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  1. Book ; Conference proceedings: Proceedings from the Symposium Involuntary Weight Loss and the Nonhealing Wound

    Demling, Robert H. / Desanti, Leslie

    the role of anabolic agents ; held at the 13th Annual Clinical Symposium on Wound Care in Atlanta, GA, October 9, 1998

    (Advances in wound care ; 12, Suppl. 1)

    1999  

    Institution Symposium Involuntary Weight Loss and the Nonhealing Wound: The Role of Anabolic Agents
    Event/congress Clinical Symposium on Wound Care (13, 1998, AtlantaGa.)
    Author's details Robert H. Demling and Leslie DeSanti
    Series title Advances in wound care ; 12, Suppl. 1
    Collection
    Language English
    Size 16 S. : Ill., graph. Darst.
    Publishing place S.l.
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT009973388
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 3164 -12,Suppl.1- not available for loan Zeitschriften-Lesesaal

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  2. Book: Decision making in surgical critical care

    Demling, Robert H. / Wilson, Robert F.

    (Clinical decision making series)

    1988  

    Author's details Robert H. Demling ; Robert F. Wilson
    Series title Clinical decision making series
    Keywords Critical Care ; Decision Making
    Size 247 S. : graph. Darst.
    Edition 1. [Dr.]
    Publisher Decker
    Publishing place Toronto u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT003185783
    ISBN 1-55664-001-3 ; 978-1-55664-001-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1988 A 4469 order for loan Magazin

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  3. Book: Burn trauma

    Demling, Robert H. / LaLonde, Cheryl

    (Trauma management ; 4)

    1989  

    Author's details Robert H. Demling ; Cheryl LaLonde
    Series title Trauma management ; 4
    Collection
    Keywords Burns ; Burns / therapy ; Multiple Trauma ; Verbrennung
    Subject Brandverletzung ; Brandwunde
    Language English
    Size X, 318 S. : Ill., graph. Darst.
    Edition 1. [Dr.]
    Publisher Thieme u.a.
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT003364758
    ISBN 0-86577-281-9 ; 3-13-736301-2 ; 978-0-86577-281-6 ; 978-3-13-736301-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1983 A 2266 -4- order for loan Magazin

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  4. Article ; Online: Nutrition, anabolism, and the wound healing process: an overview.

    Demling, Robert H

    Eplasty

    2009  Volume 9, Page(s) e9

    Abstract: Objective: To develop a clear, concise, and up-to-date treatise on the role of anabolism from nutrition in wound healing. Special emphasis was to be placed on the effect of the stress response to wounding and its effect.: Methods: A compilation of ... ...

    Abstract Objective: To develop a clear, concise, and up-to-date treatise on the role of anabolism from nutrition in wound healing. Special emphasis was to be placed on the effect of the stress response to wounding and its effect.
    Methods: A compilation of both the most important and most recent reports in the literature was used to also develop the review. The review was divided into sections to emphasize specific nutrition concepts of importance.
    Results: General and specific concepts were developed from this material. Topics included body composition and lean body mass, principles of macronutritional utilization, the stress response to wounding, nutritional assessment, nutritional support, and use of anabolic agents.
    Conclusions: We found that nutrition is a critical component in all the wound healing processes. The stress response to injury and any preexistent protein-energy malnutrition will alter this response, impeding healing and leading to potential severe morbidity. A decrease in lean body mass is of particular concern as this component is responsible for all protein synthesis necessary for healing. Nutritional assessment and support needs to be well orchestrated and precise. The use of anabolic agents can significantly increase overall lean mass synthesis and directly or indirectly improves healing by increasing protein synthesis.
    Language English
    Publishing date 2009-02-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2412803-X
    ISSN 1937-5719 ; 1937-5719
    ISSN (online) 1937-5719
    ISSN 1937-5719
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Smoke inhalation lung injury: an update.

    Demling, Robert H

    Eplasty

    2008  Volume 8, Page(s) e27

    Abstract: Objectives: The purpose of this study is to present a multifaceted, definitive review of the past and current status of smoke inhalation injury. History along with current understanding of anatomical, physiology, and biologic components will be ... ...

    Abstract Objectives: The purpose of this study is to present a multifaceted, definitive review of the past and current status of smoke inhalation injury. History along with current understanding of anatomical, physiology, and biologic components will be discussed.
    Methods: The literature has been reviewed from the early onset of the concept of smoke inhalation in the 1920s to our current understanding as of 2007.
    Results: The results indicate that the current pathophysiologic concept is of a disease process that leads to immediate and delayed pulmonary injury best managed by aggressive physiologic support. Management approaches for the biochemical changes have not kept up with current knowledge. The lung injury process is activated by toxins in the smoke's gas and particle components and perpetuated by a resulting lung inflammation. This inflammatory process becomes self-perpetuating through the activation of a large number of inflammatory cascades. In addition, smoke injury leads to significant systemic abnormalities injuring other organs and accentuating the burn injury process and subsequently leading to mediator-induced cellular injury leading potentially to multisystem organ failure.
    Conclusions: Smoke inhalation injury results in the anatomic finding of denuded and sometimes sloughed airways mucosa. Physiologic findings include small airways containing fibrin casts of mucosa and neutrophils. Airway hyper-reactivity results as well, leading to further decreased collapse, causing obstruction.
    Language English
    Publishing date 2008-05-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2412803-X
    ISSN 1937-5719 ; 1937-5719
    ISSN (online) 1937-5719
    ISSN 1937-5719
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Burns: what are the pharmacological treatment options?

    Demling, Robert H

    Expert opinion on pharmacotherapy

    2008  Volume 9, Issue 11, Page(s) 1895–1908

    Abstract: Background: Many advances have been made in the understanding and management of burn injury, dramatically increasing pharmacological decision options for burn care professionals. Since burn injury is so multi-faceted, these advances cross many injury ... ...

    Abstract Background: Many advances have been made in the understanding and management of burn injury, dramatically increasing pharmacological decision options for burn care professionals. Since burn injury is so multi-faceted, these advances cross many injury processes, both acute and chronic.
    Objective: The purpose of this review was to highlight the advances and decision options across the entire scope of the burn injury process. The burn-related processes with the most significant pharmacological options of approved products are highlighted.
    Methods: The scope of the current research is the most pertinent literature, which has been summarized with the addition of a personal perspective.
    Results/conclusions: Many advances over the past decade in multiple fields have made pharmacological options plentiful in burn care. That said, there are many problems for the burn patient which persist, making burn injury still the most severe form of trauma. These issues range from management of a catabolic state with involuntary weight loss in the critical burn to severe itching in the rehabilitating patient. There are also many more treatment options available today. Two key reasons stand out as the most prominent. One reason is the fact that burn care has become much more proactive, by searching out new approaches to solve old problems. Now the treatment approach is altering its focus on manipulating the course of a burn. Examples include the use of temporary skin substitutes in partial thickness or second degree burns, decreasing pain and increasing the healing rate. Another is the use of slow release silver dressing as the topical burn wound antimicrobial of choice, markedly reducing discomfort, the need for dressing changes and an overall decrease in infection. In larger, deeper burns, the approach has changed from the chronic management of an open burn wound to rapid excision and wound closure, eliminating the burn as a source of complications. In addition, there has been a very aggressive approach to controlling the profound hypermetabolic, catabolic response to burns, rather than simply treating the outcome of this predictable post-burn complication. Approaching psychosocial stress again by prevention rather than treatment of established problems is another example. The second reason for increased options and differences in management involves the mindset of those individuals taking care of burns. Tremendous differences in experience are involved in decision-making. Different opinions are based on the expertise and also the personal preferences of those managing the burn.
    MeSH term(s) Acute Disease ; Burns/complications ; Burns/drug therapy ; Burns/physiopathology ; Chronic Disease ; Decision Making ; Humans ; Occlusive Dressings ; Pain/drug therapy ; Pain/etiology ; Silver Compounds/therapeutic use ; Stress, Psychological/etiology ; Stress, Psychological/prevention & control ; Wound Healing
    Chemical Substances Silver Compounds
    Language English
    Publishing date 2008-06-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2001535-5
    ISSN 1744-7666 ; 1465-6566
    ISSN (online) 1744-7666
    ISSN 1465-6566
    DOI 10.1517/14656566.9.11.1895
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5130: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: The role of anabolic hormones for wound healing in catabolic states.

    Demling, Robert H

    Journal of burns and wounds

    2005  Volume 4, Page(s) e2

    Abstract: Objective: The purpose of this paper is to present an overview of the interrelationship between hormones, nutrition, and wound healing.: Methods: The data on various hormones and their effects on specific elements of nutrition and wound healing are ... ...

    Abstract Objective: The purpose of this paper is to present an overview of the interrelationship between hormones, nutrition, and wound healing.
    Methods: The data on various hormones and their effects on specific elements of nutrition and wound healing are reviewed.
    Results: The key anabolic hormones are human growth hormone, insulin-like growth factor-1, insulin, and testosterone and its analogs. Although each has specific metabolic actions, there is also a very important hormone-hormone interaction. A deficiency of these hormones occurs in acute and chronic catabolic states, resulting in lean mass loss and impairing the healing process.
    Conclusion: There is a well-recognized interrelationship between hormones, nutrition, and wound healing. The anabolic process of protein synthesis, with new tissue formation, requires the action of anabolic hormones. Exogenous administration of these agents has been shown to maintain or increase lean body mass as well as directly stimulate the healing process through their anabolic and anticatabolic actions.
    Language English
    Publishing date 2005-01-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2412801-6
    ISSN 1554-0766 ; 1554-0766
    ISSN (online) 1554-0766
    ISSN 1554-0766
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: The burn edema process: current concepts.

    Demling, Robert H

    The Journal of burn care & rehabilitation

    2005  Volume 26, Issue 3, Page(s) 207–227

    Abstract: Massive tissue edema after thermal injury is a well-recognized entity. Although this process is responsible for the patient's large fluid needs during resuscitation and also for local problems, such as a compartment syndrome, there have been no effective ...

    Abstract Massive tissue edema after thermal injury is a well-recognized entity. Although this process is responsible for the patient's large fluid needs during resuscitation and also for local problems, such as a compartment syndrome, there have been no effective treatment modalities introduced into clinical care to control the degree of edema. A review of what is now known about the edema process is presented here, including attempted prevention and treatment modalities. The pathogenesis involves changes in most of the physical forces controlling fluid flux across the capillary and also how fluid accumulates in the interstitium. Increased capillary permeability to protein is but one of these changes. The presence of an initial profound negative interstitial pressure "sucking" fluid into the tissues and a marked increase in interstitial space compliance are equally important components. A host of mediators, especially oxidants, have been reported to cause these physical changes, and some mediator inhibitors appear to be of benefit, especially antioxidants. However, few clinical trials, aimed at decreasing edema, have been performed. With these new insights into the edema process, future prevention and treatment modalities can be developed.
    MeSH term(s) Burns/complications ; Burns/physiopathology ; Burns/therapy ; Capillary Permeability ; Edema/etiology ; Edema/physiopathology ; Edema/therapy ; Extracellular Fluid ; Humans ; Osmotic Pressure
    Language English
    Publishing date 2005-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 605562-x
    ISSN 1534-5939 ; 0273-8481
    ISSN (online) 1534-5939
    ISSN 0273-8481
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1897: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Article: The clinical relevance of defining the mechanism for altered gut permeability in a "two-hit" model of injury and infection.

    Demling, Robert H

    Critical care medicine

    2004  Volume 32, Issue 11, Page(s) 2356–2357

    MeSH term(s) Animals ; Bacterial Translocation/physiology ; Burns/complications ; Burns/immunology ; Burns/metabolism ; Burns/physiopathology ; Capillary Permeability/physiology ; Disease Models, Animal ; Immunity, Mucosal ; Infection/complications ; Infection/immunology ; Infection/metabolism ; Infection/physiopathology ; Inflammation ; Intestinal Mucosa/immunology ; Intestinal Mucosa/microbiology ; Intestinal Mucosa/physiopathology ; Multiple Organ Failure/etiology ; Neutrophils/immunology ; Rats
    Language English
    Publishing date 2004-11
    Publishing country United States
    Document type Comment ; Editorial ; Review
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/01.ccm.0000146139.93373.95
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1261: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  10. Article: The incidence and impact of pre-existing protein energy malnutrition on outcome in the elderly burn patient population.

    Demling, Robert H

    The Journal of burn care & rehabilitation

    2004  Volume 26, Issue 1, Page(s) 94–100

    Abstract: Protein energy malnutrition (PEM) and involuntary weight loss is a common problem in the elderly population. Our purpose was to determine the incidence and the effect on outcome of PEM in the elderly burn patient population. A chart review and review of ... ...

    Abstract Protein energy malnutrition (PEM) and involuntary weight loss is a common problem in the elderly population. Our purpose was to determine the incidence and the effect on outcome of PEM in the elderly burn patient population. A chart review and review of the burn data registry was undertaken to determine the incidence and effect of PEM in patients older than 65 years of age with major burns from 1% to 30% TBSA. PEM was diagnosed using standard physiological and biochemical markers. Data were compared with those from a well-nourished elderly burn group to assess the impact. Of the 123 patients studied, we found that PEM was present in 61%. There was a significant increase in infection rate, decrease in the rate of healing of a standard skin graft donor site, and an increase in length of stay in the PEM group compared with the nourished elderly burn group. Mortality with PEM was 17% compared with 9% without PEM, a significant increase. We conclude that PEM is a common comorbid factor in the elderly burn population that increases morbidity and mortality.
    MeSH term(s) Age Factors ; Aged ; Burns/complications ; Burns/mortality ; Burns/therapy ; Female ; Humans ; Incidence ; Infection ; Length of Stay ; Male ; Morbidity ; Nutritional Status ; Nutritional Support ; Protein-Energy Malnutrition/complications ; Registries/statistics & numerical data ; Retrospective Studies ; Severity of Illness Index ; Skin Transplantation ; Treatment Outcome ; Weight Loss
    Language English
    Publishing date 2004-06-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605562-x
    ISSN 1534-5939 ; 0273-8481
    ISSN (online) 1534-5939
    ISSN 0273-8481
    DOI 10.1097/01.bcr.0000150302.71007.80
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1897: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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