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Article ; Online: A Population-Based Family Case-Control Study of Sun Exposure and Follicular Lymphoma Risk.

Odutola, Michael K / van Leeuwen, Marina T / Bruinsma, Fiona / Turner, Jennifer / Hertzberg, Mark / Seymour, John F / Prince, H Miles / Trotman, Judith / Verner, Emma / Roncolato, Fernando / Opat, Stephen / Lindeman, Robert / Tiley, Campbell / Milliken, Samuel T / Underhill, Craig R / Benke, Geza / Giles, Graham G / Vajdic, Claire M

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

2023 Volume 33, Issue 1, Page(s) 106–116

Abstract: Background: Epidemiologic evidence suggests an inverse association between sun exposure and follicular lymphoma risk.: Methods: We conducted an Australian population-based family case-control study based on 666 cases and 459 controls (288 related, ... ...

Abstract	Background: Epidemiologic evidence suggests an inverse association between sun exposure and follicular lymphoma risk. Methods: We conducted an Australian population-based family case-control study based on 666 cases and 459 controls (288 related, 171 unrelated). Participants completed a lifetime residence and work calendar and recalled outdoor hours on weekdays, weekends, and holidays in the warmer and cooler months at ages 10, 20, 30, and 40 years, and clothing types worn in the warmer months. We used a group-based trajectory modeling approach to identify outdoor hour trajectories over time and examined associations with follicular lymphoma risk using logistic regression. Results: We observed an inverse association between follicular lymphoma risk and several measures of high lifetime sun exposure, particularly intermittent exposure (weekends, holidays). Associations included reduced risk with increasing time outdoors on holidays in the warmer months [highest category OR = 0.56; 95% confidence interval (CI), 0.42-0.76; Ptrend < 0.01], high outdoor hours on weekends in the warmer months (highest category OR = 0.71; 95% CI, 0.52-0.96), and increasing time outdoors in the warmer and cooler months combined (highest category OR = 0.66; 95% CI, 0.50-0.91; Ptrend 0.01). Risk was reduced for high outdoor hour maintainers in the warmer months across the decade years (OR = 0.71; 95% CI, 0.53-0.96). Conclusions: High total and intermittent sun exposure, particularly in the warmer months, may be protective against the development of follicular lymphoma. Impact: Although sun exposure is not recommended as a cancer control policy, confirming this association may provide insights regarding the future control of this intractable malignancy.
MeSH term(s)	Humans ; Skin Neoplasms/epidemiology ; Skin Neoplasms/etiology ; Lymphoma, Follicular/epidemiology ; Lymphoma, Follicular/etiology ; Sunlight/adverse effects ; Case-Control Studies ; Australia/epidemiology ; Risk Factors
Language	English
Publishing date	2023-09-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1153420-5
ISSN	1538-7755 ; 1055-9965
ISSN (online)	1538-7755
ISSN	1055-9965
DOI	10.1158/1055-9965.EPI-23-0578
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Zs.A 3693: Show issues

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Article ; Online: Identification of a novel fentanyl analog: p-Hydroxy-butyrylfentanyl.

Oldenhof, Sander / Ten Pierick, Angela / Bruinsma, Jildert / Eustace, Stephen / Hulshof, Janneke / van den Berg, Jorrit / Hoitink, Marnix

Drug testing and analysis

2019 Volume 12, Issue 1, Page(s) 152–155

MeSH term(s)	Analgesics, Opioid/chemistry ; Chromatography, High Pressure Liquid ; Fentanyl/analogs & derivatives ; Fentanyl/chemistry ; Gas Chromatography-Mass Spectrometry ; Humans ; Illicit Drugs/chemistry ; Magnetic Resonance Spectroscopy
Chemical Substances	Analgesics, Opioid ; Illicit Drugs ; butyrfentanyl (07V1H7R6ZN) ; Fentanyl (UF599785JZ)
Language	English
Publishing date	2019-12-15
Publishing country	England
Document type	Letter
ZDB-ID	2462336-2
ISSN	1942-7611 ; 1942-7603
ISSN (online)	1942-7611
ISSN	1942-7603
DOI	10.1002/dta.2695
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Zs.A 6792: Show issues

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Article: Dietary intake of animal-based products and likelihood of follicular lymphoma and survival: A population-based family case-control study.

Frontiers in nutrition

2023 Volume 9, Page(s) 1048301

Abstract: Background: The association between dietary intake of foods of animal origin and follicular lymphoma (FL) risk and survival is uncertain. In this study, we examined the relationship between dietary intake of dairy foods and fats, meat, fish and seafoods, ...

Abstract	Background: The association between dietary intake of foods of animal origin and follicular lymphoma (FL) risk and survival is uncertain. In this study, we examined the relationship between dietary intake of dairy foods and fats, meat, fish and seafoods, and the likelihood of FL and survival. Methods: We conducted a population-based family case-control study in Australia between 2011 and 2016 and included 710 cases, 303 siblings and 186 spouse/partner controls. We assessed dietary intake of animal products prior to diagnosis (the year before last) using a structured food frequency questionnaire and followed-up cases over a median of 6.9 years using record linkage to national death data. We examined associations with the likelihood of FL using logistic regression and used Cox regression to assess association with all-cause and FL-specific mortality among cases. Results: We observed an increased likelihood of FL with increasing daily quantity of oily fish consumption in the year before last (highest category OR = 1.96, CI = 1.02-3.77; Conclusion: Our study showed suggestive evidence of a positive association between oily fish intake and the likelihood of FL, but findings varied by control type. Further investigation of the potential role of environmental contaminants in oily fish on FL etiology is warranted.
Language	English
Publishing date	2023-01-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2022.1048301
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Article ; Online: Occupational exposure to extremely low-frequency magnetic fields and follicular lymphoma risk: a family case-control study.

Occupational and environmental medicine

2023 Volume 80, Issue 10, Page(s) 599–602

Abstract: Objectives: We aimed to examine the relationship between occupational exposure to extremely low-frequency magnetic fields (ELF-MFs) and follicular lymphoma (FL) risk.: Methods: We conducted a family case-control study between 2011 and 2016 in ... ...

Abstract	Objectives: We aimed to examine the relationship between occupational exposure to extremely low-frequency magnetic fields (ELF-MFs) and follicular lymphoma (FL) risk. Methods: We conducted a family case-control study between 2011 and 2016 in Australia and included 681 cases. Controls were either a family member of cases (related (n=294), unrelated (n=179)) or were unrelated recruited for a similarly designed Australian multiple myeloma study (n=711). We obtained detailed job histories using lifetime work calendars. We assigned exposure to ELF-MFs using an enhanced job exposure matrix, with a lag period of 10 years. We examined associations with FL risk using logistic regression accounting for relatedness between cases and controls. We performed sensitivity analyses including by control type, by sex, complete case analyses, ELF-MF exposure percentiles in addition to quartiles, ELF-MF exposure in the maximum exposed job, a shorter lag period (1 year) and the cumulative exposure in the most recent time period (1-9 years). Results: We observed no association with the average intensity, duration or lifetime cumulative exposure to occupational ELF-MF exposure in the primary or sensitivity analyses. Conclusions: Our findings do not support an association between occupational ELF-MF exposure and FL risk. Although the inclusion of family members as part of the larger control group may have biased our risk estimates towards the null, findings were similar in sensitivity analyses restricted to cases and unrelated controls. Further research incorporating enhanced exposure assessment to ELF-MF is warranted to inform occupational safety regulations and any potential role in lymphomagenesis.
MeSH term(s)	Humans ; Lymphoma, Follicular/epidemiology ; Lymphoma, Follicular/etiology ; Case-Control Studies ; Risk Factors ; Australia/epidemiology ; Magnetic Fields ; Occupational Exposure/adverse effects ; Electromagnetic Fields/adverse effects
Language	English
Publishing date	2023-09-18
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1180733-7
ISSN	1470-7926 ; 1351-0711
ISSN (online)	1470-7926
ISSN	1351-0711
DOI	10.1136/oemed-2023-108949
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Un I Zs.461: Show issues

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Article: Associations between Smoking and Alcohol and Follicular Lymphoma Incidence and Survival: A Family-Based Case-Control Study in Australia.

Odutola, Michael K / van Leeuwen, Marina T / Turner, Jennifer / Bruinsma, Fiona / Seymour, John F / Prince, Henry M / Milliken, Samuel T / Trotman, Judith / Verner, Emma / Tiley, Campbell / Roncolato, Fernando / Underhill, Craig R / Opat, Stephen S / Harvey, Michael / Hertzberg, Mark / Benke, Geza / Giles, Graham G / Vajdic, Claire M

Cancers

2022 Volume 14, Issue 11

Abstract: The association between smoking and alcohol consumption and follicular lymphoma (FL) incidence and clinical outcome is uncertain. We conducted a population-based family case-control study (709 cases: 490 controls) in Australia. We assessed lifetime ... ...

Abstract	The association between smoking and alcohol consumption and follicular lymphoma (FL) incidence and clinical outcome is uncertain. We conducted a population-based family case-control study (709 cases: 490 controls) in Australia. We assessed lifetime history of smoking and recent alcohol consumption and followed-up cases (median = 83 months). We examined associations with FL risk using unconditional logistic regression and with all-cause and FL-specific mortality of cases using Cox regression. FL risk was associated with ever smoking (OR = 1.38, 95%CI = 1.08−1.74), former smoking (OR = 1.36, 95%CI = 1.05−1.77), smoking initiation before age 17 (OR = 1.47, 95%CI = 1.06−2.05), the highest categories of cigarettes smoked per day (OR = 1.44, 95%CI = 1.04−2.01), smoking duration (OR = 1.53, 95%CI = 1.07−2.18) and pack-years (OR = 1.56, 95%CI = 1.10−2.22). For never smokers, FL risk increased for those exposed indoors to >2 smokers during childhood (OR = 1.84, 95%CI = 1.11−3.04). For cases, current smoking and the highest categories of smoking duration and lifetime cigarette exposure were associated with elevated all-cause mortality. The hazard ratio for current smoking and FL-specific mortality was 2.97 (95%CI = 0.91−9.72). We found no association between recent alcohol consumption and FL risk, all-cause or FL-specific mortality. Our study showed consistent evidence of an association between smoking and increased FL risk and possibly also FL-specific mortality. Strengthening anti-smoking policies and interventions may reduce the population burden of FL.
Language	English
Publishing date	2022-05-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14112710
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Article ; Online: Associations between early-life growth pattern and body size and follicular lymphoma risk and survival: a family-based case-control study.

Odutola, Michael K / van Leeuwen, Marina T / Turner, Jennifer / Bruinsma, Fiona / Seymour, John F / Prince, H Miles / Milliken, Samuel T / Hertzberg, Mark / Trotman, Judith / Opat, Stephen S / Lindeman, Robert / Roncolato, Fernando / Verner, Emma / Harvey, Michael / Tiley, Campbell / Underhill, Craig R / Benke, Geza / Giles, Graham G / Vajdic, Claire M

Cancer epidemiology

2022 Volume 80, Page(s) 102241

Abstract: Background: The influence of early-life growth pattern and body size on follicular lymphoma (FL) risk and survival is unclear. In this study, we aimed to investigate the association between gestational age, growth during childhood, body size, changes in ...

Abstract	Background: The influence of early-life growth pattern and body size on follicular lymphoma (FL) risk and survival is unclear. In this study, we aimed to investigate the association between gestational age, growth during childhood, body size, changes in body shape over time, and FL risk and survival. Methods: We conducted a population-based family case-control study and included 706 cases and 490 controls. We ascertained gestational age, growth during childhood, body size and body shape using questionnaires and followed-up cases (median=83 months) using record linkage with national death records. We used a group-based trajectory modeling approach to identify body shape trajectories from ages 5-70. We examined associations with FL risk using unconditional logistic regression and used Cox regression to assess the association between body mass index (BMI) and all-cause and FL-specific mortality among cases. Results: We found no association between gestational age, childhood height and FL risk. We observed a modest increase in FL risk with being obese 5 years prior to enrolment (OR=1.43, 95 %CI=0.99-2.06; BMI ≥30 kg/m Conclusion: We observed a weak association between elevated BMI and FL risk, and no association with all-cause or FL-specific mortality, consistent with previous studies. Future studies incorporating biomarkers are needed to elucidate possible mechanisms underlying the role of body composition in FL etiology.
MeSH term(s)	Adolescent ; Adult ; Aged ; Body Mass Index ; Body Size ; Case-Control Studies ; Child ; Child, Preschool ; Humans ; Lymphoma, Follicular/epidemiology ; Middle Aged ; Obesity ; Risk Factors ; Young Adult
Language	English
Publishing date	2022-09-01
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2508729-0
ISSN	1877-783X ; 1877-7821
ISSN (online)	1877-783X
ISSN	1877-7821
DOI	10.1016/j.canep.2022.102241
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Zs.A 1427: Show issues

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Article ; Online: Beta2-chimaerin in cancer signaling: connecting cell adhesion and MAP kinase activation.

Bruinsma, Stephen P / Baranski, Thomas J

Cell cycle (Georgetown, Tex.)

2007 Volume 6, Issue 20, Page(s) 2440–2444

Abstract: The chimaerins are Rac GTPase-activating proteins that bind diacylglycerol. Emerging evidence implicates beta2-chimaerin in tumor progression. Here, we discuss our recent work in Drosophila melanogaster in the context of previous studies performed in ... ...

Abstract	The chimaerins are Rac GTPase-activating proteins that bind diacylglycerol. Emerging evidence implicates beta2-chimaerin in tumor progression. Here, we discuss our recent work in Drosophila melanogaster in the context of previous studies performed in human cancer cell lines that together lend new mechanistic insight into the role of chimaerins in cancer.
MeSH term(s)	Animals ; Cell Adhesion ; Disease Progression ; Enzyme Activation ; Humans ; Mitogen-Activated Protein Kinases/metabolism ; Neoplasm Proteins/metabolism ; Neoplasms/metabolism ; Neoplasms/pathology ; Signal Transduction
Chemical Substances	Neoplasm Proteins ; beta-chimaerin ; Mitogen-Activated Protein Kinases (EC 2.7.11.24)
Language	English
Publishing date	2007-07-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2146183-1
ISSN	1551-4005 ; 1538-4101 ; 1554-8627
ISSN (online)	1551-4005
ISSN	1538-4101 ; 1554-8627
DOI	10.4161/cc.6.20.4786
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Zs.A 5881: Show issues

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Article ; Online: Small molecules that inhibit the late stage of Munc13-4-dependent secretory granule exocytosis in mast cells.

Bruinsma, Stephen / James, Declan J / Quintana Serrano, Melanie / Esquibel, Joseph / Woo, Sang Su / Kielar-Grevstad, Elle / Crummy, Ellen / Qurashi, Rehan / Kowalchyk, Judy A / Martin, Thomas F J

The Journal of biological chemistry

2018 Volume 293, Issue 21, Page(s) 8217–8229

Abstract: ... ...

Abstract	Ca
MeSH term(s)	Animals ; Cell Degranulation/drug effects ; Exocytosis ; Leukemia, Basophilic, Acute/drug therapy ; Leukemia, Basophilic, Acute/metabolism ; Leukemia, Basophilic, Acute/pathology ; Mast Cells/drug effects ; Mast Cells/pathology ; Membrane Fusion ; Proteins/genetics ; Proteins/metabolism ; Rats ; Secretory Vesicles/drug effects ; Secretory Vesicles/pathology ; Small Molecule Libraries/pharmacology ; Tumor Cells, Cultured
Chemical Substances	Proteins ; Small Molecule Libraries ; Unc13d protein, rat
Language	English
Publishing date	2018-04-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1074/jbc.RA117.001547
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Uc I Zs.108: Show issues

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Article ; Online: CAPS and Munc13 utilize distinct PIP2-linked mechanisms to promote vesicle exocytosis.

Kabachinski, Greg / Yamaga, Masaki / Kielar-Grevstad, D Michelle / Bruinsma, Stephen / Martin, Thomas F J

Molecular biology of the cell

2013 Volume 25, Issue 4, Page(s) 508–521

Abstract: Phosphoinositides provide compartment-specific signals for membrane trafficking. Plasma membrane phosphatidylinositol 4,5-bisphosphate (PIP2) is required for Ca(2+)-triggered vesicle exocytosis, but whether vesicles fuse into PIP2-rich membrane domains ... ...

Abstract	Phosphoinositides provide compartment-specific signals for membrane trafficking. Plasma membrane phosphatidylinositol 4,5-bisphosphate (PIP2) is required for Ca(2+)-triggered vesicle exocytosis, but whether vesicles fuse into PIP2-rich membrane domains in live cells and whether PIP2 is metabolized during Ca(2+)-triggered fusion were unknown. Ca(2+)-dependent activator protein in secretion 1 (CAPS-1; CADPS/UNC31) and ubMunc13-2 (UNC13B) are PIP2-binding proteins required for Ca(2+)-triggered vesicle exocytosis in neuroendocrine PC12 cells. These proteins are likely effectors for PIP2, but their localization during exocytosis had not been determined. Using total internal reflection fluorescence microscopy in live cells, we identify PIP2-rich membrane domains at sites of vesicle fusion. CAPS is found to reside on vesicles but depends on plasma membrane PIP2 for its activity. Munc13 is cytoplasmic, but Ca(2+)-dependent translocation to PIP2-rich plasma membrane domains is required for its activity. The results reveal that vesicle fusion into PIP2-rich membrane domains is facilitated by sequential PIP2-dependent activation of CAPS and PIP2-dependent recruitment of Munc13. PIP2 hydrolysis only occurs under strong Ca(2+) influx conditions sufficient to activate phospholipase Cη2 (PLCη2). Such conditions reduce CAPS activity and enhance Munc13 activity, establishing PLCη2 as a Ca(2+)-dependent modulator of exocytosis. These studies provide a direct view of the spatial distribution of PIP2 linked to vesicle exocytosis via regulation of lipid-dependent protein effectors CAPS and Munc13.
MeSH term(s)	Amino Acid Sequence ; Animals ; Biological Transport ; Calcium/metabolism ; Calcium-Binding Proteins/genetics ; Calcium-Binding Proteins/metabolism ; Cell Membrane/metabolism ; Cytoplasm/metabolism ; Exocytosis ; Gene Expression Regulation ; Isoenzymes/genetics ; Isoenzymes/metabolism ; Microscopy, Video ; Models, Molecular ; Molecular Sequence Data ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; PC12 Cells ; Phosphatidylinositol 4,5-Diphosphate/metabolism ; Phosphoinositide Phospholipase C/genetics ; Phosphoinositide Phospholipase C/metabolism ; Rats ; Sequence Alignment ; Signal Transduction ; Transport Vesicles/metabolism
Chemical Substances	Cadps protein, rat ; Calcium-Binding Proteins ; Isoenzymes ; Nerve Tissue Proteins ; Phosphatidylinositol 4,5-Diphosphate ; Unc13b protein, rat ; Phosphoinositide Phospholipase C (EC 3.1.4.11) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2013-12-19
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1098979-1
ISSN	1939-4586 ; 1059-1524
ISSN (online)	1939-4586
ISSN	1059-1524
DOI	10.1091/mbc.E12-11-0829
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Zs.A 2853: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Frizzled receptors signal through G proteins.

Nichols, Andrea S / Floyd, Desiree H / Bruinsma, Stephen P / Narzinski, Kirk / Baranski, Thomas J

Cellular signalling

2013 Volume 25, Issue 6, Page(s) 1468–1475

Abstract: Frizzled receptors have long been thought to couple to G proteins but biochemical evidence supporting such an interaction has been lacking. Here we expressed mammalian Wnt-Frizzled fusion proteins in Saccharomyces cerevisiae and tested the receptors' ... ...

Abstract	Frizzled receptors have long been thought to couple to G proteins but biochemical evidence supporting such an interaction has been lacking. Here we expressed mammalian Wnt-Frizzled fusion proteins in Saccharomyces cerevisiae and tested the receptors' ability to activate the yeast mitogen-activated protein kinase (MAPK) pathway via heterotrimeric G proteins. Our results show that Frizzled receptors can interact with Gαi, Gαq, and Gαs proteins, thus confirming that Frizzled functions as a G protein coupled receptor (GPCR). However, the activity level of Frizzled-mediated G protein signaling was much lower than that of a typical GPCR and, surprisingly, was highest when coupled to Gαs. The Frizzled/Gαs interaction was further established in vivo as Drosophila expressing a loss-of-function Gαs allele rescued the photoreceptor differentiation phenotype of Frizzled mutant flies. Together, these data point to an important role for Frizzled as a nontraditional GPCR that preferentially couples to Gαs heterotrimeric G proteins.
MeSH term(s)	Animals ; Drosophila/metabolism ; Drosophila Proteins/metabolism ; Frizzled Receptors/genetics ; Frizzled Receptors/metabolism ; GTP-Binding Protein alpha Subunits/metabolism ; GTP-Binding Protein alpha Subunits, Gi-Go/metabolism ; GTP-Binding Protein alpha Subunits, Gq-G11/metabolism ; GTP-Binding Protein alpha Subunits, Gs/metabolism ; Humans ; Low Density Lipoprotein Receptor-Related Protein-6/genetics ; Low Density Lipoprotein Receptor-Related Protein-6/metabolism ; Mitogen-Activated Protein Kinases/metabolism ; Receptors, G-Protein-Coupled/metabolism ; Recombinant Fusion Proteins/biosynthesis ; Recombinant Fusion Proteins/genetics ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/metabolism ; Signal Transduction ; Wnt Proteins/genetics ; Wnt Proteins/metabolism
Chemical Substances	Drosophila Proteins ; Frizzled Receptors ; GTP-Binding Protein alpha Subunits ; LRP6 protein, human ; Low Density Lipoprotein Receptor-Related Protein-6 ; Receptors, G-Protein-Coupled ; Recombinant Fusion Proteins ; Saccharomyces cerevisiae Proteins ; Wnt Proteins ; Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; GTP-Binding Protein alpha Subunits, Gi-Go (EC 3.6.5.1) ; GTP-Binding Protein alpha Subunits, Gq-G11 (EC 3.6.5.1) ; GTP-Binding Protein alpha Subunits, Gs (EC 3.6.5.1)
Language	English
Publishing date	2013-03-19
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1002702-6
ISSN	1873-3913 ; 0898-6568
ISSN (online)	1873-3913
ISSN	0898-6568
DOI	10.1016/j.cellsig.2013.03.009
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