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Article ; Online: The massive assimilation of indigenous East Asian populations in the origin of Muslim Hui people inferred from paternal Y chromosome.

Wang, Chuan-Chao / Lu, Yan / Kang, Longli / Ding, Huiqian / Yan, Shi / Guo, Jianxin / Zhang, Qun / Wen, Shao-Qing / Wang, Ling-Xiang / Zhang, Manfei / Tong, Xinzhu / Huang, Xiufeng / Nie, Shengjie / Deng, Qiongying / Zhu, Bofeng / Jin, Li / Li, Hui

American journal of physical anthropology

2019 Volume 169, Issue 2, Page(s) 341–347

Abstract: Objectives: The Hui people are the adherents of Muslim faith and distributing throughout China ... There are two contrasting hypotheses about the origin and diversification of the Hui people, namely ... methods: We collected 621 unrelated male individuals from 23 Hui populations all over China ...

Abstract	Objectives: The Hui people are the adherents of Muslim faith and distributing throughout China. There are two contrasting hypotheses about the origin and diversification of the Hui people, namely, the demic diffusion involving the mass movement of people or simple cultural diffusion. Materials and methods: We collected 621 unrelated male individuals from 23 Hui populations all over China. We comprehensively genotyped more than 100 informative Y-chromosomal single nucleotide polymorphisms and 17 Y-chromosomal short tandem repeats (STRs) on those samples. Results: Co-analyzed with published worldwide populations, our results suggest the origin of Hui people has involved massive assimilation of indigenous East Asians with about 70% in total of the paternal ancestry could be traced back to East Asia and the left 30% to various regions in West Eurasia. Discussion: The genetic structure of the extant Hui populations was primarily shaped by the indigenous East Asian populations as they contribute the majority part of the paternal lineages of Hui people. The West Eurasian admixture was probably a sex-biased male-driven process since we have not found such a high proportion of West Eurasian gene flow on autosomal STRs and maternal mtDNA.
MeSH term(s)	Anthropology, Physical ; Asian Continental Ancestry Group/genetics ; China ; Chromosomes, Human, Y/genetics ; Ethnic Groups/genetics ; Gene Flow/genetics ; Genetics, Population ; Humans ; Islam ; Male ; Polymorphism, Single Nucleotide/genetics
Language	English
Publishing date	2019-03-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	219376-0
ISSN	1096-8644 ; 0002-9483
ISSN (online)	1096-8644
ISSN	0002-9483
DOI	10.1002/ajpa.23823
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Conference proceedings: Shou jie zhong guo shao shu min zu gu ji wen xian guo ji xue shu yan tao hui lun wen ji

Huang, Jianming / Nie, Hongyin / Ma, Lan

Proceedings of the 1st International Colloquium on Ancient Manuscripts and Literatures of the Minorities in China

2012

Abstract: 本书是“首届中国少数民族古籍文献国际学术研讨会”的论文集汇编，收录了《中国少数民族文字古籍研究简论》、《西夏文“洪州”文献再考》、《元刊〈河西藏〉考补》、《重提搠思吉斡节儿》、《宽温仁圣皇帝信牌与清太宗遣使漠北》、《伊犁河流域厄鲁特人民间收藏托忒文文献概述》等论文。 ...

Title variant	Proceedings of the 1st International Colloquium on Ancient Manuscripts and Literatures of the Minorities in China
Institution	International Colloquium on Ancient Manuscripts and Literatures of the Minorities in China
Event/congress	International Colloquium on Ancient Manuscripts and Literatures of the Minorities in China (1, 2010.10.20-22, Beijing)
Author's details	Huang jian ming, nie hong yin, ma lan zhu bian
Abstract	本书是“首届中国少数民族古籍文献国际学术研讨会”的论文集汇编，收录了《中国少数民族文字古籍研究简论》、《西夏文“洪州”文献再考》、《元刊〈河西藏〉考补》、《重提搠思吉斡节儿》、《宽温仁圣皇帝信牌与清太宗遣使漠北》、《伊犁河流域厄鲁特人民间收藏托忒文文献概述》等论文。
Keywords	Ethnology ; Minorities ; Rare books
Language	Chinese ; English
Size	3, 633 S, Ill
Edition	Di 1 ban
Publisher	Min zu chu ban she
Publishing place	Bei jing
Document type	Book ; Conference proceedings
Note	In chines. und lat. Schr.; Beitr. teilw. chines., teilw. engl.
ISBN	7105120452 ; 9787105120451
Database	Former special subject collection: coastal and deep sea fishing

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Article: DNA methylation biomarkers for early detection of gastric and colorectal cancers.

Gao, Xianchun / Liu, Hui / Yu, Jun / Nie, Yongzhan

Cancer biology & medicine

2024 Volume 20, Issue 12

MeSH term(s)	Humans ; DNA Methylation ; Biomarkers ; Epigenesis, Genetic ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/genetics
Chemical Substances	Biomarkers
Language	English
Publishing date	2024-03-12
Publishing country	China
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2676322-9
ISSN	2095-3941
ISSN	2095-3941
DOI	10.20892/j.issn.2095-3941.2023.0443
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Article: [Effect and mechanism of Maxing Shigan Decoction on reducing inflammatory response in rats with cough variant asthma via TLR4/MyD88/NF-κB and p38 MAPK signaling pathways].

Fu, Zhi-Hui / Zhou, Lin / Nie, An-Zheng

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2024 Volume 49, Issue 4, Page(s) 1000–1006

Abstract: This study aims to investigate the effect and mechanism of Maxingshigan Decoction on inflammation in the rat model of cough variant asthma(CVA). The SPF-grade SD rats of 6-8 weeks were randomized into normal, model, Montelukast sodium, and low-, medium-, ...

Abstract	This study aims to investigate the effect and mechanism of Maxingshigan Decoction on inflammation in the rat model of cough variant asthma(CVA). The SPF-grade SD rats of 6-8 weeks were randomized into normal, model, Montelukast sodium, and low-, medium-, and high-dose Maxing Shigan Decoction groups, with 8 rats in each group. The CVA rat model was induced by ovalbumin(OVA) and aluminum hydroxide sensitization and ovalbumin stimulation. The normal group and model group were administrated with equal volume of normal saline by gavage, and other groups with corresponding drugs by gavage. After the experiment, the number of white blood cells in blood and the levels of interleukin-6(IL-6), interleukin-10(IL-10), and tumor necrosis factor-α(TNF-α) in the serum were measured. The lung tissue was stained with hematoxylin-eosin(HE). Western blot was employed to determine the protein levels of nuclear factor-κB(NF-κB), Toll-like receptor 4(TLR4), myeloid differentiation protein(MyD88), and mitogen-activated protein kinase(MAPK) in the lung tissue. Real-time PCR was carried out to measure the mRNA levels of TLR4 and MyD88 in the lung tissue. Compared with the normal group, the model group showed increased white blood cells, elevated IL-6 and TNF-α levels(P<0.01), lowered IL-10 level(P<0.01), up-regulated protein levels of TLR4, MyD88, p-p65/NF-κB p65, and p-p38 MAPK/p38 MAPK(P<0.01) and mRNA levels of TLR4 and MyD88(P<0.01) in the lung tissue. HE staining showed obvious infiltration of inflammatory cells around the airway and cell disarrangement in the model group. Compared with the model group, Montelukast sodium and high-dose Maxing Shigan Decoction reduced the white blood cells, lowered the IL-6 and TNF-α levels(P<0.01), and elevated the IL-10 level(P<0.01). Moreover, they down-regulated the protein levels of TLR4, MyD88, p-p65/NF-κB p65, p-p38 MAPK/p38 MAPK in the lung tissue(P<0.01) and the mRNA levels of TLR4 and MyD88 in the lung tissue(P<0.01). HE staining showed that Montelukast sodium and high-dose Maxing Shigan Decoction reduced inflammatory cell infiltration and cell disarrangement. The number of white blood cells, the levels of IL-10 and TNF-α in the serum, the protein levels of TLR4, MyD88, p-p65/NF-κB p65, and p-p38 MAPK/p38 MAPK, and the mRNA levels of TLR4 and MyD88 in the lung tissue showed no significant differences between the Montelukast sodium group and high-dose Maxing Shigan Decoction group. Maxing Shigan Decoction can inhibit airway inflammation in CVA rats by inhibiting the activation of TLR4/MyD88/NF-κB and p38 MAPK signaling pathways.
MeSH term(s)	Rats ; Animals ; NF-kappa B/genetics ; NF-kappa B/metabolism ; Myeloid Differentiation Factor 88/genetics ; Myeloid Differentiation Factor 88/metabolism ; Interleukin-10/genetics ; Signal Transduction ; Tumor Necrosis Factor-alpha/metabolism ; Interleukin-6/genetics ; Interleukin-6/metabolism ; Cough-Variant Asthma ; Rats, Sprague-Dawley ; Ovalbumin ; Toll-Like Receptor 4/genetics ; Toll-Like Receptor 4/metabolism ; Inflammation ; p38 Mitogen-Activated Protein Kinases/genetics ; p38 Mitogen-Activated Protein Kinases/metabolism ; RNA, Messenger ; Acetates ; Cyclopropanes ; Quinolines ; Sulfides
Chemical Substances	NF-kappa B ; montelukast (MHM278SD3E) ; Myeloid Differentiation Factor 88 ; Interleukin-10 (130068-27-8) ; Tumor Necrosis Factor-alpha ; Interleukin-6 ; Ovalbumin (9006-59-1) ; Toll-Like Receptor 4 ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; RNA, Messenger ; Acetates ; Cyclopropanes ; Quinolines ; Sulfides
Language	Chinese
Publishing date	2024-03-11
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
DOI	10.19540/j.cnki.cjcmm.20230921.406
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Article: Research progress on antidepressant effects and mechanisms of berberine.

Gao, Yang / Nie, Kexin / Wang, Hongzhan / Dong, Hui / Tang, Yueheng

Frontiers in pharmacology

2024 Volume 15, Page(s) 1331440

Abstract: Depression, a global health problem with growing prevalence, brings serious impacts on the daily life of patients. However, the antidepressants currently used in clinical are not perfectly effective, which greatly reduces the compliance of patients. ... ...

Abstract	Depression, a global health problem with growing prevalence, brings serious impacts on the daily life of patients. However, the antidepressants currently used in clinical are not perfectly effective, which greatly reduces the compliance of patients. Berberine is a natural quaternary alkaloid which has been shown to have a variety of pharmacological effects, such as hypoglycemic, lipid-regulation, anti-cancer, antibacterial, anti-oxidation, anti-inflammatory, and antidepressant. This review summarizes the evidence of pharmacological applications of berberine in treating depression and elucidates the mechanisms of berberine regulating neurotransmitter levels, promoting the regeneration of hippocampal neurons, improving hypothalamic-pituitary-adrenal axis dysfunction, anti-oxidative stress, and suppressing inflammatory status in order to provide a reference for further research and clinical application of berberine.
Language	English
Publishing date	2024-01-22
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2024.1331440
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Article ; Online: DNA nanodevice as a multi-module co-delivery platform for combination cancer immunotherapy.

Nie, Cunpeng / Ye, Jingxuan / Jiang, Jian-Hui / Chu, Xia

Journal of colloid and interface science

2024 Volume 667, Page(s) 1–11

Abstract: A major challenge in combining cancer immunotherapy is the efficient delivery of multiple types of immunological stimulators to elicit a robust anti-tumor immune response and reprogram the immunosuppressive tumor microenvironment (TME). Here, we ... ...

Abstract	A major challenge in combining cancer immunotherapy is the efficient delivery of multiple types of immunological stimulators to elicit a robust anti-tumor immune response and reprogram the immunosuppressive tumor microenvironment (TME). Here, we developed a DNA nanodevice that was generated by precisely assembling three types of immunological stimulators. The doxorubicin (Dox) component induced immunogenic cell death (ICD) in tumor cells and enhanced phagocytosis of antigen-presenting cells (APCs). Exogenous double-stranded DNA (dsDNA) could act as a molecular adjuvant to activate the stimulator of interferon genes (STING) signaling in APCs by engulfing dying tumor cells. Interleukin (IL)-12 and small hairpin programmed cell death-ligand 1 (shPD-L1) transcription templates were designed to regulate TME. Additionally, for targeted drug delivery, multiple cyclo[Arg-Gly-Asp-(d-Phe)-Cys] (cRGD) peptide units on DNA origami were employed. The incorporation of disulfide bonds allowed the release of multiple modules in response to intracellular glutathione (GSH) in tumors. The nanodevice promoted the infiltration of CD8
Language	English
Publishing date	2024-04-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2024.04.069
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Article ; Online: Application of Hydromorphone and Ropivacaine in Ultrasound-Guided Brachial Plexus Block of Children.

Lin, Hui / Nie, Liang

Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses

2022 Volume 37, Issue 5, Page(s) 662–668

Abstract: Purpose: This research was designed to investigate the effects of hydromorphone combined with ropivacaine anesthesia on brachial plexus block of upper limbs in children.: Design: This was a randomized prospective study.: Methods: A total of 120 ... ...

Abstract	Purpose: This research was designed to investigate the effects of hydromorphone combined with ropivacaine anesthesia on brachial plexus block of upper limbs in children. Design: This was a randomized prospective study. Methods: A total of 120 children with upper limb fractures were included in this study and treated wtih open reduction and internal fixation (ORIF). The children were randomized into control group and research group. All of them were given a brachial plexus block and anesthetics (control group: 0.2% ropivacaine; research group: additional 5 μg/kg hydromorphone. Findings: The time of onset and exercise recovery of the research group increased, and the use times of analgesic drugs decreased, which were significantly different from those of the control group (all P<.05). Conclusions: Hydromorphone can enhance the effectiveness of ropivacaine in blocking the brachial plexus and reduce postoperative pain and the demand for analgesics. Strong postoperative sedation can improve sleep quality and nursing satisfaction.
MeSH term(s)	Analgesics ; Anesthetics, Local ; Brachial Plexus Block ; Child ; Humans ; Hydromorphone ; Prospective Studies ; Ropivacaine/therapeutic use ; Ultrasonography, Interventional
Chemical Substances	Analgesics ; Anesthetics, Local ; Ropivacaine (7IO5LYA57N) ; Hydromorphone (Q812464R06)
Language	English
Publishing date	2022-04-02
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	1329844-6
ISSN	1532-8473 ; 0883-9433 ; 1089-9472
ISSN (online)	1532-8473
ISSN	0883-9433 ; 1089-9472
DOI	10.1016/j.jopan.2021.11.013
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Article ; Online: Author Correction: Duality of the SVIL expression in bladder cancer and its correlation with immune infiltration.

Nie, Zhenyu / Guo, Na / Peng, Yanling / Gao, Yuanhui / Cao, Hui / Zhang, Shufang

Scientific reports

2024 Volume 14, Issue 1, Page(s) 2369

Language	English
Publishing date	2024-01-29
Publishing country	England
Document type	Published Erratum
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-52867-x
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Article ; Online: The Effects of Long-Term Walking Exercise on Structural Progression, Symptoms, and Extensor Muscle Strength in Patients with Mild or at High Risk of Knee Osteoarthritis: Data from the Osteoarthritis Initiative.

Zhang, Hui / Wang, Junqing / Shuai, Tao / Li, Kang / Nie, Yong

American journal of physical medicine & rehabilitation

2024

Abstract: Objective: To assess the relationship between walking exercise and medial joint space narrowing (JSN) progression, symptoms, and knee extensor muscle strength (EMS) in early knee osteoarthritis (OA) patients.: Methods: This nested cohort study within ...

Abstract	Objective: To assess the relationship between walking exercise and medial joint space narrowing (JSN) progression, symptoms, and knee extensor muscle strength (EMS) in early knee osteoarthritis (OA) patients. Methods: This nested cohort study within the Osteoarthritis Initiative included participants aged 50 and above with knee OA (Kellgren-Lawrence grades 0-2). Walking exercisers were identified using a modified Historical Physical Activity Survey Instrument. Differences in medial JSN, Knee Injury and Osteoarthritis Outcome Score (KOOS), and knee EMS were evaluated through the three-way ANOVA. Results: Among 896 participants, 83.4% reported walking exercise. Female walkers showed significant improvements in symptoms (KOOS-Pain: P < 0.001; KOOS-Symptom: P < 0.001; KOOS-Quality of Life (QOL): P < 0.001; KOOS-Function, Sports, and Recreational Activities (FSR): P = 0.007). Similar results were observed in male walkers (KOOS-Pain: P < 0.001; KOOS-Symptom: P < 0.001; KOOS- QOL: P = 0.001; KOOS- FSR: P = 0.009). Walkers showed significantly increased knee EMS at 24 months (Female: P < 0.001; Male: P = 0.003). Female non-walkers had significantly decreased knee EMS at 24 months (P < 0.001). Walkers showed significant improvement in medial JSN (OR = 1.1, 95% CI: 1.0 to 1.2) and KL grade (OR = 1.0, 95% CI: 1.0 to 1.1) compared to non-walkers. Conclusion: Walking exercise prevents structural progression and improves symptoms. Meanwhile, the increased knee EMS in all walkers further supports the validity of recommending walking exercises for early-stage knee OA patients.
Language	English
Publishing date	2024-01-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	219390-5
ISSN	1537-7385 ; 0002-9491 ; 0894-9115
ISSN (online)	1537-7385
ISSN	0002-9491 ; 0894-9115
DOI	10.1097/PHM.0000000000002403
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Article ; Online: Extra-abdominal infections caused by Comamonas kerstersii: Case report.

Wang, Mingxi / Wang, Hui / Chen, Shicheng / Ming, Desong / Nie, Qingbin

Medicine

2024 Volume 103, Issue 5, Page(s) e37161

Abstract: Rationale: Comamonas kerstersii mainly causes intra-abdominal infections with favorable outcomes due to high antibiotic susceptibility. We report the first case of pneumonia caused by C Kerstersii, which promoted patient death, and a second urinary ... ...

Abstract	Rationale: Comamonas kerstersii mainly causes intra-abdominal infections with favorable outcomes due to high antibiotic susceptibility. We report the first case of pneumonia caused by C Kerstersii, which promoted patient death, and a second urinary tract infection by C Kerstersii with extensive drug resistance. Patient concerns: A 46-year-old male (Case 1) with craniocerebral injury underwent emergency decompressive craniectomy, but his condition deteriorated further and presented with discontinuous fever, small moist rales on both lungs, and respiratory failure. Retrospective average nucleotide identity (ANI) analysis of the genomic sequence of the sputum isolate identified it as C Kerstersii 12322-1, antimicrobial susceptibility testing (AST) revealed that it was sensitive to 18 of 21 tested antibiotics.An 82-year-old male (Case 2) with hypertrophic prostate experienced gradual obstruction during urination, and a urine test revealed WBC ++. Retrospective ANI analysis of the urine isolate identified it as C Kerstersii 121606, which was resistant to 18 of 21 tested antibiotics. Diagnoses: Case 1 was diagnosed empirically as pneumonia caused by C Kerstersii strain 12322-1 secondary to craniocerebral injury and confirmed by retrospective ANI analysis; case 2 was diagnosed empirically as urinary infection secondary to prostate hyperplasia caused by C Kerstersii strain 121606 confirmed by the retrospective ANI analysis. Interventions: Case 1 was administered cefoxitin, cefodizime, imipenem-cilastatin sodium, and underwent comprehensive salvage management. Case 2 was administered doxycycline alone. Outcomes: Case 1 died partially because of untimely identification of the responsible bacteria-12322-1. Case 2 was cured even 121606 exhibited an extensive drug resistance feature. Lessons: Except for intra-abdominal infections with good prognosis, we verified that C Kerstersii could also cause extra-abdominal infections, such as the first pneumonia case and urinary infection. It could promote patient death; actual infections were underestimated due to identification difficulties, posing a health threat due to the presence of extensive drug resistance.
MeSH term(s)	Male ; Humans ; Middle Aged ; Aged, 80 and over ; Retrospective Studies ; Intraabdominal Infections/diagnosis ; Intraabdominal Infections/drug therapy ; Anti-Bacterial Agents/therapeutic use ; Urinary Tract Infections/drug therapy ; Pneumonia ; Craniocerebral Trauma ; Comamonas
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2024-02-02
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000037161
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