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  1. Article ; Online: Response to Licinio et al.

    Sato, Ken / Hosonuma, Kenichi / Kusano, Motoyasu / Yamada, Masanobu

    The American journal of gastroenterology

    2015  Volume 110, Issue 7, Page(s) 1086–1087

    MeSH term(s) Bezafibrate ; Dyslipidemias/drug therapy ; Female ; Humans ; Liver Cirrhosis, Biliary/drug therapy ; Male ; Myalgia ; Renal Insufficiency ; Ursodeoxycholic Acid
    Chemical Substances Ursodeoxycholic Acid (724L30Y2QR) ; Bezafibrate (Y9449Q51XH)
    Language English
    Publishing date 2015-07
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 390122-1
    ISSN 1572-0241 ; 0002-9270
    ISSN (online) 1572-0241
    ISSN 0002-9270
    DOI 10.1038/ajg.2015.166
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  2. Article ; Online: Impact of the Prognostic Nutritional Index on the Survival of Japanese Patients with Hepatocellular Carcinoma Treated with Sorafenib: A Multicenter Retrospective Study.

    Hatanaka, Takeshi / Kakizaki, Satoru / Uehara, Daisuke / Nagashima, Tamon / Ueno, Takashi / Namikawa, Masashi / Saito, Shuichi / Hosonuma, Kenichi / Suzuki, Hideyuki / Naganuma, Atsushi / Takagi, Hitoshi / Sato, Ken / Uraoka, Toshio

    Internal medicine (Tokyo, Japan)

    2019  Volume 58, Issue 13, Page(s) 1835–1844

    Abstract: Objective The purpose of this multicenter retrospective study was to investigate the impact of the prognostic nutritional index (PNI) on the survival of Japanese patients with hepatocellular carcinoma (HCC) treated with sorafenib. Methods A total of 178 ... ...

    Abstract Objective The purpose of this multicenter retrospective study was to investigate the impact of the prognostic nutritional index (PNI) on the survival of Japanese patients with hepatocellular carcinoma (HCC) treated with sorafenib. Methods A total of 178 HCC patients from May 2009 to December 2015 at our affiliated hospitals was included in this study. The PNI was calculated as follows: 10×serum albumin (g/dL) +0.005×total lymphocyte count (per mm
    MeSH term(s) Aged ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/mortality ; Female ; Humans ; Japan ; Liver Neoplasms/drug therapy ; Liver Neoplasms/mortality ; Lymphocyte Count ; Male ; Middle Aged ; Multivariate Analysis ; Nutrition Assessment ; Nutritional Status ; Predictive Value of Tests ; Prognosis ; Proportional Hazards Models ; Retrospective Studies ; Serum Albumin/analysis ; Sorafenib/therapeutic use
    Chemical Substances Serum Albumin ; Sorafenib (9ZOQ3TZI87)
    Language English
    Publishing date 2019-03-28
    Publishing country Japan
    Document type Journal Article ; Multicenter Study
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.1594-18
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  3. Article: Incidence, mortality, and predictive factors of hepatocellular carcinoma in primary biliary cirrhosis.

    Hosonuma, Kenichi / Sato, Ken / Yanagisawa, Masatoshi / Kakizaki, Satoru / Takagi, Hitoshi / Hirato, Junko / Mori, Masatomo

    Gastroenterology research and practice

    2013  Volume 2013, Page(s) 168012

    Abstract: Background. The study aims to analyze in detail the incidence, mortality using the standardized incidence ratio (SIR), and standardized mortality ratio (SMR) of hepatocellular carcinoma (HCC) in primary biliary cirrhosis (PBC), because no large case ... ...

    Abstract Background. The study aims to analyze in detail the incidence, mortality using the standardized incidence ratio (SIR), and standardized mortality ratio (SMR) of hepatocellular carcinoma (HCC) in primary biliary cirrhosis (PBC), because no large case studies have focused on the detailed statistical analysis of them in Asia. Methods. The study cohorts were consecutively diagnosed at Gunma University and its affiliated hospitals. Age- or sex-specific annual cancer incidence and deaths were obtained from Japanese Cancer Registry and Death Registry as a reference for the comparison of SIR or SMR of HCC. Moreover, univariate analyses and multivariate analyses were performed to clarify predictive factors for the incidence of HCC. Results. The overall 179 patients were followed up for a median of 97 months. HCC had developed in 13 cases. SIR for HCC was 11.6 (95% confidence interval (CI), 6.2-19.8) and SMR for HCC was 11.2 (95% CI, 5.4-20.6) in overall patients. The serum albumin levels were a predictive factor for the incidence of HCC in overall patients. Conclusions. The incidence and mortality of HCC in PBC patients were significantly higher than those in Japanese general population. PBC patients with low serum albumin levels were populations at high risk for HCC.
    Language English
    Publishing date 2013-02-25
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2435460-0
    ISSN 1687-630X ; 1687-6121
    ISSN (online) 1687-630X
    ISSN 1687-6121
    DOI 10.1155/2013/168012
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  4. Article ; Online: Incidence, Mortality, and Predictive Factors of Hepatocellular Carcinoma in Primary Biliary Cirrhosis

    Kenichi Hosonuma / Ken Sato / Masatoshi Yanagisawa / Satoru Kakizaki / Hitoshi Takagi / Junko Hirato / Masatomo Mori

    Gastroenterology Research and Practice, Vol

    2013  Volume 2013

    Keywords Diseases of the digestive system. Gastroenterology ; RC799-869 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R
    Language English
    Publishing date 2013-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: A prospective randomized controlled study of long-term combination therapy using ursodeoxycholic acid and bezafibrate in patients with primary biliary cirrhosis and dyslipidemia.

    Hosonuma, Kenichi / Sato, Ken / Yamazaki, Yuichi / Yanagisawa, Masatoshi / Hashizume, Hiroaki / Horiguchi, Norio / Kakizaki, Satoru / Kusano, Motoyasu / Yamada, Masanobu

    The American journal of gastroenterology

    2015  Volume 110, Issue 3, Page(s) 423–431

    Abstract: Objectives: The aim of this study was to assess the long-term prognosis, efficacy, and safety of combination therapy using ursodeoxycholic acid (UDCA) and bezafibrate (BF) for primary biliary cirrhosis (PBC) patients exhibiting dyslipidemia.: Methods!# ...

    Abstract Objectives: The aim of this study was to assess the long-term prognosis, efficacy, and safety of combination therapy using ursodeoxycholic acid (UDCA) and bezafibrate (BF) for primary biliary cirrhosis (PBC) patients exhibiting dyslipidemia.
    Methods: We performed a prospective, randomized, controlled, multicenter study to compare the long-term clinical results between combination therapy and UDCA monotherapy for patients refractory to UDCA monotherapy. Twenty-seven consecutive PBC patients were enrolled.
    Results: The median treatment period in the UDCA and UDCA+BF groups was 107 and 110 months, respectively. The serum alkaline phosphatase (ALP) levels and the Mayo risk score in the combination therapy group (mean 290 IU/l and 0.91, respectively) were significantly lower than those in the UDCA monotherapy group (mean 461 IU/l and 1.42, respectively) at 8 years after the beginning of the study (P<0.05). The serum creatinine levels in the combination therapy group (mean 0.94 mg/dl) were significantly higher than those in the UDCA monotherapy group (mean 0.56 mg/dl) at 8 years after the beginning of the study (P<0.05). However, the survival rate was not significantly different between the groups. We observed dose reduction or discontinuation of the administration of BF, but not UDCA, due to renal dysfunction or muscle pain.
    Conclusions: Long-term combination therapy significantly improved the serum ALP levels and the Mayo risk score. However, the survival rate was not significantly different between the groups. In addition, long-term combination therapy significantly increased the serum creatinine levels. We should pay close attention to adverse events during this long-term combination therapy.
    MeSH term(s) Alkaline Phosphatase/blood ; Bezafibrate/administration & dosage ; Bezafibrate/adverse effects ; Cholagogues and Choleretics/administration & dosage ; Cholagogues and Choleretics/adverse effects ; Creatinine/blood ; Dose-Response Relationship, Drug ; Drug Monitoring/methods ; Drug Therapy, Combination ; Dyslipidemias/complications ; Dyslipidemias/drug therapy ; Female ; Humans ; Hypolipidemic Agents/administration & dosage ; Hypolipidemic Agents/adverse effects ; Liver Cirrhosis, Biliary/complications ; Liver Cirrhosis, Biliary/drug therapy ; Male ; Middle Aged ; Myalgia/blood ; Myalgia/chemically induced ; Prognosis ; Renal Insufficiency/blood ; Renal Insufficiency/chemically induced ; Survival Rate ; Time ; Treatment Outcome ; Ursodeoxycholic Acid/administration & dosage ; Ursodeoxycholic Acid/adverse effects
    Chemical Substances Cholagogues and Choleretics ; Hypolipidemic Agents ; Ursodeoxycholic Acid (724L30Y2QR) ; Creatinine (AYI8EX34EU) ; Alkaline Phosphatase (EC 3.1.3.1) ; Bezafibrate (Y9449Q51XH)
    Language English
    Publishing date 2015-03
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 390122-1
    ISSN 1572-0241 ; 0002-9270
    ISSN (online) 1572-0241
    ISSN 0002-9270
    DOI 10.1038/ajg.2015.20
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  6. Article ; Online: Combination Therapy with Ombitasvir/Paritaprevir/Ritonavir for Dialysis Patients Infected with Hepatitis C Virus: A Prospective Multi-Institutional Study.

    Sato, Ken / Hosonuma, Kenichi / Yamazaki, Yuichi / Kobayashi, Takeshi / Takakusagi, Satoshi / Horiguchi, Norio / Kakizaki, Satoru / Kusano, Motoyasu / Ohnishi, Hiroshi / Okamoto, Hiroaki / Yamada, Masanobu

    The Tohoku journal of experimental medicine

    2016  Volume 241, Issue 1, Page(s) 45–53

    Abstract: Hepatitis C virus (HCV) infection is common in dialysis patients worldwide and nosocomial HCV spread within dialysis facilities continues to develop. Combination therapy with daclatasvir and asunaprevir (DCV/ASV) that has proven efficacy for dialysis ... ...

    Abstract Hepatitis C virus (HCV) infection is common in dialysis patients worldwide and nosocomial HCV spread within dialysis facilities continues to develop. Combination therapy with daclatasvir and asunaprevir (DCV/ASV) that has proven efficacy for dialysis patients infected with genotype 1b HCV (HCV/1b) has several concerns in Japan. The recently available combination therapy with ombitasvir, paritaprevir, and ritonavir (OBV/PTV/r) is not contraindicated in patients with chronic renal failure and has more safety profile and shorter treatment period than that with DCV/ASV. We evaluated the effects of combination therapy with OBV/PTV/r in four dialysis patients infected with HCV/1b, who were eligible for our study. On-treatment assessments included standard laboratory testing, serum HCV RNA and symptom-directed physical examinations. Three patients had a sustained virological response at 12 weeks after treatment, but one remaining patient had viral breakthrough. Notably, the patient with viral breakthrough had been coinfected with HCV/1b and HCV/2b; namely, HCV/2b with resistance-associated variations was not eradicated by the combination therapy. Among the three patients responsive to the combination therapy, one patient complained of appetite loss and itching, while in another patient the therapy was discontinued due to itching, exacerbation of wamble, and a falling tendency probably due to interaction with valsartan. These AEs were ameliorated or disappeared after the completion of the therapy. The significance of our study is persuasive virological evaluation associated to the combination therapy and reasonable interpretation of AEs. In conclusion, combination therapy with OBV/PTV/r may have promise as an efficacious therapy, but caution regarding AEs should be practiced.
    MeSH term(s) Aged ; Anilides/pharmacology ; Anilides/therapeutic use ; Carbamates/pharmacology ; Carbamates/therapeutic use ; Demography ; Disease Progression ; Drug Resistance, Viral ; Drug Therapy, Combination ; Hepacivirus/drug effects ; Hepacivirus/genetics ; Hepacivirus/physiology ; Hepatitis C, Chronic/drug therapy ; Hepatitis C, Chronic/virology ; Humans ; Macrocyclic Compounds/pharmacology ; Macrocyclic Compounds/therapeutic use ; Male ; Middle Aged ; Renal Dialysis ; Ritonavir/pharmacology ; Ritonavir/therapeutic use
    Chemical Substances Anilides ; Carbamates ; Macrocyclic Compounds ; ombitasvir (2302768XJ8) ; Ritonavir (O3J8G9O825) ; paritaprevir (OU2YM37K86)
    Language English
    Publishing date 2016-12-24
    Publishing country Japan
    Document type Case Reports ; Journal Article ; Multicenter Study
    ZDB-ID 123477-8
    ISSN 1349-3329 ; 0040-8727
    ISSN (online) 1349-3329
    ISSN 0040-8727
    DOI 10.1620/tjem.241.45
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  7. Article: Small-cell carcinoma of the extrahepatic bile duct: a case report and review of the literature.

    Hosonuma, Kenichi / Sato, Ken / Honma, Manabu / Kashiwabara, Kenji / Takahashi, Hitomi / Takagi, Hitoshi / Mori, Masatomo

    Hepatology international

    2007  Volume 2, Issue 1, Page(s) 129–132

    Abstract: A small-cell carcinoma of the extrahepatic bile duct in a 69-year-old woman is herein reported. A tumor measuring approximately 3 cm in diameter was located at the confluence of the common bile duct, cystic duct, and common hepatic duct. ... ...

    Abstract A small-cell carcinoma of the extrahepatic bile duct in a 69-year-old woman is herein reported. A tumor measuring approximately 3 cm in diameter was located at the confluence of the common bile duct, cystic duct, and common hepatic duct. Histopathologically, the tumor was small-cell neuroendocrine carcinoma without any gland formation or differentiation to squamous cell carcinoma. Tumor cells were immunoreactive for epithelial markers such as epithelial membrane antigen and cytokeratin and for the neuroendocrine markers such as neuron-specific enolase, chromogranin A, and synaptophysin. Although the carcinomas in more than half of the reported cases have been reported to be associated with well-to-moderately differentiated squamous or glandular components, seven cases, including our case, showed the carcinomas without squamous or glandular components. According to the review of 16 previously reported cases and our case of small-cell carcinoma of the extrahepatic bile ducts, there is no significant difference in the clinicopathological findings, namely, age, sex, site of carcinoma, and prognosis between the cases with or without squamous or glandular components. No CD34-positive multipotent adult progenitor cells, which might be the origin of the small-cell carcinoma, were detected in the bile duct epithelium in our case.
    Language English
    Publishing date 2007-12-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2270316-0
    ISSN 1936-0541 ; 1936-0533
    ISSN (online) 1936-0541
    ISSN 1936-0533
    DOI 10.1007/s12072-007-9027-0
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  8. Article ; Online: Familial clustering and genetic background of primary biliary cirrhosis in Japan.

    Yanagisawa, Masatoshi / Takagi, Hitoshi / Takahashi, Hitomi / Uehara, Masahiro / Otsuka, Toshiyuki / Yuasa, Kazuhisa / Hosonuma, Kenichi / Mori, Masatomo

    Digestive diseases and sciences

    2009  Volume 55, Issue 9, Page(s) 2651–2658

    Abstract: Background: Primary biliary cirrhosis (PBC) is regarded as an autoimmune liver disease and familial clustering of PBC could represent some genetic predisposition to the disease.: Aims: To elucidate the genetic background of PBC by investigating ... ...

    Abstract Background: Primary biliary cirrhosis (PBC) is regarded as an autoimmune liver disease and familial clustering of PBC could represent some genetic predisposition to the disease.
    Aims: To elucidate the genetic background of PBC by investigating familial cases of PBC.
    Methods: Familial cases were picked out from 171 PBC patients who enrolled in this study. We analyzed them and their family members, and compared them clinically and immunogenetically to non-familial cases.
    Results: Out of 171 PBC patients, ten (5.8%) were identified as familial PBC in five families. The clinical features of familial PBC were almost comparable to those of non-familial PBC. The distribution of human leukocyte antigens (HLA)-A, -B and -DR in familial PBC showed no specificity. Two new PBC patients were identified in one family in addition to the two originally enrolled PBC patients, resulting in four patients with PBC within the same family. The two new PBC patients had an identical HLA haplotype. On the other hand, one HLA-identical sister of a PBC patient in another family did not develop PBC.
    Conclusions: Primary biliary cirrhosis can exhibit familial clustering without any HLA predisposition, however, a survey of families for PBC could be useful for identifying new patients with PBC in the asymptomatic stage for earlier diagnosis and treatment.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Asian Continental Ancestry Group/genetics ; Biomarkers/blood ; Child ; Female ; Genetic Predisposition to Disease ; HLA Antigens/genetics ; Haplotypes ; Humans ; Japan ; Liver Cirrhosis, Biliary/diagnosis ; Liver Cirrhosis, Biliary/ethnology ; Liver Cirrhosis, Biliary/genetics ; Male ; Middle Aged ; Pedigree ; Phenotype ; Young Adult
    Chemical Substances Biomarkers ; HLA Antigens
    Language English
    Publishing date 2009-12-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-009-1057-0
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  9. Article ; Online: Interferon treatment for patients with chronic hepatitis C complicated with chronic renal failure receiving hemodialysis.

    Kojima, Akira / Kakizaki, Satoru / Hosonuma, Ken-ichi / Yamazaki, Yuichi / Horiguchi, Norio / Sato, Ken / Kitahara, Tokuyuki / Mori, Masatomo

    Journal of gastroenterology and hepatology

    2013  Volume 28, Issue 4, Page(s) 690–699

    Abstract: Background and aims: The Japan Society for Dialysis Therapy established "Guidelines for the Treatment of Hepatitis C Virus Infection in Dialysis Patients." We evaluated the status of HCV infection and the treatment of hemodialysis patients in Gunma ... ...

    Abstract Background and aims: The Japan Society for Dialysis Therapy established "Guidelines for the Treatment of Hepatitis C Virus Infection in Dialysis Patients." We evaluated the status of HCV infection and the treatment of hemodialysis patients in Gunma prefecture.
    Methods: Questionnaires concerning the infection rate, recognition of the guidelines, and treatment status were sent to all 64 hospitals/clinics that had hemodialysis systems in Gunma prefecture. The hepatitis C virus-infected hemodialysis patients who received pegylated interferon (peg-IFN) were analyzed at Gunma University Hospital.
    Results: The positive rate for hepatitis C virus antibody was 256/2582 hemodialysis patients (9.9%). The positive rate varied between institutions (range 0-40.0%; median 9.0%). All institutes recognized the establishment of the guidelines. Conventional or peg-IFN treatment was being given at 37.5% of the institutions. The other 62.5% institutions answered that they intended to provide the treatment in the future if collaboration with a hepatologist could be arranged. The most common answers regarding the indication for IFN treatment were as follows: few complications, under 60 years of age, more than 10 years of survival expected on hemodialysis. Eighteen patients received peg-IFN treatment. The sustained virological response rate of all patients was 33.3%, 0% in 1b/high viral titer, 50% in genotype 2, and 100% in genotype 2/low viral titer. The sustained virological response rate was worse in the patients with 1b/high viral load and diabetic nephropathy (P < 0.05).
    Conclusions: Recognition of the publication of the guidelines was high. However, the number of patients treated with peg-IFN was still low. Further enlightenment and cooperation between hemodialysis teams and hepatologists are therefore needed.
    MeSH term(s) Adult ; Aged ; Antiviral Agents/therapeutic use ; Female ; Guideline Adherence/statistics & numerical data ; Health Knowledge, Attitudes, Practice ; Hepatitis C, Chronic/drug therapy ; Humans ; Interferon-alpha/therapeutic use ; Kidney Failure, Chronic/therapy ; Male ; Middle Aged ; Polyethylene Glycols/therapeutic use ; Recombinant Proteins/therapeutic use ; Renal Dialysis ; Surveys and Questionnaires ; Treatment Outcome ; Viral Load
    Chemical Substances Antiviral Agents ; Interferon-alpha ; Recombinant Proteins ; Polyethylene Glycols (30IQX730WE) ; peginterferon alfa-2a (Q46947FE7K)
    Language English
    Publishing date 2013-04
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 632882-9
    ISSN 1440-1746 ; 0815-9319
    ISSN (online) 1440-1746
    ISSN 0815-9319
    DOI 10.1111/jgh.12118
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  10. Article: Familial Clustering and Genetic Background of Primary Biliary Cirrhosis in Japan

    Yanagisawa, Masatoshi / Takagi, Hitoshi / Takahashi, Hitomi / Uehara, Masahiro / Otsuka, Toshiyuki / Yuasa, Kazuhisa / Hosonuma, Kenichi / Mori, Masatomo

    Digestive diseases and sciences. 2010 Sept., v. 55, no. 9

    2010  

    Abstract: Background Primary biliary cirrhosis (PBC) is regarded as an autoimmune liver disease and familial clustering of PBC could represent some genetic predisposition to the disease. Aims To elucidate the genetic background of PBC by investigating familial ... ...

    Abstract Background Primary biliary cirrhosis (PBC) is regarded as an autoimmune liver disease and familial clustering of PBC could represent some genetic predisposition to the disease. Aims To elucidate the genetic background of PBC by investigating familial cases of PBC. Methods Familial cases were picked out from 171 PBC patients who enrolled in this study. We analyzed them and their family members, and compared them clinically and immunogenetically to non-familial cases. Results Out of 171 PBC patients, ten (5.8%) were identified as familial PBC in five families. The clinical features of familial PBC were almost comparable to those of non-familial PBC. The distribution of human leukocyte antigens (HLA)-A, -B and -DR in familial PBC showed no specificity. Two new PBC patients were identified in one family in addition to the two originally enrolled PBC patients, resulting in four patients with PBC within the same family. The two new PBC patients had an identical HLA haplotype. On the other hand, one HLA-identical sister of a PBC patient in another family did not develop PBC. Conclusions Primary biliary cirrhosis can exhibit familial clustering without any HLA predisposition, however, a survey of families for PBC could be useful for identifying new patients with PBC in the asymptomatic stage for earlier diagnosis and treatment.
    Language English
    Dates of publication 2010-09
    Size p. 2651-2658.
    Publisher Springer US
    Publishing place Boston
    Document type Article
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-009-1057-0
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