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Article: Complement Proteins L-Ficolin and M-Ficolin Are Increased in Patients With Axial Spondyloarthritis and Decrease After Tumor Necrosis Factor Inhibitor Treatment.

Mistegaard, Clara Elbæk / Troldborg, Anne / Hansen, Annette / Thiel, Steffen / Jurik, Anne Grethe / Kiil, Rosa M / Christiansen, Alice A / Schiøttz-Christensen, Berit / Hendricks, Oliver / Pedersen, Susanne Juhl / Sørensen, Inge Juul / Østergaard, Mikkel / Loft, Anne Gitte

The Journal of rheumatology

2023

Abstract: ... liver 1, H-ficolin, L-ficolin, M-ficolin, MBL-associated serine protease [MASP]-1, MASP-2, MASP-3, MBL ... determined using immunoassays.: Results: Plasma levels of L-ficolin and M-ficolin were significantly ... relevant controls with uLBP (all : Conclusion: L-ficolin and M-ficolin levels are elevated in newly ...

Abstract	Objective: We have previously reported elevated levels of the complement lectin pathway proteins L-ficolin and H-ficolin in patients with axial spondyloarthritis (axSpA) compared with healthy controls. The aim of the present study was to investigate these biomarkers in a cross-sectional cohort of patients suffering from low back pain (LBP). Further, we aimed to investigate changes in lectin pathway protein levels after initiation of adalimumab (ADA; a tumor necrosis factor inhibitor) in a longitudinal cohort of patients with axSpA. Methods: Lectin pathway protein levels (mannan-binding lectin [MBL], collectin liver 1, H-ficolin, L-ficolin, M-ficolin, MBL-associated serine protease [MASP]-1, MASP-2, MASP-3, MBL-associated protein 19 [MAp19], and MAp44) in EDTA plasma were determined in 2 well-characterized cohorts: (1) a clinical cross-sectional cohort of patients with LBP, including patients with axSpA (n = 23), patients with unspecific LBP (uLBP) with ≥ 1 SpA features (n = 55), and patients with uLBP without SpA features or magnetic resonance imaging findings suggestive of axSpA (n = 64); and (2) a randomized double-blinded, placebo-controlled trial cohort of patients with axSpA (n = 49) initiating ADA therapy. Lectin pathway protein levels were determined using immunoassays. Results: Plasma levels of L-ficolin and M-ficolin were significantly increased in the cross-sectional cohort of newly diagnosed patients with axSpA compared with clinically relevant controls with uLBP (all Conclusion: L-ficolin and M-ficolin levels are elevated in newly diagnosed patients with axSpA compared with clinically relevant controls. Both L-ficolin and M-ficolin levels decrease significantly after initiating ADA therapy. These findings provide new insights into the inflammatory processes in axSpA and support the involvement of complement in axSpA pathogenesis.
Language	English
Publishing date	2023-09-15
Publishing country	Canada
Document type	Journal Article
ZDB-ID	194928-7
ISSN	1499-2752 ; 0315-162X
ISSN (online)	1499-2752
ISSN	0315-162X
DOI	10.3899/jrheum.2023-0164
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Zs.A 1168: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 135: Show issues

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Article ; Online: Reply to M. Nayan et al.

Larsen, Signe Benzon / Dehlendorff, Christian / Skriver, Charlotte / Dalton, Susanne Oksbjerg / Jespersen, Christina Gade / Borre, Michael / Brasso, Klaus / Nørgaard, Mette / Johansen, Christoffer / Sørensen, Henrik Toft / Hallas, Jesper / Friis, Søren

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

2017 Volume 36, Issue 6, Page(s) 629–630

MeSH term(s)	Denmark ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Male ; Prostatic Neoplasms
Chemical Substances	Hydroxymethylglutaryl-CoA Reductase Inhibitors
Language	English
Publishing date	2017-12-20
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	604914-x
ISSN	1527-7755 ; 0732-183X
ISSN (online)	1527-7755
ISSN	0732-183X
DOI	10.1200/JCO.2017.76.7186
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Zs.A 1847: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 650: Show issues

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Article ; Online: Apolipoprotein M in patients with chronic kidney disease.

Sørensen, Ida Mh / Bertelsen, Marianne / Freese, Ellen / Lindhard, Kristine / Ullum, Henrik / Feldt-Rasmussen, Bo / Nielsen, Lars Bo / Christoffersen, Christina / Bro, Susanne

Atherosclerosis

2018 Volume 275, Page(s) 304–311

Abstract: Background and aims: Plasma apolipoprotein M (APOM) is bound to HDL-particles and has anti ...

Abstract	Background and aims: Plasma apolipoprotein M (APOM) is bound to HDL-particles and has anti-atherogenic effects. The present study explored whether plasma APOM is reduced in patients with chronic kidney disease (CKD), and associated with cardiovascular disease (CVD). In addition, we tested the hypothesis that the excretion of APOM into the urine is increased in patients with kidney disease. Methods: Plasma samples were collected from a cohort of patients with CKD stages 1 to 5D (N = 409) and controls (N = 35). Urine was collected from 47 subjects. Plasma APOM was measured with sandwich ELISA and urine APOM with competitive ELISA. Results: Plasma APOM levels were reduced in patients with CKD stages 3-5D as compared to patients with CKD stages 1 + 2 and controls (p < 0.01). CKD patients with known CVD displayed even further reduction in plasma APOM levels than CKD patients without known CVD (p < 0.001). Fast-phase liquid chromatography showed that plasma APOM was primarily associated with HDL-cholesterol (HDL-C) across CKD stages. Accordingly, when plasma APOM values were corrected for HDL-C, a significant difference only persisted between patients with CKD stage 3 and stages 1 + 2 (p < 0.05), and the difference between CKD patients with and without known CVD disappeared. Urine APOM/creatinine ratio was not significantly increased in patients with kidney disease. Conclusions: The results show that the difference in plasma APOM levels observed between patients with mild and advanced CKD may mainly be due to differences in plasma HDL-C. Whether APOM plays a role in human uremic atherogenesis warrants further experimental studies.
MeSH term(s)	Adult ; Aged ; Apolipoproteins M/blood ; Apolipoproteins M/urine ; Biomarkers/blood ; Biomarkers/urine ; Cardiovascular Diseases/blood ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/urine ; Case-Control Studies ; Cholesterol, HDL/blood ; Chromatography, High Pressure Liquid ; Denmark/epidemiology ; Down-Regulation ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Male ; Middle Aged ; Renal Insufficiency, Chronic/blood ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/epidemiology ; Renal Insufficiency, Chronic/urine ; Risk Assessment ; Risk Factors ; Urinalysis
Chemical Substances	APOM protein, human ; Apolipoproteins M ; Biomarkers ; Cholesterol, HDL
Language	English
Publishing date	2018-06-15
Publishing country	Ireland
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	80061-2
ISSN	1879-1484 ; 0021-9150
ISSN (online)	1879-1484
ISSN	0021-9150
DOI	10.1016/j.atherosclerosis.2018.06.815
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Article ; Online: Binding to carboxypeptidase M mediates protective effects of fibrinopeptide Bβ

Sörensen-Zender, Inga / Chen, Rongjun / Rong, Song / David, Sascha / Melk, Anette / Haller, Hermann / Schmitt, Roland

Translational research : the journal of laboratory and clinical medicine

2019 Volume 213, Page(s) 124–135

Abstract: During fibrinolysis a 28-amino-acid peptide is generated besides other degradation products of fibrin. This peptide, called ... ...

Abstract	During fibrinolysis a 28-amino-acid peptide is generated besides other degradation products of fibrin. This peptide, called Bβ
MeSH term(s)	Animals ; Aristolochic Acids ; Cell Line ; Fibrin Fibrinogen Degradation Products/pharmacology ; Fibrin Fibrinogen Degradation Products/therapeutic use ; GPI-Linked Proteins/metabolism ; Humans ; Kidney Tubules/metabolism ; Male ; Metalloendopeptidases/metabolism ; Mice, Inbred C57BL ; Peptide Fragments/pharmacology ; Peptide Fragments/therapeutic use ; Protective Agents/pharmacology ; Protective Agents/therapeutic use ; Protein Binding ; Receptors, Bradykinin/metabolism ; Ureteral Obstruction/drug therapy
Chemical Substances	Aristolochic Acids ; Fibrin Fibrinogen Degradation Products ; GPI-Linked Proteins ; Peptide Fragments ; Protective Agents ; Receptors, Bradykinin ; fibrinogen Bbeta (15-42) ; aristolochic acid I (94218WFP5T) ; carboxypeptidase M (EC 3.4.17.12) ; Metalloendopeptidases (EC 3.4.24.-)
Language	English
Publishing date	2019-07-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2246684-8
ISSN	1878-1810 ; 1532-6543 ; 1931-5244
ISSN (online)	1878-1810 ; 1532-6543
ISSN	1931-5244
DOI	10.1016/j.trsl.2019.07.008
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Article ; Online: Platelet-Dependent Neutrophil Function Is Dysregulated by M Protein from Streptococcus pyogenes.

Hurley, Sinéad M / Kahn, Fredrik / Nordenfelt, Pontus / Mörgelin, Matthias / Sørensen, Ole E / Shannon, Oonagh

Infection and immunity

2015 Volume 83, Issue 9, Page(s) 3515–3525

Abstract: Platelets are rapidly responsive sentinel cells that patrol the bloodstream and contribute to the host response to infection. Platelets have been reported to form heterotypic aggregates with leukocytes and may modulate their function. Here, we have ... ...

Abstract	Platelets are rapidly responsive sentinel cells that patrol the bloodstream and contribute to the host response to infection. Platelets have been reported to form heterotypic aggregates with leukocytes and may modulate their function. Here, we have investigated platelet-neutrophil complex formation and neutrophil function in response to distinct agonists. The endogenous platelet activator thrombin gave rise to platelet-dependent neutrophil activation, resulting in enhanced phagocytosis and bacterial killing. Streptococcus pyogenes is an important causative agent of severe infectious disease, which can manifest as sepsis and septic shock. M1 protein from S. pyogenes also mediated platelet-neutrophil complex formation; however, these neutrophils were dysfunctional and exhibited diminished chemotactic ability and bacterial killing. This reveals an important agonist-dependent neutrophil dysfunction during platelet-neutrophil complex formation and highlights the role of platelets during the immune response to streptococcal infection.
MeSH term(s)	Adult ; Antigens, Bacterial/immunology ; Antigens, Bacterial/metabolism ; Bacterial Outer Membrane Proteins/immunology ; Bacterial Outer Membrane Proteins/metabolism ; Blood Platelets/immunology ; Carrier Proteins/immunology ; Carrier Proteins/metabolism ; Enzyme-Linked Immunosorbent Assay ; Female ; Flow Cytometry ; Humans ; Male ; Microscopy, Electron, Scanning ; Microscopy, Fluorescence ; Neutrophil Activation/immunology ; Neutrophils/immunology ; Phagocytosis ; Platelet Activation/immunology ; Streptococcal Infections/immunology ; Streptococcal Infections/metabolism ; Streptococcus pyogenes/immunology ; Streptococcus pyogenes/metabolism ; Thrombin/immunology
Chemical Substances	Antigens, Bacterial ; Bacterial Outer Membrane Proteins ; Carrier Proteins ; streptococcal M protein ; Thrombin (EC 3.4.21.5)
Language	English
Publishing date	2015-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218698-6
ISSN	1098-5522 ; 0019-9567
ISSN (online)	1098-5522
ISSN	0019-9567
DOI	10.1128/IAI.00508-15
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Zs.A 684: Show issues

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Article ; Online: PALB2 connects BRCA1 and BRCA2 in the G2/M checkpoint response.

Simhadri, Srilatha / Vincelli, Gabriele / Huo, Yanying / Misenko, Sarah / Foo, Tzeh Keong / Ahlskog, Johanna / Sørensen, Claus S / Oakley, Gregory G / Ganesan, Shridar / Bunting, Samuel F / Xia, Bing

Oncogene

2018 Volume 38, Issue 10, Page(s) 1585–1596

Abstract: The G2/M checkpoint inhibits mitotic entry upon DNA damage, thereby preventing segregation ... the maintenance of the G2/M checkpoint, while BRCA2 and PALB2 have been shown to be critical for its maintenance ...

Abstract	The G2/M checkpoint inhibits mitotic entry upon DNA damage, thereby preventing segregation of broken chromosomes and preserving genome stability. The tumor suppressor proteins BRCA1, PALB2 and BRCA2 constitute a BRCA1-PALB2-BRCA2 axis that is essential for homologous recombination (HR)-based DNA doublestrand break repair. Besides HR, BRCA1 has been implicated in both the initial activation and the maintenance of the G2/M checkpoint, while BRCA2 and PALB2 have been shown to be critical for its maintenance. Here we show that all three proteins can play a significant role in both checkpoint activation and checkpoint maintenance, depending on cell type and context, and that PALB2 links BRCA1 and BRCA2 in the checkpoint response. The BRCA1-PALB2 interaction can be important for checkpoint activation, whereas the PALB2-BRCA2 complex formation appears to be more critical for checkpoint maintenance. Interestingly, the function of PALB2 in checkpoint response appears to be independent of CHK1 and CHK2 phosphorylation. Following ionizing radiation, cells with disengaged BRCA1-PALB2 interaction show greatly increased chromosomal abnormalities due apparently to combined defects in HR and checkpoint control. These findings provide new insights into DNA damage checkpoint control and further underscore the critical importance of the proper cooperation of the BRCA and PALB2 proteins in genome maintenance.
MeSH term(s)	Animals ; BRCA1 Protein/genetics ; BRCA1 Protein/metabolism ; BRCA2 Protein/genetics ; BRCA2 Protein/metabolism ; Cell Line, Tumor ; Checkpoint Kinase 1/metabolism ; Checkpoint Kinase 2/metabolism ; Fanconi Anemia Complementation Group N Protein/genetics ; Fanconi Anemia Complementation Group N Protein/metabolism ; G2 Phase Cell Cycle Checkpoints ; HCT116 Cells ; HEK293 Cells ; Humans ; Mice ; Phosphorylation ; Recombinational DNA Repair
Chemical Substances	BRCA1 Protein ; BRCA1 protein, human ; BRCA2 Protein ; BRCA2 protein, human ; Fanconi Anemia Complementation Group N Protein ; PALB2 protein, human ; Checkpoint Kinase 2 (EC 2.7.1.11) ; CHEK1 protein, human (EC 2.7.11.1) ; CHEK2 protein, human (EC 2.7.11.1) ; Checkpoint Kinase 1 (EC 2.7.11.1)
Language	English
Publishing date	2018-10-18
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	639046-8
ISSN	1476-5594 ; 0950-9232
ISSN (online)	1476-5594
ISSN	0950-9232
DOI	10.1038/s41388-018-0535-2
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Book ; Online: Modelling and Experimental Validation for Battery Lifetime Estimation in NB-IoT and LTE-M

Sørensen, André / Wang, Hua / Remy, Maxime Jérôme / Kjettrup, Nicolaj / Sørensen, René Brandborg / Nielsen, Jimmy Jessen / Popovski, Petar / Madueño, Germán Corrales

2021

Abstract: ... IoT) and Long Term Evolution for Machines (LTE-M). A measurement testbed has been setup and ...

Abstract	Internet of Things (IoT) is one of the main features in 5G. Low-power wide-area networking (LPWAN) has attracted enormous research interests to enable large scale deployment of IoT, with the design objectives of low cost, wide coverage area, as well as low power consumption. In particular, long battery lifetime is essential since many of the IoT devices will be deployed in hard-to-access locations. Prediction of the battery lifetime depends on the accurate modelling of energy consumption. This paper presents a comprehensive power consumption model for battery lifetime estimation, which is based on User Equipment(UE) states and procedures, for two cellular IoT technologies: Narrowband Internet of Things (NB-IoT) and Long Term Evolution for Machines (LTE-M). A measurement testbed has been setup and the proposed model has been tested and validated via extensive measurements under various traffic patterns and network scenarios, achieving the modelling inaccuracy within5%. The measurement results show that the battery lifetime of an IoT device can reach up to 10 years as required by 3GPP, with proper configuration of the traffic profile, the coverage scenario, as well as the network configuration parameters. Comment: 16 pages, 12 figures
Keywords	Computer Science - Networking and Internet Architecture
Publishing date	2021-06-24
Publishing country	us
Document type	Book ; Online
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Article ; Online: A Decision-Making Tool for Planning O&M Activities of Offshore Wind Farms Using Simulated Actual Decision Drivers

Pietro D. Tomaselli / Martin Dixen / Rodolfo Bolaños Sanchez / Jacob Tornfeldt Sørensen

Frontiers in Marine Science, Vol

2021 Volume 7

Abstract: Safe and cost-efficient planning Operation&Maintenance (O&M) activities for the turbines ... than mere metocean thresholds, which are, in practical cases, discretionally judged by the O&M ... for the wind industry and safer environment for O&M operators. The paper shows an application of the tool ...

Abstract	Safe and cost-efficient planning Operation&Maintenance (O&M) activities for the turbines of Offshore Wind Farms is crucial for the offshore wind industry. The execution of the planned tasks depends on the workability at sea. Workability assessments aim to find time periods, called weather windows, during which the personnel can execute the job at hand safely. Traditionally, weather windows analyses are based on thresholds applied on relevant metocean conditions in the area of interest, commonly wave height, wave period and wind speed. In this way, tasks are planned in windows during which the forecast metocean conditions do not exceed the defined thresholds. This paper presents a numerical tool that provides weather windows based on more direct measures of workability, that is seasickness on board during the trip to the turbines and bow motions, which endanger crew transfers from vessel to turbine. When assessing weather windows, such parameters better describe the actual decision drivers in a real operational setting than mere metocean thresholds, which are, in practical cases, discretionally judged by the O&M operator upon experience. Therefore, the reliability of workability predictions can increase, leading to financial gains for the wind industry and safer environment for O&M operators. The paper shows an application of the tool, where a full O&M scenario is simulated. The scenario comprises the transit from the port to the offshore site, the work carried out on the turbine and the transit back to the port. In particular, the application highlights the key capability of the tool of calculating vessel motions, which are elaborated to produce weather windows. With its low computational time-demand, the tool aims to support the decision-making processes that produce short- and long-term O&M plans.
Keywords	offshore wind farm ; Operation&Maintenance ; decision-making ; weather windows ; vessel motions ; O&M cost ; Science ; Q ; General. Including nature conservation ; geographical distribution ; QH1-199.5
Subject code	690
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
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Article ; Online: NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint.

Melixetian, Marina / Klein, Ditte Kjaersgaard / Sørensen, Claus Storgaard / Helin, Kristian

Nature cell biology

2009 Volume 11, Issue 10, Page(s) 1247–1253

Abstract: ... involved in the G2/M checkpoint we performed a large-scale short hairpin RNA (shRNA) library screen ... G2/M arrest. Depletion of NEK11 prevents proteasome-dependent degradation of CDC25A ... component of the pathway enforcing the G2/M checkpoint, suggesting that genetic mutations in NEK11 ...

Abstract	DNA damage-induced cell-cycle checkpoints have a critical role in maintaining genomic stability. A key target of the checkpoints is the CDC25A (cell division cycle 25 homologue A) phosphatase, which is essential for the activation of cyclin-dependent kinases and cell-cycle progression. To identify new genes involved in the G2/M checkpoint we performed a large-scale short hairpin RNA (shRNA) library screen. We show that NIMA (never in mitosis gene A)-related kinase 11 (NEK11) is required for DNA damage-induced G2/M arrest. Depletion of NEK11 prevents proteasome-dependent degradation of CDC25A, both in unperturbed and DNA-damaged cells. We show that NEK11 directly phosphorylates CDC25A on residues whose phosphorylation is required for beta-TrCP (beta-transducin repeat-containing protein)-mediated polyubiquitylation and degradation of CDC25A. Furthermore, we demonstrate that CHK1 (checkpoint kinase 1) directly activates NEK11 by phosphorylating it on Ser 273, indicating that CHK1 and NEK11 operate in a single pathway that controls proteolysis of CDC25A. Taken together, these results demonstrate that NEK11 is an important component of the pathway enforcing the G2/M checkpoint, suggesting that genetic mutations in NEK11 may contribute to the development of human cancer.
MeSH term(s)	Amino Acid Sequence ; Checkpoint Kinase 1 ; Enzyme Activation ; G2 Phase/genetics ; G2 Phase/radiation effects ; HeLa Cells ; Humans ; Hydrophobic and Hydrophilic Interactions ; Mitosis ; Molecular Sequence Data ; NIMA-Related Kinases ; Phosphorylation ; Protein Kinases/chemistry ; Protein Kinases/genetics ; Protein Kinases/metabolism ; RNA, Small Interfering/metabolism ; Radiation, Ionizing ; Recombinant Proteins/metabolism ; Serine/metabolism ; Transfection ; Ubiquitination ; beta-Transducin Repeat-Containing Proteins/genetics ; beta-Transducin Repeat-Containing Proteins/metabolism ; cdc25 Phosphatases/chemistry ; cdc25 Phosphatases/genetics ; cdc25 Phosphatases/metabolism
Chemical Substances	RNA, Small Interfering ; Recombinant Proteins ; beta-Transducin Repeat-Containing Proteins ; Serine (452VLY9402) ; Protein Kinases (EC 2.7.-) ; CHEK1 protein, human (EC 2.7.11.1) ; Checkpoint Kinase 1 (EC 2.7.11.1) ; NIMA-Related Kinases (EC 2.7.11.1) ; Nek11 protein, human (EC 2.7.11.1) ; cdc25 Phosphatases (EC 3.1.3.48)
Language	English
Publishing date	2009-09-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1474722-4
ISSN	1476-4679 ; 1465-7392
ISSN (online)	1476-4679
ISSN	1465-7392
DOI	10.1038/ncb1969
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Zs.A 5169: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 12: Show issues

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Article ; Online: Prognostic value of cardiac time intervals measured by tissue Doppler imaging M-mode in the general population.

Biering-Sørensen, Tor / Mogelvang, Rasmus / Jensen, Jan Skov

Heart (British Cardiac Society)

2015 Volume 101, Issue 12, Page(s) 954–960

Abstract: Objective: Tissue Doppler imaging (TDI) M-mode through the mitral leaflet is an easy and precise ... IVRT), isovolumic contraction time (IVCT) and ejection time (ET), were obtained by TDI M-mode ...

Abstract	Objective: Tissue Doppler imaging (TDI) M-mode through the mitral leaflet is an easy and precise method to estimate the cardiac time intervals. The aim was to evaluate the usability of the cardiac time intervals in predicting major cardiovascular events (MACE) in the general population. Methods: In a large prospective community-based study, cardiac function was evaluated in 1915 participants by both conventional echocardiography and TDI. The cardiac time intervals, including the isovolumic relaxation time (IVRT), isovolumic contraction time (IVCT) and ejection time (ET), were obtained by TDI M-mode through the mitral leaflet. IVCT/ET, IVRT/ET and the myocardial performance index (MPI=(IVRT+IVCT)/ET) were calculated. Results: During follow-up (median 10.8 years), 383 (20%) participants reached the combined endpoint MACE (ischaemic heart disease, heart failure or cardiac death). After multivariable adjustment for clinical predictors and conventional echocardiography, only the combined indexes, including information on both systolic and diastolic performance (IVRT/ET and MPI), remained significant prognosticators (p<0.05 for both). Adding IVRT/ET or MPI to a model already including all other echocardiographic parameters resulted in a significant increase in the c-statistics (0.76 vs 0.75 p<0.01 for both). IVRT/ET or MPI improved reclassification significantly when added to the clinical predictors (p<0.05 for both). Conclusions: In the general population, the combined cardiac time intervals that include information on both systolic and diastolic function in one index (IVRT/ET and MPI) are not only powerful and independent predictors of future MACE, but provide additional prognostic information to clinical and conventional echocardiographic measures of systolic and diastolic function.
MeSH term(s)	Echocardiography ; Echocardiography, Doppler ; Female ; Heart Diseases/diagnostic imaging ; Heart Diseases/physiopathology ; Humans ; Male ; Middle Aged ; Prognosis ; Prospective Studies
Language	English
Publishing date	2015-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1303417-0
ISSN	1468-201X ; 1355-6037
ISSN (online)	1468-201X
ISSN	1355-6037
DOI	10.1136/heartjnl-2014-307137
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Zs.MO 112: Show issues

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