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  1. Article ; Online: Current and Future Perspectives of Health-Related Quality of Life in Resectable EGFR-Mutated Non-Small Cell Lung Cancer: A Podcast.

    John, Thomas / Majem, Margarita / Legg, Diane / Goldman, Jonathan

    Targeted oncology

    2022  Volume 18, Issue 1, Page(s) 1–8

    MeSH term(s) Humans ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/psychology ; ErbB Receptors/genetics ; Erlotinib Hydrochloride ; Lung Neoplasms/genetics ; Lung Neoplasms/psychology ; Mutation ; Quality of Life
    Chemical Substances EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1) ; Erlotinib Hydrochloride (DA87705X9K)
    Language English
    Publishing date 2022-12-19
    Publishing country France
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2222136-0
    ISSN 1776-260X ; 1776-2596
    ISSN (online) 1776-260X
    ISSN 1776-2596
    DOI 10.1007/s11523-022-00927-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: BTS clinical statement on aspiration pneumonia.

    Simpson, A John / Allen, Jamie-Leigh / Chatwin, Michelle / Crawford, Hannah / Elverson, Joanna / Ewan, Victoria / Forton, Julian / McMullan, Ronan / Plevris, John / Renton, Kate / Tedd, Hilary / Thomas, Rhys / Legg, Julian

    Thorax

    2023  Volume 78, Issue Suppl 1, Page(s) s3–s21

    MeSH term(s) Humans ; Pneumonia, Aspiration/diagnostic imaging ; Pneumonia, Aspiration/etiology
    Language English
    Publishing date 2023-03-31
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 204353-1
    ISSN 1468-3296 ; 0040-6376
    ISSN (online) 1468-3296
    ISSN 0040-6376
    DOI 10.1136/thorax-2022-219699
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui III Zs.83: Show issues Location:
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  3. Article ; Online: BTS Clinical Statement on the prevention and management of community-acquired pneumonia in people with learning disability.

    Legg, Julian / Allen, Jamie-Leigh / Andrew, Morag / Annesley, Charlotte / Chatwin, Michelle / Crawford, Hannah / Elverson, Joanna / Forton, Julian / Oulton, Kate / Renton, Kate / Tavare, Alison / Tedd, Hilary / Simpson, A John

    Thorax

    2023  Volume 78, Issue Suppl 1, Page(s) s22–s52

    MeSH term(s) Humans ; Community-Acquired Infections/prevention & control ; Learning Disabilities ; Pneumonia/prevention & control
    Language English
    Publishing date 2023-03-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 204353-1
    ISSN 1468-3296 ; 0040-6376
    ISSN (online) 1468-3296
    ISSN 0040-6376
    DOI 10.1136/thorax-2022-219698
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  4. Book ; Conference proceedings: Proceedings of the International Symposium on Plant Genetic Resources in Agricultural Environmental Sustabinability. International Conference, hosted by NIAB at St. John's College, Cambridge, United Kingdom, 21-23 August 2002

    Legg, Brian

    2003  

    Event/congress International Conference Plant Genetic Resources in Agricultural and Environmental Sustainability (CambridgeUnitedKingdom2002.08.21-23)
    Author's details ed. Brian Legg
    Language English
    Size 44 S
    Publishing place Cambridge
    Document type Book ; Conference proceedings
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  5. Article ; Online: Association of Diet Patterns and Post-Operative Tympanostomy Tube Otorrhea: A Pilot Study.

    Dedhia, Kavita / Li, Yun / Stallings, Virginia A / Germiller, John / Giordano, Terri / Dailey, Julia / Kong, Maria / Durkin, Alexandra / Legg-Jack, Ibikari / Nessen, Sarah / Schapira, Marilyn M

    The Laryngoscope

    2023  Volume 133, Issue 12, Page(s) 3575–3581

    Abstract: Objective: The objective of this study was to explore diet patterns in children with tympanostomy tube placement (TTP) complicated by postoperative tympanostomy tube otorrhea.: Study design: Cross-sectional survey and retrospective cohort study.: ... ...

    Abstract Objective: The objective of this study was to explore diet patterns in children with tympanostomy tube placement (TTP) complicated by postoperative tympanostomy tube otorrhea.
    Study design: Cross-sectional survey and retrospective cohort study.
    Methods: Caregivers of children (0-12 years old), at a tertiary-care pediatric hospital who underwent TTP within 6 months to 2 years prior to enrollment were included. Children with a history of Down syndrome, cleft palate, craniofacial syndromes, known immunodeficiency, or a non-English-speaking family were excluded. Our primary outcome variable was the number of otorrhea episodes. The primary predictor was diet patterns, particularly dessert intake, which was captured through a short food questionnaire.
    Results: A total of 286 participants were included in this study. The median age was 1.8 years (IQR, 1.3, 2.9). A total of 174 (61%) participants reported at least one episode of otorrhea. Children who consumed dessert at least two times per week had a higher risk of otorrhea compared to children who consumed one time per week or less (odds ratio [OR], 3.22, 95% Confidence Interval [CI]: 1.69, 6.12). The odds ratio increase continued when considering more stringent criteria for otorrhea (multiple episodes or one episode occurring 4 weeks after surgery), with a 2.33 (95% CI: 1.24, 4.39) higher odds of otorrhea in children with dessert intake at least 2 times per week.
    Conclusions: Our pilot data suggest that episodes of otorrhea among children with TTP were associated with more frequent dessert intake. Future studies using prospectively administered diet questionnaires are necessary to confirm these findings.
    Level of evidence: 4 Laryngoscope, 133:3575-3581, 2023.
    MeSH term(s) Child ; Humans ; Infant ; Infant, Newborn ; Child, Preschool ; Otitis Media with Effusion/etiology ; Otitis Media with Effusion/surgery ; Pilot Projects ; Middle Ear Ventilation/adverse effects ; Retrospective Studies ; Cross-Sectional Studies ; Diet
    Language English
    Publishing date 2023-03-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.30672
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  6. Article ; Online: A systematic review of the evidence on home care reablement services.

    Legg, Lynn / Gladman, John / Drummond, Avril / Davidson, Alex

    Clinical rehabilitation

    2016  Volume 30, Issue 8, Page(s) 741–749

    Abstract: Objective: To determine whether publically funded 'reablement services' have any effect on patient health or use of services.: Design: Systematic review of randomized controlled trials and non-randomized studies in which reablement interventions were ...

    Abstract Objective: To determine whether publically funded 'reablement services' have any effect on patient health or use of services.
    Design: Systematic review of randomized controlled trials and non-randomized studies in which reablement interventions were compared with no care or usual care in people referred to public-funded personal care services. Data sources included: Cochrane Central Register of Controlled Trials, EPOC register of studies, trials registers, Medline, EMBASE, and CINHAL. Searches were from 2000 up to end February 2015.
    Setting: Not applicable.
    Participants: Investigators' definition of the target population for reablement interventions.
    Main outcome measures: Use of publically funded personal care services and dependence in personal activities of daily living.
    Results: We found no studies fulfilling our inclusion criteria that assessed the effectiveness of reablement interventions. We did note the lack of an agreed understanding of the nature of reablement.
    Conclusions: Reablement is an ill-defined intervention targeted towards an ill-defined and potentially highly heterogeneous population/patient group. There is no evidence to suggest it is effective at either of its goals; increasing personal independence or reducing use of personal care services.
    MeSH term(s) Activities of Daily Living ; Home Care Services ; Humans ; Rehabilitation
    Language English
    Publishing date 2016-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 639276-3
    ISSN 1477-0873 ; 0269-2155
    ISSN (online) 1477-0873
    ISSN 0269-2155
    DOI 10.1177/0269215515603220
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  7. Article ; Online: Self-similar mesocrystals form via interface-driven nucleation and assembly.

    Zhu, Guomin / Sushko, Maria L / Loring, John S / Legg, Benjamin A / Song, Miao / Soltis, Jennifer A / Huang, Xiaopeng / Rosso, Kevin M / De Yoreo, James J

    Nature

    2021  Volume 590, Issue 7846, Page(s) 416–422

    Abstract: Crystallization by particle attachment (CPA) is a frequently occurring mechanism of colloidal crystallization that results in hierarchical ... ...

    Abstract Crystallization by particle attachment (CPA) is a frequently occurring mechanism of colloidal crystallization that results in hierarchical morphologies
    Language English
    Publishing date 2021-02-17
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-021-03300-0
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  8. Article ; Online: Depletion of exhausted alloreactive T cells enables targeting of stem-like memory T cells to generate tumor-specific immunity.

    Minnie, Simone A / Waltner, Olivia G / Ensbey, Kathleen S / Nemychenkov, Nicole S / Schmidt, Christine R / Bhise, Shruti S / Legg, Samuel R W / Campoy, Gabriela / Samson, Luke D / Kuns, Rachel D / Zhou, Ting / Huck, John D / Vuckovic, Slavica / Zamora, Danniel / Yeh, Albert / Spencer, Andrew / Koyama, Motoko / Markey, Kate A / Lane, Steven W /
    Boeckh, Michael / Ring, Aaron M / Furlan, Scott N / Hill, Geoffrey R

    Science immunology

    2022  Volume 7, Issue 76, Page(s) eabo3420

    Abstract: Some hematological malignancies such as multiple myeloma are inherently resistant to immune-mediated antitumor responses, the cause of which remains unknown. Allogeneic bone marrow transplantation (alloBMT) is the only curative immunotherapy for ... ...

    Abstract Some hematological malignancies such as multiple myeloma are inherently resistant to immune-mediated antitumor responses, the cause of which remains unknown. Allogeneic bone marrow transplantation (alloBMT) is the only curative immunotherapy for hematological malignancies due to profound graft-versus-tumor (GVT) effects, but relapse remains the major cause of death. We developed murine models of alloBMT where the hematological malignancy is either sensitive [acute myeloid leukemia (AML)] or resistant (myeloma) to GVT effects. We found that CD8
    MeSH term(s) Animals ; Chromatin ; Cyclophosphamide ; Graft vs Host Disease ; Hematologic Neoplasms ; Immune Checkpoint Inhibitors ; Interleukin-18 ; Isoantigens ; Memory T Cells ; Mice ; Multiple Myeloma/therapy ; Transplantation, Homologous
    Chemical Substances Chromatin ; Immune Checkpoint Inhibitors ; Interleukin-18 ; Isoantigens ; Cyclophosphamide (8N3DW7272P)
    Language English
    Publishing date 2022-10-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ISSN 2470-9468
    ISSN (online) 2470-9468
    DOI 10.1126/sciimmunol.abo3420
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Inventing the Grand Banks: A deep chart: Humanities GIS, Cartesian, and literary perceptions of the north-west Atlantic fishery ca 1500-1800.

    Travis, Charles / Ludlow, Francis / Matthews, Al / Lougheed, Kevin / Rankin, Kieran / Allaire, Bernard / Legg, Robert / Hayes, Patrick / Breen, Richard / Nicholls, John / Towns, Lydia / Holm, Poul

    Geo : geography and environment

    2020  Volume 7, Issue 1, Page(s) e00085

    Abstract: As a feature of the Fish Revolution (1400-1700), the early modern "invention" of the Grand Banks in literary and cartographical documents facilitated a massive and unprecedented extraction of cod from the waters of the north Atlantic and created the Cod/ ... ...

    Abstract As a feature of the Fish Revolution (1400-1700), the early modern "invention" of the Grand Banks in literary and cartographical documents facilitated a massive and unprecedented extraction of cod from the waters of the north Atlantic and created the Cod/Sack trade Triangle. This overlapped with the southern Atlantic Slave, Sugar, and Tobacco Triangle to capitalise modern European and North American societies. In 1719, Pierre de Charlevoix claimed that the Grand Banks was "properly a mountain, hid under water," and noted its cod population "seems to equal that of the grains of sand which cover this bank." However, two centuries later in 1992, in the face of the collapse of the fishery, and fearing its extinction, a moratorium was placed on five centuries of harvesting Grand Banks cod. The invention and mining of its waters serves as a bellwether for the massive resource extractions of modernity that drive the current leviathan and "wicked problem" of global warming. The digital environmental humanities narrative of this study is parsed together from 83 pieces of Grand Banks charting from 1504 to 1833, which are juxtaposed through Humanities GIS applications with English and French cod-catch records kept between 1675 and 1831, letters regarding Cabot's 1497 voyage, Shakespeare's
    Language English
    Publishing date 2020-03-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2778711-4
    ISSN 2054-4049
    ISSN 2054-4049
    DOI 10.1002/geo2.85
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  10. Article: Cultural Values, Deep Mining Operations and the Use of Surplus Groundwater for Towns, Landscapes and Jobs

    Legg, Peter / Hatton MacDonald, Darla / Bark, Rosalind H / Tocock, Mark / Tinch, Dugald / Rose, John M

    Ecological economics. 2020 Dec., v. 178

    2020  

    Abstract: Trade-offs involving land use change, cultural values, water resources and jobs are critically important to understand the opportunity cost of resource extraction. Stated preference techniques can be particularly useful in eliciting the non-market values ...

    Abstract Trade-offs involving land use change, cultural values, water resources and jobs are critically important to understand the opportunity cost of resource extraction. Stated preference techniques can be particularly useful in eliciting the non-market values expressed as trade-offs. This study assesses preferences over the management of groundwater released from deep mining operations in Western Australia. A discrete choice experiment is used to investigate the trade-offs Australians are prepared to make for remote economic, ecological and cultural goods against costs. The results suggest that there is heterogeneity of preferences as indicated by a three-class structure of a latent class model. One class supports the use of released groundwater across a range of economic, ecological and cultural uses modelled: extending town water supply, restoring rangeland habitat, creating jobs for Aboriginal Australians and preserving cultural waterholes. The smallest class supports all these uses except job creation and the final class only supports preserving cultural waterholes. These results illustrate public attitudes towards cultural values as well as wider environmental policy tensions between instrumental and intrinsic values.
    Keywords Australians ; administrative management ; cultural values ; ecological economics ; employment ; environmental policy ; extraction ; groundwater ; habitats ; land use change ; landscapes ; methodology ; models ; opportunity costs ; public opinion ; rangelands ; towns ; underground mining ; water supply ; Western Australia
    Language English
    Dates of publication 2020-12
    Publishing place Elsevier B.V.
    Document type Article
    Note NAL-light
    ISSN 0921-8009
    DOI 10.1016/j.ecolecon.2020.106808
    Database NAL-Catalogue (AGRICOLA)

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