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  1. Book ; Online: Appearance, Discrimination and the Media

    Johanssen, Jacob / Janciute, Laima / Garrisi, Diana

    2018  

    Abstract: The portrayal of disfigurement in the UK media must change. This policy brief is based on recent research that found a general negative and sensationalised attitude towards disfigurement in the media.Disfigurement is a condition that can affect anyone at ...

    Abstract The portrayal of disfigurement in the UK media must change. This policy brief is based on recent research that found a general negative and sensationalised attitude towards disfigurement in the media.Disfigurement is a condition that can affect anyone at any time in life regardless their social or demographic background due to accidents or health conditions or be congenital. In the UK, one in 111 people have facial disfigurements.In order to improve the ways in which media portray disfigurement, this policy brief argues that media should move away from sensationalised coverage on disfigurement and focus instead on the lived experiences of individuals with this condition. It recommends strengthening diversity-oriented editorial practices and training as well as media literacy education. In addition, it addresses the lack of guidelines on the portrayal of disfigurement and urges regulatory bodies to be more efficient in handling complaints
    Keywords Biology (General) ; Law in general. Comparative and uniform law. Jurisprudence ; Communication. Mass media ; Social sciences (General)
    Size 1 electronic resource (28 p.)
    Publisher University of Westminster Press
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020101516
    ISBN 9781912656233 ; 9781912656240 ; 9781912656257 ; 191265623X ; 1912656248 ; 1912656256
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Social Media and Coronavirus: Paranoid-Schizoid Technology and Pandemic?

    Johanssen, Jacob

    Hu Arenas

    Abstract: This article draws on the psychoanalyst Melanie Klein’s ‘paranoid-schizoid position’ to discuss some exemplary social media posts about the coronavirus. I argue that posts often express experiences, thoughts, and fantasies in a schematic manner. They ... ...

    Abstract This article draws on the psychoanalyst Melanie Klein’s ‘paranoid-schizoid position’ to discuss some exemplary social media posts about the coronavirus. I argue that posts often express experiences, thoughts, and fantasies in a schematic manner. They reproduce a paranoid-schizoid logic by which particular views on the current crisis are articulated and different ones are negated. The Kleinian framework is supplemented with Lacan’s notion of the Discourse of the Hysteric. I argue that the examples discussed in this article are instances of hysteric modes of relating to an Other (e.g. the expert) that is allegedly withholding important information from the subject. Splitting is amplified by the technological functioning of social media themselves which split users along a paranoid-schizoid dynamic for purposes of surveillance, advertising and profit maximization. I conclude by outlining steps towards the Kleinian ‘depressive position’ both in relation to how we engage with COVID-19 and social media. The depressive position acknowledges both good and bad aspects of a given situation. I further show how it can be supplemented via the Lacanian Discourse of the Analyst which includes a commitment to the limits of knowledge, certainty, and prediction.
    Keywords covid19
    Publisher PMC
    Document type Article ; Online
    DOI 10.1007/s42087-020-00162-2
    Database COVID19

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  4. Article ; Online: Social Media and Coronavirus

    Johanssen, Jacob

    Paranoid-Schizoid Technology and Pandemic?

    2020  

    Abstract: This article draws on the psychoanalyst Melanie Klein’s ‘paranoid-schizoid position’ to discuss some exemplary social media posts about the Coronavirus. I argue that posts often express experiences, thoughts and fantasies in a schematic manner. They ... ...

    Abstract This article draws on the psychoanalyst Melanie Klein’s ‘paranoid-schizoid position’ to discuss some exemplary social media posts about the Coronavirus. I argue that posts often express experiences, thoughts and fantasies in a schematic manner. They reproduce a paranoid-schizoid logic by which particular views on the current crisis are articulated and different ones are negated. The Kleinian framework is supplemented with Lacan’s notion of the Discourse of the Hysteric. I argue that the examples discussed in this article are instances of hysteric modes of relating to an Other (e.g. the expert) that is allegedly withholding important information from the subject. Splitting is amplified by the technological functioning of social media themselves which split users along a paranoid-schizoid dynamic for purposes of surveillance, advertising and profit maximization. I conclude by outlining steps towards the Kleinian ‘depressive position’ both in relation to how we engage with COVID-19 and social media. The depressive position acknowledges both good and bad aspects of a given situation. I further show how it can be supplemented via the Lacanian Discourse of the Analyst which includes a commitment to the limits of knowledge, certainty and prediction.
    Keywords 070 News media ; journalism & publishing ; covid19
    Subject code 070
    Language English
    Publishing date 2020-11-07
    Publishing country uk
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Media and the Skin.

    Johanssen, Jacob / Garrisi, Diana

    Skinmed

    2018  Volume 16, Issue 1, Page(s) 11–12

    MeSH term(s) Face/abnormalities ; Facial Dermatoses ; Humans ; Motion Pictures/standards ; Social Media/standards ; Social Perception ; Stereotyping
    Language English
    Publishing date 2018-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171125-2
    ISSN 1540-9740
    ISSN 1540-9740
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book: Festskrift til [Professor Dr. juris] Carl Jacob Arnholm fra de juridiske studenter ved Universitetet i Oslo

    Arnholm, Carl Jacob / Kristen-Johanssen jr., Erik / Thune, Sverre / Verfling, Gunnar

    1959  

    Institution Universitetet i Oslo
    Author's details Redaksjon: Erik Kristen-Johanssen jr.; Sverre Thune; Gunnar Verfling
    Language Undetermined
    Size 194 S, Ill
    Publisher Universitetsforlaget
    Publishing place Oslo
    Document type Book
    Note mit Bildn. Arnholms
    Database ECONomics Information System

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  7. Article ; Online: Age of thawed plasma does not affect clinical outcomes or biomarker expression in patients receiving prehospital thawed plasma: a PAMPer secondary analysis.

    Reitz, Katherine M / Gruen, Danielle S / Guyette, Frances / Brown, Joshua B / Yazer, Mark H / Vodovotz, Yoram / Johanssen, Pär I / Stensballe, Jakob / Daley, Brian / Miller, Richard S / Harbrecht, Brian G / Claridge, Jeffrey / Phelan, Herb A / Neal, Matthew D / Zuckerbraun, Brian S / Sperry, Jason L

    Trauma surgery & acute care open

    2021  Volume 6, Issue 1, Page(s) e000648

    Abstract: Background: Prehospital plasma administration during air medical transport reduces the endotheliopathy of trauma, circulating pro-inflammatory cytokines, and 30-day mortality among traumatically injured patients at risk of hemorrhagic shock. No clinical ...

    Abstract Background: Prehospital plasma administration during air medical transport reduces the endotheliopathy of trauma, circulating pro-inflammatory cytokines, and 30-day mortality among traumatically injured patients at risk of hemorrhagic shock. No clinical data currently exists evaluating the age of thawed plasma and its association with clinical outcomes and biomarker expression post-injury.
    Methods: We performed a secondary analysis from the prehospital plasma administration randomized controlled trial, PAMPer. We dichotomized the age of thawed plasma creating three groups: standard-care, YOUNG (day 0-1) plasma, and OLD (day 2-5) plasma. We generated HRs and 95% CIs for mortality. Among all patients randomized to plasma, we compared predicted biomarker values at hospital admission (T0) and 24 hours later (T24) controlling for key difference between groups with a multivariable linear regression. Analyses were repeated in a severely injured subgroup.
    Results: Two hundred and seventy-one patients were randomized to standard-care and 230 to plasma (40% YOUNG, 60% OLD). There were no clinically or statistically significant differences in demographics, injury, admission vital signs, or laboratory values including thromboelastography between YOUNG and OLD. Compared with standard-care, YOUNG (HR 0.66 (95% CI 0.41 to 1.07), p=0.09) and OLD (HR 0.64 (95% CI 0.42 to 0.96), p=0.03) plasma demonstrated reduced 30-day mortality. Among those randomized to plasma, plasma age did not affect mortality (HR 1.04 (95% CI 0.60 to 1.82), p=0.90) and/or adjusted serum markers by plasma age at T0 or T24 (p>0.05). However, among the severely injured subgroup, OLD plasma was significantly associated with increased adjusted inflammatory and decreased adjusted endothelial biomarkers at T0.
    Discussion: Age of thawed plasma does not result in clinical outcome or biomarker expression differences in the overall PAMPer study cohort. There were biomarker expression differences in those patients with severe injury. Definitive investigation is needed to determine if the age of thawed plasma is associated with biomarker expression and outcome differences following traumatic injury.
    Level of evidence: II.
    Language English
    Publishing date 2021-02-11
    Publishing country England
    Document type Journal Article
    ISSN 2397-5776
    ISSN (online) 2397-5776
    DOI 10.1136/tsaco-2020-000648
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Generating recombinant C-terminal prion protein fragments of exact native sequence.

    Johanssen, V A / Barnham, K J / Masters, C L / Hill, A F / Collins, S J

    Neurochemistry international

    2012  Volume 60, Issue 3, Page(s) 318–326

    Abstract: ... such as Creutzfeldt-Jakob disease (CJD) and murine models, the moderately extended C2 fragment predominates in the brain suggesting ...

    Abstract Transmissibility and distinctive neuropathology are hallmark features of prion diseases differentiating them from other neurodegenerative disorders, with pathogenesis and transmission appearing closely linked to misfolded conformers (PrP(Sc)) of the ubiquitously expressed cellular form of the prion protein (PrP(C)). Given the apparent pathogenic primacy of misfolded PrP, the utilisation of peptides based on the prion protein has formed an integral approach for providing insights into misfolding pathways and pathogenic mechanisms. In parallel with studies employing prion peptides, similar approaches in other neurodegenerative disorders such as Alzheimer Disease, have demonstrated that differential processing of parent proteins and quite minor variations in the primary sequence of cognate peptides generated from the same constitutive processing (such as Aβ1-40 versus Aβ1-42 produced from γ-secretase activity) can be associated with very different pathogenic consequences. PrP(C) also undergoes constitutive α- or β-cleavage yielding C1 (residues 112-231 human sequence) or C2 (residues 90-231), respectively, with the full cell biological significance of such processing unresolved; however, it is noteworthy that in prion diseases, such as Creutzfeldt-Jakob disease (CJD) and murine models, the moderately extended C2 fragment predominates in the brain suggesting that the two cleavage events and the consequent C-terminal fragments may differ in their pathogenic significance. Accordingly, studies characterising biologically relevant peptides like C1 and C2, would be most valid if undertaken using peptides completely free of any inherent non-native sequence that arises as a by-product of commonly employed recombinant production techniques. To achieve this aim and thereby facilitate more representative biophysical and neurotoxicity studies, we adapted the combination of high fidelity Taq TA cloning with a SUMO-Hexa-His tag-type approach, incorporating the SUMO protease step. This technique consistently produced sufficient yields (∼10 mg/L) of high purity peptides (>95%) equating to C1 and C2 of exact native primary sequence in the α-helical conformation suitable for biological and biophysical investigations.
    MeSH term(s) Amino Acid Sequence ; Blotting, Western ; Chromatography, Affinity ; Circular Dichroism ; DNA/genetics ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Genetic Vectors ; Inclusion Bodies/chemistry ; Molecular Sequence Data ; Oxidation-Reduction ; Peptide Fragments/biosynthesis ; Peptide Fragments/chemistry ; Prions/biosynthesis ; Prions/chemistry ; Protein Folding ; Protein Structure, Secondary ; Recombinant Proteins/biosynthesis ; Recombinant Proteins/chemistry ; Small Ubiquitin-Related Modifier Proteins ; Spectrometry, Mass, Electrospray Ionization
    Chemical Substances Peptide Fragments ; Prions ; Recombinant Proteins ; Small Ubiquitin-Related Modifier Proteins ; DNA (9007-49-2)
    Language English
    Publishing date 2012-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 283190-9
    ISSN 1872-9754 ; 0197-0186
    ISSN (online) 1872-9754
    ISSN 0197-0186
    DOI 10.1016/j.neuint.2011.12.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1610: Show issues Location:
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  9. Article ; Online: Unusual clinical and molecular-pathological profile of gerstmann-Sträussler-Scheinker disease associated with a novel PRNP mutation (V176G).

    Simpson, Marion / Johanssen, Vanessa / Boyd, Alison / Klug, Genevieve / Masters, Colin L / Li, Qiao-Xin / Pamphlett, Roger / McLean, Catriona / Lewis, Victoria / Collins, Steven J

    JAMA neurology

    2013  Volume 70, Issue 9, Page(s) 1180–1185

    Abstract: ... gene mutation.: Observations: This case report from the Australian National Creutzfeldt-Jakob ...

    Abstract Importance: Here we describe the unusual clinical and molecular-neuropathological profile of a case of Gerstmann-Sträussler-Scheinker disease associated with a novel prion protein (PRNP) gene mutation.
    Observations: This case report from the Australian National Creutzfeldt-Jakob Disease Registry concerns a 61-year-old British-born woman with no history of neurodegenerative disorder in first-degree relatives. Rapidly progressive dementia, altered behavior, and cerebellar ataxia dominated the clinical picture in the period immediately following minor elective surgery, with death 1 month later in an akinetic-mute state. Brain histopathological examination revealed neuronal loss, scant foci of spongiform change, and diffuse multicentric amyloid plaques, selectively immunoreactive for prion protein, within the cerebral and cerebellar cortices and deep gray matter. Tau immune-reactive neurofibrillary tangles and neuritic threads were present in the cerebral cortex. PRNP sequencing demonstrated a valine to glycine mutation at codon 176, with valine homozygosity at polymorphic codon 129. Western-blot analysis of frozen brain tissue displayed a nonclassic protease-resistant prion protein banding pattern, with a prominent approximately 8-kDa protease-resistant fragment.
    Conclusions and relevance: Reported is a proband with a novel PRNP mutation associated with neuropathologically confirmed Gerstmann-Sträussler-Scheinker disease displaying a somewhat unusual constellation of clinicopathological features, which overall subserve to further broaden an already diverse phenotypic spectrum.
    MeSH term(s) Creutzfeldt-Jakob Syndrome/diagnosis ; Creutzfeldt-Jakob Syndrome/genetics ; Creutzfeldt-Jakob Syndrome/pathology ; Female ; Genetic Predisposition to Disease ; Gerstmann-Straussler-Scheinker Disease/diagnosis ; Gerstmann-Straussler-Scheinker Disease/genetics ; Gerstmann-Straussler-Scheinker Disease/pathology ; Glycine/genetics ; Humans ; Middle Aged ; Mutation/genetics ; Neurofibrillary Tangles/genetics ; Neurofibrillary Tangles/pathology ; Pedigree ; Phenotype ; Prion Proteins ; Prions/genetics ; Valine/genetics
    Chemical Substances PRNP protein, human ; Prion Proteins ; Prions ; Valine (HG18B9YRS7) ; Glycine (TE7660XO1C)
    Language English
    Publishing date 2013-09-01
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2702023-X
    ISSN 2168-6157 ; 2168-6149
    ISSN (online) 2168-6157
    ISSN 2168-6149
    DOI 10.1001/jamaneurol.2013.165
    Database MEDical Literature Analysis and Retrieval System OnLINE

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