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  1. Article ; Online: N

    Bernès, Sylvain / Hernández-Linares, María Guadalupe

    IUCrData

    2021  Volume 6, Issue Pt 7, Page(s) x210697

    Abstract: The mol-ecular structure of the title compound {systematic name: 1,3-di-cyclo-hexyl-1-[2-(1,3-dioxo-2,3-di-hydro- ... ...

    Abstract The mol-ecular structure of the title compound {systematic name: 1,3-di-cyclo-hexyl-1-[2-(1,3-dioxo-2,3-di-hydro-1
    Language English
    Publishing date 2021-07-13
    Publishing country England
    Document type Journal Article
    ISSN 2414-3146
    ISSN (online) 2414-3146
    DOI 10.1107/S2414314621006970
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: N

    Sixto-López, Yudibeth / Rosales-Hernández, Martha Cecilia / Contis-Montes de Oca, Arturo / Fragoso-Morales, Leticia Guadalupe / Mendieta-Wejebe, Jessica Elena / Correa-Basurto, Ana María / Abarca-Rojano, Edgar / Correa-Basurto, José

    International journal of molecular sciences

    2020  Volume 21, Issue 16

    Abstract: N ...

    Abstract N
    MeSH term(s) Active Transport, Cell Nucleus/drug effects ; Amides/chemistry ; Amides/pharmacology ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Binding Sites ; Cell Line, Tumor ; Cell Nucleus/metabolism ; Cell Proliferation/drug effects ; Female ; HMGB1 Protein/metabolism ; Histone Deacetylase 1/antagonists & inhibitors ; Histone Deacetylase 1/chemistry ; Histone Deacetylase 1/metabolism ; Histone Deacetylase Inhibitors/chemistry ; Histone Deacetylase Inhibitors/pharmacology ; Humans ; Molecular Docking Simulation ; Pentanes/chemistry ; Pentanes/pharmacology ; Protein Binding ; Uterine Cervical Neoplasms/metabolism
    Chemical Substances Amides ; Antineoplastic Agents ; HMGB1 Protein ; HMGB1 protein, human ; Histone Deacetylase Inhibitors ; N-(2-hydroxyphenyl)-2-propylpentanamide ; Pentanes ; HDAC1 protein, human (EC 3.5.1.98) ; Histone Deacetylase 1 (EC 3.5.1.98)
    Language English
    Publishing date 2020-08-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21165873
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  3. Article ; Online: N

    Contis-Montes de Oca, Arturo / Rodarte-Valle, Estefanía / Rosales-Hernández, Martha Cecilia / Abarca-Rojano, Edgar / Rojas-Hernández, Saúl / Fragoso-Vázquez, Manuel Jonathan / Mendieta-Wejebe, Jessica Elena / Correa-Basurto, Ana María / Vázquez-Moctezuma, Ismael / Correa-Basurto, José

    Oncotarget

    2018  Volume 9, Issue 70, Page(s) 33368–33381

    Abstract: N-(2'-Hydroxyphenyl)-2-propylpentanamide (OH-VPA) is a valproic acid (VPA) derivative with improved ...

    Abstract N-(2'-Hydroxyphenyl)-2-propylpentanamide (OH-VPA) is a valproic acid (VPA) derivative with improved antiproliferative activity toward breast cancer (MCF-7, MDA-MB-231, and SKBr3) and human cervical cancer cell lines (HeLa) compared to that of VPA. However, the pharmacological mechanism of OH-VPA activity remains unknown. High-mobility group box 1 (HMGB1) is an important enzyme that is highly expressed in tumor cells and has a subcellular localization that is dependent on its acetylation or oxidative state. Therefore, in this study, we analyzed changes in HMGB1 sub-cellular localization and reactive oxygen species (ROS) as well as changes in HeLa cell viability in response to treatment with various concentrations of OH-VPA. This compound is formed by the covalent bond coupling VPA to a phenol group, which is capable of acting as a free radical scavenger due to its chemical similarities to quercetin. Our results show that OH-VPA induces nuclear to cytoplasmic translocation of HMGB1, as demonstrated by confocal microscopy observations and infrared spectra that revealed high quantities of acetylated HMGB1 in HeLa cells. Cells treated with 0.8 mM OH-VA exhibited decreased viability and increased ROS levels compared with the lower OH-VPA concentrations tested. Therefore, the antiproliferative mechanism of OH-VPA may be related to histone deacetylase (HDAC) inhibition, as is the case for VPA, which promotes high HMBG1 acetylation, which alters its subcellular localization. In addition, OH-VPA generates an imbalance in cellular ROS levels due to its biochemical activity.
    Language English
    Publishing date 2018-09-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.26077
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  4. Article: Photocatalytic effect of N-TiO

    Oliveira, Raphaella I S / de Oliveira, Iracema N / de Conto, Juliana F / de Souza, Augusto M / Batistuzzo de Medeiros, Silvia R / Egues, Silvia M / Padilha, Francine F / Hernández-Macedo, Maria L

    Heliyon

    2023  Volume 9, Issue 11, Page(s) e22108

    Abstract: ... nitrogen-doped titanium dioxide (N-TiO ...

    Abstract Antibiotic resistance challenges the treatment of bacterial biofilm-related infections, but the use of nanoparticles as a treatment is a promising strategy to overcome bacterial infections. This study applied nitrogen-doped titanium dioxide (N-TiO
    Language English
    Publishing date 2023-11-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e22108
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Can an n

    Sandoval-Lira, Jacinto / Solano-Altamirano, Juan M / Cortezano-Arellano, Omar / Cruz-Gregorio, Silvano / Meza-León, Rosa L / Hernández-Pérez, Julio M / Sartillo-Piscil, Fernando

    The Journal of organic chemistry

    2019  Volume 84, Issue 4, Page(s) 2126–2132

    Abstract: ... stability of ceph E, relative to ceph F, is caused by an n → π* interaction between a lone electron pair ... of the oxygen atom of the spiroketal ring (n ...

    Abstract The stereocontrolled synthesis of naturally occurring products containing a 5,5-spiroketal molecular structure represents a major synthetic problem. Moreover, in a previous work, the stereocontrolled synthesis of cephalosporolide E (ceph E), which presumably was obtained from its epimer congener (ceph F) through an acid-mediated equilibration process, was reported. Consequently, we performed a theoretical investigation to provide relevant information regarding the title question, and it was found that the higher thermodynamic stability of ceph E, relative to ceph F, is caused by an n → π* interaction between a lone electron pair of the oxygen atom of the spiroketal ring (n
    Language English
    Publishing date 2019-01-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.8b03116
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4473: Show issues Location:
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  6. Article ; Online: Well-defined N

    Huang, Senhe / Tranca, Diana / Rodríguez-Hernández, Fermin / Zhang, Jichao / Lu, Chenbao / Zhu, Jinhui / Liang, Hai-Wei / Zhuang, Xiaodong

    Angewandte Chemie (International ed. in English)

    2023  Volume 63, Issue 1, Page(s) e202314833

    Abstract: N-, C-, O-, S-coordinated single-metal-sites (SMSs) have garnered significant attention due ... In this work, the well-defined molecular catalysts with N ...

    Abstract N-, C-, O-, S-coordinated single-metal-sites (SMSs) have garnered significant attention due to the potential for significantly enhanced catalytic capabilities resulting from charge redistribution. However, significant challenges persist in the precise design of well-defined such SMSs, and the fundamental comprehension has long been impeded in case-by-case reports using carbon materials as investigation targets. In this work, the well-defined molecular catalysts with N
    Language English
    Publishing date 2023-11-30
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202314833
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  7. Article ; Online: Effect of a nitrogenous nanocomposite on leaching and N content in lettuce in soil columns.

    Rojas-Velázquez, Ángel N / Guillén-Castillo, Oscar I / Alcalá-Jauregui, Jorge A / Loredo-Osti, Catarina / Ramírez-Tobías, Hugo M / Romero-Méndez, Mauricio J / Méndez-Cortés, Heriberto / Hernández-Montoya, Alejandra

    Discover nano

    2023  Volume 18, Issue 1, Page(s) 98

    Abstract: ... The objective of this study was to evaluate a nitrogenous nanocomposite (NCN) and its effect on leaching and N ... with NCN. Treatments with NCN have higher N content in the leaf. In regard to biomass growth, leaf area ... leaf N, drained variables, electrical conductivity and NO ...

    Abstract Nanofertilizers could promote nutrient efficiency with slow release compared to conventional fertilizers (CF). Most of the applied nitrogen is lost on the soil by leaching, due to the rapid release behavior of CF. Clays can function as a nanosized porous structure to retain and slowly release nutrients. The objective of this study was to evaluate a nitrogenous nanocomposite (NCN) and its effect on leaching and N content of lettuce (Lactuca sativa). The treatments applied were: 100% conventional fertilizer, 100% nitrogenous nanocomposite and the mixture in percentage of CF/NCN 25/75, 50/50, 75/25 and 25/0, 50/0 75/0% on columns of soil with lettuce for 45 days. Leachates at the end of the cycle increased in treatments with NCN. Treatments with NCN have higher N content in the leaf. In regard to biomass growth, leaf area, leaf N, drained variables, electrical conductivity and NO
    Language English
    Publishing date 2023-07-31
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2731-9229
    ISSN (online) 2731-9229
    DOI 10.1186/s11671-023-03874-w
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  8. Article: N-terminal region is responsible for mHv1 channel activity in MDSCs.

    Peña-Pichicoi, Antonio / Fernández, Miguel / Navarro-Quezada, Nieves / Alvear-Arias, Juan J / Carrillo, Christian A / Carmona, Emerson M / Garate, Jose / Lopez-Rodriguez, Angelica M / Neely, Alan / Hernández-Ochoa, Erick O / González, Carlos

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1265130

    Abstract: ... of which are translated into distinct N-terminal isoforms of mHv1: mHv1.1 (269 aa), mHv1.2 (269 + 42 aa), and ...

    Abstract Voltage-gated proton channels (Hv1) are important regulators of the immunosuppressive function of myeloid-derived suppressor cells (MDSCs) in mice and have been proposed as a potential therapeutic target to alleviate dysregulated immunosuppression in tumors. However, till date, there is a lack of evidence regarding the functioning of the Hvcn1 and reports on mHv1 isoform diversity in mice and MDSCs. A computational prediction has suggested that the Hvcn1 gene may express up to six transcript variants, three of which are translated into distinct N-terminal isoforms of mHv1: mHv1.1 (269 aa), mHv1.2 (269 + 42 aa), and mHv1.3 (269 + 4 aa). To validate this prediction, we used RT-PCR on total RNA extracted from MDSCs, and the presence of all six predicted mRNA variances was confirmed. Subsequently, the open-reading frames (ORFs) encoding for mHv1 isoforms were cloned and expressed in
    Language English
    Publishing date 2023-10-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1265130
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  9. Article ; Online: Eficacia de infiltración intratimpánica de N-acetilcisteína en ototoxicidad por cisplatino.

    Rosas-Gutiérrez, Goretti Del Carmen / Fernández-Hernández, Juan Pablo / Olea-González, Atzin Itaí

    Revista medica del Instituto Mexicano del Seguro Social

    2023  Volume 61, Issue Suppl 2, Page(s) S318–S322

    Abstract: ... to treat ototoxicity caused by cisplatin. N-acetyl cysteine (NAC) is a safe and inexpensive antioxidant ...

    Title translation Efficacy of intratympanic infiltration of N-acetyl cysteine in cisplatin ototoxicity.
    Abstract Introduction: Currently there is no approved preventive or therapeutic pharmacological treatment to treat ototoxicity caused by cisplatin. N-acetyl cysteine (NAC) is a safe and inexpensive antioxidant that has been studied as an otoprotective alternative.
    Objective: To describe the efficacy of intratympanic infiltration of NAC as prevention and treatment of ototoxicity induced in patients treated with cisplatin.
    Material and methods: Open, longitudinal, prospective, randomized clinical trial in cancer patients treated with cisplatin who met the inclusion criteria. Out of the sample of 22 patients, 11 underwent intratympanic NAC infiltration and 11 were taken as a control group. It was performed an audiometry at the beginning and one month after on all patients.
    Results: A sample of 22 patients with a mean age of 53 (±13) was collected. In our sample of 11 patients with infiltration in both ears, 1 ear showed improvement; on the other hand, in the control group that was not infiltrated, 4 showed an increase in hearing loss from mild to moderate in all 4 cases, 2 in the left ear and 2 in the right ear (Spearman's Rho = 0.93, p ≤ 0.001). Relative risk was of 1.22.
    Conclusions: An association can be observed that intratympanic NAC could become an alternative for the prevention and treatment of cisplatin-induced ototoxicity.
    MeSH term(s) Humans ; Middle Aged ; Cisplatin/adverse effects ; Antineoplastic Agents/adverse effects ; Acetylcysteine/therapeutic use ; Acetylcysteine/pharmacology ; Ototoxicity ; Prospective Studies
    Chemical Substances Cisplatin (Q20Q21Q62J) ; Antineoplastic Agents ; Acetylcysteine (WYQ7N0BPYC)
    Language Spanish
    Publishing date 2023-09-18
    Publishing country Mexico
    Document type Randomized Controlled Trial ; Clinical Trial ; English Abstract ; Journal Article
    ZDB-ID 732133-8
    ISSN 2448-5667 ; 0443-5117 ; 0484-7849
    ISSN (online) 2448-5667
    ISSN 0443-5117 ; 0484-7849
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2225: Show issues Location:
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  10. Article: Combination of Recombinant Proteins S1/N and RBD/N as Potential Vaccine Candidates.

    Mendoza-Ramírez, Noe Juvenal / García-Cordero, Julio / Martínez-Frías, Sandra Paola / Roa-Velázquez, Daniela / Luria-Pérez, Rosendo / Bustos-Arriaga, José / Hernández-Lopez, Jesús / Cabello-Gutiérrez, Carlos / Zúñiga-Ramos, Joaquín Alejandro / Morales-Ríos, Edgar / Pérez-Tapia, Sonia Mayra / Espinosa-Cantellano, Martha / Cedillo-Barrón, Leticia

    Vaccines

    2023  Volume 11, Issue 4

    Abstract: ... B-cells. The nucleocapsid (N) protein, Spike protein S1 domain, and receptor binding domain (RBD ... with the N protein induced higher levels of IgG antibodies, increased the percentage of neutralization, and ...

    Abstract Despite all successful efforts to develop a COVID-19 vaccine, the need to evaluate alternative antigens to produce next-generation vaccines is imperative to target emerging variants. Thus, the second generation of COVID-19 vaccines employ more than one antigen from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to induce an effective and lasting immune response. Here, we analyzed the combination of two SARS-CoV-2 viral antigens that could elicit a more durable immune response in both T- and B-cells. The nucleocapsid (N) protein, Spike protein S1 domain, and receptor binding domain (RBD) of the SARS-CoV-2 spike surface glycoproteins were expressed and purified in a mammalian expression system, taking into consideration the posttranscriptional modifications and structural characteristics. The immunogenicity of these combined proteins was evaluated in a murine model. Immunization combining S1 or RBD with the N protein induced higher levels of IgG antibodies, increased the percentage of neutralization, and elevated the production of cytokines TNF-α, IFN-γ, and IL-2 compared to the administration of a single antigen. Furthermore, sera from immunized mice recognized alpha and beta variants of SARS-CoV-2, which supports ongoing clinical results on partial protection in vaccinated populations, despite mutations. This study identifies potential antigens for second-generation COVID-19 vaccines.
    Language English
    Publishing date 2023-04-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines11040864
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