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  1. Article ; Online: The Neighborhood Atlas Area Deprivation Index And Recommendations For Area-Based Deprivation Measures.

    Rehkopf, David H / Phillips, Robert L

    Health affairs (Project Hope)

    2023  Volume 42, Issue 5, Page(s) 710–711

    Abstract: Edward Hannan and colleagues found that a lack of standardization of input variables to the Area Deprivation Index (ADI) available from the Neighborhood Atlas overweights the index for median home value and thus potentially further disadvantages already ... ...

    Abstract Edward Hannan and colleagues found that a lack of standardization of input variables to the Area Deprivation Index (ADI) available from the Neighborhood Atlas overweights the index for median home value and thus potentially further disadvantages already disadvantaged communities. We recommend that a revised ADI be created that addresses the error, and we offer five steps to avoid future errors in the creation of area deprivation measures.
    MeSH term(s) Humans ; Vulnerable Populations ; Residence Characteristics ; Retrospective Studies
    Language English
    Publishing date 2023-05-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632712-6
    ISSN 1544-5208 ; 0278-2715
    ISSN (online) 1544-5208
    ISSN 0278-2715
    DOI 10.1377/hlthaff.2023.00282
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2118: Show issues Location:
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  2. Article: First-line therapy in drug reaction with eosinophilia and systemic symptoms (DReSS): Thinking beyond corticosteroids.

    Verstegen, Ruud H J / Phillips, Elizabeth J / Juurlink, David N

    Frontiers in medicine

    2023  Volume 10, Page(s) 1138464

    Language English
    Publishing date 2023-02-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1138464
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  3. Article ; Online: Editorial: 40th Anniversary of UKEMS.

    Phillips, David H

    Mutagenesis

    2018  Volume 32, Issue 6, Page(s) 543–544

    MeSH term(s) Anniversaries and Special Events ; Environment ; Genomic Instability ; Molecular Epidemiology ; Mutagens/toxicity ; Toxicology ; United Kingdom
    Chemical Substances Mutagens
    Language English
    Publishing date 2018-02-12
    Publishing country England
    Document type Editorial
    ZDB-ID 632903-2
    ISSN 1464-3804 ; 0267-8357
    ISSN (online) 1464-3804
    ISSN 0267-8357
    DOI 10.1093/mutage/gex038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Optical and EPR Detection of a Triplet Ground State Phenyl Nitrenium Ion.

    Qiu, Yunfan / Du, Lili / Cady, Sarah D / Phillips, David Lee / Winter, Arthur H

    Journal of the American Chemical Society

    2024  Volume 146, Issue 15, Page(s) 10679–10686

    Abstract: Nitrenium ions are important reactive intermediates participating in the synthetic chemistry and biological processes. Little is known about triplet phenyl nitrenium ions regarding their reactivity, lifetimes, spectroscopic features, and electronic ... ...

    Abstract Nitrenium ions are important reactive intermediates participating in the synthetic chemistry and biological processes. Little is known about triplet phenyl nitrenium ions regarding their reactivity, lifetimes, spectroscopic features, and electronic configurations, and no ground state triplet nitrenium ion has been directly detected. In this work,
    Language English
    Publishing date 2024-04-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.4c00511
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Reply.

    Kilgore, David Alex / Sallam, Ahmed B / Phillips, Paul H

    Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus

    2022  Volume 26, Issue 1, Page(s) 51

    Language English
    Publishing date 2022-01-22
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1412476-2
    ISSN 1528-3933 ; 1091-8531
    ISSN (online) 1528-3933
    ISSN 1091-8531
    DOI 10.1016/j.jaapos.2021.12.001
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    Zs.A 5188: Show issues Location:
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  6. Article ; Online: Structural and Genetic Determinants of Convergence in the Drosophila tRNA Structure-Function Map.

    Phillips, Julie Baker / Ardell, David H

    Journal of molecular evolution

    2021  Volume 89, Issue 1-2, Page(s) 103–116

    Abstract: The evolution of tRNA multigene families remains poorly understood, exhibiting unusual phenomena such as functional conversions of tRNA genes through anticodon shift substitutions. We improved FlyBase tRNA gene annotations from twelve Drosophila species, ...

    Abstract The evolution of tRNA multigene families remains poorly understood, exhibiting unusual phenomena such as functional conversions of tRNA genes through anticodon shift substitutions. We improved FlyBase tRNA gene annotations from twelve Drosophila species, incorporating previously identified ortholog sets to compare substitution rates across tRNA bodies at single-site and base-pair resolution. All rapidly evolving sites fell within the same metal ion-binding pocket that lies at the interface of the two major stacked helical domains. We applied our tRNA Structure-Function Mapper (tSFM) method independently to each Drosophila species and one outgroup species Musca domestica and found that, although predicted tRNA structure-function maps are generally highly conserved in flies, one tRNA Class-Informative Feature (CIF) within the rapidly evolving ion-binding pocket-Cytosine 17 (C17), ancestrally informative for lysylation identity-independently gained asparaginylation identity and substituted in parallel across tRNA
    MeSH term(s) Animals ; Anticodon/genetics ; Drosophila melanogaster/genetics ; Genome, Insect ; RNA, Transfer/genetics
    Chemical Substances Anticodon ; RNA, Transfer (9014-25-9)
    Language English
    Publishing date 2021-02-02
    Publishing country Germany
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 120148-7
    ISSN 1432-1432 ; 0022-2844
    ISSN (online) 1432-1432
    ISSN 0022-2844
    DOI 10.1007/s00239-021-09995-z
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    Zs.A 1129: Show issues Location:
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  7. Article ; Online: Mutational spectra and mutational signatures: Insights into cancer aetiology and mechanisms of DNA damage and repair.

    Phillips, David H

    DNA repair

    2018  Volume 71, Page(s) 6–11

    Abstract: Reporter gene assays, in which a single mutation from each experiment can contribute to the assembly of a mutation spectrum for an agent, have provided the basis for understanding the mutational processes induced by mutagenic agents and for providing ... ...

    Abstract Reporter gene assays, in which a single mutation from each experiment can contribute to the assembly of a mutation spectrum for an agent, have provided the basis for understanding the mutational processes induced by mutagenic agents and for providing clues to the origins of mutations in human tumours. More recently exome and whole genome sequencing of human tumours has revealed distinct patterns of mutation that could provide additional clues for the causative origins of cancer. This can be tested by examining the mutational signatures induced in experimental systems by putative cancer-causing agents. Such signatures are now being generated in vitro in a number of different mutagen-exposed cellular systems. Results reveal that mutagens induce characteristic mutation signatures that, in some cases, match signatures found in human tumours. Proof of principle has been established with mutational signatures generated by simulated sunlight and aristolochic acid, which match those signatures found in human melanomas and urothelial cancers, respectively. In an analysis of somatic mutations in cancers for which tobacco smoking confers an elevated risk, it was found that smoking is associated with increased mutation burdens of multiple different mutational signatures, which contribute to different extents in different tissues. One of these signatures, mainly found in tissues directly exposed to tobacco smoke, is attributable to misreplication of DNA damage caused by tobacco carcinogens. Others likely reflect indirect activation of DNA editing by APOBEC cytidine deaminases and of an endogenous clock-like mutational process. The results are consistent with the proposition that smoking increases cancer risk by increasing the somatic mutation load although direct evidence for this mechanism is lacking in some cancer types. Thus, next generation sequencing of exomes or whole genomes is providing new insights into processes underlying the causes of human cancer.
    MeSH term(s) Animals ; DNA/metabolism ; DNA Damage ; DNA Mutational Analysis ; DNA Repair ; Genome, Human ; High-Throughput Nucleotide Sequencing ; Humans ; Mutation ; Neoplasms/genetics
    Chemical Substances DNA (9007-49-2)
    Language English
    Publishing date 2018-08-24
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2071608-4
    ISSN 1568-7856 ; 1568-7864
    ISSN (online) 1568-7856
    ISSN 1568-7864
    DOI 10.1016/j.dnarep.2018.08.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5555: Show issues Location:
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  8. Article ; Online: The ophthalmologist's guide to evaluating the certainty of evidence using the GRADE approach.

    Zeraatkar, Dena / Pitre, Tyler / Phillips, Mark / Steel, David H / Wykoff, Charles C / Wong, Tien Yin / Bhandari, Mohit / Chaudhary, Varun

    Eye (London, England)

    2024  

    Language English
    Publishing date 2024-02-05
    Publishing country England
    Document type Editorial
    ZDB-ID 91001-6
    ISSN 1476-5454 ; 0950-222X
    ISSN (online) 1476-5454
    ISSN 0950-222X
    DOI 10.1038/s41433-024-02937-1
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  9. Article ; Online: First-line therapy in drug reaction with eosinophilia and systemic symptoms (DReSS)

    Ruud H. J. Verstegen / Elizabeth J. Phillips / David N. Juurlink

    Frontiers in Medicine, Vol

    Thinking beyond corticosteroids

    2023  Volume 10

    Keywords DReSS (drug reaction with eosinophilia and systemic symptoms) ; adverse (side) effects ; cyclosporine ; targeted therapy ; severe cutaneous adverse drug reaction ; Medicine (General) ; R5-920
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: A Real-Time Endoscope Motion Tracker.

    Phillips, Ian H D / Armstrong, David / Fang, Qiyin

    IEEE journal of translational engineering in health and medicine

    2022  Volume 10, Page(s) 1801009

    Abstract: Objective: In colonoscopy, it is desirable to accurately localize the position of the endoscope's distal tip. Current tip localization techniques are not sufficient for recording the position and movement of the tip, nor is its rotation measured. We ... ...

    Abstract Objective: In colonoscopy, it is desirable to accurately localize the position of the endoscope's distal tip. Current tip localization techniques are not sufficient for recording the position and movement of the tip, nor is its rotation measured. We hypothesize that integration of multiple tracking modalities can effectively record the endoscope's motion in real time and continuously corrects cumulative errors.
    Methods: A dual modality tracking method is developed to measure the motion of the endoscope's insertion tube in real time, including insertion length, rotation angle, and their velocities. Optical trackballs were used to measure the endoscope insertion tube's motion and cameras were used to correct cumulative errors.
    Results: The accuracy of insertion length and rotational angle were measured. For speeds ≤ 10 mm/s, the median and 90th percentile insertion position errors were 0.88 mm and 2.2 mm, respectively. The insertion position error increases with the speed, reaching a maximum of 10 mm for speeds < 40 mm/s. 11° and 21° were the median and 90th percentile rotation angle errors for angular speeds < 40°/s. Cumulative errors are sufficiently reduced by the imaging modality.
    Conclusion: The prototype device can precisely measure an unmodified endoscope's position, rotation, and motion in real time without significant accumulative error. The prototype device is small and compatible with existing commercial endoscopes as an add-on accessory, which could be used for reporting, localizing the lesions in follow up procedures, operational guidance, quality assurance, and training. Clinical and Translational Impact Statement-This preclinical research develops an endoscope tracker that can be integrated into colonoscopy training, automatically record endoscope motion, and be further developed to improve polyp and tumor localization during colonoscopy.
    MeSH term(s) Humans ; Endoscopes ; Rotation ; Colonoscopy ; Movement ; Polyps
    Language English
    Publishing date 2022-09-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2696555-0
    ISSN 2168-2372 ; 2168-2372
    ISSN (online) 2168-2372
    ISSN 2168-2372
    DOI 10.1109/JTEHM.2022.3214148
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