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Article ; Online: Nature of a H

Nakajima, Yusuke / Momotake, Atsuya / Suzuki, Akihiro / Neya, Saburo / Yamamoto, Yasuhiko

2022 Volume 61, Issue 7, Page(s) 523–534

Abstract: ... studies of a complex possessing a low-spin ferric heme with a water molecule (H ...

Abstract	Heme binds selectively to the 3'-terminal G-quartet of all parallel G-quadruplex DNAs to form stable heme-DNA complexes. Interestingly, the heme-DNA complexes exhibit various spectroscopic and functional properties similar to those of hemoproteins. Since the nature of the axial ligands is crucial in determining the physicochemical properties of heme, identification and characterization of the axial ligands in a heme-DNA complex are essential to elucidate the structure-function relationship in the complex. NMR studies of a complex possessing a low-spin ferric heme with a water molecule (H
MeSH term(s)	DNA/chemistry ; G-Quadruplexes ; Heme/chemistry ; Hemeproteins ; Ligands
Chemical Substances	Hemeproteins ; Ligands ; Heme (42VZT0U6YR) ; DNA (9007-49-2)
Language	English
Publishing date	2022-03-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1108-3
ISSN	1520-4995 ; 0006-2960
ISSN (online)	1520-4995
ISSN	0006-2960
DOI	10.1021/acs.biochem.1c00751
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Article ; Online: Recovery of the histamine H

Watanabe, Ayami / Nakajima, Ami / Shiroishi, Mitsunori

Scientific reports

2023 Volume 13, Issue 1, Page(s) 16127

Abstract: ... histamine H ...

Abstract	G protein-coupled receptors (GPCRs) are the largest protein family in humans and are important drug targets. Yeast, especially Saccharomyces cerevisiae, is a useful host for modifying the function and stability of GPCRs through protein engineering, which is advantageous for mammalian cells. When GPCRs are expressed in yeast, their function is often impaired. In this study, we performed random mutagenesis using error-prone PCR and then an in vivo screening to obtain mutants that recovered the activity of the human histamine H
MeSH term(s)	Animals ; Humans ; Histamine/metabolism ; Mammals/metabolism ; Polymerase Chain Reaction ; Receptors, G-Protein-Coupled/genetics ; Receptors, G-Protein-Coupled/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Signal Transduction ; Receptors, Histamine/genetics ; Receptors, Histamine/metabolism ; Receptors, Histamine H3/genetics ; Receptors, Histamine H3/metabolism ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism
Chemical Substances	Histamine (820484N8I3) ; Receptors, G-Protein-Coupled ; Receptors, Histamine ; Receptors, Histamine H3 ; Recombinant Proteins
Language	English
Publishing date	2023-09-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-43389-z
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Article ; Online: Walsogynes H-O from Walsura chrysogyne.

Nugroho, Alfarius Eko / Nakajima, Saori / Wong, Chin Piow / Hirasawa, Yusuke / Kaneda, Toshio / Shirota, Osamu / Tougan, Takahiro / Horii, Toshihiro / Hadi, A Hamid A / Morita, Hiroshi

Journal of natural medicines

2021 Volume 76, Issue 1, Page(s) 94–101

Abstract: Eight new limonoids, walsogynes H-O (1-8) were isolated from the barks of Walsura chrysogyne, and ... their structures were determined on the basis of the 1D and 2D NMR data. Walsogynes H-M (1-6) and O (8) were ... skeleton. Walsogynes H-O (1-8) exhibited potent antimalarial activity against Plasmodium falciparum 3D7 ...

Abstract	Eight new limonoids, walsogynes H-O (1-8) were isolated from the barks of Walsura chrysogyne, and their structures were determined on the basis of the 1D and 2D NMR data. Walsogynes H-M (1-6) and O (8) were concluded to be 11,12-seco limonoids with a dodecahydro-1H-naphtho[1,8-bc:3,4-c']difuran skeleton, and walsogyne N (7) to be 11,12-seco limonoid sharing a unique dodecahydronaphtho[1,8-bc:5,4-b'c']difuran skeleton. Walsogynes H-O (1-8) exhibited potent antimalarial activity against Plasmodium falciparum 3D7 strain with IC
MeSH term(s)	Antimalarials/pharmacology ; Limonins ; Magnetic Resonance Spectroscopy ; Meliaceae ; Molecular Structure ; Plasmodium falciparum
Chemical Substances	Antimalarials ; Limonins
Language	English
Publishing date	2021-08-05
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2227540-X
ISSN	1861-0293 ; 1340-3443
ISSN (online)	1861-0293
ISSN	1340-3443
DOI	10.1007/s11418-021-01556-4
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Article ; Online: DFT Study of α-Keggin-type Iso-polyoxotungstate Anions [H

Eda, Kazuo / Akune, Masahiko / Yasuma, Chie / Hotta, Hiroki / Osakai, Toshiyuki / Nakajima, Takahito

Inorganic chemistry

2021 Volume 60, Issue 20, Page(s) 15336–15342

Abstract: The Keggin-type iso-polyoxotungstate (iso-POT) anions [H ...

Abstract	The Keggin-type iso-polyoxotungstate (iso-POT) anions [H
Language	English
Publishing date	2021-09-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	1484438-2
ISSN	1520-510X ; 0020-1669
ISSN (online)	1520-510X
ISSN	0020-1669
DOI	10.1021/acs.inorgchem.1c01962
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Article ; Online: Walsogynes H–O from Walsura chrysogyne

Nugroho, Alfarius Eko / Nakajima, Saori / Wong, Chin Piow / Hirasawa, Yusuke / Kaneda, Toshio / Shirota, Osamu / Tougan, Takahiro / Horii, Toshihiro / Hadi, A. Hamid A. / Morita, Hiroshi

J Nat Med. 2022 Jan., v. 76, no. 1 p.94-101

2022

Abstract: Eight new limonoids, walsogynes H–O (1–8) were isolated from the barks of Walsura chrysogyne, and ... their structures were determined on the basis of the 1D and 2D NMR data. Walsogynes H–M (1–6) and O (8) were ... skeleton. Walsogynes H–O (1–8) exhibited potent antimalarial activity against Plasmodium falciparum 3D7 ...

Abstract	Eight new limonoids, walsogynes H–O (1–8) were isolated from the barks of Walsura chrysogyne, and their structures were determined on the basis of the 1D and 2D NMR data. Walsogynes H–M (1–6) and O (8) were concluded to be 11,12-seco limonoids with a dodecahydro-1H-naphtho[1,8-bc:3,4-c′]difuran skeleton, and walsogyne N (7) to be 11,12-seco limonoid sharing a unique dodecahydronaphtho[1,8-bc:5,4-b′c′]difuran skeleton. Walsogynes H–O (1–8) exhibited potent antimalarial activity against Plasmodium falciparum 3D7 strain with IC₅₀ value of 2.5, 2.6, 1.6, 2.5, 1.5, 2.6, 2.1, and 1.1 µM, respectively.
Keywords	Plasmodium falciparum ; antimalarials ; limonoids ; skeleton
Language	English
Dates of publication	2022-01
Size	p. 94-101.
Publishing place	Springer Singapore
Document type	Article ; Online
ZDB-ID	1201350-x
ISSN	1340-3443
ISSN	1340-3443
DOI	10.1007/s11418-021-01556-4
Database	NAL-Catalogue (AGRICOLA)

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Article: [Expression of the cGAS-STING Pathway in dMMR/MSI-H in Colorectal Cancer].

Kaneta, Akinao / Nakajima, Shotaro / Mimura, Kosaku / Kono, Koji

Gan to kagaku ryoho. Cancer & chemotherapy

2022 Volume 49, Issue 10, Page(s) 1130–1132

Abstract: Deficient mismatch repair (dMMR)/microsatellite instability (MSI)-H colorectal cancer (CRC) has ... TILs), its role in dMMR/MSI-H CRC is largely unknown. In this study, we investigated the association ... suggest that dMMR/MSI -H CRC has maintained a high cGAS-STING expression, which may contribute to abundant ...

Abstract	Deficient mismatch repair (dMMR)/microsatellite instability (MSI)-H colorectal cancer (CRC) has high immunogenicity. Although the cyclic GMP-AMP synthase( cGAS)-stimulator of interferon genes( STING) pathway activation has considerably contributed to the high number of CD8+ tumor-infiltrating lymphocytes (TILs), its role in dMMR/MSI-H CRC is largely unknown. In this study, we investigated the association between cGAS-STING expression and CD8+ TILs in CRC. Data analysis using the TCGA dataset CRC cohort showed that cGAS, STING, and CD8 gene expression levels were significantly higher in the MSI group. Immunohistochemistry examination of resected clinical CRC samples showed that cGAS-STING expression in tumor cells was high in the MSI CRC, and CD8+ TILs was also significantly infiltrated in the MSI group. Moreover, significant CD8+ TILs infiltration was observed in CRC with high cGAS and STING expression levels. The results suggest that dMMR/MSI -H CRC has maintained a high cGAS-STING expression, which may contribute to abundant CD8+ TILs.
MeSH term(s)	Humans ; Microsatellite Instability ; DNA Mismatch Repair ; Nucleotidyltransferases/genetics ; Nucleotidyltransferases/metabolism ; Colorectal Neoplasms/pathology ; Interferons/genetics
Chemical Substances	Nucleotidyltransferases (EC 2.7.7.-) ; Interferons (9008-11-1)
Language	Japanese
Publishing date	2022-08-08
Publishing country	Japan
Document type	English Abstract ; Journal Article
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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Article ; Online: Ptpn20 deletion in H-Tx rats enhances phosphorylation of the NKCC1 cotransporter in the choroid plexus: an evidence of genetic risk for hydrocephalus in an experimental study.

Xu, Hanbing / Miyajima, Masakazu / Nakajima, Madoka / Ogino, Ikuko / Kawamura, Kaito / Akiba, Chihiro / Kamohara, Chihiro / Sakamoto, Koichiro / Karagiozov, Kostadin / Nakamura, Eri / Tada, Nobuhiro / Arai, Hajime / Kondo, Akihide

Fluids and barriers of the CNS

2022 Volume 19, Issue 1, Page(s) 39

Abstract: ... potential genetic causes in this condition. The Hydrocephalus-Texas (H-Tx) rat strain is one of the most ... on non-hydrocephalic and hydrocephalic H-Tx rats was used to identify causative genes of hydrocephalus ... Results: CGH array revealed a copy number loss in chromosome 16p16 region in hydrocephalic H-Tx rats ...

Abstract	Background: Congenital hydrocephalus occurs with some inheritable characteristics, but the mechanisms of its development remain poorly understood. Animal models provide the opportunity to identify potential genetic causes in this condition. The Hydrocephalus-Texas (H-Tx) rat strain is one of the most studied animal models for investigating the causative genetic alterations and analyzing downstream pathogenetic mechanisms of congenital hydrocephalus. Methods: Comparative genomic hybridization (CGH) array on non-hydrocephalic and hydrocephalic H-Tx rats was used to identify causative genes of hydrocephalus. Targeted gene knockout mice were generated by CRISPR/Cas9 to study the role of this gene in hydrocephalus. Results: CGH array revealed a copy number loss in chromosome 16p16 region in hydrocephalic H-Tx rats at 18 days gestation, encompassing the protein tyrosine phosphatase non-receptor type 20 (Ptpn20), a non-receptor tyrosine phosphatase, without change in most non-hydrocephalic H-Tx rats. Ptpn20-knockout (Ptpn20 Conclusions: This study determined the chromosomal location of the hydrocephalus-associated Ptpn20 gene in hydrocephalic H-Tx rats. The high level of pNKCC1 mediated by Ptpn20 deletion in CP epithelium may cause overproduction of cerebrospinal fluid and contribute to the formation of hydrocephalus in Ptpn20
MeSH term(s)	Animals ; Choroid Plexus/metabolism ; Comparative Genomic Hybridization ; Hydrocephalus/cerebrospinal fluid ; Mice ; Phosphoric Monoester Hydrolases/metabolism ; Phosphorylation ; Rats ; Solute Carrier Family 12, Member 2/genetics ; Solute Carrier Family 12, Member 2/metabolism ; Texas
Chemical Substances	Slc12a2 protein, rat ; Solute Carrier Family 12, Member 2 ; Phosphoric Monoester Hydrolases (EC 3.1.3.2)
Language	English
Publishing date	2022-06-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2595406-4
ISSN	2045-8118 ; 2045-8118
ISSN (online)	2045-8118
ISSN	2045-8118
DOI	10.1186/s12987-022-00341-z
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Article ; Online: Heterolytic cleavage of a Si-H bond by a metal-ligand cooperation of a cationic iridium amido complex and hydrosilylation of aldehydes.

Iizuka, Kosuke / Nakajima, Yumiko / Sato, Kazuhiko

Dalton transactions (Cambridge, England : 2003)

2022 Volume 51, Issue 34, Page(s) 12781–12785

Abstract: Heterolytic cleavage of a Si-H bond was achieved mediated by a metal-ligand cooperation ...

Abstract	Heterolytic cleavage of a Si-H bond was achieved mediated by a metal-ligand cooperation of a cationic iridium amido complex. The reaction was applied to the catalytic hydrosilylation of benzaldehyde and its derivatives, affording the corresponding hydrosilylated products in moderate to good yields.
Language	English
Publishing date	2022-08-30
Publishing country	England
Document type	Journal Article
ZDB-ID	1472887-4
ISSN	1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
ISSN (online)	1477-9234 ; 1364-5447
ISSN	0300-9246 ; 1477-9226
DOI	10.1039/d2dt01733d
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Article ; Online: Application of 2'-O-(2-N-Methylcarbamoylethyl) Nucleotides in RNase H-Dependent Antisense Oligonucleotides.

Masaki, Yoshiaki / Iriyama, Yusuke / Nakajima, Hiroyuki / Kuroda, Yusuke / Kanaki, Tatsuro / Furukawa, Satoshi / Sekine, Mitsuo / Seio, Kohji

Nucleic acid therapeutics

2018 Volume 28, Issue 5, Page(s) 307–311

Abstract: An RNase H-dependent antisense oligonucleotide (ASO), having the 2'-O-(2-N-methylcarbamoylethyl ...

Abstract	An RNase H-dependent antisense oligonucleotide (ASO), having the 2'-O-(2-N-methylcarbamoylethyl) (MCE) modification, was evaluated in vitro and in vivo. The antisense activities of an ASO having the MCE modification were comparable with those of an ASO having the 2'-O-methoxyethyl (MOE) modification in both in vitro and in vivo experiments. In contrast, the hepatotoxic potential of the ASO having the MCE modification was lower than that of the ASO having the MOE modification. Thus, these findings suggested that the MCE modification could be used as an alternative to the MOE modification.
MeSH term(s)	Animals ; Humans ; Liver/drug effects ; Mice ; Nucleotides/adverse effects ; Nucleotides/chemistry ; Nucleotides/genetics ; Oligodeoxyribonucleotides/administration & dosage ; Oligodeoxyribonucleotides/chemistry ; Oligodeoxyribonucleotides/genetics ; Oligonucleotides, Antisense/administration & dosage ; Oligonucleotides, Antisense/adverse effects ; Oligonucleotides, Antisense/chemistry ; Oligonucleotides, Antisense/genetics ; RNA, Messenger/administration & dosage ; RNA, Messenger/chemistry ; RNA, Messenger/genetics ; Ribonuclease H/administration & dosage ; Ribonuclease H/chemistry ; Ribonuclease H/genetics
Chemical Substances	2'-O-(2-(methylthio)ethyl) RNA ; Nucleotides ; Oligodeoxyribonucleotides ; Oligonucleotides, Antisense ; RNA, Messenger ; Ribonuclease H (EC 3.1.26.4)
Language	English
Publishing date	2018-07-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2639888-6
ISSN	2159-3345 ; 2159-3337
ISSN (online)	2159-3345
ISSN	2159-3337
DOI	10.1089/nat.2018.0738
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Article ; Online: Asteltoxins from the Entomopathogenic Fungus Pochonia bulbillosa 8-H-28.

Adachi, Hayamitsu / Doi, Hiroyasu / Kasahara, Yuichi / Sawa, Ryuichi / Nakajima, Kaori / Kubota, Yumiko / Hosokawa, Nobuo / Tateishi, Ken / Nomoto, Akio

Journal of natural products

2015 Volume 78, Issue 7, Page(s) 1730–1734

Abstract: ... bulbillosa 8-H-28. Compound 2, which was spectroscopically identical with the known asteltoxin B, was ...

Abstract	New asteltoxins C (3) and D (4) were found in the extract of the entomopathogenic fungus Pochonia bulbillosa 8-H-28. Compound 2, which was spectroscopically identical with the known asteltoxin B, was isolated, and structural analysis led to a revision of the structure of asteltoxin B. Compounds 2 and 4 have a novel tricyclic ring system connected to a dienyl α-pyrone structure. Compound 3 has a 2,8-dioxabicyclo[3.3.0]octane ring similar to that of asteltoxin (1). Compound 3 showed potent antiproliferative activity against NIAS-SL64 cells derived from the fat body of Spodoptera litura larvae, while 2 and 4 were inactive.
MeSH term(s)	Animals ; Cell Survival/drug effects ; Depsipeptides/pharmacology ; Hypocreales/chemistry ; Japan ; Larva/drug effects ; Molecular Structure ; Nuclear Magnetic Resonance, Biomolecular ; Pyrones/chemistry ; Pyrones/isolation & purification ; Pyrones/pharmacology ; Spodoptera/drug effects
Chemical Substances	Depsipeptides ; Pyrones ; asteltoxin C ; asteltoxin D ; beauvericin (26S048LS2R) ; asteltoxin (72061-91-7)
Language	English
Publishing date	2015-07-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	304325-3
ISSN	1520-6025 ; 0163-3864
ISSN (online)	1520-6025
ISSN	0163-3864
DOI	10.1021/np500676j
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