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  1. Article ; Online: Microglial inflammation modulates opioid analgesic tolerance.

    Pahan, Priyanka / Xie, Jennifer Yanhua

    Journal of neuroscience research

    2023  Volume 101, Issue 9, Page(s) 1383–1392

    Abstract: As we all know, opioids are the drugs of choice for treating severe pain. However, very often, opioid use leads to tolerance, dependence, and hyperalgesia. Therefore, understanding the mechanisms underlying opioid tolerance and designing strategies for ... ...

    Abstract As we all know, opioids are the drugs of choice for treating severe pain. However, very often, opioid use leads to tolerance, dependence, and hyperalgesia. Therefore, understanding the mechanisms underlying opioid tolerance and designing strategies for increasing the efficacy of opioids in chronic pain are important areas of research. Microglia are brain macrophages that remove debris and dead cells from the brain and participate in immune defense of the central nervous system during an insult or injury. However, recent studies indicate that microglial activation and generation of proinflammatory molecules (e.g., cytokines, nitric oxide, eicosanoids, etc.) in the brain may contribute to opioid tolerance and other side effects of opioid use. In this review, we will summarize the evidence and possible mechanisms by which proinflammatory molecules produced by activated microglia may antagonize the analgesic effect induced by opioids, and thus, lead to opioid tolerance. We will also delineate specific examples of studies that suggest therapeutic targets to counteract the development of tolerance clinically using suppressors of microglial inflammation.
    MeSH term(s) Humans ; Analgesics, Opioid/pharmacology ; Microglia ; Morphine/pharmacology ; Drug Tolerance/physiology ; Hyperalgesia/drug therapy ; Inflammation/drug therapy
    Chemical Substances Analgesics, Opioid ; Morphine (76I7G6D29C)
    Language English
    Publishing date 2023-04-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 195324-2
    ISSN 1097-4547 ; 0360-4012
    ISSN (online) 1097-4547
    ISSN 0360-4012
    DOI 10.1002/jnr.25199
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Smooth or Risky Revisit of an Old Malaria Drug for COVID-19?

    Pahan, Priyanka / Pahan, Kalipada

    Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology

    2020  Volume 15, Issue 2, Page(s) 174–180

    Abstract: Hydroxychloroquine (HCQ) is an old medication for malaria. In addition to handling this parasitic disease, HCQ is also used to treat a number of autoimmune disorders including rheumatoid arthritis and systemic lupus erythematosus when other medications ... ...

    Abstract Hydroxychloroquine (HCQ) is an old medication for malaria. In addition to handling this parasitic disease, HCQ is also used to treat a number of autoimmune disorders including rheumatoid arthritis and systemic lupus erythematosus when other medications are not effective. Recently a new viral infection (COVID-19) is rocking the entire world so much that it has already taken more than 200,000 lives throughout the world within the last two months and the World Health Organization was forced to declare it as a pandemic on March 11, 2020. Interestingly, some reports indicate that this wonder drug may be also beneficial for COVID-19 and accordingly, many clinical trials have begun. Here, we discuss different modes of action (anti-inflammatory, antioxidant, inhibition of endosomal acidification, suppression of angiotensin-converting enzyme 2 or ACE2 glycosylation, etc.) of HCQ that might be responsible for its possible anti-COVID-19 effect. On the other hand, this review also makes an honest attempt to delineate mechanisms (increase in vasoconstriction, inhibition of autophagy, depletion of T cells, etc.) indicating how it may aggravate certain conditions and why caution should be taken before granting widespread repurposing of HCQ for COVID-19. Graphical Abstract.
    MeSH term(s) Animals ; Anti-Inflammatory Agents/pharmacology ; Antimalarials/pharmacology ; Betacoronavirus/drug effects ; COVID-19 ; Coronavirus Infections/drug therapy ; Drug Repositioning ; Humans ; Hydroxychloroquine/pharmacology ; Pandemics ; Pneumonia, Viral/drug therapy ; SARS-CoV-2
    Chemical Substances Anti-Inflammatory Agents ; Antimalarials ; Hydroxychloroquine (4QWG6N8QKH)
    Keywords covid19
    Language English
    Publishing date 2020-05-15
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 2227405-4
    ISSN 1557-1904 ; 1557-1890
    ISSN (online) 1557-1904
    ISSN 1557-1890
    DOI 10.1007/s11481-020-09923-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Smooth or Risky Revisit of an Old Malaria Drug for COVID-19?

    Pahan, Priyanka / Pahan, Kalipada

    Journal of Neuroimmune Pharmacology

    2020  Volume 15, Issue 2, Page(s) 174–180

    Keywords Immunology ; Immunology and Allergy ; Pharmacology ; Neuroscience (miscellaneous) ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2227405-4
    ISSN 1557-1904 ; 1557-1890
    ISSN (online) 1557-1904
    ISSN 1557-1890
    DOI 10.1007/s11481-020-09923-w
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Smooth or Risky Revisit of an Old Malaria Drug for COVID-19?

    Pahan, Priyanka / Pahan, Kalipada

    J Neuroimmune Pharmacol

    Abstract: Hydroxychloroquine (HCQ) is an old medication for malaria. In addition to handling this parasitic disease, HCQ is also used to treat a number of autoimmune disorders including rheumatoid arthritis and systemic lupus erythematosus when other medications ... ...

    Abstract Hydroxychloroquine (HCQ) is an old medication for malaria. In addition to handling this parasitic disease, HCQ is also used to treat a number of autoimmune disorders including rheumatoid arthritis and systemic lupus erythematosus when other medications are not effective. Recently a new viral infection (COVID-19) is rocking the entire world so much that it has already taken more than 200,000 lives throughout the world within the last two months and the World Health Organization was forced to declare it as a pandemic on March 11, 2020. Interestingly, some reports indicate that this wonder drug may be also beneficial for COVID-19 and accordingly, many clinical trials have begun. Here, we discuss different modes of action (anti-inflammatory, antioxidant, inhibition of endosomal acidification, suppression of angiotensin-converting enzyme 2 or ACE2 glycosylation, etc.) of HCQ that might be responsible for its possible anti-COVID-19 effect. On the other hand, this review also makes an honest attempt to delineate mechanisms (increase in vasoconstriction, inhibition of autophagy, depletion of T cells, etc.) indicating how it may aggravate certain conditions and why caution should be taken before granting widespread repurposing of HCQ for COVID-19. Graphical Abstract.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32415419
    Database COVID19

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  5. Article: Can cinnamon bring aroma in Parkinson's disease treatment?

    Pahan, Priyanka / Pahan, Kalipada

    Neural regeneration research

    2015  Volume 10, Issue 1, Page(s) 30–32

    Language English
    Publishing date 2015-03-04
    Publishing country India
    Document type Journal Article
    ZDB-ID 2388460-5
    ISSN 1876-7958 ; 1673-5374
    ISSN (online) 1876-7958
    ISSN 1673-5374
    DOI 10.4103/1673-5374.150647
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Low-Dose Aspirin Upregulates Tyrosine Hydroxylase and Increases Dopamine Production in Dopaminergic Neurons: Implications for Parkinson's Disease.

    Rangasamy, Suresh B / Dasarathi, Sridevi / Pahan, Priyanka / Jana, Malabendu / Pahan, Kalipada

    Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology

    2018  Volume 14, Issue 2, Page(s) 173–187

    Abstract: Increasing the function of residual dopaminergic neurons in the nigra of PD patients is an important area of research as it may eventually compensate the loss. Although tyrosine hydroxylase (TH) is the rate-limiting enzyme in the dopamine (DA) ... ...

    Abstract Increasing the function of residual dopaminergic neurons in the nigra of PD patients is an important area of research as it may eventually compensate the loss. Although tyrosine hydroxylase (TH) is the rate-limiting enzyme in the dopamine (DA) biosynthesis pathway, there are no effective drugs/molecules to upregulate TH and increase the production of DA in nigral dopaminergic neurons. This study underlines the importance of aspirin in stimulating the expression of TH and increasing the level of DA in dopaminergic neurons. At low doses, aspirin increased the expression of TH and the production of DA in mouse MN9D dopaminergic neuronal cells. Accordingly, oral administration of aspirin increased the expression of TH in the nigra and upregulated the level of DA in striatum of normal C57/BL6 mice and aged A53T α-syn transgenic mice. Oral aspirin also improved locomotor activities of normal mice and A53T transgenic mice. While investigating mechanisms, we found the presence of cAMP response element (CRE) in the promoter of TH gene and the rapid induction of cAMP response element binding (CREB) activation by aspirin in dopaminergic neuronal cells. Aspirin treatment also increased the level of phospho-CREB in the nigra of C57/BL6 mice. The abrogation of aspirin-induced expression of TH by siRNA knockdown of CREB and the recruitment of CREB to the TH gene promoter by aspirin suggest that aspirin stimulates the transcription of TH in dopaminergic neurons via CREB. These results highlight a new property of aspirin in stimulating the TH-DA pathway, which may be beneficial in PD patients. Graphical Abstract ᅟ.
    MeSH term(s) Animals ; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Aspirin/administration & dosage ; Aspirin/pharmacology ; Cell Line ; Cyclic AMP Response Element-Binding Protein/biosynthesis ; Cyclic AMP Response Element-Binding Protein/genetics ; Dopamine/biosynthesis ; Dopaminergic Neurons/drug effects ; Dopaminergic Neurons/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Motor Activity/drug effects ; Parkinson Disease/metabolism ; RNA, Small Interfering/pharmacology ; Transcriptional Activation ; Tyrosine 3-Monooxygenase/biosynthesis ; Up-Regulation/drug effects ; alpha-Synuclein/biosynthesis ; alpha-Synuclein/genetics
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Creb1 protein, mouse ; Cyclic AMP Response Element-Binding Protein ; RNA, Small Interfering ; Snca protein, mouse ; alpha-Synuclein ; Tyrosine 3-Monooxygenase (EC 1.14.16.2) ; Aspirin (R16CO5Y76E) ; Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2018-09-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2227405-4
    ISSN 1557-1904 ; 1557-1890
    ISSN (online) 1557-1904
    ISSN 1557-1890
    DOI 10.1007/s11481-018-9808-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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