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Article ; Online: Effect of Maternal Diet and Milk Lipid Composition on the Infant Gut and Maternal Milk Microbiomes.

Babakobi, Michal Dayagi / Reshef, Leah / Gihaz, Shalev / Belgorodsky, Bogdan / Fishman, Ayelet / Bujanover, Yoram / Gophna, Uri

Nutrients

2020 Volume 12, Issue 9

Abstract: Inter-subject variability in human milk microbiome is well known; however, its origins and possible relationship to the mother's diet are still debated. We investigated associations between maternal nutrition, milk fatty acids composition and microbiomes ...

Abstract	Inter-subject variability in human milk microbiome is well known; however, its origins and possible relationship to the mother's diet are still debated. We investigated associations between maternal nutrition, milk fatty acids composition and microbiomes in mother-infant dyads. Breast milk and infant fecal samples were collected across three time points (one week, one month and three months postpartum) from 22 mother-infant pairs. Food frequency questionnaires for the months of pregnancy and three months postpartum were collected. Milk fatty acids were analyzed by GC-MS and the microbiome in breast milk and infant feces was determined by 16S rRNA sequencing. Statistical interactions were computed using Spearman's method and corrected for multiple comparisons. We found significant negative correlation between
MeSH term(s)	Dietary Supplements ; Eating/physiology ; Fatty Acids/analysis ; Fatty Acids, Unsaturated/administration & dosage ; Feeding Behavior/physiology ; Female ; Gastrointestinal Microbiome ; Humans ; Infant ; Infant, Newborn ; Lactation/metabolism ; Male ; Maternal Nutritional Physiological Phenomena/physiology ; Milk, Human/metabolism ; Milk, Human/microbiology ; Mother-Child Relations ; Pregnancy ; Streptococcus ; Surveys and Questionnaires ; Vitamin B 12/administration & dosage
Chemical Substances	Fatty Acids ; Fatty Acids, Unsaturated ; Vitamin B 12 (P6YC3EG204)
Language	English
Publishing date	2020-08-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu12092539
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Polyclonal lymphoid expansion drives paraneoplastic autoimmunity in neuroblastoma.

Cell reports

2023 Volume 42, Issue 8, Page(s) 112879

Abstract: Neuroblastoma is a lethal childhood solid tumor of developing peripheral nerves. Two percent of children with neuroblastoma develop opsoclonus myoclonus ataxia syndrome (OMAS), a paraneoplastic disease characterized by cerebellar and brainstem-directed ... ...

Abstract	Neuroblastoma is a lethal childhood solid tumor of developing peripheral nerves. Two percent of children with neuroblastoma develop opsoclonus myoclonus ataxia syndrome (OMAS), a paraneoplastic disease characterized by cerebellar and brainstem-directed autoimmunity but typically with outstanding cancer-related outcomes. We compared tumor transcriptomes and tumor-infiltrating T and B cell repertoires from 38 OMAS subjects with neuroblastoma to 26 non-OMAS-associated neuroblastomas. We found greater B and T cell infiltration in OMAS-associated tumors compared to controls and showed that both were polyclonal expansions. Tertiary lymphoid structures (TLSs) were enriched in OMAS-associated tumors. We identified significant enrichment of the major histocompatibility complex (MHC) class II allele HLA-DOB
MeSH term(s)	Child ; Humans ; Autoimmunity ; Neuroblastoma/complications ; Neuroblastoma/metabolism ; Opsoclonus-Myoclonus Syndrome/complications ; Opsoclonus-Myoclonus Syndrome/pathology ; Autoantibodies ; Genes, MHC Class II ; Ataxia
Chemical Substances	Autoantibodies
Language	English
Publishing date	2023-08-02
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2023.112879
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Article: Effect of Maternal Diet and Milk Lipid Composition on the Infant Gut and Maternal Milk Microbiomes

Babakobi, Michal Dayagi / Reshef, Leah / Gihaz, Shalev / Belgorodsky, Bogdan / Fishman, Ayelet / Bujanover, Yoram / Gophna, Uri

Nutrients. 2020 Aug. 21, v. 12, no. 9

2020

Abstract: Inter-subject variability in human milk microbiome is well known; however, its origins and possible relationship to the mother’s diet are still debated. We investigated associations between maternal nutrition, milk fatty acids composition and microbiomes ...

Abstract	Inter-subject variability in human milk microbiome is well known; however, its origins and possible relationship to the mother’s diet are still debated. We investigated associations between maternal nutrition, milk fatty acids composition and microbiomes in mother–infant dyads. Breast milk and infant fecal samples were collected across three time points (one week, one month and three months postpartum) from 22 mother–infant pairs. Food frequency questionnaires for the months of pregnancy and three months postpartum were collected. Milk fatty acids were analyzed by GC–MS and the microbiome in breast milk and infant feces was determined by 16S rRNA sequencing. Statistical interactions were computed using Spearman’s method and corrected for multiple comparisons. We found significant negative correlation between Streptococcus relative abundance in maternal milk and intake of unsaturated fatty acids and folic acid at one month postpartum. At three months postpartum, vitamin B-12 consumption was significantly associated with a single operational taxonomic unit belonging to Streptococcus. Comparison between milk microbiome and lipid composition showed, one-month postpartum, significant negative correlation between Streptococcus relative abundance and the abundance of oleic acid. Additional correlations were detected between Staphylococcus hominis and two medium-chain saturated fatty acids. Our results reinforce the hypothesis that maternal nutrition may affect milk microbiome.
Keywords	Staphylococcus hominis ; Streptococcus ; breast milk ; correlation ; digestive system ; fatty acid composition ; feces ; folic acid ; food frequency questionnaires ; maternal nutrition ; microbiome ; milk ; milk fatty acids ; mother-child relationships ; nutrients ; oleic acid ; pregnancy ; variability ; vitamin B12
Language	English
Dates of publication	2020-0821
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
Note	NAL-light
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu12092539
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Polyclonal lymphoid expansion drives paraneoplastic autoimmunity in neuroblastoma

Cell Reports, Vol 42, Iss 8, Pp 112879- (2023)

2023

Abstract: Summary: Neuroblastoma is a lethal childhood solid tumor of developing peripheral nerves. Two percent of children with neuroblastoma develop opsoclonus myoclonus ataxia syndrome (OMAS), a paraneoplastic disease characterized by cerebellar and brainstem- ... ...

Abstract	Summary: Neuroblastoma is a lethal childhood solid tumor of developing peripheral nerves. Two percent of children with neuroblastoma develop opsoclonus myoclonus ataxia syndrome (OMAS), a paraneoplastic disease characterized by cerebellar and brainstem-directed autoimmunity but typically with outstanding cancer-related outcomes. We compared tumor transcriptomes and tumor-infiltrating T and B cell repertoires from 38 OMAS subjects with neuroblastoma to 26 non-OMAS-associated neuroblastomas. We found greater B and T cell infiltration in OMAS-associated tumors compared to controls and showed that both were polyclonal expansions. Tertiary lymphoid structures (TLSs) were enriched in OMAS-associated tumors. We identified significant enrichment of the major histocompatibility complex (MHC) class II allele HLA-DOB∗01:01 in OMAS patients. OMAS severity scores were associated with the expression of several candidate autoimmune genes. We propose a model in which polyclonal auto-reactive B lymphocytes act as antigen-presenting cells and drive TLS formation, thereby supporting both sustained polyclonal T cell-mediated anti-tumor immunity and paraneoplastic OMAS neuropathology.
Keywords	CP: Cancer ; CP: Immunology ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2023-08-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: High-Reynolds Microfluidic Sorting of Large Yeast Populations

Eliezer Keinan / Ayelet Chen Abraham / Aaron Cohen / Alexander I. Alexandrov / Reshef Mintz / Merav Cohen / Dana Reichmann / Daniel Kaganovich / Yaakov Nahmias

Scientific Reports, Vol 8, Iss 1, Pp 1-

2018 Volume 12

Abstract: Abstract Microfluidic sorting offers a unique ability to isolate large numbers of cells for bulk proteomic or metabolomics studies but is currently limited by low throughput and persistent clogging at low flow rates. Recently we uncovered the physical ... ...

Abstract	Abstract Microfluidic sorting offers a unique ability to isolate large numbers of cells for bulk proteomic or metabolomics studies but is currently limited by low throughput and persistent clogging at low flow rates. Recently we uncovered the physical principles governing the inertial focusing of particles in high-Reynolds numbers. Here, we superimpose high Reynolds inertial focusing on Dean vortices, to rapidly isolate large quantities of young and adult yeast from mixed populations at a rate of 107 cells/min/channel. Using a new algorithm to rapidly quantify budding scars in isolated yeast populations and system-wide proteomic analysis, we demonstrate that protein quality control and expression of established yeast aging markers such as CalM, RPL5, and SAM1 may change after the very first replication events, rather than later in the aging process as previously thought. Our technique enables the large-scale isolation of microorganisms based on minute differences in size (±1.5 μm), a feat unmatched by other technologies.
Keywords	Medicine ; R ; Science ; Q
Subject code	612
Language	English
Publishing date	2018-09-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: High-Reynolds Microfluidic Sorting of Large Yeast Populations.

Keinan, Eliezer / Abraham, Ayelet Chen / Cohen, Aaron / Alexandrov, Alexander I / Mintz, Reshef / Cohen, Merav / Reichmann, Dana / Kaganovich, Daniel / Nahmias, Yaakov

Scientific reports

2018 Volume 8, Issue 1, Page(s) 13739

Abstract: Microfluidic sorting offers a unique ability to isolate large numbers of cells for bulk proteomic or metabolomics studies but is currently limited by low throughput and persistent clogging at low flow rates. Recently we uncovered the physical principles ... ...

Abstract	Microfluidic sorting offers a unique ability to isolate large numbers of cells for bulk proteomic or metabolomics studies but is currently limited by low throughput and persistent clogging at low flow rates. Recently we uncovered the physical principles governing the inertial focusing of particles in high-Reynolds numbers. Here, we superimpose high Reynolds inertial focusing on Dean vortices, to rapidly isolate large quantities of young and adult yeast from mixed populations at a rate of 10
MeSH term(s)	Equipment Design ; Lab-On-A-Chip Devices ; Microfluidics/instrumentation ; Microfluidics/methods ; Proteomics ; Saccharomyces cerevisiae/growth & development
Language	English
Publishing date	2018-09-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-018-31726-6
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Article ; Online: Small-molecule biomarkers for clinical PET imaging of apoptosis.

Reshef, Ayelet / Shirvan, Anat / Akselrod-Ballin, Ayelet / Wall, Anders / Ziv, Ilan

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

2010 Volume 51, Issue 6, Page(s) 837–840

Abstract: Apoptosis is a fundamental biologic process. Molecular imaging of apoptosis in vivo may have important implications for clinical practice, assisting in early detection of disease, monitoring of disease course, assessment of treatment efficacy, or ... ...

Abstract	Apoptosis is a fundamental biologic process. Molecular imaging of apoptosis in vivo may have important implications for clinical practice, assisting in early detection of disease, monitoring of disease course, assessment of treatment efficacy, or development of new therapies. Although a PET probe for clinical imaging of apoptosis would be highly desirable, this is yet an unachieved goal, mainly because of the required challenging integration of various features, including sensitive and selective detection of the apoptotic cells, clinical aspects such as favorable biodistribution and safety profiles, and compatibility with the radiochemistry and imaging routines of clinical PET centers. Several approaches are being developed to address this challenge, all based on novel small-molecule structures targeting various steps of the apoptotic cascade. This novel concept of small-molecule PET probes for apoptosis is the focus of this review.
MeSH term(s)	Animals ; Apoptosis ; Biomarkers/metabolism ; Caspases/metabolism ; Enzyme Activation ; Humans ; Membrane Potential, Mitochondrial ; Positron-Emission Tomography/methods
Chemical Substances	Biomarkers ; Caspases (EC 3.4.22.-)
Language	English
Publishing date	2010-06
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	80272-4
ISSN	1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
ISSN (online)	1535-5667
ISSN	0097-9058 ; 0161-5505 ; 0022-3123
DOI	10.2967/jnumed.109.063917
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Zs.A 114: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 328: Show issues

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Article ; Online: Detection of Apoptotic Cells in a Rabbit Model with Atherosclerosis-Like Lesions Using the Positron Emission Tomography Radiotracer [

Hyafil, Fabien / Tran-Dinh, Alexy / Burg, Samuel / Leygnac, Sébastien / Louedec, Liliane / Milliner, Milan / Ben Azzouna, Rana / Reshef, Ayelet / Ben Ami, Miri / Meilhac, Olivier / Le Guludec, Dominique

Molecular imaging

2015 Volume 14, Issue 8, Page(s) 7290201500017

Abstract: ...

Abstract	[
Language	English
Publishing date	2015-08-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2137435-1
ISSN	1536-0121 ; 1535-3508
ISSN (online)	1536-0121
ISSN	1535-3508
DOI	10.2310/7290.2015.00017
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Zs.A 5994: Show issues

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Article ; Online: Molecular imaging of neurodegeneration by a novel cross-disease biomarker.

Shirvan, Anat / Reshef, Ayelet / Yogev-Falach, Merav / Ziv, Ilan

Experimental neurology

2009 Volume 219, Issue 1, Page(s) 274–283

Abstract: Current pre-mortem diagnosis of neurodegenerative disorders such as Alzheimer's disease (AD) or amyotrophic lateral sclerosis (ALS) is based on clinical assessment of neurological deficits. However, symptoms and signs emerge only late in the disease ... ...

Abstract	Current pre-mortem diagnosis of neurodegenerative disorders such as Alzheimer's disease (AD) or amyotrophic lateral sclerosis (ALS) is based on clinical assessment of neurological deficits. However, symptoms and signs emerge only late in the disease course, thus indicating an urgent need for novel tools for detection of the underlying neuropathology. NST-729 (MW=310) is a novel molecular imaging probe, which is a member of the ApoSense family of small molecule detectors of apoptosis. We now report on the ability of NST-729, upon its systemic administration in vivo, to detect characteristic neuropathology in pre-clinical models of AD (Tg2576 transgenic mice) and ALS (transgenic SOD-1 G93A mutation mice). In the AD model, NST-729 clearly and selectively bound and imaged amyloid plaques, in excellent correlation with a typical amyloid ex vivo staining (Congo red). In the ALS model, NST-729 distinctly and selectively imaged multiple degenerating neurons in the motor nuclei in the pons, medulla and spinal cord, manifesting numerous multifocal irregularities and disruptions of neuritic projections, typical of axonal apoptosis. Study results therefore support the potential utility of NST-729 as a cross-disease biomarker for neurodegeneration, and also its potential role as the first molecular probe for ALS. Future radio-labeled NST-729 analogues may assist in the early diagnosis of disease, and in the development of neuroprotective therapies for these severe neurological disorders.
MeSH term(s)	Alzheimer Disease/diagnosis ; Alzheimer Disease/metabolism ; Alzheimer Disease/physiopathology ; Amyotrophic Lateral Sclerosis/diagnosis ; Amyotrophic Lateral Sclerosis/metabolism ; Amyotrophic Lateral Sclerosis/physiopathology ; Animals ; Apoptosis/drug effects ; Apoptosis/physiology ; Biomarkers/analysis ; Biomarkers/metabolism ; Central Nervous System/metabolism ; Central Nervous System/pathology ; Central Nervous System/physiopathology ; Dansyl Compounds/chemical synthesis ; Dansyl Compounds/metabolism ; Disease Models, Animal ; Female ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Molecular Probes/chemical synthesis ; Molecular Probes/metabolism ; Molecular Structure ; Motor Neurons/metabolism ; Motor Neurons/pathology ; Nerve Degeneration/diagnosis ; Nerve Degeneration/metabolism ; Nerve Degeneration/physiopathology ; Plaque, Amyloid/metabolism ; Plaque, Amyloid/pathology ; Predictive Value of Tests ; Sensitivity and Specificity
Chemical Substances	Biomarkers ; Dansyl Compounds ; Molecular Probes ; N-(2-mercaptoethyl)dansylamide
Language	English
Publishing date	2009-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	207148-4
ISSN	1090-2430 ; 0014-4886
ISSN (online)	1090-2430
ISSN	0014-4886
DOI	10.1016/j.expneurol.2009.05.032
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Zs.A 184: Show issues

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Article ; Online: A Structured Gradual Exposure Protocol to Baked and Heated Milk in the Treatment of Milk Allergy.

Efron, Adi / Zeldin, Yuri / Gotesdyner, Leora / Stauber, Tali / Maoz Segal, Ramit / Binson, Inga / Dinkin, Mira / Dinkowitz, Larisa / Shahar, Danit / Deutch, Michal / Yaron, Mazal / Nevet, Ayelet / Reshef, Avner / Agmon-Levin, Nancy / Kenett, Ron S / Kidon, Mona I

The Journal of pediatrics

2018 Volume 203, Page(s) 204–209.e2

Abstract: Objective: To evaluate the efficacy and safety of a structured gradual exposure protocol (SGEP) with extensively heated and baked milk in promoting allergy resolution in children with cow milk allergy (CMA).: Study design: In a case control study, ... ...

Abstract	Objective: To evaluate the efficacy and safety of a structured gradual exposure protocol (SGEP) with extensively heated and baked milk in promoting allergy resolution in children with cow milk allergy (CMA). Study design: In a case control study, children with CMA aged 1-4 years who were treated with SGEP including extensively heated and baked milk, were compared with children treated with strict avoidance. Data were collected from medical records and from validated telephone questionnaires. Data analysis was performed using a nonparametric Kaplan-Meier and proportional hazard Cox regression model, after evaluation of the adequacy of the case control matching. Results: There were 43 children with milk allergy-26 (62%) males with a mean age at intervention of 21 months (range, 12-47 months)-who were treated with SGEP and followed to a mean age of 40 months (range, 20-82 months). The median age at resolution of CMA was compared with a matched group of 67 children treated with strict avoidance at least until 4 years of age or followed until earlier resolution, with a mean age at follow-up of 71 months (range, 11-176 months). The median estimated age at CMA resolution in the SGEP group was 36 months (95% CI, 34.5-49.7) compared with 98 months (95% CI, 82.4-114.1) in controls (P < .001). At last follow-up, 86% of treated children were tolerant to unheated milk proteins vs 52% of controls (P = .003). Conclusion: A structured protocol with extensively heated and baked milk seems to promote faster resolution of CMA.
MeSH term(s)	Adaptation, Physiological/immunology ; Age Factors ; Animals ; Case-Control Studies ; Child, Preschool ; Female ; Hot Temperature ; Humans ; Immunization/methods ; Infant ; Kaplan-Meier Estimate ; Male ; Milk/immunology ; Milk Hypersensitivity/diagnosis ; Milk Hypersensitivity/therapy ; Milk Proteins/immunology ; Prognosis ; Proportional Hazards Models ; Severity of Illness Index ; Sex Factors ; Skin Tests ; Time Factors
Chemical Substances	Milk Proteins
Language	English
Publishing date	2018-09-27
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	3102-1
ISSN	1097-6833 ; 0022-3476
ISSN (online)	1097-6833
ISSN	0022-3476
DOI	10.1016/j.jpeds.2018.07.091
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