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  1. Book: Aktuelle Schwerpunkte der Orthopädie / 3 / Bearb. von H. P. Berlien ...

    Bauer, Rudolf / Becker, Wolfgang / Berlien, Hans-Peter / Springorum, Hans-Werner

    Fortbildungskurse der DGOT

    1992  

    Institution Deutsche Gesellschaft für Orthopädie und Traumatologie
    Author's details hrsg. von Hans-Werner Springorum
    Collection Aktuelle Schwerpunkte der Orthopädie
    Keywords Orthopädie ; Ärztliche Fortbildung
    Subject Arzt
    Size X, 161 S. : Ill., graph. Darst.
    Publisher Thieme
    Publishing place Stuttgart u.a.
    Document type Book
    HBZ-ID HT004194773
    ISBN 3-13-774701-5 ; 978-3-13-774701-7
    Database Catalogue ZB MED Medicine, Health

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    1991 A 4292 -3- order for loan Magazin

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  2. Article ; Online: Metabolic Imaging of Urothelial Carcinoma by Simultaneous Autofluorescence Lifetime Imaging (FLIM) of NAD(P)H and FAD.

    Suarez-Ibarrola, Rodrigo / Braun, Lukas / Pohlmann, Philippe Fabian / Becker, Wolfgang / Bergmann, Axel / Gratzke, Christian / Miernik, Arkadiusz / Wilhelm, Konrad

    Clinical genitourinary cancer

    2020  Volume 19, Issue 1, Page(s) e31–e36

    MeSH term(s) Carcinoma, Transitional Cell ; Cell Line, Tumor ; Flavin-Adenine Dinucleotide ; Humans ; NAD ; Urinary Bladder Neoplasms/diagnostic imaging
    Chemical Substances NAD (0U46U6E8UK) ; Flavin-Adenine Dinucleotide (146-14-5)
    Language English
    Publishing date 2020-07-16
    Publishing country United States
    Document type Case Reports ; Research Support, Non-U.S. Gov't
    ZDB-ID 2225121-2
    ISSN 1938-0682 ; 1558-7673
    ISSN (online) 1938-0682
    ISSN 1558-7673
    DOI 10.1016/j.clgc.2020.07.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Metabolic Imaging by Simultaneous FLIM of NAD(P)H and FAD

    Becker Wolfgang / Braun Lukas / Suarez-Ibarrol Rodrigo / Miernik Arkadiusz

    Current Directions in Biomedical Engineering, Vol 6, Iss 3, Pp 254-

    2020  Volume 256

    Abstract: ... of 375nm and 410 nm, are multiplexed to alternatingly excite NAD(P)H and FAD. One FLIM channel detects ... in the emission band of NAD(P)H, the other in the emission band of FAD. For both channels, the data analysis ... We describe a metabolic imaging system based on simultaneous recording of lifetime images of NAD(P ...

    Abstract We describe a metabolic imaging system based on simultaneous recording of lifetime images of NAD(P)H and FAD. The system uses one-photon excitation by ps diode lasers, scanning by galvanometer mirrors, confocal detection, and two parallel TCSPC FLIM recording channels. Two lasers, with wavelengths of 375nm and 410 nm, are multiplexed to alternatingly excite NAD(P)H and FAD. One FLIM channel detects in the emission band of NAD(P)H, the other in the emission band of FAD. For both channels, the data analysis delivers images of the amplitudes of the decay components, a1 and a2. We show that these are robust parameters to characterize the metabolic state of cells. FLIM results obtained from excised human-bladder tissue were in perfect agreement with histology.
    Keywords nad(p)h ; fad ; metabolic imaging ; flim ; Medicine ; R
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher De Gruyter
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Correlative NAD(P)H-FLIM and oxygen sensing-PLIM for metabolic mapping.

    Kalinina, Sviatlana / Breymayer, Jasmin / Schäfer, Patrick / Calzia, Enrico / Shcheslavskiy, Vladislav / Becker, Wolfgang / Rück, Angelika

    Journal of biophotonics

    2016  Volume 9, Issue 8, Page(s) 800–811

    Abstract: ... of FLIM of coenzymes as NAD(P)H and FAD(+) and PLIM of oxygen sensors could provide information ... about correlation of metabolic pathways and oxygen tension. We investigated correlative NAD(P)H-FLIM and oxygen ... cases a decrease in the lifetime of NAD(P)H which is in agreement to the expected decrease ...

    Abstract Cellular responses to oxygen tension have been studied extensively. Oxygen tension can be determined by considering the phosphorescence lifetime of a phosphorescence sensor. The simultaneous usage of FLIM of coenzymes as NAD(P)H and FAD(+) and PLIM of oxygen sensors could provide information about correlation of metabolic pathways and oxygen tension. We investigated correlative NAD(P)H-FLIM and oxygen sensing-PLIM for simultaneously analyzing cell metabolism and oxygen tension. Cell metabolism and pO2 were observed under different hypoxic conditions in squamous carcinoma cell cultures and in complex ex vivo systems. Increased hypoxia induced an increase of the phosphorescence lifetime of Ru(BPY)3 and in most cases a decrease in the lifetime of NAD(P)H which is in agreement to the expected decrease of the protein-bound NAD(P)H during hypoxia. Oxygen was modulated directly in the mitochondrial membrane. Blocking of complex III and accumulation of oxygen could be observed by both the decrease of the phosphorescence lifetime of Ru(BPY)3 and a reduction of the lifetime of NAD(P)H which was a clear indication of acute changes in the redox state of the cells. For the first time simultaneous FLIM/PLIM has been shown to be able to visualize intracellular oxygen tension together with a change from oxidative to glycolytic phenotype.
    MeSH term(s) Carcinoma, Squamous Cell/metabolism ; Cell Hypoxia ; Cell Line, Tumor ; Humans ; Microscopy, Confocal ; NADP/metabolism ; Oxidation-Reduction ; Oxygen/metabolism
    Chemical Substances NADP (53-59-8) ; Oxygen (S88TT14065)
    Language English
    Publishing date 2016-03-15
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2390063-5
    ISSN 1864-0648 ; 1864-063X
    ISSN (online) 1864-0648
    ISSN 1864-063X
    DOI 10.1002/jbio.201500297
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    Zs.A 6723: Show issues Location:
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  5. Article ; Online: Immunomodulatory effects of H.P. Acthar Gel on B cell development in the NZB/W F1 mouse model of systemic lupus erythematosus.

    Decker, D A / Grant, C / Oh, L / Becker, P M / Young, D / Jordan, S

    Lupus

    2014  Volume 23, Issue 8, Page(s) 802–812

    Abstract: H.P. Acthar Gel® (Acthar) is a highly purified repository gel preparation ...

    Abstract H.P. Acthar Gel® (Acthar) is a highly purified repository gel preparation of adrenocorticotropic hormone (ACTH1-39), a melanocortin peptide that can bind and activate specific receptors expressed on a range of systemic lupus erythematosus (SLE)-relevant target cells and tissues. This study was performed to evaluate the effects of Acthar in a mouse model of SLE, using an F1 hybrid of the New Zealand Black and New Zealand White strains (NZB/W F1). Twenty-eight week old NZB/W F1 mice with established autoimmune disease were treated with Acthar, Placebo Gel (Placebo), or prednisolone and monitored for 19 weeks. Outcomes assessed included disease severity (severe proteinuria, ≥ 20% body weight loss, or prostration), measurement of serial serum autoantibody titers, terminal spleen immunophenotyping, and evaluation of renal histopathology. Acthar treatment was linked with evidence of altered B cell differentiation and development, manifested by a significant reduction in splenic B cell follicular and germinal center cells, and decreased levels of circulating total and anti-double-stranded DNA (IgM, IgG, and IgG2a) autoantibodies as compared with Placebo. Additionally, Acthar treatment resulted in a significant decrease of proteinuria, reduced renal lymphocyte infiltration, and attenuation of glomerular immune complex deposition. These data suggest that Acthar diminished pathogenic autoimmune responses in the spleen, peripheral blood, and kidney of NZB/W F1 mice. This is the first preclinical evidence demonstrating Acthar's potential immunomodulatory activity and efficacy in a murine model of systemic lupus erythematosus.
    MeSH term(s) Adrenocorticotropic Hormone/pharmacology ; Animals ; B-Lymphocytes/drug effects ; B-Lymphocytes/physiology ; Disease Models, Animal ; Female ; Gels ; Hormones/pharmacology ; Lupus Erythematosus, Systemic/immunology ; Mice ; Mice, Inbred NZB/immunology
    Chemical Substances Gels ; Hormones ; Adrenocorticotropic Hormone (9002-60-2)
    Language English
    Publishing date 2014-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1154407-7
    ISSN 1477-0962 ; 0961-2033
    ISSN (online) 1477-0962
    ISSN 0961-2033
    DOI 10.1177/0961203314531840
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    Zs.A 3717: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  6. Article ; Online: Time-correlated single photon counting for simultaneous monitoring of zinc oxide nanoparticles and NAD(P)H in intact and barrier-disrupted volunteer skin.

    Lin, Lynlee L / Grice, Jeffrey E / Butler, Margaret K / Zvyagin, Andrei V / Becker, Wolfgang / Robertson, Thomas A / Soyer, H Peter / Roberts, Michael S / Prow, Tarl W

    Pharmaceutical research

    2011  Volume 28, Issue 11, Page(s) 2920–2930

    Abstract: ... signals (i.e. nicotinamide adenine dinucleotide phosphate, NAD(P)H and keratin) and the ZnO-NP signal ... using advanced TCSPC to simultaneously determine ZnO-NP penetration profiles and NAD(P)H changes ... h of treatment, respectively. Free NAD(P)H signal significantly increased in tape-stripped viable ...

    Abstract Purpose: There is a lack of relevant, non-animal alternatives for assessing exposure and toxicity of nanoparticle-containing cosmetics, e.g. sunscreens. Our goal was to evaluate timecorrelated single photon counting (TCSPC) for simultaneous monitoring of zinc oxide nanoparticles (ZnO-NP) and the metabolic state of volunteer skin.
    Methods: We separated the fluorescence lifetime signatures of endogenous fluorophore signals (i.e. nicotinamide adenine dinucleotide phosphate, NAD(P)H and keratin) and the ZnO-NP signal using advanced TCSPC to simultaneously determine ZnO-NP penetration profiles and NAD(P)H changes in subjects with altered barrier function, including tape-stripped skin and in psoriasis or atopic dermatitis lesions.
    Results: We detected no ZnO-NP penetration into viable human skin in any group. ZnO-NP signal was significantly increased (p < 0.01) on the surface of tape-stripped and lesional skin after 4 and 2 h of treatment, respectively. Free NAD(P)H signal significantly increased in tape-stripped viable epidermis treated for 4 h of ZnO-NP compared to vehicle control. No significant NAD(P)H changes were noted in the lesional study.
    Conclusion: TCSPC techniques enabled simultaneous, real-time quantification of ZnO-NP concentration and NAD(P)H via non-invasive imaging in the stratum corneum and viable epidermis of volunteers.
    MeSH term(s) Administration, Topical ; Cosmetics/metabolism ; Dermatitis, Atopic/drug therapy ; Dermatitis, Atopic/metabolism ; Dose-Response Relationship, Drug ; Drug Delivery Systems ; Humans ; Metal Nanoparticles/administration & dosage ; Metal Nanoparticles/analysis ; Metal Nanoparticles/therapeutic use ; NADP/analysis ; NADP/metabolism ; Photons ; Psoriasis/drug therapy ; Psoriasis/metabolism ; Skin/chemistry ; Skin/metabolism ; Skin Absorption ; Sunscreening Agents/administration & dosage ; Sunscreening Agents/analysis ; Sunscreening Agents/metabolism ; Sunscreening Agents/therapeutic use ; Surgical Tape ; Time Factors ; Toxicity Tests/methods ; Water Loss, Insensible/physiology ; Zinc Oxide/administration & dosage ; Zinc Oxide/analysis ; Zinc Oxide/metabolism ; Zinc Oxide/therapeutic use
    Chemical Substances Cosmetics ; Sunscreening Agents ; NADP (53-59-8) ; Zinc Oxide (SOI2LOH54Z)
    Language English
    Publishing date 2011-06-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 843063-9
    ISSN 1573-904X ; 0724-8741 ; 0739-0742
    ISSN (online) 1573-904X
    ISSN 0724-8741 ; 0739-0742
    DOI 10.1007/s11095-011-0515-5
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    Zs.A 1937: Show issues Location:
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  7. Article: Stellungnahme zur Arbeit von P.H. Höger: "Topische Antibiotika und Antiseptika".

    Sunderkötter, C / Herrmann, M / Becker, K / Luger, T / Peters, G

    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete

    1999  Volume 50, Issue 5, Page(s) 370–371

    Title translation Comment on the contribution by P. H. Höger: "Topical antibiotics and antiseptics".
    MeSH term(s) Administration, Topical ; Anti-Bacterial Agents/administration & dosage ; Anti-Infective Agents, Local/administration & dosage ; Drug Resistance, Multiple ; Humans ; Mupirocin/administration & dosage ; Skin Diseases, Bacterial/drug therapy ; Skin Diseases, Bacterial/microbiology ; Staphylococcal Skin Infections/drug therapy ; Staphylococcal Skin Infections/microbiology
    Chemical Substances Anti-Bacterial Agents ; Anti-Infective Agents, Local ; Mupirocin (D0GX863OA5)
    Language German
    Publishing date 1999-05
    Publishing country Germany
    Document type Letter
    ZDB-ID 2403-x
    ISSN 1432-1173 ; 0017-8470
    ISSN (online) 1432-1173
    ISSN 0017-8470
    DOI 10.1007/s001050050924
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  8. Article: NAD(P)H oxidase-dependent platelet superoxide anion release increases platelet recruitment.

    Krötz, Florian / Sohn, Hae Young / Gloe, Torsten / Zahler, Stefan / Riexinger, Tobias / Schiele, Thomas M / Becker, Bernhard F / Theisen, Karl / Klauss, Volker / Pohl, Ulrich

    Blood

    2002  Volume 100, Issue 3, Page(s) 917–924

    Abstract: ... nicotinamide adenine dinucleotide (phosphate) (NAD(P)H) oxidases can be specifically activated by certain agonists and are found ... as shown in platelet lysates. Consistent with a role of a platelet, NAD(P)H oxidase expression ... NAD(P)H oxidase-dependent O release in platelets, which in turn enhances availability of released ADP, resulting ...

    Abstract Platelets, although not phagocytotic, have been suggested to release O. Since O-producing reduced nicotinamide adenine dinucleotide (phosphate) (NAD(P)H) oxidases can be specifically activated by certain agonists and are found in several nonphagocytotic tissues, we investigated whether such an enzyme is the source of platelet-derived O. We further studied which agonists cause platelet O release and whether platelet-derived O influences thrombus formation in vitro. Collagen, but not adenosine 5'-diphosphate (ADP) or thrombin, increased O formation in washed human platelets. This was a reduced nicotinamide adenine dinucleotide (NADH)-dependent process, as shown in platelet lysates. Consistent with a role of a platelet, NAD(P)H oxidase expression of its subunits p47(phox) and p67(phox) and inhibition of platelet O formation by diphenylene-iodoniumchloride (DPI) and by the specific peptide-antagonist gp91ds-tat were observed. Whereas platelet-derived O did not influence initial aggregation, platelet recruitment to a preformed thrombus following collagen stimulation was significantly attenuated by superoxide dismutase (SOD) or DPI. It was also inhibited when ADP released during aggregation was cleaved by the ectonucleotidase apyrase. ADP in supernatants of collagen-activated platelets was decreased in the presence of SOD, resulting in lower ADP concentrations available for recruitment of further platelets. Exogenous O increased ADP- concentrations in supernatants of collagen-stimulated platelets and induced irreversible aggregation when platelets were stimulated with otherwise subthreshold concentrations of ADP. These results strongly suggest that collagen activation induces NAD(P)H oxidase-dependent O release in platelets, which in turn enhances availability of released ADP, resulting in increased platelet recruitment.
    MeSH term(s) Adenosine Diphosphate/pharmacology ; Blood Platelets/drug effects ; Blood Platelets/enzymology ; Blood Platelets/metabolism ; Collagen/pharmacology ; Drug Interactions ; Humans ; Kinetics ; Models, Biological ; NADPH Oxidases/metabolism ; NADPH Oxidases/physiology ; Platelet Aggregation/drug effects ; Superoxide Dismutase/pharmacology ; Superoxides/metabolism ; Superoxides/pharmacology ; Thrombin/pharmacology ; Thrombosis/etiology ; Thrombosis/pathology
    Chemical Substances Superoxides (11062-77-4) ; Adenosine Diphosphate (61D2G4IYVH) ; Collagen (9007-34-5) ; Superoxide Dismutase (EC 1.15.1.1) ; NADPH Oxidases (EC 1.6.3.-) ; Thrombin (EC 3.4.21.5)
    Language English
    Publishing date 2002-08-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.v100.3.917
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    Zs.MO 364: Show issues

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  9. Book ; Online: Malaria control and longitudinal changes in levels of DDT and its metabolites in human serum from KwaZulu / H. Bouwman, P. J. Becker, & C. H. J. Schutte

    Bouwman, H / Becker, P. J / Schutte, C. H. J

    1994  

    Keywords Malaria ; DDT ; Dichlorodiphenyldichloroethane ; Dichlorodiphenyl dichloroethylene ; South Africa ; Vector Control and Pesticides ; prevention and control ; adverse effects
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  10. Book ; Online: Malaria control and longitudinal changes in levels of DDT and its metabolites in human serum from KwaZulu / H. Bouwman, P. J. Becker, & C. H. J. Schutte

    Bouwman, H / Becker, P. J / Schutte, C. H. J

    1994  

    Keywords Malaria ; DDT ; Dichlorodiphenyldichloroethane ; Dichlorodiphenyl dichloroethylene ; South Africa ; Vector Control and Pesticides ; prevention and control ; adverse effects
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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