ...

    Abstract Objectives: Implantable hypoglossal nerve stimulation (HNS) therapy is an evolving therapeutic alternative for patients with refractory obstructive sleep apnea (OSA). The muscular anatomy of this region has implications for surgical access through this zone as well as positioning and anchoring of hardware in this area. The purpose of this study was to radiologically describe the topography of the mylohyoid muscle and adjacent structures across a wide age spectrum.
    Methods: We retrospectively evaluated computed tomography scans of the neck in 102 patients who were imaged for reasons unrelated to the floor of mouth or submental space. Patients with prior surgery or pathology in the area of interest were excluded. Fourteen relevant muscle measurements were made on a midline sagittal image and a coronal image positioned at the midpoint between the hyoid bone and the mandible.
    Results: We included 49 men and 53 women with an average age of 44 years (range 19-70). The average mylohyoid length was 42 mm; the average distance between the anterior digastric bellies was 17 mm. The average angle of the central mylohyoid was 174° in the sagittal plane and 164° in the coronal plane. Several measurements were significantly correlated with patient age, including the angle measurements and the distance between the digastric muscles. Aberrant digastric anatomy was common.
    Conclusions: The mylohyoid muscle has multiple radiologically distinct segments with predictable curvatures. An understanding of submental muscular anatomy, along with its variability between patients, may be beneficial to the development of bilateral implantable neurostimulation technology for the treatment of refractory OSA.
    Level of evidence: N/A Laryngoscope, 134:2970-2975, 2024.
    Mesh-Begriff(e) Humans ; Male ; Adult ; Middle Aged ; Aged ; Aged, 80 and over ; Neck Muscles/anatomy & histology ; Neck Muscles/diagnostic imaging ; Retrospective Studies ; Tomography, X-Ray Computed
    Sprache Englisch
    Erscheinungsdatum 2024-03-07
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.31374
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