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  1. Article ; Online: Toxic epidermal necrolysis.

    Piérard, Gérald E

    Current drug safety

    2012  Volume 7, Issue 5, Page(s) 331

    MeSH term(s) Humans ; Stevens-Johnson Syndrome/etiology
    Language English
    Publishing date 2012-11-01
    Publishing country United Arab Emirates
    Document type Editorial
    ZDB-ID 2250840-5
    ISSN 2212-3911 ; 1574-8863
    ISSN (online) 2212-3911
    ISSN 1574-8863
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  2. Article: Simulants of Malignant Melanoma.

    Piérard, Gérald E / Piérard-Franchimont, Claudine / Delvenne, Philippe

    Oncology reviews

    2015  Volume 9, Issue 1, Page(s) 278

    Abstract: During the recent period, dermoscopy has yielded improvement in the early disclosure of various atypical melanocytic neoplasms (AMN) of the skin. Beyond this clinical procedure, AMN histopathology remains mandatory for establishing their precise ... ...

    Abstract During the recent period, dermoscopy has yielded improvement in the early disclosure of various atypical melanocytic neoplasms (AMN) of the skin. Beyond this clinical procedure, AMN histopathology remains mandatory for establishing their precise diagnosis. Of note, panels of experts in AMN merely report moderate agreement in various puzzling cases. Divergences in opinion and misdiagnosis are likely increased when histopathological criteria are not fine-tuned and when facing a diversity of AMN types. Furthermore, some AMN have been differently named in the literature including atypical Spitz tumor, metastasizing Spitz tumor, borderline and intermediate melanocytic tumor, malignant Spitz nevus, pigmented epithelioid melanocytoma or animal-type melanoma. Some acronyms have been further suggested such as MELTUMP (after melanocytic tumor of uncertain malignant potential) and STUMP (after Spitzoid melanocytic tumor of uncertain malignant potential). In this review, such AMN at the exclusion of cutaneous malignant melanoma (MM) variants, are grouped under the tentative broad heading skin melanocytoma. Such set of AMN frequently follows an indolent course, although they exhibit atypical and sometimes worrisome patterns or cytological atypia. Rare cases of skin melanocytomas progress to loco regional clusters of lesions (agminate melanocytomas), and even to regional lymph nodes. At times, the distinction between a skin melanocytoma and MM remains puzzling. However, multipronged immunohistochemistry and emerging molecular biology help profiling any malignancy risk if present.
    Language English
    Publishing date 2015-08-05
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 2390302-8
    ISSN 1970-5565 ; 1970-5565 ; 1970-5557
    ISSN (online) 1970-5565
    ISSN 1970-5565 ; 1970-5557
    DOI 10.4081/oncol.2015.278
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  3. Article ; Online: Nail Histomycology, Onychochromobiology, and Fungal Thigmatropism

    Gérald E. Piérard / Sébastien L. Piérard

    Open Access Journal of Science and Technology, Vol 4, Pp 1-

    2016  Volume 6

    Abstract: Background: Thigmotropism is a biologic feature coping with the directional growth of cells following topographical guidance cues. This mechanism is involved in the invasive phase of pathogen and opportunistic fungi. It was shown experimentally with ... ...

    Abstract Background: Thigmotropism is a biologic feature coping with the directional growth of cells following topographical guidance cues. This mechanism is involved in the invasive phase of pathogen and opportunistic fungi. It was shown experimentally with fungal hyphae of both dermatophytes and nondermatophyte molds, as well as with the mycelial phase of the dimorphic yeast Candida albicans. Objective: To revisit histomycology in onychomycoses of a diversity of fungal origins. Method: Histopathological section of nails plates were oriented parallel to the nail direction of growth. Result: Thigmotropism in part explains the patterns of orientations and shapes of fungi invading nail plates. It is probably influenced by onychochronobiology (speed of growth of the affected nails), and it governs various clinical presentations of onychomycoses.
    Keywords contact-sensing ; Histomycology ; Hyphal growth ; Fungus ; Onychomycosis ; Onychochronobiology ; Fungal nail infection ; Technology ; T ; Science ; Q
    Language English
    Publishing date 2016-09-01T00:00:00Z
    Publisher AgiAl Publishing House
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Skin viscoelasticity in incipient gravitational syndrome.

    Piérard, Gérald E / Paquet, Philippe / Piérard-Franchimont, Claudine

    Journal of cosmetic dermatology

    2014  Volume 13, Issue 1, Page(s) 52–55

    Abstract: Background: The gravitational syndrome resulting from venous pressure elevation occasionally develops on the legs during pregnancy. The limb tends to enlarge and become stiffer. The body contours are altered.: Aims: To assess incipient gravitational ... ...

    Abstract Background: The gravitational syndrome resulting from venous pressure elevation occasionally develops on the legs during pregnancy. The limb tends to enlarge and become stiffer. The body contours are altered.
    Aims: To assess incipient gravitational edema due to chronic venous insufficiency using measurements of the skin tensile strength.
    Method: A total of 21 women aged 28-37 years were enrolled in the study. Evaluations were made twice in each subject following an alternate use and avoidance of daytime elastic contention. Skin viscoelasticity was measured on the mid portion of the calves using a computerized suction device.
    Results: The discretely increased consistency of skin showing abnormal rheological characteristics at the site of incipient gravitational edema was significantly improved by contention therapy. Under progressive suction measurements, both skin distensibility, biologic elasticity and hysteresis were increased after wearing tight stockings. The biologic elasticity appears to be the most sensitive parameter pointing to the diagnosis of gravitational syndrome.
    Conclusion: Noninvasive measurements of the skin viscoelasticity, particularly the biologic elasticity, represent an objective assessment of both early gravitational edema and its control by contention therapy.
    MeSH term(s) Adult ; Edema/etiology ; Edema/physiopathology ; Elasticity/physiology ; Female ; Gravitation ; Humans ; Leg/blood supply ; Postpartum Period ; Rheology ; Skin/physiopathology ; Stockings, Compression ; Syndrome ; Tensile Strength/physiology ; Venous Insufficiency/complications ; Venous Insufficiency/physiopathology ; Viscosity
    Language English
    Publishing date 2014-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2280551-5
    ISSN 1473-2165 ; 1473-2130
    ISSN (online) 1473-2165
    ISSN 1473-2130
    DOI 10.1111/jocd.12077
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  5. Book ; Thesis: Structure et propriétés mécaniques des compartiments adventitiel et réticulaire du derme

    Pierard, Gérald E.

    1984  

    Author's details Gérald E. Pierard
    Language French
    Size 416 S. : Ill., graph. Darst.
    Publishing country Belgium
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Liège, Univ., Diss., 1984
    HBZ-ID HT011244244
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2000 E 1283 order for loan Magazin

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  6. Article ; Online: Simulants of malignant melanoma

    Gérald E. Piérard / Claudine Piérard-Franchimont / Philippe Delvenne

    Oncology Reviews, Vol 9, Iss

    2015  Volume 1

    Abstract: During the recent period, dermoscopy has yielded improvement in the early disclosure of various atypical melanocytic neoplasms (AMN) of the skin. Beyond this clinical procedure, AMN histopathology remains mandatory for establishing their precise ... ...

    Abstract During the recent period, dermoscopy has yielded improvement in the early disclosure of various atypical melanocytic neoplasms (AMN) of the skin. Beyond this clinical procedure, AMN histopathology remains mandatory for establishing their precise diagnosis. Of note, panels of experts in AMN merely report moderate agreement in various puzzling cases. Divergences in opinion and misdiagnosis are likely increased when histopathological criteria are not fine-tuned and when facing a diversity of AMN types. Furthermore, some AMN have been differently named in the literature including atypical Spitz tumor, metastasizing Spitz tumor, borderline and intermediate melanocytic tumor, malignant Spitz nevus, pigmented epithelioid melanocytoma or animal-type melanoma. Some acronyms have been further suggested such as MELTUMP (after melanocytic tumor of uncertain malignant potential) and STUMP (after Spitzoid melanocytic tumor of uncertain malignant potential). In this review, such AMN at the exclusion of cutaneous malignant melanoma (MM) variants, are grouped under the tentative broad heading skin melanocytoma. Such set of AMN frequently follows an indolent course, although they exhibit atypical and sometimes worrisome patterns or cytological atypia. Rare cases of skin melanocytomas progress to loco regional clusters of lesions (agminate melanocytomas), and even to regional lymph nodes. At times, the distinction between a skin melanocytoma and MM remains puzzling. However, multipronged immunohistochemistry and emerging molecular biology help profiling any malignancy risk if present.
    Keywords Melanoma ; melanocytoma ; prognostic factor ; risk stratification ; Spitzoid tumor ; immunohistochemistry ; Other systems of medicine ; RZ201-999 ; Internal medicine ; RC31-1245
    Subject code 610
    Language English
    Publishing date 2015-08-01T00:00:00Z
    Publisher PAGEPress Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: In vivo evaluation of the skin tensile strength by the suction method: pilot study coping with hysteresis and creep extension.

    Piérard, Gérald E / Piérard, Sébastien / Delvenne, Philippe / Piérard-Franchimont, Claudine

    ISRN dermatology

    2013  Volume 2013, Page(s) 841217

    Abstract: From an engineering standpoint, both the skin and subcutaneous tissue act as interconnected load-transmitting structures. They are subject to a variety of intrinsic and environmental influences. Changes in the cutaneous viscoelasticity represent an ... ...

    Abstract From an engineering standpoint, both the skin and subcutaneous tissue act as interconnected load-transmitting structures. They are subject to a variety of intrinsic and environmental influences. Changes in the cutaneous viscoelasticity represent an important aspect in a series of skin conditions. The aim of this work was to explore the methodology of biomechanical measurements in order to better appreciate the evolution and severity of some connective tissue diseases. The Cutometer MPA 580 (C+K electronic) was used in the steep and progressive suction procedures. Adapting measurement modalities was explored in order to mitigate any variability in data collection. The repeat steep suction procedure conveniently reveals the creep phenomenon. By contrast, the progressive suction procedure highlights the hysteresis phenomenon. These viscoelastic characteristics are presently described using the 2 and 4 mm probes on normal skin and in scleroderma, acromegaly, corticosteroid-induced dermatoporosis, and Ehlers-Danlos syndrome. The apposition of an additional outer contention on the skin altered differently the manifestations of the creep extension and hysteresis among the tested skin conditions. Any change in the mechanical test procedure affects the data. In clinical and experimental settings, it is mandatory to adhere to a strict and controlled protocol.
    Language English
    Publishing date 2013-08-05
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2612990-5
    ISSN 2090-4606 ; 2090-4592
    ISSN (online) 2090-4606
    ISSN 2090-4592
    DOI 10.1155/2013/841217
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  8. Article ; Online: Critical assessment of diabetic xerosis.

    Piérard, Gérald E / Piérard-Franchimont, Claudine / Scheen, André

    Expert opinion on medical diagnostics

    2013  Volume 7, Issue 2, Page(s) 201–207

    Abstract: Introduction: Diabetes mellitus is commonly responsible for skin changes including discrete to mild xerosis.: Areas covered: This review focuses on some selected relevant bioinstrumental methods assessing diabetes xerosis. Peer-reviewed articles on ... ...

    Abstract Introduction: Diabetes mellitus is commonly responsible for skin changes including discrete to mild xerosis.
    Areas covered: This review focuses on some selected relevant bioinstrumental methods assessing diabetes xerosis. Peer-reviewed articles on objective non-invasive methods were scrutinized. The reviewed methods address i) the xerosis severity grading scale, ii) corneodynamics referring to the desquamation rate, iii) electrometric assessment of skin hydration including skin capacitance mapping and iv) implication of the imperceptible perspiration. The subjective clinical assessment often fails to disclose diabetic xerosis with confidence and precision. By contrast, a multipronged biometrological approach identifies a cluster of diabetic patients who experience alterations in the structural and functional maturation of the stratum corneum.
    Expert opinion: A multipronged biometrological approach helps identifying the changes in the stratum corneum of diabetic xerosis. There is a continuum between the 'dry skin' feeling, xerosis and ichthyosiform presentations, particularly on the shins and feet of diabetic patients.
    MeSH term(s) Diabetes Complications/diagnosis ; Diabetes Mellitus/diagnosis ; Humans ; Ichthyosis/diagnosis
    Language English
    Publishing date 2013-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2393880-8
    ISSN 1753-0067 ; 1753-0059
    ISSN (online) 1753-0067
    ISSN 1753-0059
    DOI 10.1517/17530059.2013.728585
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6540: Show issues Location:
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  9. Article ; Online: Alterations in hair follicle dynamics in women.

    Piérard-Franchimont, Claudine / Piérard, Gérald E

    BioMed research international

    2013  Volume 2013, Page(s) 957432

    Abstract: Endocrine changes supervening after parturition and menopause participate in the control of sebum production and hair growth modulation. The ensuing conditions include some peculiar aspects of hair loss (effluvium), alopecia, and facial hirsutism. The ... ...

    Abstract Endocrine changes supervening after parturition and menopause participate in the control of sebum production and hair growth modulation. The ensuing conditions include some peculiar aspects of hair loss (effluvium), alopecia, and facial hirsutism. The hair cycling is of major clinical relevance because most hair growth disorders result from disturbances in this chronobiological feature. Of note, any correlation between a biologic abnormality and hair cycling disturbance does not prove a relationship of causality. The proportion of postmenopausal women is rising in the overall population. Therefore, the prevalence of these hair follicle disturbances is globally on the rise. Current therapies aim at correcting the underlying hormonal imbalances, and at improving the overall cosmetic appearance. However, in absence of pathogenic diagnosis and causality criteria, chances are low that a treatment given by the whims of fate will adequately control hair effluvium. The risk and frequency of therapeutic inertia are further increased. When the hair loss is not controlled and/or compensated by growth of new hairs, several clinical aspects of alopecia inexorably develop. Currently, there is little evidence supporting any specific treatment for these endocrine hair disorders in post-partum and postmenopausal women. Current hair treatment strategies are symptomatic and nonspecific so current researchers aim at developing new, targeted methods.
    MeSH term(s) Alopecia/pathology ; Female ; Hair/growth & development ; Hair/pathology ; Hair Diseases/pathology ; Hair Follicle/growth & development ; Hair Follicle/pathology ; Humans ; Menopause/metabolism ; Menopause/physiology ; Sebum/metabolism
    Language English
    Publishing date 2013-12-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2698540-8
    ISSN 2314-6141 ; 2314-6133
    ISSN (online) 2314-6141
    ISSN 2314-6133
    DOI 10.1155/2013/957432
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Sunscreen remanence on the skin: a noninvasive real time in vivo spectral analysis assessing the quenching of specular ultraviolet A light reflectance.

    Piérard, Gérald E / Khazaka, Diana / Khazaka, Gabriel

    Journal of cosmetic dermatology

    2016  Volume 15, Issue 1, Page(s) 3–9

    Abstract: Background: Under specific light illumination, particularly ultraviolet radiation (UVR), the skin produces both specular light reflectance and, possibly, specific fluorescent emission. A quenching effect of fluorescence is observed following the ... ...

    Abstract Background: Under specific light illumination, particularly ultraviolet radiation (UVR), the skin produces both specular light reflectance and, possibly, specific fluorescent emission. A quenching effect of fluorescence is observed following the application of sunscreens active against UVA radiations.
    Aims: To assess noninvasively in a real-time process, the potential sunscreen remanence/substantivity after application on the skin.
    Methods: The Visiopor® device was used in a real-time procedure after application of sunscreens to the skin. A quenching effect of follicular fluorescence due to bacterial porphyrins was evaluated at 30-min intervals. The Visioscan(®) device was used as a distinct UVA emitter in a control procedure of spectral analysis of specular UVR emission and reflectance by dermal fibers.
    Results: Under UVA-1 irradiations, facial skin produced different patterns of specular UVR reflectance and fluorescent emission as well. The porphyrin-related follicular fluorescence was instantly abated by UVA blockers present in suncare products. The potential sunscreen remanence/substantivity was assessed by the follicular and interfollicular fluorescence recurrence all along the next hours.
    Conclusions: All UVA blocker-containing suncare products exhibited a similar overall quenching effect on porphyrin-enriched facial hair follicles and dermal fibers. This effect lasted for a few hours. Differences in the fluorescence recovery were likely related to the amount in suncare application and the nature of the formulation components.
    MeSH term(s) Adult ; Face ; Female ; Fluorescence ; Hair Follicle/chemistry ; Hair Follicle/microbiology ; Hair Follicle/radiation effects ; Humans ; Male ; Porphyrins/metabolism ; Porphyrins/radiation effects ; Propionibacterium acnes/metabolism ; Skin/diagnostic imaging ; Skin Absorption/drug effects ; Spectrum Analysis/methods ; Sunscreening Agents/analysis ; Sunscreening Agents/pharmacology ; Time Factors ; Ultraviolet Rays
    Chemical Substances Porphyrins ; Sunscreening Agents
    Language English
    Publishing date 2016-03
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 2280551-5
    ISSN 1473-2165 ; 1473-2130
    ISSN (online) 1473-2165
    ISSN 1473-2130
    DOI 10.1111/jocd.12169
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