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Article: Annotating Human P-Glycoprotein Bioassay Data.

Zdrazil, Barbara / Pinto, Marta / Vasanthanathan, Poongavanam / Williams, Antony J / Balderud, Linda Zander / Engkvist, Ola / Chichester, Christine / Hersey, Anne / Overington, John P / Ecker, Gerhard F

Molecular informatics

2012 Volume 31, Issue 8, Page(s) 599–609

Abstract: ... for the determination of bioactivities of human P-glycoprotein inhibitors and substrates as they are represented ... that for inhibitors of human P-glycoprotein it is possible to combine data coming from the same assay type ...

Abstract	Huge amounts of small compound bioactivity data have been entering the public domain as a consequence of open innovation initiatives. It is now the time to carefully analyse existing bioassay data and give it a systematic structure. Our study aims to annotate prominent in vitro assays used for the determination of bioactivities of human P-glycoprotein inhibitors and substrates as they are represented in the ChEMBL and TP-search open source databases. Furthermore, the ability of data, determined in different assays, to be combined with each other is explored. As a result of this study, it is suggested that for inhibitors of human P-glycoprotein it is possible to combine data coming from the same assay type, if the cell lines used are also identical and the fluorescent or radiolabeled substrate have overlapping binding sites. In addition, it demonstrates that there is a need for larger chemical diverse datasets that have been measured in a panel of different assays. This would certainly alleviate the search for other inter-correlations between bioactivity data yielded by different assay setups.
Language	English
Publishing date	2012-08-07
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2537668-8
ISSN	1868-1751 ; 1868-1743
ISSN (online)	1868-1751
ISSN	1868-1743
DOI	10.1002/minf.201200059
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Book ; Online ; E-Book: OSCEs for intensive care medicine

Hersey, Peter / O'Connor, Laura / Sams, Tom / Sturman, Jon

(Oxford higher specialty training)

2020

Author's details	Peter Herse, Laura O'Connor, Tom Sams, Jon Sturman
Series title	Oxford higher specialty training
Keywords	Critical care medicine-Examinations, questions, etc ; Electronic books
Language	English
Size	1 Online-Ressource (xiv, 336 Seiten), Illustrationen
Edition	First edition
Publisher	Oxford University Press
Publishing place	Oxford
Publishing country	Great Britain
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT021184396
ISBN	978-0-19-255773-5 ; 9780198824374 ; 0-19-255773-4 ; 0198824378
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Re: Pyrexia in patients treated with dabrafenib plus trametinib across clinical trials in BRAF-mutant cancers.

Hersey, Peter

European journal of cancer (Oxford, England : 1990)

2021 Volume 162, Page(s) 241–242

MeSH term(s)	Fever/chemically induced ; Humans ; Imidazoles ; Neoplasms/chemically induced ; Neoplasms/drug therapy ; Neoplasms/genetics ; Oximes/adverse effects ; Proto-Oncogene Proteins B-raf/genetics ; Pyridones/adverse effects ; Pyrimidinones
Chemical Substances	Imidazoles ; Oximes ; Pyridones ; Pyrimidinones ; trametinib (33E86K87QN) ; BRAF protein, human (EC 2.7.11.1) ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; dabrafenib (QGP4HA4G1B)
Language	English
Publishing date	2021-12-20
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	82061-1
ISSN	1879-0852 ; 0277-5379 ; 0959-8049 ; 0964-1947
ISSN (online)	1879-0852
ISSN	0277-5379 ; 0959-8049 ; 0964-1947
DOI	10.1016/j.ejca.2021.10.037
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Zs.A 456: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Improving the in vitro prediction of in vivo central nervous system penetration: integrating permeability, P-glycoprotein efflux, and free fractions in blood and brain.

Summerfield, Scott G / Stevens, Alexander J / Cutler, Leanne / del Carmen Osuna, Maria / Hammond, Beverley / Tang, Sac-Pham / Hersey, Ann / Spalding, David J / Jeffrey, Phil

The Journal of pharmacology and experimental therapeutics

2006 Volume 316, Issue 3, Page(s) 1282–1290

Abstract: ... homogenate, passive membrane permeability, P-glycoprotein (Pgp) efflux ratio, and log octanol/water partition ...

Abstract	This work examines the inter-relationship between the unbound drug fractions in blood and brain homogenate, passive membrane permeability, P-glycoprotein (Pgp) efflux ratio, and log octanol/water partition coefficients (cLogP) in determining the extent of central nervous system (CNS) penetration observed in vivo. The present results demonstrate that compounds often considered to be Pgp substrates in rodents (efflux ratio greater than 5 in multidrug resistant Madin-Darby canine kidney cells) with poor passive permeability may still exhibit reasonable CNS penetration in vivo; i.e., where the unbound fractions and nonspecific tissue binding act as a compensating force. In these instances, the efflux ratio and in vitro blood-brain partition ratio may be used to predict the in vivo blood-brain ratio. This relationship may be extended to account for the differences in CNS penetration observed in vivo between mdr1a/b wild type and knockout mice. In some instances, cross-species differences that might initially seem to be related to differing transporter expression can be rationalized from knowledge of unbound fractions alone. The results presented in this article suggest that the information exists to provide a coherent picture of the nature of CNS penetration in the drug discovery setting, allowing the focus to be shifted away from understanding CNS penetration toward the more important aspect of understanding CNS efficacy.
MeSH term(s)	ATP-Binding Cassette, Sub-Family B, Member 1/metabolism ; Animals ; Blood-Brain Barrier ; Brain/metabolism ; Dialysis ; Dogs ; Male ; Mice ; Permeability ; Rats ; Solubility ; Species Specificity
Chemical Substances	ATP-Binding Cassette, Sub-Family B, Member 1
Language	English
Publishing date	2006-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	3106-9
ISSN	1521-0103 ; 0022-3565
ISSN (online)	1521-0103
ISSN	0022-3565
DOI	10.1124/jpet.105.092916
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Article ; Online: Abortion policies at the bedside: incorporating an ethical framework in the analysis and development of abortion legislation.

Hersey, Alicia E / Potter-Rutledge, Jai-Me / Brown, Benjamin P

Journal of medical ethics

2023 Volume 50, Issue 1, Page(s) 2–5

Abstract: About 6% of women in the world live in countries that ban all abortions, and 34% in countries that only allow abortion to preserve maternal life or health. In the USA, over the last decades-even before Dobbs v. Jackson Women's Health Organization ... ...

Abstract	About 6% of women in the world live in countries that ban all abortions, and 34% in countries that only allow abortion to preserve maternal life or health. In the USA, over the last decades-even before Dobbs v. Jackson Women's Health Organization overturned the federal right to abortion-various states have sought to restrict abortion access. Often times, this legislation has been advanced based on legislators' personal moral values. At the bedside, in contrast, provision of abortion care should adhere to the normative principles of medical ethics and reproductive justice, centreing patients and their individual reproductive intentions and desires. Abortion regulations, through their influence on patients and providers, may facilitate or impede such ethical care at the bedside. In this paper, we present a framework to model how abortion legislation should fit into the patient-provider relationship and to clarify the dynamics by which legislation may affect healthcare encounters. Our proposed framework serves as a tool to analyse the ethical impact of abortion regulations. We propose a model for assessing abortion policies based not on legislators' or advocates' individual moral claims, but on the shared, normative framework of clinical medical ethics. Through contrasting case studies, we demonstrate how a robust normative ethical framework can recentre patients and their reproductive needs. Our model is one way to account for-and safeguard-patients' diverse viewpoints and needs in the development of abortion policy, and it can serve to ground narratives for advocacy by healthcare workers and their professional organisations.
MeSH term(s)	Pregnancy ; Female ; Humans ; Abortion, Induced ; Morals ; Policy ; Ethics, Medical
Language	English
Publishing date	2023-12-14
Publishing country	England
Document type	Journal Article
ZDB-ID	194927-5
ISSN	1473-4257 ; 0306-6800
ISSN (online)	1473-4257
ISSN	0306-6800
DOI	10.1136/jme-2022-108412
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Article ; Online: Integrating the monoamine and cytokine hypotheses of depression: Is histamine the missing link?

Hersey, Melinda / Hashemi, Parastoo / Reagan, Lawrence P

The European journal of neuroscience

2021 Volume 55, Issue 9-10, Page(s) 2895–2911

Abstract: Psychiatric diseases, like depression, largely affect the central nervous system (CNS). While the underlying neuropathology of depressive illness remains to be elucidated, several hypotheses have been proposed as molecular underpinnings for major ... ...

Abstract	Psychiatric diseases, like depression, largely affect the central nervous system (CNS). While the underlying neuropathology of depressive illness remains to be elucidated, several hypotheses have been proposed as molecular underpinnings for major depressive disorder, including the monoamine hypothesis and the cytokine hypothesis. The monoamine hypothesis has been largely supported by the pharmaceuticals that target monoamine neurotransmitters as a treatment for depression. However, these antidepressants have come under scrutiny due to their limited clinical efficacy, side effects, and delayed onset of action. The more recent, cytokine hypothesis of depression is supported by the ability of immune-active agents to induce "sickness behaviour" akin to that seen with depression. However, treatments that more selectively target inflammation have yielded inconsistent antidepressive results. As such, neither of these hypotheses can fully explain depressive illness pathology, implying that the underlying neuropathological mechanisms may encompass aspects of both theories. The goal of the current review is to integrate these two well-studied hypotheses and to propose a role for histamine as a potential unifying factor that links monoamines to cytokines. Additionally, we will focus on stress-induced depression, to provide an updated perspective of depressive illness research and thereby identify new potential targets for the treatment of major depressive disorder.
MeSH term(s)	Antidepressive Agents/pharmacology ; Antidepressive Agents/therapeutic use ; Cytokines ; Depression/drug therapy ; Depressive Disorder, Major/drug therapy ; Histamine/therapeutic use ; Humans
Chemical Substances	Antidepressive Agents ; Cytokines ; Histamine (820484N8I3)
Language	English
Publishing date	2021-08-02
Publishing country	France
Document type	Journal Article ; Review ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
ZDB-ID	645180-9
ISSN	1460-9568 ; 0953-816X
ISSN (online)	1460-9568
ISSN	0953-816X
DOI	10.1111/ejn.15392
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Article ; Online: Community experience of vemurafenib for BRAF(V600) melanoma.

Hersey, Peter

The Lancet. Oncology

2014 Volume 15, Issue 4, Page(s) 369–370

MeSH term(s)	Antineoplastic Agents/therapeutic use ; Humans ; Indoles/therapeutic use ; Melanoma/drug therapy ; Melanoma/secondary ; Mutation ; Protein Kinase Inhibitors/therapeutic use ; Proto-Oncogene Proteins B-raf/antagonists & inhibitors ; Proto-Oncogene Proteins B-raf/genetics ; Skin Neoplasms/drug therapy ; Sulfonamides/therapeutic use
Chemical Substances	Antineoplastic Agents ; Indoles ; Protein Kinase Inhibitors ; Sulfonamides ; vemurafenib (207SMY3FQT) ; BRAF protein, human (EC 2.7.11.1) ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1)
Language	English
Publishing date	2014-04
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	2049730-1
ISSN	1474-5488 ; 1470-2045
ISSN (online)	1474-5488
ISSN	1470-2045
DOI	10.1016/S1470-2045(14)70079-8
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Zs.A 5696: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Utilizing International Classification of Diseases Codes to Identify Shoulder Dystocia and Neonatal Brachial Plexus Injury.

Hersey, Alicia E / Wagner, Stephen M / Gupta, Megha / Chang, Kate / Yang, Lynda / Chauhan, Suneet P

Pediatric neurology

2023 Volume 144, Page(s) 115–118

Abstract: ... with an NBBP ICD-9/10 code than those infants with upper nerve involvement (77% vs 39%, P < 0.02 ...

Abstract	Background: The utilization of International Classification of Diseases, Ninth or Tenth Revision, (ICD-9/10) coding to identify the incidence of disease is frequently performed in medical research. This study attempts to assess the validity of using ICD-9/10 codes to identify patients with shoulder dystocia (SD) with concurrent neonatal brachial plexus palsy (NBPP). Methods: This retrospective cohort study examined patients evaluated at the University of Michigan Brachial Plexus and Peripheral Nerve Program (UM-BP/PN) from 2004 to 2018. We reported the percentage of patients with reported NBPP ICD-9/10 and SD ICD-9/10 discharged at birth who were later diagnosed with NBPP by a specialty clinic by interdisciplinary faculty and staff utilizing physical evaluations and ancillary testing such as such as electrodiagnostics and imaging. The relationship of reported NBPP ICD-9/10, SD ICD-9/10, extent of NBPP nerve involvement, and NBPP persistence at age two years were examined via chi-square or Fischer exact test. Results: Of the 51 mother-infant dyads with complete birth discharge records evaluated at the UM-BP/PN, 26 (51%) were discharged without an ICD-9/10 code documenting NBPP; of these 26 patients, only four had ICD-9/10 documentation of SD at discharge, which left 22 patients with no ICD-9/10 code documentation of either SD or NBPP (43%). Patients with pan-plexopathy were more likely to be discharged with an NBBP ICD-9/10 code than those infants with upper nerve involvement (77% vs 39%, P < 0.02). Conclusion: Use of ICD-9/10 codes for the identification of NBPP appears to undercount the true incidence. This underestimation is more pronounced for milder forms of NBPP.
MeSH term(s)	Infant, Newborn ; Infant ; Pregnancy ; Female ; Humans ; Child, Preschool ; Brachial Plexus Neuropathies/diagnosis ; Brachial Plexus Neuropathies/epidemiology ; Shoulder Dystocia ; Retrospective Studies ; International Classification of Diseases ; Brachial Plexus
Language	English
Publishing date	2023-04-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	639164-3
ISSN	1873-5150 ; 0887-8994
ISSN (online)	1873-5150
ISSN	0887-8994
DOI	10.1016/j.pediatrneurol.2023.04.002
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Article ; Online: Left- vs right-sided migraine: a scoping review.

Blum, Adam S Sprouse / Riggins, Nina Y / Hersey, Denise P / Atwood, Gary S / Littenberg, Benjamin

Journal of neurology

2023 Volume 270, Issue 6, Page(s) 2938–2949

Abstract: Background: Migraine is a historically unilateral head pain condition, the cause of which is not currently known. A growing body of literature suggests individuals who experience migraine with left-sided headache ("left-sided migraine") may be ... ...

Abstract	Background: Migraine is a historically unilateral head pain condition, the cause of which is not currently known. A growing body of literature suggests individuals who experience migraine with left-sided headache ("left-sided migraine") may be distinguished from those who experience migraine with right-sided headache ("right-sided migraine"). Objective: In this scoping review, we explore migraine unilaterality by summarizing what is currently known about left- and right-sided migraine. Methods: Two senior medical librarians worked with the lead authors to construct and refine a set of search terms to identify studies of subjects with left- or right-sided migraine published between 1988, which is the year of publication of the first edition of the International Classification of Headache Disorders (ICHD), and December 8, 2021 (the date the searches were conducted). The following databases were searched: Medline, Embase, PsycINFO, PubMed, Cochrane Library, and Web of Science. Abstracts were loaded into Covidence review software, deduplicated, then screened by two authors to determine study eligibility. Eligible studies were those involving subjects diagnosed with migraine (according to ICHD criteria) in which the authors either: a) compared left- to right-sided migraine; or b) described (with analysis) a characteristic that differentiated the two. Data were extracted by the lead author, including ICHD version, the definition of unilateral migraine used by the authors, sample size, whether the findings were collected during or between attacks, and their key findings. The key findings were grouped into the following themes: handedness, symptoms, psychiatric assessments, cognitive testing, autonomic function, and imaging. Results: After deduplication, the search yielded 5428 abstracts for screening. Of these, 179 met eligibility criteria and underwent full text review. 26 articles were included in the final analysis. All of the studies were observational. One study was performed during attack, nineteen between attacks, and six both during and between attacks. Left- and right-sided migraine were found to differ across multiple domains. In several cases, reciprocal findings were reported in left- and right-migraine. For example, both left- and right-sided migraine were associated with ipsilateral handedness, tinnitus, onset of first Parkinson's symptoms, changes in blood flow across the face, white matter hyperintensities on MRI, activation of the dorsal pons, hippocampal sclerosis, and thalamic NAA/Cho and NAA/Cr concentrations. In other cases, however, the findings were specific to one migraine laterality. For example, left-sided migraine was associated with worse quality of life, anxiety, bipolar disorder, PTSD, lower sympathetic activity, and higher parasympathetic activity. Whereas right-sided migraine was associated with poorer performance on multiple cognitive tests, a greater degree of anisocoria, changes in skin temperature, higher diastolic blood pressure, changes in blood flow through the middle cerebral and basilar arteries, and changes on EEG. Conclusion: Left- and right-sided migraine differed across a wide range of domains, raising the possibility that the pathophysiology of left- and right-migraine may not be identical.
MeSH term(s)	Humans ; Quality of Life ; Migraine Disorders ; Functional Laterality/physiology ; Headache Disorders ; Headache
Language	English
Publishing date	2023-03-07
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	187050-6
ISSN	1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
ISSN (online)	1432-1459
ISSN	0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
DOI	10.1007/s00415-023-11609-1
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Article ; Online: The interrelationship between food security, climate change, and gender-based violence: A scoping review with system dynamics modeling.

Agrawal, Pooja / Post, Lori Ann / Glover, Janis / Hersey, Denise / Oberoi, Piya / Biroscak, Brian

PLOS global public health

2023 Volume 3, Issue 2, Page(s) e0000300

Abstract: Gender-based violence (GBV) is a global public health and human rights problem that is exacerbated by social and environmental stressors for a multitude of interpersonal, cultural, and economic reasons. Through sudden disruptions in the microclimate of a ...

Abstract	Gender-based violence (GBV) is a global public health and human rights problem that is exacerbated by social and environmental stressors for a multitude of interpersonal, cultural, and economic reasons. Through sudden disruptions in the microclimate of a region, climate shocks often have a negative impact on food security, which correlates with increases in GBV. Associations between the various combinations of GBV, climate change, and food insecurity have been documented in the growing international literature, but questions remain about these associations that require further clarification. The impact of the COVID-19 pandemic caused by SARS-CoV-2 provides insight through a real time demonstration into these interactions. This review of the global literature examines the interplay between GBV, climate change, and food insecurity-including recent literature regarding the COVID-19 pandemic. This review covers original research studies employing both quantitative and qualitative methodology, those that conducted secondary analyses of existing data sources and perspective pieces derived from observed evidence. An additional analytic layer of system dynamics modeling allowed for the integration of findings from the scoping review and discovery of additional insights into the interplay between disasters, food insecurity, and GBV. Findings from this review suggest that the development and adaptation of evidence-based, focused interventions and policies to reduce the effects of climate shocks and bolster food security may ultimately decrease GBV prevalence and impact.
Language	English
Publishing date	2023-02-24
Publishing country	United States
Document type	Journal Article
ISSN	2767-3375
ISSN (online)	2767-3375
DOI	10.1371/journal.pgph.0000300
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