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  1. Article: Molecular Bases Underlying the Hepatoprotective Effects of Coffee

    Salomone, Federico / Galvano, Fabio / Li Volti, Giovanni

    Nutrients, 9(1):85

    2017  

    Abstract: Coffee is the most consumed beverage worldwide. Epidemiological studies with prospective cohorts showed that coffee intake is associated with reduced cardiovascular and all-cause mortality independently of caffeine content. Cohort and case-control ... ...

    Abstract Coffee is the most consumed beverage worldwide. Epidemiological studies with prospective cohorts showed that coffee intake is associated with reduced cardiovascular and all-cause mortality independently of caffeine content. Cohort and case-control studies reported an inverse association between coffee consumption and the degree of liver fibrosis as well as the development of liver cancer. Furthermore, the beneficial effects of coffee have been recently confirmed by large meta-analyses. In the last two decades, various in vitro and in vivo studies evaluated the molecular determinants for the hepatoprotective effects of coffee. In the present article, we aimed to critically review experimental evidence regarding the active components and the molecular bases underlying the beneficial role of coffee against chronic liver diseases. Almost all studies highlighted the beneficial effects of this beverage against liver fibrosis with the most solid results indicating a pivot role for both caffeine and chlorogenic acids. In particular, in experimental models of fibrosis, caffeine was shown to inhibit hepatic stellate cell activation by blocking adenosine receptors, and emerging evidence indicated that caffeine may also favorably impact angiogenesis and hepatic hemodynamics. On the other side, chlorogenic acids, potent phenolic antioxidants, suppress liver fibrogenesis and carcinogenesis by reducing oxidative stress and counteract steatogenesis through the modulation of glucose and lipid homeostasis in the liver. Overall, these molecular insights may have translational significance and suggest that coffee components need clinical evaluation.
    Keywords caffeine ; chlorogenic acid ; liver cancer ; liver fibrosis ; liver steatosis
    Language English
    Document type Article
    Database Repository for Life Sciences

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  2. Article ; Online: FROM PHYSIOLOGICAL TO NEOPLASTIC TRANSFORMATION

    Giovanni Li Volti

    Euromediterranean Biomedical Journal, Vol 17, Iss 12, Pp 48-

    THE CRITICAL ROLES OF CONNEXINS AND WT1

    2022  Volume 58

    Abstract: Glioblastoma and soft tissue sarcomas are tumors characterized by poor prognosis, low overall survival and critical hallmarks that allow such tumors to evade homeostatic controlling mechanisms. Herein, we revised literature on connexins, the core gap ... ...

    Abstract Glioblastoma and soft tissue sarcomas are tumors characterized by poor prognosis, low overall survival and critical hallmarks that allow such tumors to evade homeostatic controlling mechanisms. Herein, we revised literature on connexins, the core gap junction forming proteins, and WT1, a transcription factor involved tumor progression, to highlight the close connection between intercellular communication deregulation and aberrant intracellular signalling. Both connexins and WT1 have been widely studied during physiological conditions and development and they hold a critical role in recapitulating such phenomena during tumorigenesis in glioblastoma and soft tissue sarcomas.
    Keywords connexin ; wilms tumor 1 ; intercellular communication ; glioblastoma ; soft tissue sarcomas ; Medicine (General) ; R5-920
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher Associazione Italiana Giovani Medici
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Clarifying allegations regarding CoEHAR conflicts of interest.

    Li Volti, Giovanni / Polosa, Riccardo

    The Lancet. Oncology

    2021  Volume 22, Issue 9, Page(s) e378

    MeSH term(s) Biomedical Research ; Conflict of Interest ; Humans
    Language English
    Publishing date 2021-08-13
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(21)00477-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5696: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 460: Show issues

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  4. Article: The Post-Lockdown Era: What Is Next in Italy?

    Pomara, Cristoforo / Li Volti, Giovanni / Cappello, Francesco

    Frontiers in pharmacology

    2020  Volume 11, Page(s) 1074

    Keywords covid19
    Language English
    Publishing date 2020-07-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2020.01074
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Molecular Dynamic Simulations to Determine Individualized Therapy: Tetrabenazine for the GNAO1 Encephalopathy E246K Variant.

    Falsaperla, Raffaele / Sortino, Vincenzo / Marino, Simona Domenica / Collotta, Ausilia Desiree / Gammeri, Carmela / Sipala, Federica Maria / Volti, Giovanni Li / Ruggieri, Martino / Ronsisvalle, Simone

    Molecular diagnosis & therapy

    2024  

    Abstract: Introduction: GNAO1 encephalopathy is characterized by severe hypotonia, psychomotor retardation, epilepsy, and movement disorders. Genetic variations in GNAO1 have been linked to neurological symptoms including movement disorders like dystonia. The ... ...

    Abstract Introduction: GNAO1 encephalopathy is characterized by severe hypotonia, psychomotor retardation, epilepsy, and movement disorders. Genetic variations in GNAO1 have been linked to neurological symptoms including movement disorders like dystonia. The correlation between the E246K mutation in the Gα subunit and aberrant signal transduction of G proteins has been established but no data are reported regarding the efficacy of medical treatment with tetrabenazine.
    Methods: Molecular modeling studies were performed to elucidate the molecular mechanisms underlying this mutation. We developed drug efficacy models using molecular dynamic simulations that replicated the behavior of wild-type and mutated proteins in the presence or absence of ligands.
    Results and discussion: We demonstrated that the absence of the mutation leads to normal signal transduction upon receptor activation by the endogenous ligand, but not in the presence of tetrabenazine. In contrast, the presence of the mutation resulted in abnormal signal transduction in the presence of the endogenous ligand, which was corrected by the drug tetrabenazine. Tetrabenazine was identified as a promising therapeutic option for pediatric patients suffering from encephalopathy due to an E246K mutation in the GNAO1 gene validated through molecular dynamics. This is a potential first example of the use of this technique in a rare neurological pediatric disease.
    Language English
    Publishing date 2024-04-06
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2232796-4
    ISSN 1179-2000 ; 1177-1062
    ISSN (online) 1179-2000
    ISSN 1177-1062
    DOI 10.1007/s40291-024-00706-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5202: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Critical appraisal of the European Union Scientific Committee on Health, Environmental and Emerging Risks (SCHEER) Preliminary Opinion on electronic cigarettes.

    O'Leary, Renée / Polosa, Riccardo / Li Volti, Giovanni

    Harm reduction journal

    2021  Volume 18, Issue 1, Page(s) 31

    Abstract: Background: In preparation for the 2021 revision of the European Union Tobacco Products Directive, the Scientific Committee on Health, Environmental and Emerging Risks (SCHEER) has posted its Preliminary Opinion on Electronic Cigarettes. They concluded ... ...

    Abstract Background: In preparation for the 2021 revision of the European Union Tobacco Products Directive, the Scientific Committee on Health, Environmental and Emerging Risks (SCHEER) has posted its Preliminary Opinion on Electronic Cigarettes. They concluded that e-cigarettes only achieve a sub-optimal level of protection of human health. In this paper, we provide evidence that the Opinion's conclusions are not adequately backed up by scientific evidence and did not discuss the potential health benefits of using alternative combustion-free nicotine-containing products as substitute for tobacco cigarettes.
    Methods: Searches for articles were conducted in PubMed and by citation chasing in Google Scholar. Articles were also retrieved with a review of references in major publications. Primary data from World Health Organization surveys, the conclusions of reviews, and peer-reviewed non-industry studies were cited to address errors and omissions identified in the Opinion.
    Results: The Opinion omitted reporting on the individual and population health benefits of the substitution of e-cigarettes (ENDS) for cigarette smoking. Alternative hypotheses to the gateway theory were not evaluated. Its assessment of cardiovascular risk is contradicted by numerous reviews. It cites ever-use data that do not represent current patterns of use. It did not report non-nicotine use. It presented erroneous statements on trends in ENDS prevalence. It over-emphasized the role of flavours in youth ENDS initiation. It did not discuss cessation in sufficient length.
    Conclusions: For the delivery of a robust and comprehensive final report, the members of the Working Group of the Scientific Committee on Health, Environmental and Emerging Risks will need to consider (1) the potential health benefits of ENDS substitution for cigarette smoking, (2) alternative hypotheses and contradictory studies on the gateway effect, (3) its assessment of cardiovascular risk, (4) the measurements of frequency of use, (5) non-nicotine use, (6) the role of flavours, and (7) a fulsome discussion of cessation.
    MeSH term(s) Adolescent ; Electronic Nicotine Delivery Systems ; Environmental Health ; European Union ; Humans ; Smoking Cessation ; Tobacco Products
    Language English
    Publishing date 2021-03-10
    Publishing country England
    Document type Letter ; Review
    ZDB-ID 2146691-9
    ISSN 1477-7517 ; 1477-7517
    ISSN (online) 1477-7517
    ISSN 1477-7517
    DOI 10.1186/s12954-021-00476-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Smoking and SARS-CoV-2 Disease (COVID-19): Dangerous Liaisons or Confusing Relationships?

    Li Volti, Giovanni / Caruso, Massimo / Polosa, Riccardo

    Journal of clinical medicine

    2020  Volume 9, Issue 5

    Abstract: We read with great interest the article by Brake SJ and colleagues [ ... ]. ...

    Abstract We read with great interest the article by Brake SJ and colleagues [...].
    Keywords covid19
    Language English
    Publishing date 2020-05-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm9051321
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Soluble peptidoglycan fragments produced by

    Fuochi, Virginia / Spampinato, Mariarita / Distefano, Alfio / Palmigiano, Angelo / Garozzo, Domenico / Zagni, Chiara / Rescifina, Antonio / Li Volti, Giovanni / Furneri, Pio Maria

    Frontiers in molecular biosciences

    2023  Volume 10, Page(s) 1082526

    Abstract: Currently, the use of probiotic strains and their products represents a promising innovative approach as an antagonist treatment against many human diseases. Previous studies showed that a strain ... ...

    Abstract Currently, the use of probiotic strains and their products represents a promising innovative approach as an antagonist treatment against many human diseases. Previous studies showed that a strain of
    Language English
    Publishing date 2023-02-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2023.1082526
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Correction: Sigma-1 and Sigma-2 receptor ligands induce apoptosis and autophagy but have opposite effect on cell proliferation in uveal melanoma.

    Longhitano, Lucia / Castracani, Carlo Castruccio / Tibullo, Daniele / Avola, Roberto / Viola, Maria / Russo, Giuliano / Prezzavento, Orazio / Marrazzo, Agostino / Amata, Emanuele / Reibaldi, Michele / Longo, Antonio / Russo, Andrea / Parrinello, Nunziatina Laura / Volti, Giovanni Li

    Oncotarget

    2024  Volume 15, Page(s) 199

    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.28519
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: COVID-19 Deaths: Are We Sure It Is Pneumonia? Please, Autopsy, Autopsy, Autopsy!

    Pomara, Cristoforo / Li Volti, Giovanni / Cappello, Francesco

    Journal of clinical medicine

    2020  Volume 9, Issue 5

    Abstract: The current outbreak of COVID-19 severe respiratory disease, which started in Wuhan, China, is an ongoing challenge, and a major threat to public health that requires surveillance, prompt diagnosis, and research efforts to understand this emergent ... ...

    Abstract The current outbreak of COVID-19 severe respiratory disease, which started in Wuhan, China, is an ongoing challenge, and a major threat to public health that requires surveillance, prompt diagnosis, and research efforts to understand this emergent pathogen and to develop an effective response. Due to the scientific community's efforts, there is an increasing body of published studies describing the virus' biology, its transmission and diagnosis, its clinical features, its radiological findings, and the development of candidate therapeutics and vaccines. Despite the decline in postmortem examination rate, autopsy remains the gold standard to determine why and how death happens. Defining the pathophysiology of death is not only limited to forensic considerations; it may also provide useful clinical and epidemiologic insights. Selective approaches to postmortem diagnosis, such as limited postmortem sampling over full autopsy, can also be useful in the control of disease outbreaks and provide valuable knowledge for managing appropriate control measures. In this scenario, we strongly recommend performing full autopsies on patients who died with suspected or confirmed COVID-19 infection, particularly in the presence of several comorbidities. Only by working with a complete set of histological samples obtained through autopsy can one ascertain the exact cause(s) of death, optimize clinical management, and assist clinicians in pointing out a timely and effective treatment to reduce mortality. Death can teach us not only about the disease, it might also help with its prevention and, above all, treatment.
    Keywords covid19
    Language English
    Publishing date 2020-04-26
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm9051259
    Database MEDical Literature Analysis and Retrieval System OnLINE

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