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  1. Article: Perspective: rethinking therapeutic strategies in oncology.

    Patz, Edward F / Gottlin, Elizabeth B / Simon, George R

    Frontiers in oncology

    2024  Volume 13, Page(s) 1335987

    Abstract: Immuno-oncology has revolutionized cancer care, drug development, the design of clinical trials, standard treatment paradigms, and the evaluation of response to therapy. These are all areas, however, that have not fully incorporated principles of tumor ... ...

    Abstract Immuno-oncology has revolutionized cancer care, drug development, the design of clinical trials, standard treatment paradigms, and the evaluation of response to therapy. These are all areas, however, that have not fully incorporated principles of tumor immunology. Insufficient emphasis is put on the effect drugs have on the immune system, and specifically, the impact that multiple lines of therapy can have on the functioning of the immune system, hindering a robust anti-tumor immune response. A paradigm shift in how we approach the development of novel immunotherapeutic agents is necessary to facilitate the effective improvements in patient outcomes.
    Language English
    Publishing date 2024-01-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1335987
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  2. Article ; Online: Exploring the Landscape of Energy Audits

    Jishin George Oommen / Noel Simon Roy / R.D. Brittoraj

    International Journal of Energy Economics and Policy, Vol 14, Iss

    A Bibliometric Analysis

    2024  Volume 1

    Abstract: The term "sustainability" has emerged as a popular catchphrase for the challenges we face in the twenty-first century, which need a radical rethinking of our economic, social, and environmental practices. Energy audit has evolved as a significant ... ...

    Abstract The term "sustainability" has emerged as a popular catchphrase for the challenges we face in the twenty-first century, which need a radical rethinking of our economic, social, and environmental practices. Energy audit has evolved as a significant instrument in the search of a sustainable future, and it may be used to leverage other sustainability initiatives. Businesses may actively contribute to a more sustainable future and align operations with global environmental objectives by adopting energy practices. The purpose of this study is to do a bibliometric analysis of scholarly works that discuss energy auditing and its role in promoting sustainability. We may learn more about the major issues, trends, and contributions to green energy audit for sustainable development by reviewing the relevant academic literature.
    Keywords Bibliometric Analysis ; Energy Audit ; Sustainable Development ; Environmental sciences ; GE1-350 ; Energy industries. Energy policy. Fuel trade ; HD9502-9502.5
    Subject code 690
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher EconJournals
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Chitogel improves long-term health economic outcomes following endoscopic sinus surgery in severe chronic rhinosinusitis patients.

    Barber, Jacqueline M / Bouras, George / Robinson, Grace S / Robinson, Simon R

    Frontiers in health services

    2024  Volume 4, Page(s) 1196499

    Abstract: Introduction: Chronic rhinosinusitis causes severe symptoms that can affect patient quality of life. Endoscopic sinus surgery can be effective in improving symptoms, although surgical outcomes can be compromised post-operatively, and revision surgery is ...

    Abstract Introduction: Chronic rhinosinusitis causes severe symptoms that can affect patient quality of life. Endoscopic sinus surgery can be effective in improving symptoms, although surgical outcomes can be compromised post-operatively, and revision surgery is required in a proportion of patients. This study compares outcomes and healthcare resource use in patients undergoing sinus surgery with or without Chitogel as a post-operative dressing.
    Methods: A retrospective cohort study was conducted using deidentified audit data from adult patients with severe chronic rhinosinusitis, who underwent endoscopic sinus surgery between January 2016 and December 2021. Patients in the intervention group received Chitogel as a post-operative dressing, and control patients received standard best-practice care. Cox Proportional Hazards survival analysis was used to compare revision surgery rates and time to revision between treatment groups. The rate of revision surgery was used to estimate potential health sector savings associated with use of Chitogel following surgery compared to the control arm, considering initial treatment costs and the cost of revision surgery.
    Results: Over 18-24 months, patients treated with Chitogel demonstrated significantly lower rates of revision surgery (
    Conclusion: Severe chronic rhinosinusitis patients treated with Chitogel had lower rates of revision surgery within the first 18-24 months post-operative. These findings suggest that use of Chitogel can improve long-term patient outcomes and should improve health system efficiency.
    Language English
    Publishing date 2024-02-28
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2813-0146
    ISSN (online) 2813-0146
    DOI 10.3389/frhs.2024.1196499
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  4. Article ; Online: Impaired motor inhibition during perceptual inhibition in older, but not younger adults: a psychophysiological study.

    Healey, Rebecca / Goldsworthy, Megan / Salomoni, Sauro / Weber, Simon / Kemp, Sarah / Hinder, Mark R / St George, Rebecca J

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 2023

    Abstract: The prefrontal cortex (PFC) governs the ability to rapidly cancel planned movements when no longer appropriate (motor inhibition) and ignore distracting stimuli (perceptual inhibition). It is unclear to what extent these processes interact, and how they ... ...

    Abstract The prefrontal cortex (PFC) governs the ability to rapidly cancel planned movements when no longer appropriate (motor inhibition) and ignore distracting stimuli (perceptual inhibition). It is unclear to what extent these processes interact, and how they are impacted by age. The interplay between perceptual and motor inhibition was investigated using a Flanker Task, a Stop Signal Task and a combined Stop Signal Flanker Task in healthy young (n = 33, Mean = 24 years) and older adults (n = 32, Mean = 71 years). PFC activity was measured with functional near-infrared spectroscopy (fNIRS), while electromyography (EMG) measured muscle activity in the fingers used to respond to the visual cues. Perceptual inhibition (the degree to which incongruent flankers slowed response time to a central cue) and motor inhibition (the speed of cancellation of EMG activation following stop cues) independently declined with age. When both processes were engaged together, PFC activity increased for both age groups, however only older adults exhibited slower motor inhibition. The results indicate that cortical upregulation was sufficient to compensate for the increased task demands in younger but not older adults, suggesting potential resource sharing and neural limitations particularly in older adults.
    MeSH term(s) Cues ; Electromyography ; Fingers ; Psychophysiology ; Reaction Time ; Humans ; Young Adult
    Language English
    Publishing date 2024-01-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-52269-z
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  5. Article ; Online: Diagnostic Performance of Diastolic Hyperemia-Free Ratio Compared With Invasive Fractional Flow Reserve for Evaluation of Coronary Artery Disease.

    Vira, Amit / Balanescu, Dinu-Valentin / George, Julie A / Dixon, Simon R / Hanson, Ivan D / Safian, Robert D

    The American journal of cardiology

    2024  Volume 214, Page(s) 55–58

    Abstract: Hyperemic and nonhyperemic pressure ratios are frequently used to assess the hemodynamic significance of coronary artery disease and to guide the need for myocardial revascularization. However, there are limited data on the diagnostic performance of the ... ...

    Abstract Hyperemic and nonhyperemic pressure ratios are frequently used to assess the hemodynamic significance of coronary artery disease and to guide the need for myocardial revascularization. However, there are limited data on the diagnostic performance of the diastolic hyperemia-free ratio (DFR). We evaluated the diagnostic performance of the DFR compared with invasive fractional flow reserve (FFR). We performed a prospective, single-center study of 308 patients (343 lesions) who underwent DFR and FFR for evaluation of visually estimated 40% to 90% stenoses. Diagnostic performance of the DFR compared with FFR was evaluated using linear regression, Bland-Altman analysis, and receiver operating characteristic curves. The overall diagnostic accuracy of the DFR was 83%; the accuracy rates were 86%, 40%, and 95% when the DFR was <0.86, 0.88 to 0.90, and >0.93, respectively. The sensitivity, specificity, positive predicative value, and negative predictive value were 60%, 91%, 71%, and 87%, respectively. The Pearson correlation coefficient was 0.75 (p <0.05). The Bland-Altman analysis showed a mean difference of 0.09, and the area under the receiver operating characteristic curve was 0.88 (95% confidence interval 0.84 to 0.92, p <0.05). In conclusion, the DFR has a good diagnostic performance compared with FFR but 17% of the measurements were discordant. The diagnostic accuracy of the DFR was only 40% when the DFR was 0.88 to 0.90, suggesting that FFR may be useful in these arteries.
    MeSH term(s) Humans ; Coronary Artery Disease/diagnosis ; Fractional Flow Reserve, Myocardial ; Coronary Stenosis/diagnosis ; Prospective Studies ; Coronary Vessels/diagnostic imaging ; Reproducibility of Results ; Predictive Value of Tests ; Coronary Angiography ; Severity of Illness Index
    Language English
    Publishing date 2024-01-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80014-4
    ISSN 1879-1913 ; 0002-9149
    ISSN (online) 1879-1913
    ISSN 0002-9149
    DOI 10.1016/j.amjcard.2023.12.050
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  6. Article ; Online: The impact of hiatus hernia in hypersensitivity pneumonitis.

    Heriot, David A / Stock, Carmel J W / Mumtaz, Zain-Ul-Abideen / Jenkins, R Gisli / Chua, Felix / Molyneaux, Phillip L / Devaraj, Anand / Kouranos, Vasilis / Wells, Athol U / Renzoni, Elizabetta A / Padley, Simon P G / Desai, Sujal R / George, Peter M

    Respirology (Carlton, Vic.)

    2024  Volume 29, Issue 5, Page(s) 421–425

    MeSH term(s) Humans ; Hernia, Hiatal/complications ; Alveolitis, Extrinsic Allergic/diagnosis ; Alveolitis, Extrinsic Allergic/etiology ; Manometry
    Language English
    Publishing date 2024-03-13
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1435849-9
    ISSN 1440-1843 ; 1323-7799
    ISSN (online) 1440-1843
    ISSN 1323-7799
    DOI 10.1111/resp.14701
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  7. Article ; Online: Author Correction: An oncogenic Ezh2 mutation induces tumors through global redistribution of histone 3 lysine 27 trimethylation.

    Souroullas, George P / Jeck, William R / Parker, Joel S / Simon, Jeremy M / Liu, Jie-Yu / Paulk, Joshiawa / Xiong, Jessie / Clark, Kelly S / Fedoriw, Yuri / Qi, Jun / Burd, Christin E / Bradner, James E / Sharpless, Norman E

    Nature medicine

    2024  

    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/s41591-024-02867-1
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  8. Book: Diabetes

    Page, Simon R. / Hall, George M.

    emergency and hospital management

    1999  

    Author's details Simon R. Page ; George M. Hall
    Language English
    Size VII, 246 S. : Ill., graph. Darst.
    Publisher BMJ
    Publishing place London
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT010840435
    ISBN 0-7279-1229-1 ; 978-0-7279-1229-9
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1999 A 4934 order for loan Magazin

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  9. Article ; Online: Fluctuations in auxin levels depend upon synchronicity of cell divisions in a one-dimensional model of auxin transport.

    Simon Bellows / George Janes / Daniele Avitabile / John R King / Anthony Bishopp / Etienne Farcot

    PLoS Computational Biology, Vol 19, Iss 11, p e

    2023  Volume 1011646

    Abstract: Auxin is a well-studied plant hormone, the spatial distribution of which remains incompletely understood. Here, we investigate the effects of cell growth and divisions on the dynamics of auxin patterning, using a combination of mathematical modelling and ...

    Abstract Auxin is a well-studied plant hormone, the spatial distribution of which remains incompletely understood. Here, we investigate the effects of cell growth and divisions on the dynamics of auxin patterning, using a combination of mathematical modelling and experimental observations. In contrast to most prior work, models are not designed or tuned with the aim to produce a specific auxin pattern. Instead, we use well-established techniques from dynamical systems theory to uncover and classify ranges of auxin patterns as exhaustively as possible as parameters are varied. Previous work using these techniques has shown how a multitude of stable auxin patterns may coexist, each attainable from a specific ensemble of initial conditions. When a key parameter spans a range of values, these steady patterns form a geometric curve with successive folds, often nicknamed a snaking diagram. As we introduce growth and cell division into a one-dimensional model of auxin distribution, we observe new behaviour which can be explained in terms of this diagram. Cell growth changes the shape of the snaking diagram, and this corresponds in turn to deformations in the patterns of auxin distribution. As divisions occur this can lead to abrupt creation or annihilation of auxin peaks. We term this phenomenon 'snake-jumping'. Under rhythmic cell divisions, we show how this can lead to stable oscillations of auxin. We also show that this requires a high level of synchronisation between cell divisions. Using 18 hour time-lapse imaging of the auxin reporter DII:Venus in roots of Arabidopsis thaliana, we show auxin fluctuates greatly, both in terms of amplitude and periodicity, consistent with the snake-jumping events observed with non-synchronised cell divisions. Periodic signals downstream of the auxin signalling pathway have previously been recorded in plant roots. The present work shows that auxin alone is unlikely to play the role of a pacemaker in this context.
    Keywords Biology (General) ; QH301-705.5
    Subject code 612
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Medication Adherence Across the Life Span in Inflammatory Bowel Disease: Implications and Recommendations for Nurses and Other Health Providers.

    Knowles, Simon R / Alex, George

    Gastroenterology nursing : the official journal of the Society of Gastroenterology Nurses and Associates

    2020  Volume 43, Issue 1, Page(s) 76–88

    Abstract: This article reviews the differences and similarities in medication adherence between adolescent and adult cohorts with inflammatory bowel disease. The review covers the rates of medication adherence, as well as predictors, consequences, and related ... ...

    Abstract This article reviews the differences and similarities in medication adherence between adolescent and adult cohorts with inflammatory bowel disease. The review covers the rates of medication adherence, as well as predictors, consequences, and related interventions. Rates of adherence were more favorable among adolescents (65%-90%) than among adults (55%-70%). Major risk factors for poor adherence in adolescents include low medication knowledge, not establishing good medication habits initially, and peer victimization with low social support. For adults, nonadherence is more frequently unintentional (e.g., forgetting) and occurs more often in the context of a poor-quality patient-physician relationship, low medication knowledge, infrequent/missed appointments, busy lifestyle, and concurrent mental health concerns. Nonadherence to medication is associated with worsening of symptoms and risk of relapse in adults and adolescents. Nurses can play a significant role in influencing adherence to medication in patients with inflammatory bowel disease. In particular, nurses can help to impart knowledge on the importance of medication and identify factors that may help or hinder an individual in terms of adherence. Based on the current review, implications for practice and recommendations for nurses to promote medication adherence across both adolescent and adult cohorts are provided. Limitations of the currently available evidence and suggestions for future research are discussed.
    MeSH term(s) Adolescent ; Adult ; Age Factors ; Humans ; Inflammatory Bowel Diseases/drug therapy ; Inflammatory Bowel Diseases/psychology ; Medication Adherence ; Nurse's Role
    Language English
    Publishing date 2020-01-25
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1109536-2
    ISSN 1538-9766 ; 1042-895X
    ISSN (online) 1538-9766
    ISSN 1042-895X
    DOI 10.1097/SGA.0000000000000467
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    Zs.A 3422: Show issues Location:
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