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Article ; Online: Intravenous Lipid Emulsion for treating Tramadol-Induced Seizures: Surprising but Worth Considering for Future Studies; a Letter to Editor.

Mégarbane, Bruno / Gouda, Ahmed S

Archives of academic emergency medicine

2022 Volume 10, Issue 1, Page(s) e14

Language	English
Publishing date	2022-02-09
Publishing country	Iran
Document type	Journal Article
ISSN	2645-4904
ISSN (online)	2645-4904
DOI	10.22037/aaem.v10i1.1541
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Article ; Online: Developing a rapid analytical method for simultaneous determination of apigenin and gallic acid: validation and application in a nanoliposomal formulation.

Gouda, Ahmed / Sakr, Omar S / Nasr, Maha / Sammour, Omaima A

Drug development and industrial pharmacy

2024 Volume 50, Issue 3, Page(s) 274–283

Abstract: Objective: Apigenin and gallic acid are natural compounds that are useful as antioxidant, anti-inflammatory and anticancer agents, especially when used together in combination. Therefore, the development and validation of a simultaneous method of ... ...

Abstract	Objective: Apigenin and gallic acid are natural compounds that are useful as antioxidant, anti-inflammatory and anticancer agents, especially when used together in combination. Therefore, the development and validation of a simultaneous method of analysis for both compounds in pure form and when encapsulated in an advanced delivery system such as liposomes would be useful. Methods: Analysis was performed using C18 column under isocratic conditions. The mobile phase was acetonitrile: water containing 0.2% orthophosphoric acid at a ratio of 67:33, flow rate 1 ml/min, and detection wavelength 334 nm for apigenin and 271 nm for gallic acid. Results: The assay method was linear at the concentration range (5-600 µg/mL) with R Conclusion: The described HPLC method was shown to be suitable, sensitive, and reproducible for the simultaneous identification and quantification of apigenin and gallic acid. The analytical results were accurate and precise, with good recovery, low limit of detection, and the chromatographic assay was accomplished in less than 3 min, suggesting the suitability of the method for routine analysis of both drugs in pharmaceutical formulations.
MeSH term(s)	Apigenin ; Gallic Acid ; Pharmaceutical Preparations ; Chromatography, High Pressure Liquid/methods
Chemical Substances	Apigenin (7V515PI7F6) ; Gallic Acid (632XD903SP) ; Pharmaceutical Preparations
Language	English
Publishing date	2024-02-28
Publishing country	England
Document type	Journal Article
ZDB-ID	751874-2
ISSN	1520-5762 ; 0363-9045
ISSN (online)	1520-5762
ISSN	0363-9045
DOI	10.1080/03639045.2024.2318386
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Article: Molecular Bases of Serotonin Reuptake Inhibitor Antidepressant-Attributed Effects in COVID-19: A New Insight on the Role of Bradykinins.

Gouda, Ahmed S / Mégarbane, Bruno

Journal of personalized medicine

2022 Volume 12, Issue 9

Abstract: Widely available effective drugs to treat coronavirus disease-2019 (COVID-19) are still limited. Various studies suggested the potential contribution of selective serotonin-reuptake inhibitor (SSRI) antidepressants to alleviate the clinical course of ... ...

Abstract	Widely available effective drugs to treat coronavirus disease-2019 (COVID-19) are still limited. Various studies suggested the potential contribution of selective serotonin-reuptake inhibitor (SSRI) antidepressants to alleviate the clinical course of COVID-19. Initially, SSRI antidepressant-attributed anti-COVID-19 activity was attributed to their direct agonistic or indirect serotonin-mediated stimulation of sigma-1 receptors (Sig1-R). Thereafter, attention was drawn to the property of SSRI antidepressants to decrease ceramide production, as functional inhibitors of acid sphingomyelinase. Ceramides are cell membrane waxy lipids formed by sphingosine and a fatty acid, playing a major role in receptor signaling and infection. In COVID-19 patients, ceramide production is increased due to acid sphingomyelinase activation. Here, we aimed to review the relationships between bradykinins and the proposed pathways supporting SSRI antidepressant-attributed effectiveness in COVID-19. In COVID-19 patients, bradykinin receptor-B1 stimulation is enhanced following the downregulation of angiotensin-converting enzyme-2, which is responsible for the inactivation of des-Arg9-bradykinin, a bradykinin metabolite, contrasting with the decrease in bradykinin receptor-B2 (BDKRB2) stimulation, which results from the inhibition of cathepsin L, a kininogenase involved in bradykinin production and present at the infection site. Sig1-R stimulation modulates the inflammatory response by regulating cytokine production and counterbalances COVID-19-attributed BDKRB2 inhibition by potentiating its effects on the cytosolic calcium concentration. Moreover, the beneficial effects obtained with acid sphingomyelinase inhibition are parallel to those expected with BDKRB2 stimulation in COVID-19. Altogether, these findings suggest that one ultimate pathway of SSRI antidepressant-attributed anti-COVID-19 activity is the potentiation of BDKRB2 effects shown to be inhibited in COVID-19. In conclusion, SSRI antidepressants are able to interact positively with the pathophysiological mechanisms involved in COVID-19. However, their exact benefits in preventing morbidities or improving the outcome in COVID-19 patients remain unknown.
Language	English
Publishing date	2022-09-11
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm12091487
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Article ; Online: ZnO@ activated carbon derived from wood sawdust as adsorbent for removal of methyl red and methyl orange from aqueous solutions.

Sayed, Nessma S M / Ahmed, Abdelaal S A / Abdallah, Mohamed H / Gouda, Gamal A

Scientific reports

2024 Volume 14, Issue 1, Page(s) 5384

Abstract: Activated carbon (AC) and ZnO@AC composite derived from wood sawdust were prepared to be utilized as adsorbents for methyl red (MR) and methyl orange (MO) anionic dyes from the aqueous solutions. The maximum adsorption capacity of the AC and ZnO@AC ... ...

Abstract	Activated carbon (AC) and ZnO@AC composite derived from wood sawdust were prepared to be utilized as adsorbents for methyl red (MR) and methyl orange (MO) anionic dyes from the aqueous solutions. The maximum adsorption capacity of the AC and ZnO@AC composite toward both dyes was achieved in the strong acidic medium (pH = 3), and under stirring for 60 min. The kinetic studies revealed that the adsorption of MR and MO dyes onto the AC and ZnO@AC composite fitted well with the pseudo-second-order model. Furthermore, the intraparticle diffusion and Elovich kinetic models confirmed the adsorption is controlled by external surfaces, and the adsorption is chemisorption process. The isotherm results indicated that the MR and MO dye adsorption occurred via monolayer adsorption, and the estimated maximum adsorption capacities of both dyes onto the ZnO@AC composite were higher than those achieved by AC. Thermodynamic analysis suggested that the adsorption is endothermic and spontaneous. The mechanism for MR, and MO dyes adsorption onto the AC and ZnO@AC composite is proposed to be controlled by electrostatic bonding, π-π interactions, and ion exchange, while H-bonding and n-π interactions were minor contributors. This study reveals the potential use of carbon-based adsorbents derived from wood sawdust for the removal of anionic dyes from wastewater.
Language	English
Publishing date	2024-03-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-55158-7
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Article: Comparing the Efficacy of Local Corticosteroid Injection, Platelet-Rich Plasma, and Extracorporeal Shockwave Therapy in the Treatment of Pes Anserine Bursitis: A Prospective, Randomized, Comparative Study.

Gouda, Wesam / Abbas, Awad S / Abdel-Aziz, Tarek M / Shoaeir, Mohamed Z / Ahmed, Walid / Moshrif, Abdelhfeez / Mosallam, Ahmed / Kamal, Mohamed

Advances in orthopedics

2023 Volume 2023, Page(s) 5545520

Abstract: Background: Pes anserine bursitis (PAB) is one of the most common causes of painful knee syndromes. This study aimed at examining the efficacy of local corticosteroid injection, platelet-rich plasma (PRP) injection, and extracorporeal shock wave therapy ...

Abstract	Background: Pes anserine bursitis (PAB) is one of the most common causes of painful knee syndromes. This study aimed at examining the efficacy of local corticosteroid injection, platelet-rich plasma (PRP) injection, and extracorporeal shock wave therapy (ESWT) as different modalities to alleviate pain and enhance function in patients with pes anserine bursitis (PAB). Methods: A prospective, randomized, comparative study was conducted on 180 patients diagnosed with chronic PAB. They were equally divided into three groups as follows: Group I received a local corticosteroid injection of 40 mg of methylprednisolone acetate/1 ml; Group II received a PRP injection; and in Group III, ESWT was used. Outcome measures included the visual analog scale (VAS), Western Ontario and McMaster Universities (WOMAC) pain score, WOMAC physical function score, and Ritchie articular index (RAI) for tenderness, which were recorded at the baseline, after 1 week, and after 8 weeks. Results: Before the application of procedures, there was a statistically significant increase in the WOMAC pain score in the local corticosteroid group compared to the PRP group and the ESWT group ( Conclusion: Our data suggest that in patients with PAB, local corticosteroid injection is more efficient than PRP injection and ESWT for reducing pain and enhancing function.
Language	English
Publishing date	2023-09-30
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2621436-2
ISSN	2090-3472 ; 2090-3464
ISSN (online)	2090-3472
ISSN	2090-3464
DOI	10.1155/2023/5545520
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Article ; Online: Snake venom-derived bradykinin-potentiating peptides: A promising therapy for COVID-19?

Gouda, Ahmed S / Mégarbane, Bruno

Drug development research

2020 Volume 82, Issue 1, Page(s) 38–48

Abstract: The severe acute respiratory syndrome coronavirus-2 (SARS-COV-2), a novel coronavirus responsible for the recent infectious pandemic, is known to downregulate angiotensin-converting enzyme-2 (ACE2). Most current investigations focused on SARS-COV-2- ... ...

Abstract	The severe acute respiratory syndrome coronavirus-2 (SARS-COV-2), a novel coronavirus responsible for the recent infectious pandemic, is known to downregulate angiotensin-converting enzyme-2 (ACE2). Most current investigations focused on SARS-COV-2-related effects on the renin-angiotensin system and especially the resultant increase in angiotensin II, neglecting its effects on the kinin-kallikrein system. SARS-COV-2-induced ACE2 inhibition leads to the augmentation of bradykinin 1-receptor effects, as ACE2 inactivates des-Arg9-bradykinin, a bradykinin metabolite. SARS-COV-2 also decreases bradykinin 2-receptor effects as it affects bradykinin synthesis by inhibiting cathepsin L, a kininogenase present at the site of infection and involved in bradykinin production. The physiologies of both the renin-angiotensin and kinin-kallikrein system are functionally related suggesting that any intervention aiming to treat SARS-COV-2-infected patients by triggering one system but ignoring the other may not be adequately effective. Interestingly, the snake-derived bradykinin-potentiating peptide (BPP-10c) acts on both systems. BPP-10c strongly decreases angiotensin II by inhibiting ACE, increasing bradykinin-related effects on the bradykinin 2-receptor and increasing nitric oxide-mediated effects. Based on a narrative review of the literature, we suggest that BPP-10c could be an optimally effective option to consider when aiming at developing an anti-SARS-COV-2 drug.
MeSH term(s)	Angiotensin-Converting Enzyme 2/antagonists & inhibitors ; Angiotensin-Converting Enzyme 2/metabolism ; Animals ; Bradykinin/administration & dosage ; Bradykinin/metabolism ; COVID-19/drug therapy ; COVID-19/metabolism ; Humans ; Peptide Fragments/administration & dosage ; Peptide Fragments/metabolism ; Renin-Angiotensin System/drug effects ; Renin-Angiotensin System/physiology ; Snake Venoms/administration & dosage ; Snake Venoms/metabolism
Chemical Substances	Peptide Fragments ; Snake Venoms ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; Bradykinin (S8TIM42R2W)
Keywords	covid19
Language	English
Publishing date	2020-08-05
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	604587-x
ISSN	1098-2299 ; 0272-4391
ISSN (online)	1098-2299
ISSN	0272-4391
DOI	10.1002/ddr.21732
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Article ; Online: Outcome of intraocular lens exchange for the management of myopic shift in pseudophakic children.

Zedan, Rasha / Farag, Christina S / Gouda, Jylan / Awadein, Ahmed / Elhilali, Hala / Hassanein, Dina H

European journal of ophthalmology

2023 , Page(s) 11206721231218299

Abstract: Purpose: To evaluate the visual outcome of intraocular lens (IOL) exchange for the management of myopic shift in pseudophakic children.: Methods: The medical records of children who underwent IOL exchange for myopic shift were examined. The ... ...

Abstract	Purpose: To evaluate the visual outcome of intraocular lens (IOL) exchange for the management of myopic shift in pseudophakic children. Methods: The medical records of children who underwent IOL exchange for myopic shift were examined. The preoperative data, operative details and the postoperative outcome were analyzed. Results: Twenty-one eyes (16 patients) were identified. Mean age at cataract extraction was 20 ± 26 months (range, 2-84 months). Twelve patients (6 unilateral, 6 bilateral) had primary IOL implantation. Mean age at IOL exchange was 7.3 ± 3.2 years. Mean spherical equivalent (SE) at IOL exchange was -14 ± 5 D (range, -7 to -21 D): Mean SE at IOL exchange was -13.64 Conclusions: IOL exchange is a safe procedure that should be considered to improve visual rehabilitation in pseudophakic patients with myopic shift.
Language	English
Publishing date	2023-12-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	1089461-5
ISSN	1724-6016 ; 1120-6721
ISSN (online)	1724-6016
ISSN	1120-6721
DOI	10.1177/11206721231218299
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Zs.A 3342: Show issues

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Article ; Online: Bee venom as an alternative for antibiotics against Staphylococcus aureus infections.

Sameh, Ahmed / Gouda, Amr A / Elmligy, Esraa / Hatem, Hossam / Sadek, Salma S / Ahmed, Osama / El Amir, Azza

Scientific reports

2023 Volume 13, Issue 1, Page(s) 6436

Abstract: The misuse of antibiotics has led to antibiotic-resistant bacterial strains, making it even harder to combat and eliminate their infections. Staphylococcus aureus causes various adverse infections and diseases, including skin abscesses, bloodstream ... ...

Abstract	The misuse of antibiotics has led to antibiotic-resistant bacterial strains, making it even harder to combat and eliminate their infections. Staphylococcus aureus causes various adverse infections and diseases, including skin abscesses, bloodstream infections, pneumonia, and joint infections. In this study, we aimed to test the cytotoxic and antibacterial effects of bee venom-loaded chitosan nanoparticles (BV-loaded CS-NPs) in comparison to gamma-irradiated BV and native BV from Apis mellifera. The physiochemical characterizations of our treatments were determined by Fourier Transform Infrared Spectroscopy (FTIR), Transmission Electron Microscope (TEM), zeta-potential, release rate, and Encapsulation Efficiency (EE). Our study was conducted on both levels, in-vitro and in-vivo. For the in-vitro study, a bacterial model of Staphylococcus aureus with an ATCC number of 6538 was grown in tryptic soy agar (TSA) medium, and the inhibition zones of our drug candidates were measured with the appropriate statistical analysis performed. For the in-vivo study, levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), Creatinine, Urea, and interleukin 6 (IL-6) were analyzed. BV-loaded CS-NPs showed relatively better results than the other alternatives, which are native BV and gamma-irradiated BV. The results showed that the antibacterial effect of BV-loaded CS-NPs was greater than the alternatives. Furthermore, its cytotoxic effect was far less than the native and irradiated bee venom. These outcomes ensure that loading BV on CS-NPs makes it a promising drug candidate for an antibiotic alternative with minimal cytotoxicity and enhanced antibacterial activity.
MeSH term(s)	Bees ; Animals ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Staphylococcus aureus ; Bee Venoms/pharmacology ; Staphylococcal Infections/drug therapy ; Nanoparticles/chemistry ; Antineoplastic Agents/pharmacology ; Chitosan/pharmacology ; Chitosan/chemistry
Chemical Substances	Anti-Bacterial Agents ; Bee Venoms ; Antineoplastic Agents ; Chitosan (9012-76-4)
Language	English
Publishing date	2023-04-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-33536-x
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Article ; Online: Radiation attenuation properties of chemically prepared MgO nanoparticles/HDPE composites.

El-Khatib, Ahmed M / Gouda, Mona M / Fouad, Mohamed S / Abd-Elzaher, Mohamed / Ramadan, Wegdan

Scientific reports

2023 Volume 13, Issue 1, Page(s) 9945

Abstract: Sheets of high-density polyethylene (HDPE) loaded with magnesium oxide in micro and nano were synthesized with different weight percentages of micro-MgO (0,5,10,20 and 30% by weight) and nano-MgO (5 and 30%) and shaped in form of disc and dog bone shape. ...

Abstract	Sheets of high-density polyethylene (HDPE) loaded with magnesium oxide in micro and nano were synthesized with different weight percentages of micro-MgO (0,5,10,20 and 30% by weight) and nano-MgO (5 and 30%) and shaped in form of disc and dog bone shape. The morphological, mechanical, and attenuation characteristics of each concentration were determined. The linear attenuation coefficients (LAC) of the prepared discs were calculated using a well-calibrated scintillation detector and five standard gamma-ray point sources (
Language	English
Publishing date	2023-06-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-37088-y
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Article ; Online: Ecofriendly stability-indicating UHPLC-PDA method for determination of the new influenza antiviral prodrug Baloxavir marboxil; application to degradation kinetic studies and structure elucidation of the major degradation products using LC-MS

Gouda, Amira S. / Marzouk, Hoda M. / Rezk, Mamdouh R. / Abdel-Megied, Ahmed M.

Sustainable Chemistry and Pharmacy. 2023, p.101093-

2023 , Page(s) 101093–

Abstract: Implementation of green chemistry principles in analytical procedures is of great importance. Green analytical chemistry minimizes the dangerous impact on human beings and the environment that is the primary objective nowadays. In the proposed work, a ... ...

Abstract	Implementation of green chemistry principles in analytical procedures is of great importance. Green analytical chemistry minimizes the dangerous impact on human beings and the environment that is the primary objective nowadays. In the proposed work, a well-developed, fully validated and ecofriendly stability indicating UHPLC coupled with photodiode array detector (PDA) method was established for the determination of Baloxavir Marboxil (BXM), a novel antiviral drug for the treatment of influenza A and B, in raw materials and pharmaceutical formulations. The method employed Inertsil ODS-3 C₁₈ column to separate BXM from its forced degradation products using a mobile phase composed of 0.1% citric acid (pH 2.5 ± 0.05)-methanol (50:50, v/v), at a flow rate of 0.8 mL/min in an isocratic separation mode. BXM was monitored using diode array detector at 260.0 nm. BXM stability was inspected using various stress conditions as per ICH recommendations. The impact of acid, base hydrolysis, and oxidative stress conditions was greater on BXM in comparison to photo and thermal hydrolysis. The formed degradation products were injected into the mass spectrometer (MS) to elucidate their structures. The suggested pathways for degradation mechanisms were presented. Moreover, the proposed method was effectively utilized to study the degradation kinetics of acid, base and oxidative degradation of BXM. Additionally, four assessment tools were employed to evaluate the greenness of the developed method, namely; the National Environmental Method Index, the Analytical Eco-scale, Green Analytical Procedure tool, and the Analytical Greenness metric. Moreover, a comparative study of the method's greenness was conducted with the reported HPLC method and the results confirming that the suggested method is superior regarding the guidelines and principles of green chemistry. In addition to, having higher qualitative and quantitative scores in comparison to the reported method, and providing reliable and precise results of the method greenness.
Keywords	analytical chemistry ; antiviral agents ; citric acid ; comparative study ; diodes ; green chemistry ; influenza ; oxidative stress ; pH ; spectrometers ; thermal hydrolysis ; Baloxavir marboxil ; UHPLC-PDA ; Mass spectrometry ; Greenness assessment ; Kinetic study
Language	English
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Pre-press version
ISSN	2352-5541
DOI	10.1016/j.scp.2023.101093
Database	NAL-Catalogue (AGRICOLA)

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