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  1. Article ; Online: Unlocking the therapeutic potential of antiviral RNAi.

    Sanchez-David, Raul Y / Maillard, Pierre V

    Immunity

    2021  Volume 54, Issue 10, Page(s) 2180–2182

    Abstract: RNA interference (RNAi) provides antiviral defense in many organisms, including plants, insects, and nematodes. In this issue of Immunity, Fang et al. (2021) utilize designer peptides targeting viral suppressors of RNAi to provide evidence for the ... ...

    Abstract RNA interference (RNAi) provides antiviral defense in many organisms, including plants, insects, and nematodes. In this issue of Immunity, Fang et al. (2021) utilize designer peptides targeting viral suppressors of RNAi to provide evidence for the relevance of RNAi to antiviral immunity in mammals, also revealing the potential of this approach toward antiviral therapy.
    MeSH term(s) Animals ; Antiviral Agents/therapeutic use ; RNA Interference
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2021-10-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2021.09.013
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  2. Article ; Online: Mammalian antiviral RNAi is on the move.

    Schierhorn, Kristina L / Sanchez-David, Raul Y / Maillard, Pierre V

    The EMBO journal

    2022  Volume 41, Issue 11, Page(s) e111210

    Abstract: Recent work reported the existence of a mammalian cell-autonomous antiviral defence based on RNA interference (RNAi), which relies on the accumulation of virus-derived small interfering RNAs (vsiRNAs) to guide the degradation of complementary viral RNAs. ...

    Abstract Recent work reported the existence of a mammalian cell-autonomous antiviral defence based on RNA interference (RNAi), which relies on the accumulation of virus-derived small interfering RNAs (vsiRNAs) to guide the degradation of complementary viral RNAs. In a new study, Zhang et al (2022) find that, in infected mice, vsiRNAs can enter the bloodstream via their incorporation into extracellular vesicles (EVs) and confer sequence-specific antiviral activity to recipient cells, thus indicating that mammalian antiviral RNAi participates in both cell-autonomous and non-cell-autonomous host defence.
    MeSH term(s) Animals ; Antiviral Agents ; Mammals/genetics ; Mice ; RNA Interference ; RNA, Double-Stranded ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; RNA, Viral/genetics ; Viruses
    Chemical Substances Antiviral Agents ; RNA, Double-Stranded ; RNA, Small Interfering ; RNA, Viral
    Language English
    Publishing date 2022-04-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 586044-1
    ISSN 1460-2075 ; 0261-4189
    ISSN (online) 1460-2075
    ISSN 0261-4189
    DOI 10.15252/embj.2022111210
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  3. Article ; Online: Slicing and dicing viruses: antiviral RNA interference in mammals.

    Maillard, Pierre V / van der Veen, Annemarthe G / Poirier, Enzo Z / Reis e Sousa, Caetano

    The EMBO journal

    2019  Volume 38, Issue 8

    Abstract: To protect against the harmful consequences of viral infections, organisms are equipped with sophisticated antiviral mechanisms, including cell-intrinsic means to restrict viral replication and propagation. Plant and invertebrate cells utilise mostly RNA ...

    Abstract To protect against the harmful consequences of viral infections, organisms are equipped with sophisticated antiviral mechanisms, including cell-intrinsic means to restrict viral replication and propagation. Plant and invertebrate cells utilise mostly RNA interference (RNAi), an RNA-based mechanism, for cell-intrinsic immunity to viruses while vertebrates rely on the protein-based interferon (IFN)-driven innate immune system for the same purpose. The RNAi machinery is conserved in vertebrate cells, yet whether antiviral RNAi is still active in mammals and functionally relevant to mammalian antiviral defence is intensely debated. Here, we discuss cellular and viral factors that impact on antiviral RNAi and the contexts in which this system might be at play in mammalian resistance to viral infection.
    MeSH term(s) Animals ; Antiviral Agents/administration & dosage ; Host-Pathogen Interactions/genetics ; Host-Pathogen Interactions/immunology ; Mammals/genetics ; Mammals/immunology ; Mammals/virology ; RNA Interference ; RNA, Viral/genetics ; Virus Diseases/genetics ; Virus Diseases/immunology ; Virus Diseases/virology ; Virus Replication ; Viruses/immunology ; Viruses/isolation & purification
    Chemical Substances Antiviral Agents ; RNA, Viral
    Keywords covid19
    Language English
    Publishing date 2019-03-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 586044-1
    ISSN 1460-2075 ; 0261-4189
    ISSN (online) 1460-2075
    ISSN 0261-4189
    DOI 10.15252/embj.2018100941
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  4. Article ; Online: Metabolic connectivity is associated with seizure outcome in surgically treated temporal lobe epilepsies: A

    Doyen, Matthieu / Chawki, Mohammad B / Heyer, Sébastien / Guedj, Eric / Roch, Véronique / Marie, Pierre-Yves / Tyvaert, Louise / Maillard, Louis / Verger, Antoine

    NeuroImage. Clinical

    2022  Volume 36, Page(s) 103210

    Abstract: 18: Methods: The study included 107 right-handed patients that had undergone a presurgical interictal : Results: Increased metabolic connectivity was observed in the >IA compared to the IA group within the operated temporal lobe (respective ... ...

    Abstract 18
    Methods: The study included 107 right-handed patients that had undergone a presurgical interictal
    Results: Increased metabolic connectivity was observed in the >IA compared to the IA group within the operated temporal lobe (respective clusters of 7.5 vs 3.3 cm
    Conclusion: Metabolic connectivity is associated with outcome in surgically treated TLE with a strengthened epileptogenic connectome in patients with non-free-seizure outcomes. The added value of seed correlation analysis in left TLE underlines the importance of evaluating metabolic connectivity in network related diseases.
    Language English
    Publishing date 2022-09-24
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2701571-3
    ISSN 2213-1582 ; 2213-1582
    ISSN (online) 2213-1582
    ISSN 2213-1582
    DOI 10.1016/j.nicl.2022.103210
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  5. Article ; Online: Adherence to Recommendations and Quality of Endoscopic Colorectal Cancer Surveillance in Long-Standing Ulcerative Colitis.

    Santi, Giulia / Michetti, Pierre / Froehlich, Florian / Rossel, Jean-Benoît / Pittet, Valérie / Maillard, Michel H

    Inflammatory intestinal diseases

    2020  Volume 6, Issue 1, Page(s) 25–31

    Abstract: Background: Long-standing ulcerative colitis has been associated with an increased risk of colorectal cancer (CRC). Current guidelines recommend endoscopic CRC screening after 8 years of disease duration. The objectives of our study were to assess the ... ...

    Abstract Background: Long-standing ulcerative colitis has been associated with an increased risk of colorectal cancer (CRC). Current guidelines recommend endoscopic CRC screening after 8 years of disease duration. The objectives of our study were to assess the adherence to recommendations and the quality of endoscopic procedure in long-standing ulcerative colitis.
    Methods: This is a retrospective cohort study. We selected patients included in the Swiss IBD cohort with a disease duration of ≥8 years and an extension above the rectosigmoid junction. The complementary medical chart review focused on endoscopy and associated histological reports in 8 Swiss centers. Descriptive analyses focused on patients and their colonoscopies.
    Results: 309 colonoscopies were conducted among 116 patients with the following characteristics: women 47%, mean age at diagnosis 31 years, and pancolitis disease extent in 65.5% of cases; 38.8% of patients had a first screening colonoscopy <8 years, 13.8% between 8 and 10 years, and 47.4% >10 years. Cecal intubation was performed in 94.5% of cases, and bowel preparation was good to excellent in 61.5% of endoscopies. Chromoendoscopy was used in 7.4% of cases, and the mean withdrawal time was 16.4 min. Dysplasia was found in 6.2% of cases.
    Conclusion: Despite current international recommendations, a significant number of patients did not receive a proper endoscopic surveillance. An increased use of chromoendoscopy, monitoring of withdrawal time, and appropriate bowel preparation would increase the quality of CRC screening. The adherence to screening guidelines and endoscopic quality should be promoted and standardized.
    Language English
    Publishing date 2020-10-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2817967-5
    ISSN 2296-9365 ; 2296-9403
    ISSN (online) 2296-9365
    ISSN 2296-9403
    DOI 10.1159/000511010
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  6. Article ; Online: Predictive value of health-related quality of life on radiotherapy-related toxicities in patients with head and neck cancer.

    Billa, Oumar / Bonnetain, Franck / Chamois, Jérôme / Ligey, Angeline / Ganansia, Valérie / Renard, Sophie / Maillard, Sophie / Quivrin, Magali / Vulquin, Noémie / Truntzer, Pierre / Noel, Georges / Maingon, Philippe / Dabakuyo-Yonli, Tienhan Sandrine

    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

    2023  Volume 31, Issue 5, Page(s) 268

    Abstract: Purpose: Little is known about whether baseline health-related quality of life (HRQoL) scores also could predict occurrence radiotherapy-related toxicities, which we aim to assess in this study.: Methods: This study analyzed data from 200 patients ... ...

    Abstract Purpose: Little is known about whether baseline health-related quality of life (HRQoL) scores also could predict occurrence radiotherapy-related toxicities, which we aim to assess in this study.
    Methods: This study analyzed data from 200 patients enrolled in randomized study investigating the utility of HRQoL. HRQOL was assessed at baseline and during follow up using QLQ-C30 questionnaire and major toxicity was considered as adverse event ≥ 3 according to NCI-CTCAE classification. Cox regressions adjusting for clinical and sociodemographic data were used to assess prognostic significance of HRQOL scores.
    Results: In multivariable analyses adjusted on clinical and sociodemographic data, every 10-point improvement in physical (HR = 0.74), role (HR = 0.87) and social (HR = 0.88) functioning was associated with 24%, 13% and 12% lower hazard of occurrence of major toxicity respectively while every 10 point-increase in dyspnea (HR = and loss appetite was associated with 15% and 16% increased hazard of major toxicity.
    Conclusion: Certain baseline HRQoL scores were found to be significantly associated with the occurrence of major toxicity.
    MeSH term(s) Humans ; Head and Neck Neoplasms/radiotherapy ; Prognosis ; Quality of Life ; Surveys and Questionnaires
    Language English
    Publishing date 2023-04-14
    Publishing country Germany
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 1134446-5
    ISSN 1433-7339 ; 0941-4355
    ISSN (online) 1433-7339
    ISSN 0941-4355
    DOI 10.1007/s00520-023-07736-0
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  7. Article ; Online: Drosha cuts the tethers of myelopoiesis.

    van der Veen, Annemarthe G / Maillard, Pierre V / Reis e Sousa, Caetano

    Nature immunology

    2015  Volume 16, Issue 11, Page(s) 1110–1112

    MeSH term(s) Animals ; Dendritic Cells/immunology ; Dendritic Cells/metabolism ; Myelopoiesis/immunology ; RNA, Messenger/metabolism ; Ribonuclease III/immunology
    Chemical Substances RNA, Messenger ; Ribonuclease III (EC 3.1.26.3)
    Language English
    Publishing date 2015-10-21
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/ni.3297
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  8. Article ; Online: Seven cases of hereditary haemorrhagic telangiectasia-like hepatic vascular abnormalities associated with

    Guilhem, Alexandre / Dupuis-Girod, Sophie / Espitia, Olivier / Rivière, Sophie / Seguier, Julie / Kerjouan, Mallorie / Lavigne, Christian / Maillard, Hélène / Magro, Pascal / Alric, Laurent / Lipsker, Dan / Parrot, Antoine / Leguy, Vanessa / Vanlemmens, Claire / Guibaud, Laurent / Vikkula, Miikka / Eyries, Melanie / Valette, Pierre-Jean / Giraud, Sophie

    Journal of medical genetics

    2023  Volume 60, Issue 9, Page(s) 905–909

    Abstract: Background: EPHB4: Methods: Members of the French HHT network reported their cases of : Results: Among 21 patients with : Conclusion: ... ...

    Abstract Background: EPHB4
    Methods: Members of the French HHT network reported their cases of
    Results: Among 21 patients with
    Conclusion: EPHB4
    MeSH term(s) Male ; Humans ; Female ; Telangiectasia, Hereditary Hemorrhagic/complications ; Telangiectasia, Hereditary Hemorrhagic/diagnosis ; Telangiectasia, Hereditary Hemorrhagic/genetics ; Epistaxis/complications ; Liver ; Intracranial Arteriovenous Malformations ; Mutation
    Language English
    Publishing date 2023-02-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 220881-7
    ISSN 1468-6244 ; 0022-2593
    ISSN (online) 1468-6244
    ISSN 0022-2593
    DOI 10.1136/jmg-2022-109107
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  9. Article: Severe Anaplasma phagocytophilum and Babesia divergens Concomitant Infection in Imported Captive Reindeer (Rangifer tarandus)

    Romanos, Lola / Maillard, Renaud Pierre

    Macedonian veterinary review. 2020 Oct. 01, v. 43, no. 2

    2020  

    Abstract: Tick-borne diseases are highly prevalent in domestic and wild ruminants and they may be distributed in wide geographical ranges by animal transportation. The aim of the current study was to investigate the presence of European strains of Babesia spp. and/ ...

    Abstract Tick-borne diseases are highly prevalent in domestic and wild ruminants and they may be distributed in wide geographical ranges by animal transportation. The aim of the current study was to investigate the presence of European strains of Babesia spp. and/or Anaplasma spp. in oversea imported reindeer specimens. Imported specimens (n=7) were hospitalized with visible tick infestation (Ixodes ricinus) and signs of cachexia, anemia, and hemoglobinuria. Using blood smears, PCR, and BLAST comparisons, it was confirmed that the animals were infected with a French strain of Anaplasma phagocytophilum and Babesia divergens which is considered to be absent in the USA. We conclude that oversea importation of reindeers must be followed with a routine check for geographically-specific strains of pathogens from the place of origin. This monitoring process must be dynamic and according to recent reports of tick-borne pathogens.
    Keywords Anaplasma phagocytophilum ; Babesia divergens ; Ixodes ricinus ; Rangifer tarandus ; animal transport ; blood ; cachexia ; captive animals ; hemoglobinuria ; mixed infection ; monitoring ; pathogens ; polymerase chain reaction ; reindeer ; tick infestations ; tick-borne diseases ; United States
    Language English
    Dates of publication 2020-1001
    Size p. 185-191.
    Publishing place Sciendo
    Document type Article
    ZDB-ID 2732553-2
    ISSN 1857-7415 ; 1409-7621
    ISSN (online) 1857-7415
    ISSN 1409-7621
    DOI 10.2478/macvetrev-2020-0023
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  10. Article ; Online: The HUSH complex is a gatekeeper of type I interferon through epigenetic regulation of LINE-1s

    Hale Tunbak / Rocio Enriquez-Gasca / Christopher H. C. Tie / Poppy A. Gould / Petra Mlcochova / Ravindra K. Gupta / Liane Fernandes / James Holt / Annemarthe G. van der Veen / Evangelos Giampazolias / Kathleen H. Burns / Pierre V. Maillard / Helen M. Rowe

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Volume 15

    Abstract: The HUSH complex has been implicated in repressing LINE-1 elements. Here the authors reveal that the complex negatively regulates the type I IFN response in human cells through epigenetic regulation of LINE-1 ... ...

    Abstract The HUSH complex has been implicated in repressing LINE-1 elements. Here the authors reveal that the complex negatively regulates the type I IFN response in human cells through epigenetic regulation of LINE-1 elements
    Keywords Science ; Q
    Language English
    Publishing date 2020-11-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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