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  1. Article ; Online: Tonsillectomy for recurrent tonsillitis: the NATTINA trial.

    Jones, Christopher R / Guy, Rebecca L / Mirfenderesky, Mariyam / Brown, Colin S / Lamagni, Theresa

    Lancet (London, England)

    2024  Volume 403, Issue 10437, Page(s) 1632

    MeSH term(s) Humans ; Tonsillitis/surgery ; Tonsillectomy ; Recurrence ; Child ; Treatment Outcome
    Language English
    Publishing date 2024-04-10
    Publishing country England
    Document type Journal Article ; Letter
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(24)00191-0
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    Ua VI Zs.5: Show issues Location:
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  2. Article ; Online: Community-acquired Staphylococcus aureus bacteraemia among people who inject drugs: a national cohort study in England, 2017-2020.

    McGuire, Emma / Collin, Simon M / Brown, Colin S / Saito, Makoto

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2024  

    Abstract: Background: People who inject drugs (PWID) are at increased risk of community-acquired Staphylococcus aureus bacteraemia (CA-SAB), but little is known about clinical outcomes of CA-SAB in PWID compared with the wider population of patients with CA-SAB.!# ...

    Abstract Background: People who inject drugs (PWID) are at increased risk of community-acquired Staphylococcus aureus bacteraemia (CA-SAB), but little is known about clinical outcomes of CA-SAB in PWID compared with the wider population of patients with CA-SAB.
    Methods: Three national datasets were linked to provide clinical and mortality data on patients hospitalised with CA-SAB in England between 1 January 2017 and 31 December 2020. PWID were identified using the ICD-10 code for "mental health and behavioural disorder due to opioid use" (F11). Multivariable logistic regression was used to estimate adjusted odds ratios (aORs) for associations of PWID with 30-day all-cause mortality and 90-day hospital readmission.
    Results: In 10,045 cases of CA-SAB, 1,612 (16.0%) were PWID. Overall, 796 (7.9%) patients died within 30 days of CA-SAB admission and 1,189 (11.8%) patients were readmitted to hospital within 90 days of CA-SAB. In those without infective endocarditis there was strong evidence of lower odds of mortality among PWID compared with non-PWID (aOR: 0.47, 95% confidence interval, CI: 0.33-0.68, p < 0.001) whereas there was no association in CA-SAB case fatality with endocarditis (aOR 1.40, CI 0.87-2.25, p = 0.163). PWID were less likely to be re-admitted within 90 days of CA-SAB (aOR 0.79, CI 0.65-0.95, p = 0.011).
    Conclusions: In this large cohort study of patients with CA-SAB in England, PWID had lower odds of death in the absence of endocarditis and lower odds of re-admission within 90 days compared to non-PWID patients. This study highlights the over-representation of PWID among patients with CA-SAB nationally.
    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciae056
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    Zs.MO 480: Show issues

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  3. Article ; Online: Improving maternal outcomes through early recognition, rapid notification, and investigation of invasive GAS infection.

    Lamagni, Theresa / Guy, Rebecca L / Sriskandan, Shiranee / Decraene, Valérie / Brown, Colin S

    The Lancet. Microbe

    2023  Volume 4, Issue 10, Page(s) e766

    Language English
    Publishing date 2023-06-28
    Publishing country England
    Document type Letter
    ISSN 2666-5247
    ISSN (online) 2666-5247
    DOI 10.1016/S2666-5247(23)00186-6
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  4. Article ; Online: 24-Year-Old Patient with Klippel-Trenaunay Syndrome Underwent Cementless Robotic Cruciate-Retaining TKA: A Case Report.

    Reading, Landon / Brown, Colin / Pasqualini, Ignacio / Huffman, Nickelas / Piuzzi, Nicolas S

    JBJS case connector

    2024  Volume 14, Issue 2

    Abstract: Case: A 24-year-old man with Klippel-Trenaunay syndrome (KTS) presented with severe knee osteoarthritis unresponsive to conservative measures. Owing to end-stage, debilitating arthritic symptoms, surgery was pursued. Careful preoperative, ... ...

    Abstract Case: A 24-year-old man with Klippel-Trenaunay syndrome (KTS) presented with severe knee osteoarthritis unresponsive to conservative measures. Owing to end-stage, debilitating arthritic symptoms, surgery was pursued. Careful preoperative, multidisciplinary planning/treatment included magnetic resonance imaging to characterize the venous malformations throughout the right lower extremity, preoperative sclerotherapy, sirolimus, and robotic-assisted cementless total knee arthroplasty (TKA).
    Conclusion: Cementless robotic-assisted TKA with selective patellar resurfacing can be a viable option for young KTS patients with severe osteoarthritis when a meticulous multidisciplinary approach, including sclerotherapy and advanced imaging, is undertaken to analyze vascular abnormalities, minimize surgical risks, preserve bone stock, and optimize outcomes.
    MeSH term(s) Male ; Humans ; Young Adult ; Adult ; Klippel-Trenaunay-Weber Syndrome/complications ; Arthroplasty, Replacement, Knee ; Robotic Surgical Procedures ; Leg ; Osteoarthritis, Knee
    Language English
    Publishing date 2024-04-12
    Publishing country United States
    Document type Case Reports ; Journal Article
    ISSN 2160-3251
    ISSN (online) 2160-3251
    DOI e23.00560
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  5. Article ; Online: Significance of Organic Anion Transporter 2 and Organic Cation Transporter 2 in Creatinine Clearance: Mechanistic Evaluation Using Freshly Prepared Human Primary Renal Proximal Tubule Cells.

    Mathialagan, Sumathy / Chung, Git / Pye, Keith / Rodrigues, A David / Varma, Manthena V S / Brown, Colin

    The Journal of pharmacology and experimental therapeutics

    2024  Volume 388, Issue 1, Page(s) 201–208

    Abstract: Creatinine, a clinical marker for kidney function, is predominantly cleared by glomerular filtration, with active tubular secretion contributing to about 30% of its renal clearance. Recent studies suggested the potential involvement of organic anion ... ...

    Abstract Creatinine, a clinical marker for kidney function, is predominantly cleared by glomerular filtration, with active tubular secretion contributing to about 30% of its renal clearance. Recent studies suggested the potential involvement of organic anion transporter (OAT)2, in addition to the previously known organic cation transporter (OCT)2-mediated basolateral uptake, in creatinine active secretion. Here we characterized the transport mechanisms of creatinine using transfected human embryonic kidney (HEK)293 cells and freshly prepared human primary renal proximal tubule epithelial cells (hPTCs). Creatinine showed transport by OAT2 in transfected HEK293 cells. In addition, both creatinine and metformin showed transport by OCT2 and multidrug and toxin extrusion pump (MATE)1 and MATE2K, while penciclovir was selective for OAT2. Time-dependent cell accumulation was observed for creatinine and metformin in hPTCs. Their accumulation was increased by pyrimethamine but inhibited by decynium-22, likely due to differential inhibition of OCT2 versus MATEs. Additionally, indomethacin (an OAT2 inhibitor) reduced penciclovir uptake (∼75%) in hPTCs illustrating functional OAT2 activity. However, no modulation of creatinine and metformin cell accumulation was apparent with indomethacin. Creatinine transport characteristics in the presence of inhibitors approached those of metformin, an OCT2/MATE substrate, but were distinct from those of penciclovir, an OAT2-selective substrate. Moreover, indomethacin showed no significant effect on the basolateral-to-apical transport and net secretion of creatinine across hPTC monolayers. Collectively, the functional studies suggest OCT2 as the primary basolateral uptake mechanism and that OAT2 has a minimal role, in creatinine renal secretion. Our results highlight the utility of hPTCs to enable the functional assessment of renal transport mechanisms. SIGNIFICANCE STATEMENT: Our results obtained with primary hPTCs indicate that OCT2/MATE (vs. OAT2) play a major role in the active renal secretion of creatinine. Quantitative pharmacokinetic models should therefore focus on OCT2/MATE when describing serum creatinine and creatinine clearance modulation by inhibitor drugs and genotype- or disease-related activity changes. The present study highlights the utility of freshly isolated hPTCs to support solute carrier phenotyping to enable the functional assessment of renal transport mechanisms.
    MeSH term(s) Humans ; Organic Cation Transporter 2 ; Creatinine ; Organic Cation Transport Proteins ; HEK293 Cells ; Kidney ; Metformin/pharmacology ; Indomethacin ; Organic Anion Transporters
    Chemical Substances Organic Cation Transporter 2 ; Creatinine (AYI8EX34EU) ; Organic Cation Transport Proteins ; Metformin (9100L32L2N) ; Indomethacin (XXE1CET956) ; Organic Anion Transporters
    Language English
    Publishing date 2024-01-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3106-9
    ISSN 1521-0103 ; 0022-3565
    ISSN (online) 1521-0103
    ISSN 0022-3565
    DOI 10.1124/jpet.123.001890
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    Uf I Zs.40: Show issues Location:
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  6. Article ; Online: Evaluating the Impact of Intravenous Fluid Resuscitation on Survival for the Management of Patients With Ebola Virus Disease.

    Jacob, Shevin T / Brown, Colin S

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2019  Volume 70, Issue 6, Page(s) 1048–1049

    MeSH term(s) Administration, Intravenous ; Fluid Therapy ; Hemorrhagic Fever, Ebola/therapy ; Humans ; Resuscitation ; Retrospective Studies
    Language English
    Publishing date 2019-05-02
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciz349
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    Zs.A 1505: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MO 480: Show issues

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  7. Article ; Online: Paediatric group A streptococcal disease in England from October to December, 2022.

    Ladhani, Shamez N / Guy, Rebecca / Bhopal, Sunil S / Brown, Colin S / Lamagni, Theresa / Sharp, Ashley

    The Lancet. Child & adolescent health

    2022  Volume 7, Issue 2, Page(s) e2–e4

    MeSH term(s) Child ; Humans ; England/epidemiology ; Streptococcal Infections/epidemiology ; Streptococcus pyogenes
    Language English
    Publishing date 2022-12-22
    Publishing country England
    Document type Letter
    ISSN 2352-4650
    ISSN (online) 2352-4650
    DOI 10.1016/S2352-4642(22)00374-1
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  8. Article ; Online: The impact of COVID-19 national restrictions on dental antibiotic dispensing trends and treatment activity in England: January 2016 to July 2021.

    Falola, Angela / Demirjian, Alicia / Thompson, Wendy / Brown, Colin S / Gerver, Sarah / Bou-Antoun, Sabine

    JAC-antimicrobial resistance

    2023  Volume 5, Issue 4, Page(s) dlad081

    Abstract: Introduction: Reducing inappropriate antibiotic prescribing tempers the growing threat of antimicrobial resistance. We aimed to quantify the associated impact of COVID-19-related national restrictions in England on dental antibiotic dispensing and ... ...

    Abstract Introduction: Reducing inappropriate antibiotic prescribing tempers the growing threat of antimicrobial resistance. We aimed to quantify the associated impact of COVID-19-related national restrictions in England on dental antibiotic dispensing and describe changes in appointments and modes of delivery of care.
    Methods: Interrupted time series analyses were completed using NHS Business Service Authority (NHSBSA) ePACT2 data to measure the associated change in antibiotic dispensing in England following COVID-19-related restrictions (which began March 2020). For face-to-face dental consultations, NHS dental treatment plan (FP17) data were used. For remote consultations during the COVID-19 period, NHSBSA Compass system remote management data were used.
    Results: Between January 2016 and February 2020, there was a decreasing trend in antibiotic dispensing (-0.02 per 1000 population per month,
    Conclusions: Dental antibiotic prescribing significantly increased with the national COVID-19 restrictions when service delivery was altered with the closure of dental practices and introduction of remote consultations. Teledentistry was likely associated with inappropriate antibiotic prescribing. Continued antimicrobial stewardship and prudent use of antibiotics in dentistry is important.
    Language English
    Publishing date 2023-07-17
    Publishing country England
    Document type Journal Article
    ISSN 2632-1823
    ISSN (online) 2632-1823
    DOI 10.1093/jacamr/dlad081
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  9. Article ; Online: National Public Health Response to

    Brown, Colin S / Guy, Rebecca

    Journal of fungi (Basel, Switzerland)

    2019  Volume 5, Issue 4

    Abstract: This paper highlights the key steps undertaken by a national public health agency, working in close collaboration with academic partners and experienced healthcare professionals, in developing a response to the rapid emergence of a novel nosocomial ... ...

    Abstract This paper highlights the key steps undertaken by a national public health agency, working in close collaboration with academic partners and experienced healthcare professionals, in developing a response to the rapid emergence of a novel nosocomial pathogen. It details the key activities in national incident management team formation, surveillance activities, epidemiological investigations, laboratory developments, scientific advances, and collaborative activities. It discusses commonalities that can be adapted for dealing with the emergence of future new pathogens.
    Language English
    Publishing date 2019-10-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof5040093
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  10. Article ; Online: IS

    Wan, Yu / Sabnis, Akshay / Mumin, Zaynab / Potterill, Isabelle / Jauneikaite, Elita / Brown, Colin S / Ellington, Matthew J / Edwards, Andrew / Sriskandan, Shiranee

    Microbial genomics

    2023  Volume 9, Issue 9

    Abstract: Nitrofurantoin is a broad-spectrum first-line antimicrobial used for managing uncomplicated urinary tract infection (UTI). Loss-of-function mutations in chromosomal ... ...

    Abstract Nitrofurantoin is a broad-spectrum first-line antimicrobial used for managing uncomplicated urinary tract infection (UTI). Loss-of-function mutations in chromosomal genes
    MeSH term(s) Nitrofurantoin ; Escherichia coli ; Mutation ; Nitroreductases ; Oxygen
    Chemical Substances Nitrofurantoin (927AH8112L) ; Nitroreductases (EC 1.7.-) ; Oxygen (S88TT14065)
    Language English
    Publishing date 2023-10-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2835258-0
    ISSN 2057-5858 ; 2057-5858
    ISSN (online) 2057-5858
    ISSN 2057-5858
    DOI 10.1099/mgen.0.001102
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